Drug Database
AL

albumin (Pedialb / AlbuRel / AlbuRel LS)

✓ Approved

Reliance Life Sciences Private Limited · Cell-based Therapies · Cell-based Therapies

What is albumin?

albumin is a cell-based therapies developed by Reliance Life Sciences Private Limited. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesPedialb, AlbuRel, AlbuRel LS
CompanyReliance Life Sciences Private Limited
Drug ClassCell-based Therapies
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Reliance Life Sciences Private Limited

Therapeutic Indications

albumin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved

Related Research Articles

PubMedCancer medicine2026-09-19

Preoperative Glucose-to-Albumin Ratio as a Prognostic Marker for Survival in Pancreatic Cancer Patients Undergoing Pancreatectomy.

Feci Andrea A, Lavine Isabel I, Shah Sophia S, Kraft Matthew M et al.

Pancreatic cancer (PC) disrupts metabolic and nutritional processes, including glucose homeostasis and albumin levels. Both hyperglycemia and hypoalbuminemia have been linked to poorer outcomes in various cancers, including PC. This study investigates the preoperative glucose-to-albumin ratio (GAR) as a potential prognostic marker of overall survival in patients undergoing pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). This single-center retrospective analysis included patients who underwent curative-intent pancreatectomy for PDAC and adenosquamous carcinoma of the pancreas between 2017 and 2024. GAR was calculated from preoperative laboratory tests. Kaplan-Meier and Cox regression analyses were performed for recurrence-free and overall survival. A total of 566 patients were included (51% males and 49% females, mean age 68.3); 548 had PDAC and 18 had adenosquamous carcinoma of the pancreas. High GAR was associated with elevated CA 19-9, CEA and BMI (p < 0.0001, p < 0.0001, p = 0.02, respectively), more advanced T staging (p = 0.001), increased tumor size (p = 0.007), and AJCC staging (p = 0.04), as well as perineural invasion (p = 0.01) and lymphovascular invasion (p = 0.008). Kaplan-Meier analysis demonstrated significantly worse overall survival in high GAR patients (26.6 vs. 35.0 months, p = 0.004), while low albumin was associated with significantly worse recurrence-free survival (15.5 vs. 20.7 months, p = 0.04). Cox regression identified high GAR (HR = 1.3, p = 0.04), lower BMI (Body Mass Index) (p = 0.02), higher CA 19-9 (p = 0.006), N staging (p = 0.002), histological tumor grading (p < 0.0001), neoadjuvant chemotherapy (p = 0.002) and perineural invasion (p = 0.03) as independent risk factors for poorer overall survival. Higher preoperative GAR is associated with more advanced disease at presentation and an adverse prognosis in patients with resected PC.

PMID 42760632
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PubMedMedicine2026-09-19

Association of blood parameters and ratios with aseptic loosening after total knee arthroplasty: A retrospective cohort study.

Kurt Mehmet M, Yilmaz Selcuk S, Dulgeroglu Turan Cihan TC, Kartal Emre Mucahit EM

This study aimed to evaluate the association of blood parameters and ratios with knee prosthesis loosening in patients after knee arthroplasty. A total of 221 patient files having knee prosthesis attempting to our clinic between 2018 and 2022 were retrospectively examined. Patients were divided into 2 groups as loosening (n = 108; 48.9%) and not loosening (n = 113; 51.1%) groups. Monocyte/high-density lipoprotein (HDL) ratio monocyte-to-HDL ratio (MHR), Neutrophil/lymphocyte ratio, Albumin/ C-reactive protein (CRP) ratio, albumin-to-C-reactive protein ratio (ACR), Eosinophile-to- lymphocyte ratio, mean platelet volume /PLT ratio mean platelet volume-to-platelet ratio, Monocyte -to-lymphocyte ratio, Platelet/lymphocyte ratio (PLR) and Hemoglobin/Platelet ratio (HPR) parameters of patients were evaluated. HDL, albumin, hemoglobin, ACR, PLR and HPR levels were significantly higher in loosening patients (P < .05). CRP, neutrophile, lymphocyte, monocyte and MHR means were significantly higher in no-loosening patients (P < .05). Loosening was significantly correlated with gender (R = 0.141; P < .05), HDL (R = 0.474; P < .01), albumin (R = 0.349; P < .01), CRP (r = -0.466; P < .01), neutrophile (r = -0.167; P < .05), lymphocyte (r = -0.240; P < .01), monocyte (r = -0.380; P < .01), hemoglobin (R = 0.254; P < .01), MHR (r = -0.513; P < .01), ACR (R = 0.496; P < .01), PLR (R = 0.142; P < .05) and HPR (R = 0.204; P < .01). Binary logistic regression analysis showed that MHR (B = -0.415; P < .01), ACR (B = 0.048; P < .01), and HPR (B = 30.640; P < .05) were significantly associated with knee prosthesis loosening at the multivariate level. ROC analysis demonstrated statistically significant discriminative performance for MHR, area under the curve ([AUC] = 0.798; P < .01), ACR (AUC = 0.786; P < .01), and HPR (AUC = 0.618; P < .01). For MHR 6.2481 cutoff level, sensitivity was 72.2% and specificity was 10.6%. For ACR 8.6380 cutoff level, sensitivity was 84.3% and specificity was 59.3%. For HPR 0.0506 cutoff level, sensitivity was 63.9% and specificity was 54.0%. MHR, ACR, and HPR were significantly associated with aseptic loosening after total knee arthroplasty and may be considered potential associated markers rather than definitive predictors.

PMID 42760748
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PubMedSignal transduction and targeted therapy2026-09-19

A randomized, double-blind, active-controlled phase 3 multicenter trial of rHSA for cirrhotic ascites.

Jia Jidong J, An Yajun Y, Ou Xiaojuan X, Duan Weijia W et al.

In this multicenter, randomized, double-blind, active-controlled phase 3 trial (NCT06553456), we assessed the equivalence of recombinant human serum albumin (rHSA) expressed in Pichia pastoris to plasma-derived human serum albumin (pHSA) for elevating serum albumin (ALB) levels and non-inferiority regarding ascites improvement in patients with cirrhotic ascites. Using a rigorous dual-endpoint design, the primary endpoint was the change from baseline in serum ALB immediately after the final intravenous infusion. The key secondary endpoint was the ascites improvement rate after the final administration. Ultimately, 364 out of 390 patients completed the study. Statistical equivalence was established for the primary endpoint, with least-squares mean ALB changes of 11.16 ± 0.364 g/L (rHSA) and 10.95 ± 0.395 g/L (pHSA) (LSM difference: 0.21 g/L [95% CI: -0.75, 1.16]). For the secondary endpoint, ascites improvement was non-inferior, demonstrating a 58.0% response rate for rHSA versus 48.7% for pHSA (difference: 9.4% [95% CI: -0.56%, 19.10%]). Both endpoints of the trial were successfully achieved. The overall incidence of adverse events was similar in the two groups; crucially, no anti-drug antibodies were detected in the rHSA group. Exploratory analysis revealed that rHSA significantly reduced glycated ALB (-12.24%), whereas pHSA increased it ( + 12.52%) (P < 0.001). Corroborated by LC‒MS characterization, silver-staining purity assessment, and four biochemical quality attributes (free thiol, Hcy, AGEs, and carbonyl levels), this divergence highlights the preserved molecular integrity of rHSA. This trial demonstrated that in patients with cirrhotic ascites, rHSA was statistically equivalent to pHSA in elevating serum ALB and non-inferior in ascites improvement, with a favorable safety profile.

PMID 42760319
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PubMedMedicine2026-09-19

Prognostic value of the HALP (hemoglobin, albumin, lymphocyte, and platelet) score in emergency versus elective inguinal hernia repair: A retrospective study.

Öğüt Mehmet Zeki MZ, Ağ Onur O, Kutluer Nizamettin N, Saricik Bekir B et al.

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel prognostic biomarker that reflects a patient's immune-nutritional status. This study aimed to evaluate the diagnostic and prognostic value of the HALP score in patients undergoing emergency versus elective inguinal hernia repair. This retrospective study analyzed data from 235 patients who underwent inguinal hernia surgery at a single center. The patients were categorized into emergency (n = 97) and elective (n = 138) groups, with the emergency group further divided into intestinal resection (n = 12) and non-resection (n = 85) subgroups. Preoperative HALP scores were significantly lower in the emergency group than in the elective group (P < .001). Subgroup analysis revealed that HALP scores were significantly lower among patients who required intestinal resection compared with those who did not require resection in the emergency group and those who underwent elective surgery (P = .004 and P < .001, respectively). Univariate analysis showed that the HALP score was associated with small bowel resection. Receiver operating characteristic curve analysis demonstrated that a HALP score cutoff value of < 2.31 yielded 75% sensitivity and 90.2% specificity for predicting intestinal resection in incarcerated inguinal hernia. The accessibility and cost-effectiveness of the HALP score support its use as an adjunctive tool for risk stratification in inguinal hernia management, particularly in resource-limited settings.

PMID 42760682
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PubMedCell biochemistry and biophysics2026-09-19

Acetone Extract of Annona Muricata Linn Leaf Counteracts Hyperglycemia-Associated Metabolic Dysregulation by Modulating Oxidative Stress and Hepatic Carbohydrate Metabolism in Streptozotocin-Induced Diabetic Rats.

Omiyale Benjamin Olusola BO, Ekundayo Bidemi Emmanuel BE, Olusola Olutosin Samuel OS, Idowu Olajumoke Tolulope OT et al.

Annona muricata is widely recognized for its rich phenolic composition and potent antioxidant activity, suggesting therapeutic potential in diabetes management. This study investigated the mechanistic antidiabetic effects of acetone extract of A. muricata leaf on hepatic carbohydrate metabolism, oxidative stress, and hepatic function in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in forty-two male Wistar rats by intraperitoneal injection of STZ (55 mg/kg). Diabetic animals (n = 7 per group) were treated with 25, 50, and 100 mg/kg of the extract (yield: 10.08% w/w) for 28 days, while metformin (200 mg/kg) served as the standard drug. Hepatic antioxidant enzyme activities, lipid peroxidation, serum albumin, lactate dehydrogenase (LDH), and histopathological alterations were evaluated to assess oxidative status and hepatic function, alongside the activities of key carbohydrate-metabolizing enzymes and mRNA expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter 4 (GLUT4). Administration of the acetone extract significantly enhanced hepatic antioxidant defenses, as demonstrated by increased levels of glutathione and increased activities of antioxidant enzymes, accompanied by a marked reduction in lipid peroxidation. Additionally, the extract significantly restored serum albumin levels and reduced LDH activity, indicating improved hepatocellular integrity. Furthermore, the extract significantly impacted the activities of carbohydrate-metabolizing enzymes and restored the expression of PPAR-γ and GLUT4 toward physiological levels. These results suggest that the antidiabetic activity of A. muricata may be mediated by the attenuation of oxidative stress, preservation of hepatic function, and regulation of hepatic carbohydrate metabolism and glucose transporter signalling pathways, highlighting its potential as a promising phytotherapeutic agent for the management of diabetes.

PMID 42760481
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PubMedFrontiers in neurology2026-09-19

Impact of the red blood cell distribution width-to-albumin ratio on neurological outcomes in cardiac arrest patients.

Yang Xiaoli X, Wang Haiyan H, Wang Fei F, Peng Fei F

Brain injury remains the leading cause of mortality and morbidity among patients who experience cardiac arrest and cardiopulmonary resuscitation (CA/CPR). There is an urgent need to explore simpler and cheaper biomarkers to predict post-CA neurological outcomes. The red blood cell distribution width-to-albumin ratio (RA) has been used to assess inflammatory responses and prognosis in several diseases. This study was conducted to assess the correlation between RA levels and post-CA neurological outcomes, and to determine the value of RA in predicting neurological function after CA/CPR. We conducted a retrospective observational study on out-of-hospital cardiac arrest (OHCA) cases presenting to our hospital's emergency department between January 2023 and April 2026. All patients were divided into cohorts with good or poor neurological outcomes according to cerebral performance categories (CPCs). Cox regression models were used to estimate the correlation between RA and neurological outcomes. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the ability of RA to predict neurological outcomes in patients after CA/CPR. In total, 80 patients were involved, of whom 10 survived to hospital discharge with good neurological function (CPC ≤ 2), while the remaining subjects showed poor neurological function (CPC ≥ 3). RA levels were significantly higher in patients with poor neurological outcomes than in those with good outcomes. The AUC for the RA was 0.90, indicating excellent predictive accuracy. The RA values were independently associated with poor neurological outcomes following CA/CPR, even after adjusting for potential confounding factors. We found that RA is associated with post-CA neurological outcomes, and higher RA levels could serve as a predictor of worse neurological outcomes in patients who undergo CPR after experiencing CA.

PMID 42761066
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