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TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · Recombinant Proteins

What is teriparatide?

teriparatide is a recombinant proteins developed by Shenzhen Salubris Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesXinfutai
CompanyShenzhen Salubris Pharmaceuticals Co., Ltd.
Drug ClassRecombinant Proteins
Molecular TargetPTH1R
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

teriparatide acts on 1 molecular target:

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

teriparatide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Linolenic acid compound powder improves reproductive damage induced by high fat diet in male rats].

Wang Yibo Y, Sun Ruijie R, Ji Linpu L, Liu Qiaorui Q et al.

Objective To evaluate the effect of linolenic acid compound powder (flaxseed microcapsule powder, okra powder, mulberry leaf powder) on the reproductive function of male rats induced by high fat diet. Methods Ninety 8-week-old male SD rats were randomly divided into six groups, with 15 rats in each group. The rats in the blank group were fed with normal diet. While the rats in model group were fed with high-fat feed, and the low-, medium- and high-dose groups of linolenic acid combined powder were fed with low-, medium- and high-dose respectively, as well as the simvastatin positive control group. After 4 weeks of high-fat diet modeling, the compound powder was continuously administered by gavage for 4 weeks. The body weight, epididymis and testis weight of rats in each group were recorded. Sperm concentration and motility were detected. HE staining was used to observe testicular pathological damage, and Oil Red O staining was used to observe fat distribution. Lipid, oxidative stress and sex hormone indicators were also detected. Results Compared with the model group, treatment with the linolenic acid mixture or the positive control drug significantly increased body weight in rats to levels exceeding those in the blank control group (all P<0.05). There were no statistically significant differences in the testicular and epididymal coefficients parameters across the three experimental groups (P>0.05). Sperm motility and Sperm viability was significantly higher in all linolenic acid complex powder dose groups and the positive control group compared to the model group (all P<0.05). Compared with the model group, the testis interstitium of the linolenic acid compound powder groups returned to normal. The seminiferous tubules returned to order. The number of spermatogenic cells and Sertoli cells at all levels increased. All kinds of cells were dense and the structure was complete. Compared with the model group, the testicular tissue of the linolenic acid compound powder groups had less stained area and lighter color, and the medium-dose group had less stained area and lighter color than the low-dose group and the high-dose group. There was no significant difference in oxidative stress among groups (P>0.05). The level of LH in the model group was lower than that in the blank group. Which increased in the linolenic acid compound powder groups significantly (P<0.05). Administration of linolenic acid compound powder all doses and the positive control significantly decreased the levels of ALP, ALT and AST in liver tissue compared with the model group. Additionally, a significant reduction in serum CRE was observed in the low- and medium-dose groups (all P<0.05). Conclusion A high-fat diet leads to a decline in the physiological structure and antioxidant capacity of the testes in rats, as well as changes in sex hormone levels. Linoleic acid complex powder can improve the related symptoms and indicators of reproductive function in rats with high-fat diet.

PMID 43012198
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PubMedClinical case reports2026-11-11

False-Positive Elevation of Serum Levels of Human Chorionic Gonadotropin (hCG) Evoked by Dietary Supplements in a Patient With Testicular Seminoma-A Case Report.

Dieckmann Klaus-Peter KP, Angerer Markus M, Schnabel Claudia C, Wülfing Christian C

A 26-year-old patient developed false-positive elevation of human chorionic gonadotropin (hCG) serum levels 2 years after cure from testicular seminoma. The increased levels normalized without any intervention after cessation of oral intake of dietary supplements consisting of creatine, multivitamin pills, and amino acid powder.

PMID 43011507
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PubMedNature communications2026-11-11

Enhancing ω-transaminase catalysis of bulky substrates guided by binding mechanism.

Teng Haidong H, Yu Haoran H, Xu Zhehang Z, Xiao Lanxin L et al.

Chiral amines are indispensable building blocks in pharmaceutical synthesis. (R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol (ABP), a key chiral amine intermediate of the drug Entresto, has remained difficult to access via enzymatic asymmetric synthesis due to the inability of ω-transaminases to accommodate its bulky ketone precursor. Here, we engineer an ω-transaminase from Bacillus megaterium by integrating Funnel metadynamics, PathDetect-SOM, and path collective variables to reconstruct the free energy surface of substrate binding, pinpointing high-energy barrier regions of the binding process and the trade-off between tunnel accessibility and productive binding. Dynamic cross-correlation network analysis further identifies distal regulatory sites governing these bottleneck regions. Iterative experimental optimization yields the 13M variant, exhibiting catalytic activity 106 times that of the wild type with >99% enantiomeric excess, enabling the efficient enzymatic asymmetric synthesis of ABP. This integrated computational-experimental framework for resolving the tunnel-pocket binding trade-off offers a generalizable strategy for engineering ω-transaminases toward bulky substrates in green pharmaceutical synthesis.

PMID 43009519
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PubMedGlobal spine journal2026-11-11

Intrawound Vancomycin Powder in Posterior Lumbar Fusion: In Vitro Osteoblast Effects and Clinical Outcomes in a Historical-Control Cohort.

Truumees Heili H, Friedman Lindley I N LIN, Schmirler Joshua J, Sinclair Sarina S et al.

Study DesignRetrospective analysis.ObjectivesTo analyze the immediate post-operative effects on osteoblast activity, and long-term impact on bone healing, of intrawound vancomycin powder following posterior lumbar fusion (PLF).MethodsThis study had two phases: (1) an in vitro analysis of vancomycin effects on osteoblasts and (2) a retrospective chart review-spanning over a decade-analyzing outcomes of vancomycin use in PLF patients. Cellular metabolic and osteogenic activities were evaluated using well-established in vitro assays. The retrospective chart review included patients ages 18+ who underwent PLF (four levels or fewer) between January 2007-December 2015. Patients were divided into two groups: the pre-vancomycin group (PVG) and the vancomycin group (VG). Statistical analyses included descriptive and comparative analyses across groups.ResultsPhase One included 56 patients. Drain vancomycin concentrations peaked at POD 0, averaging 1253.67 ng/µL. Osteoblasts exposed to vancomycin concentrations of 1,250 ng/µL had significantly lower ALP activity compared to those exposed to 0, 245, 285, and 500 ng/µL (ps<0.05). Phase Two included 425 patients: 232 in the PVG and 193 in the VG. SSIs requiring debridement were observed in 3.02% of PVG patients compared to 2.07% of VG patients (p=0.761). There were no differences in pseudoarthrosis across cohorts (p=0.886), but lucency was more common in the VG (25.39%) than the PVG (11.64%; p<0.001).ConclusionsLocal drain concentrations of vancomycin decreased significantly across the postoperative period, suggesting its effects on osteoblasts are limited to the early inflammatory phase. In the long-term, intrawound vancomycin may not impact risk of SSI or pseudoarthrosis.

PMID 43012129
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PubMedMedicine2026-11-11

Clinical features of external auditory canal foreign bodies in children: A retrospective analysis of 678 cases.

Ling Zhijuan Z, Xiao Ping P, Ye Lihua L, Pan Hongguang H et al.

This study sought to characterize the clinical features of external auditory canal (EAC) foreign bodies (FBs) in pediatric patients and identify safe and effective removal strategies. A retrospective cohort study was performed on 678 children with EAC FBs who presented to the Department of Otorhinolaryngology at Shenzhen Children's Hospital between January 2022 and December 2025. Demographic data, FB types, affected ear laterality, clinical symptoms, duration of impaction, removal modalities, complications, and clinical outcomes were extracted and analyzed from medical records. The cohort comprised 437 males (64.45%) and 241 females (35.55%), with children under 8 years old accounting for 73.45% of cases. The right ear was most commonly affected (57.82%), followed by the left ear (36.73%) and bilateral ears (5.46%). Stones/sand (25.22%) and beads (23.30%) were the most prevalent FB types. Most patients (83.78%) sought medical attention within 1 day of impaction. In 635 cases (93.66%), FBs were removed by the self-made irrigator in the otolaryngology department; in 19 cases (2.80%), they were removed by McClintock forceps or gun-shaped tweezers under otoscope; while in 24 cases (3.54%), removal was performed under general anesthesia (GA). Complications included EAC abrasion (44, 6.49%), tympanic membrane injury (15, 2.21%), and tympanic membrane perforation (10, 1.47%). The self-made irrigator achieved high removal success within our selected cooperative pediatric cohort and represents a safe, efficient tool associated with lower observed charges in this cohort, with clinical practical value under appropriate patient selection. Otoscopic removal under GA is a necessary alternative for uncooperative pediatric patients with EAC FBs.

PMID 43012848
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PubMedQuality management in health care2026-11-11

"Bureaucratic Blockage" in Healthcare Resource Management: A Qualitative Study of Nurse Managers' Operational Decisions.

Alves Tiago T, Martins Maria Manuela MM, Araújo Isabel I

Reliable access to materials, pharmaceutical products, and functional equipment is essential for operational readiness and quality management in healthcare. However, nurse managers often make resource-management decisions within fragmented information systems and governance arrangements that limit timely local action. This study examined how information and governance constraints shape nurse managers' operational decisions in healthcare resource management and developed, inductively, from the qualitative findings, the concept of "bureaucratic blockage" to describe a mechanism that may constrain timely local action. A qualitative descriptive study was conducted with 16 nurse managers (8 from hospital and 8 from primary care/community settings) in Portugal. Data were collected through semi-structured interviews conducted between January and August 2025. Interviews were audio-recorded, transcribed verbatim in Portuguese, pseudonymized, and analyzed using Bardin's inductive content analysis. ATLAS.ti was used for data management. Reporting was guided by the Consolidated Criteria for Reporting Qualitative Research. Sixty-two resource-related meaning units were identified and organized into 2 thematic domains: management of material and pharmaceutical resources (reported across both settings) and management of equipment (reported by hospital managers only). Material and pharmaceutical decisions were constrained by limited order traceability, weak stock and lifecycle monitoring, restricted access to consumption and cost data, fragmented platforms, material shortages, and repeated ordering work. Equipment-related decisions, reported only by hospital managers, were shaped by unclear failure-response pathways, the absence of fault-management systems, limited autonomy in acquisition decisions, and administrative overload. In participants' accounts, information opacity, nonintegrated systems, and escalation-dependent processes co-occurred across domains, and restricted decision rights were described in hospital equipment management; their accumulation was synthesized inductively as a mechanism termed "bureaucratic blockage." Resource-management decisions are constrained by system-level factors that limit managerial capacity for timely, locally actionable responses. Quality-management interventions should strengthen resource traceability, system interoperability, and lifecycle monitoring and, in hospital equipment management, fault-management circuits and the alignment between managerial accountability and decision rights. Addressing "bureaucratic blockage" may reduce administrative escalation and support operational readiness; these consequences were inferred from participants' accounts, were not measured, and require empirical testing.

PMID 43012361
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