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vincristine sulfate

✓ Approved

Pierre Fabre S.A. · Small Molecule · Small Molecule

What is vincristine sulfate?

vincristine sulfate is a small molecule developed by Pierre Fabre S.A.. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

CompanyPierre Fabre S.A.
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Pierre Fabre S.A.

Therapeutic Indications

vincristine sulfate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

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PubMedWater environment research : a research publication of the Water Environment Federation2026-11-11

Impacts of Longwall Mining-Induced Goafs on Sulfate Generation and Biogeochemical Transformation in a Multiaquifer System: Insights From C, S, O, and H Isotopes.

Yang Zhengqiu Z, Fang Jie J, Zhao Yongqiang Y, Zhang Yaobin Y et al.

Longwall mining disrupts overlying strata and creates goafs, altering groundwater conditions and the chemical composition of affected aquifer systems. In arid and semiarid regions, understanding how deep coal extraction influences sulfate biogeochemistry is essential for assessing mining-related groundwater degradation and protecting scarce groundwater resources. This study combined major-ion chemistry, water isotopes (δD and δ18Owater), sulfate isotopes (δ34S and δ18OSO4), δ13CDIC, and Bayesian isotope mixing analysis to investigate sulfate sources and transformation in the multiaquifer system and goaf of the Jinjie Coal Mine, China. The results reveal a marked contrast between sulfate generation in the goaf and its subsequent transformation in the Jurassic aquifers. Pyrite oxidation and associated carbonate dissolution dominate sulfate and dissolved inorganic carbon (DIC) production in goaf water, whereas Bayesian source apportionment identifies pyrite oxidation as the principal sulfate source in most goaf-water samples. The spatial variation in source contributions is consistent with differences in the thickness and continuity of the Baode aquitard. Mining-induced fracturing, locally extending to the surface, facilitates the exposure of pyrite-bearing strata to oxygenated water and air, promoting sulfate generation in the goaf. The resulting sulfate subsequently enters the Jurassic aquifers, where relatively confined and reducing conditions favor bacterial sulfate reduction. Sulfate depletion, enrichment of residual sulfate in heavy sulfur and oxygen isotopes, and relatively depleted δ13CDIC values provide complementary evidence for this transformation. These findings provide a process-based framework for understanding sulfate evolution in mining-affected groundwater systems.

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PubMedCase reports in oncological medicine2026-11-11

Orbital Diffuse Large B-Cell Lymphoma Masquerading as Periorbital Cellulitis in a Paediatric Patient With Ataxia-Telangiectasia: A Case Report.

Alabdulrazzaq Fajer F, Alkanderi Arwa A, AlHazeem Bashayer B, Alenezi Abdullah A

Ataxia-telangiectasia (A-T) is a rare autosomal recessive disorder characterised by cerebellar ataxia, combined immunodeficiency and elevated predisposition to lymphoid malignancy, rendering orbital malignancy clinically and radiologically indistinguishable from infection. We report a 7-year-old female with A-T presenting with left periorbital cellulitis unresponsive to prolonged antimicrobial therapy, surgical drainage and antifungal escalation. Incisional biopsy of a persistent periorbital mass revealed diffuse large B-cell lymphoma (DLBCL), confirmed on immunohistochemistry. Staging indicated Lugano-modified Ann Arbour Stage IV disease, with a primary orbital mass and non-contiguous mediastinal and abdominal disease on cross-sectional imaging. Bone marrow assessment showed no morphological involvement, although flow cytometry detected a light chain-restricted B-cell population. The pulmonary lesions could not be radiologically distinguished from necrotising infection. She received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) with cyclophosphamide and vincristine reduced to approximately 50% of standard doses but died approximately 2 months after diagnosis, following a severe necrotising pulmonary infection after the second treatment cycle. This case underscores the importance of early malignancy consideration in immunocompromised A-T patients with refractory orbital disease, the critical role of timely tissue biopsy and the diagnostic difficulty of distinguishing lymphomatous involvement from infection on imaging alone in this population.

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PubMedSmall methods2026-11-11

Modulated Laser-Assisted Nanopore Fabrication With Ammonium Sulfate for Single-Molecule Sensing.

Matsuda Kyosuke K, Hirano Taichi T, Takahashi Shu S, Hagiwara Hidetaka H et al.

Nanopore sensing provides a label-free platform for single-molecule analysis. To achieve reliable solid-state nanopore sensing, however, it is essential to optimize appropriate nanopore fabrication methods, as variations in pore diameter, geometry, surface state, and fabrication residues can affect molecular discrimination capability. Here, we report a temporally modulated CW laser-assisted dielectric breakdown method for facilitating in-situ fabrication of nanopores in silicon nitride membranes, coupled with ammonium sulfate electrolytes to improve sensing performance. Systematic characterization revealed that temporally modulated CW laser minimizes contamination/debris formation during pore fabrication and yields improved nanopore sensing. Streaming-potential measurements and interfacial ion-transport simulations suggest that ammonium-containing electrolytes modify the SiN nanopore interface by promoting NH4 + adsorption on the inner pore surface as well as SO4 2- ions, thereby enhancing DNA-pore interactions. This effect slowed a subset of DNA translocation events, enabling longer dwell-time observations and differentiation between poly(dA) and poly(dC) blockade populations. Furthermore, aptamer-assisted detection enabled detection of Scp1-bound aptamer complexes under conditions where the protein alone tended to clog the pore. The Scp1-aptamer complex showed prolonged dwell times compared with those of free aptamers, even under 0.14 M KCl. Together, these results demonstrate that integrating our approach provides an improved approach for high-performance single-molecule nanopore detection.

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PubMedMedicine2026-11-11

Uncovering metabolite-inflammatory protein interactions in gout pathogenesis: A 2-sample bidirectional Mendelian randomization study.

Chen Shuai S, Gan Yudong Y, Jin Yan Y, Wang Feng F et al.

Gout is a widespread inflammatory arthritis whose current treatments focus mainly on symptom relief and urate lowering. Recent work suggests that circulating metabolites and inflammatory proteins interact in complex ways to influence disease risk, with fibroblast growth factor 19 (FGF19) standing out as a potential regulatory node linking metabolism and inflammation. We performed bidirectional 2-sample Mendelian randomization using genome-wide association study summary statistics for 1440 serum metabolites and 91 inflammatory proteins, with gout outcomes drawn from FinnGen R12. Mediation analyses were then applied to examine whether FGF19 acts as an intermediary in selected metabolite-gout pathways. Genetically predicted levels of vanillactate and histidine betaine were associated with higher gout risk, whereas sphingomyelin species and taurolithocholate 3-sulfate showed protective effects. Among inflammatory proteins, FGF19, adenosine deaminase and FGF5 appeared protective, while cluster of differentiation 244 increased risk. Bidirectional analyses revealed reciprocal relationships, including a negative causal effect of propionylcarnitine on FGF19. Mediation testing further showed that FGF19 explained 7.88% of the total effect of lipid-related metabolites on gout via glycodeoxycholate 3-sulfate and 9.58% via cis-3,4-methyleneheptanoylglycine. These findings indicate that FGF19 may exert protective effects against gout partly by modulating bile acid and fatty acid metabolism. The results offer genetic evidence for metabolic-immune crosstalk in gout pathogenesis and highlight FGF19-related pathways as possible targets for more precise therapeutic strategies.

PMID 43012810
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PubMedMedicine2026-11-11

Intravascular large B-cell lymphoma presenting as unilateral lymphedema in a patient with rheumatoid arthritis and sarcoidosis: A case report.

Kimura Masatoshi M, Sasaki Haruka H, Kudo Risa R, Murai Masayuki M et al.

Intravascular large B-cell lymphoma (IVLBCL) is an uncommon subtype of diffuse large B-cell lymphoma, typically presenting with nonspecific symptoms and lacking lymphadenopathy or visible tumor lesions, which makes early diagnosis challenging. A 66-year-old female developed progressive unilateral lymphedema despite ongoing treatment for rheumatoid arthritis and sarcoidosis. Sarcoidosis-related lymph node lesions were also considered as a potential cause, and the prednisolone dose was increased. Despite these measures, the edema worsened, and a fever of around 38°C developed. At the initial evaluation, the serum soluble interleukin-2 receptor level was already elevated at 9985 U/mL. Initial investigations, including imaging, bone marrow aspiration, and random skin biopsies, failed to reveal malignancy. Subsequent monitoring revealed that the serum level of serum soluble interleukin-2 receptor had risen further to 19,835 U/mL and that thrombocytopenia was present, prompting a repeat random skin biopsy that ultimately confirmed IVLBCL through the identification of intravascular cluster of differentiation 20-positive lymphoma cells. Chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone was initiated. However, the patient developed peripheral neuropathy, suspected to be an adverse drug reaction. Consequently, the regimen was switched to polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisolone. After completing 8 courses, the patient achieved remission. The left lower-limb lymphedema improved significantly. This case highlights several clinically significant points: first, IVLBCL can present solely as unilateral lymphedema without detectable lymph node enlargement or tumorous lesions, underscoring the diagnostic difficulty. Second, repeated random skin biopsies, including adipose-rich vascular tissue, are crucial in establishing a definitive diagnosis when initial biopsies are inconclusive. Third, patients with underlying autoimmune conditions such as rheumatoid arthritis and sarcoidosis, particularly those receiving immunosuppressive therapies, may have an increased susceptibility to lymphoma, suggesting that systemic immune dysregulation could contribute to disease onset.

PMID 43012796
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PubMedJournal of agricultural and food chemistry2026-11-11

Azelaic Acid Mediates the Protective Effect of Lactiplantibacillus plantarum F1m against Colitis via PPARγ Activation.

Jia Dan D, Han Yuan Y, Li Zhi Z, Zhang Xueyong X et al.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a high recurrence risk. Although probiotics show promise for UC treatment, the underlying mechanisms remain incompletely understood. Herein, we found that Lactiplantibacillus plantarum F1m, isolated from yak yogurt, alleviated dextran sulfate sodium (DSS)-induced colitis in mice, improving symptoms, restoring intestinal barrier function, and alleviating gut microbiota dysbiosis. F1m reversed DSS-induced phylum-level changes by increasing Bacteroidota and decreasing Bacillota, and enriched Faecalibaculum and Akkermansia at the genus level. Mechanistically, F1m suppressed the NF-κB and ERK/MAPK pathways while activating PPARγ signaling. Metabolomics revealed elevated azelaic acid (AzA) levels in F1m-treated mice, positively correlated with the abundances of Bifidobacterium bifidum, Bifidobacterium pluvialisilvae, and Methanobrevibacter smithii. Furthermore, AzA was identified as a microbiota-derived PPARγ ligand, and exogenous AzA alleviated colitis in a PPARγ-dependent manner. Collectively, these findings indicate that F1m enhances AzA production by modulating gut microbiota, thereby protecting against colitis via PPARγ activation.

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