Drug Database
TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · Recombinant Proteins

What is teriparatide?

teriparatide is a recombinant proteins developed by Shenzhen Salubris Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesXinfutai
CompanyShenzhen Salubris Pharmaceuticals Co., Ltd.
Drug ClassRecombinant Proteins
Molecular TargetPTH1R
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

teriparatide acts on 1 molecular target:

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

teriparatide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedJournal of biopharmaceutical statistics2026-05-24

An exploratory application of modern statistical methodology and machine learning techniques in assessment of crystallinity monitoring and control strategy development for high-risk drug manufacturing.

Chen Kevin L KL, Chen Yingjie Y, Wu Huiquan H

Pharmaceutical polymorphism and crystallinity changes may have significant impact on drug's quality, efficacy, and safety. The risk mitigation strategies include pharmaceutical development, monitoring and control strategy establishment during manufacturing, and stability monitoring program during storage. All of those are resources intensive. During data mining and analysis of risk mitigation strategies of new drug applications (NDAs) and abbreviated new drug applications (ANDAs) which may involve polymorphism and crystallinity change, one of the challenges is data heterogeneity encountered in submissions. This data heterogeneity may result in data not readily available for automated analysis which is called missing data. Modern statistical methodologies are available to handle this missing data and associated data analyses; however, very limited deployment of these methods to pharmaceutical chemistry, manufacturing, and controls (CMC) regulatory domain being reported. In big data era, consideration of statistical methodologies in this field will become continuously more important as the amount of available data in regulatory submissions increases. In this study, through data mining of approved NDAs and ANDAs by the FDA during the years 2017-2022 which had polymorphism and/or crystallinity keywords, we established a dataset which contained 148 approved NDAs and ANDAs and involved crystallinity monitoring and control strategy development of high-risk drug product manufacturing processes. Then, we applied several advanced machine learning techniques for exploratory pattern recognition and risk classification in the pharmaceutical manufacturing CMC domain. Furthermore, we conducted Monte Carlo simulations to demonstrate the feasibility of risk classification with generated synthetic outcomes using supervised machine learning techniques to the dataset established.

PMID 42177643
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PubMedChemSusChem2026-05-24

Enhancing High-Salinity Tolerance in Photocatalytic Hydrogen Evolution via Membrane-Integrated Asymmetrically Polarized Catalysts.

Shi Yuying Y, Long Jialiying J, Yang Man M, Li Runjie R et al.

Developing efficient photocatalytic hydrogen evolution (PHE) systems under a high-salinity seawater environment is extremely attractive for sustainable energy, which still suffers from the rational design of core photocatalysts. Here, a membrane-integrated collaborative strategy via incorporating asymmetric-polarization photocatalysts was proposed. The specific electron mediators (TPyB-X) bearing diverse molecular symmetry were used to modify the prototypical semiconductor graphitic carbon nitride (CN). Among them, powder-state CN-1%TPyB-A1 exhibits the best PHE performance of 4179 μmol·g-1·h-1, which is 6.7 times over pure CN. Characterization and theoretical calculations reveal that the asymmetric structure of TPyB-A1 facilitates the formation of a gradient microelectric field, which promotes directional charge separation and contributes to the enhanced PHE activity. Moreover, the membrane-based CN-A1-EEA displays a satisfactory PHE activity with both freshwater (5114 μmol·m-2·h-1) and simulated seawater (5285 μmol·m-2·h-1), exhibiting more stable performance than the powder-state CN-1%TPyB-A1 (decreasing by 34%). This work demonstrates that the membrane-integrated photocatalyst can effectively resist high-salinity environments, which gives a new clue to rationally design the related materials working in seawater.

PMID 42177633
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PubMedJournal of stomatology, oral and maxillofacial surgery2026-05-24

Synergistic Effects of Intermittent Parathyroid Hormone (1-34) and Masticatory Force for Alveolar Bone Remodeling in the Maxilla of Dogs.

Kim Min-Ji MJ, Moon Ho-Jin HJ, Kyoung Do-Kyoung DK, Kim Ji-Yeon JY et al.

Parathyroid hormone (PTH) is a key regulator of calcium homeostasis and bone remodeling. While intermittent PTH (1-34) (teriparatide) is an established treatment for osteoporosis, its effects on alveolar bone regeneration remain unclear. This study evaluated intermittent PTH (1-34) impact on the microstructure and remodeling of canine maxillary alveolar bone under physiological masticatory force. In this exploratory pilot study, three male mongrel dogs were each assigned to a single dose group (n = 1 per group) and injected weekly for 20 weeks with vehicle (CON), 1.6 μg/kg PTH (PTH1.6), or 3.2 μg/kg PTH (PTH3.2). Bone microarchitecture and remodeling were assessed using micro-computed tomography (micro-CT), fluorescence labeling, and hematoxylin and eosin (H&E) staining. Micro-CT revealed bone mass and density increased with higher occlusal force in all groups. Trabecular bone volume and mineral density were higher in PTH1.6 than in controls, whereas PTH3.2 values were lower than controls; given n = 1 per group, these differences are reported as individual-animal observations without statistical inference. Fluorescence labeling demonstrated the greatest new bone formation in PTH1.6. H&E staining showed no apparent differences in osteoclast or osteoblast numbers among those groups. In this pilot large-animal model, moderate-dose intermittent PTH (1-34) administration was associated with greater alveolar anabolic response than higher-dose administration, and the magnitude of response appeared to increase with regional masticatory loading. These hypothesis-generating observations warrant confirmatory studies in appropriately powered cohorts. Optimizing PTH dosing and considering mechanical loading is critical for effective alveolar bone regeneration in the dental medicine scenarios.

PMID 42176894
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PubMedScientific reports2026-05-24

Integrating multivariate analysis and Air Pollution Tolerance Index (APTI) to evaluate four ornamental plants for sustainable indoor air phytoremediation.

Elhadad Safinaz M SM, Ea Shalaby S, Saleh Ibrahim H IH, Omar Mohamed Y MY

Indoor air pollution, especially in pharmaceutical laboratories, poses significant health risks due to the presence of volatile organic compounds (VOCs) such as benzene, toluene, acetophenone, and benzaldehyde. This study evaluates the efficiency of air phytoremediation technology using four ornamental plant species, Cordyline fruticosa, Syngonium podophyllum, Epipremnum aureum and Chlorophytum comosum to improve Indoor Air Quality (IAQ) by acting as Plant-Based Bio-Filters (PBBFs) in both pot-based and green wall configurations. VOC concentrations were monitored in a real pharmaceutical organic laboratory. Morphological and physiological plant traits including total chlorophyll content, relative water content (RWC), leaf pH, ascorbic acid concentration, stomatal density, and cuticle wax content were evaluated. Air Pollution Tolerance Index (APTI) and dust-capturing potential were calculated to assess the resilience and effectiveness of each species under VOCs exposure. Chemometric tools Principal Component Analysis (PCA) and Orthogonal Projections to Latent Structures-Discriminant Analysis (OPLS-DA) were applied to identify species with superior removal efficiency and to explore the relationship between plant traits and VOC uptake. Among the studied species, Cordyline fruticosa demonstrated the highest removal efficiency for VOCs (87.50%), CO (88.23%), and CO₂ (36.78%), as well as the highest APTI (14.76%), stomatal density (94.34 stomata/mm2), and chlorophyll content. Syngonium podophyllum also showed up to 100% removal of particulate matter (PM2.5 and PM10) and performed effectively in CO (70.58%) and CO₂ (31.27%) reduction. Multivariate analysis confirmed that plants with higher physiological resilience and morphological surface complexity had significantly greater phytoremediation capacity. This study demonstrate the potential of PBBFs, especially using Cordyline fruticosa and Syngonium podophyllum, as a viable, cost-effective, and sustainable approach to mitigate indoor VOCs and improve air quality in pharmaceutical labs. The findings support integrating ornamental plants into indoor environment as a natural solution for IAQ management.

PMID 42177233
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PubMedPreparative biochemistry & biotechnology2026-05-24

Egg shell powder: an inexpensive material for detoxification of sugarcane bagasse acid hydrolysate, cells immobilization agent and nutritional supplement for ethanol and xylitol production.

Zhan Larissa L, A F Antunes Felipe F, Yaverino-Gutierrez Mario Alberto MA, da Silva Silvio S SS et al.

Enhancing the sustainability of fermentation processes increasingly involves the reuse of bio-residues to replace synthetic reagents and reduce environmental impact, as well as the increase process yield and optimization reducing cost of process. This study investigates the integration of eggshell as a low-cost, renewable alternative in the production of second-generation (2G) ethanol and xylitol from sugarcane bagasse hydrolysates. Eggshell naturally comprises of about 97% calcium carbonate in its composition, besides being readily available due to the extensive consumption of eggs in various sectors. Applications of eggshell were evaluated across multiple process stages, including pretreatment, detoxification, cell immobilization, and nutritional supplementation. Eggshell proved effective in supporting fermentation, particularly due to its high calcium carbonate content and natural alkalinity, which contribute to pH regulation and nutrient supply. Using immobilized cells in flask-scale fermentations, ethanol and xylitol production yields (YP/S) of 0.21 and 0.20 g/g, and productivities (QP) of 0.09 and 0.31 g/L·h, respectively were achieved. Furthermore, eggshell proved to be successful to decrease concentrations of inhibitors molecules present in hemicellulosic hydrolysate derived from sugarcane bagasse in more than 90% of 5-HMF and furfural, besides of partial removal of other compounds such as syringaldehyde and ferulic acid. These results demonstrate the feasibility of using eggshell powder as a multifunctional additive, offering an environmentally friendly and cost-effective approach to improve the overall performance of 2 G ethanol and xylitol bioproduction.

PMID 42175835
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PubMedElectrophoresis2026-05-24

Determination of Flunixin Meglumine in Veterinary Pharmaceutical Formulations by Capillary Electrophoresis With Capacitively Coupled Contactless Conductivity Detection.

de Araujo Letícia M LM, da Silva José A Fracassi JAF, de Jesus Dosil P DP

This work describes a novel, simple, fast, reliable, and environmentally friendly analytical method for the determination of the anti-inflammatory and analgesic drug flunixin meglumine (FM) in veterinary pharmaceutical formulations. The method uses capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) to quantify meglumine (N-methylglucamine), the counterion of flunixin in FM. This approach allows the use of the less expensive and more readily available meglumine, rather than FM or flunixin, as the standard reagent. Lithium ions were used as an internal standard, and the migration time of the meglumine was 2.2 min using a capillary with a total length of 50 cm (42 cm effective) and 50 µm (i.d.), filled with a background electrolyte (BGE) composed of 2-(N-morpholino)ethanesulfonic acid (MES) and histidine (His), each at 20 mmol L-1. Good linearity was attained (R2 = 0.992) in a concentration range of 100-2500 µg mL-1. The limits of detection (LOD) and quantification (LOQ) were calculated as 22.7 and 75.6 µg mL-1, respectively. The accuracy of the method was assessed using recovery tests at three concentration levels, resulting in recoveries ranging from 89% to 104%. The intra- and inter-day precisions ranged from 2.3% to 4.2%. The proposed CE-C4D was successfully applied to determine FM in commercial veterinary formulations.

PMID 42175833
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