Drug Database
IM

imatinib mesilate

✓ Approved

Dako · KIT · Companion diagnostic

What is imatinib mesilate?

imatinib mesilate is a companion diagnostic developed by Dako. It is approved for therapeutic indications via others.

Drug Profile

CompanyDako
Drug ClassCompanion diagnostic
Molecular TargetKIT
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Dako

Mechanism of Action

Molecular Targets

imatinib mesilate acts on 1 molecular target:

KITKIT proto-oncogene, receptor tyrosine kinase (MASTC, CD117)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

imatinib mesilate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

Related Research Articles

PubMedInternational journal of cancer2026-07-25

Timing of Adjuvant Imatinib Initiation and Recurrence-Free Survival After Curative Resection for Intermediate- and High-Risk Gastrointestinal Stromal Tumors: A Multicenter Real-World Cohort Study.

Cai Zhiming Z, Lin Huimei H, Lin Zihan Z, Liu Huibin H et al.

Adjuvant imatinib reduces recurrence risk after curative resection for intermediate- and high-risk gastrointestinal stromal tumors, but the optimal timing of postoperative initiation remains unclear. This multicenter real-world cohort study evaluated 596 patients with modified National Institutes of Health intermediate- or high-risk gastrointestinal stromal tumors who underwent R0 resection followed by adjuvant imatinib therapy at five centers in China. Postoperative imatinib initiation timing was modeled as a continuous variable using a multivariable restricted cubic spline Cox model, and the derived threshold was further evaluated using propensity score overlap weighting. The lowest recurrence risk occurred at 6.22 weeks after surgery, with a 95% confidence interval of 1.29-7.65 weeks; therefore, 8 weeks was selected as a clinically interpretable threshold. After overlap weighting, baseline covariates were well balanced between the planned initiation group (≤ 8 weeks, n = 476) and delayed initiation group (> 8 weeks, n = 120). Delayed initiation was associated with worse 5-year recurrence-free survival (70.8% vs. 82.4%) and remained independently associated with an increased risk of recurrence-free survival events in weighted analysis. Severe postoperative complications were independently associated with delayed initiation. These findings suggest that unnecessary delays in adjuvant imatinib initiation should be minimized once postoperative recovery permits and support timely transition to adjuvant targeted therapy as part of postoperative gastrointestinal stromal tumor management.

PMID 42499003
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PubMedBiochemical and biophysical research communications2026-07-25

Exploring the therapeutic potential of NCX1 in hematological cancers; integration of molecular docking, bioinformatics approaches, and experimental validation.

Misir Sema S, Yaman Serap Ozer SO, Petrović Nina N, Cakmak Isik I et al.

Hematological malignancies are highly heterogeneous diseases characterized by dysregulated signaling pathways and limited durable therapeutic responses. Calcium homeostasis has emerged as a critical regulator of cancer cell fate, yet the role of the sodium/calcium exchanger 1 (NCX1/SLC8A1) in leukemogenesis remains poorly defined. In this study, we comprehensively investigated the biological significance and therapeutic potential of NCX1 across major hematological malignancies by integrating transcriptomic analyses, protein-protein interaction networks, experimental validation, and in silico drug repurposing strategies. NCX1 was highly expressed in HL-60, K-562, and Jurkat cells compared to HaCaT controls. Network analyses revealed that NCX1 interacts with key regulators of calcium signaling, immune response, and signal transduction. In AML and CML patient datasets, a strong positive correlation was observed between NCX1 expression and immune-related pathways, while a negative correlation was observed with translation-related processes. Molecular docking analyses demonstrated that several clinically approved compounds, particularly imatinib and nilotinib, interact with NCX1. Molecular dynamics simulation was performed to evaluate the binding stability and safety of imatinib. Remarkably, the comprehensive analysis showed that imatinib exhibited a stable molecular dynamics profile. All these findings have demonstrated NCX1 as a biologically informative marker of myeloid differentiation and a promising therapeutic weak point within calcium signaling networks in hematological malignancies, providing a rationale for future functional and single-cell validation studies.

PMID 42497834
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PubMedVeterinary medicine and science2026-07-25

Green Tea Extract, Keratin Hydrolysate and Vitamin C Exert Anti-Ageing Effects Through the Hippo Signalling Pathway in Feline and Canine Mammary Gland Cells.

Gao Yi Y, Sun Xue X, Ma Yan Y, Li Jiaxi J et al.

Ageing is a progressive decline in organ function and tissue integrity caused by genetic, environmental and physiological factors. With the increasing lifespan of companion animals, effective anti-ageing interventions for elderly felines and canines have attracted growing attention in veterinary medicine. This study aimed to investigate the anti-ageing effects of green tea extract, keratin hydrolysate and vitamin C in feline and canine mammary gland cells and to explore the underlying molecular mechanisms. Feline and canine mammary gland cells were treated with green tea extract, keratin hydrolysate and vitamin C in vitro. Cell proliferation, oxidative stress responses and ageing-associated protein expression induced by actinomycin D were evaluated. The involvement of the Hippo signalling pathway was further analysed to determine the molecular mechanisms underlying the anti-ageing effects. Green tea extract, keratin hydrolysate and vitamin C significantly promoted the proliferation of feline and canine mammary gland cells. These treatments effectively restored the abnormal expression of ageing-related proteins induced by actinomycin D and exhibited protective effects against oxidative damage. Mechanistically, the anti-ageing effects were associated with regulation of the Hippo signalling pathway. Green tea extract, keratin hydrolysate and vitamin C exhibit significant anti-ageing effects in feline and canine mammary gland cells through modulation of the Hippo pathway. These findings suggest their potential as safe and effective anti-ageing interventions for improving health and alleviating geriatric syndromes in ageing companion animals.

PMID 42499304
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PubMedHospital pharmacy2026-07-25

Artificial Intelligence and Large Language Models as Decision-Support Tools in Hospital Compounding Pharmacy: A Proof-of-Concept Study.

Castellana Eleonora E, Chiappetta Maria Rachele MR

To evaluate the efficiency and reliability of a large language model (LLM) as a decision-support tool in hospital compounding pharmacy for pediatric extemporaneous preparations requiring assessment of drug crushability, regulatory compliance, and formulation feasibility. A proof-of-concept study compared a structured LLM-assisted workflow with the traditional manual information retrieval process in a hospital pharmacy setting. The LLM (Claude Sonnet 4.6) was configured with a standardized prompt to extract and consolidate data from multiple authoritative sources: the Friuli Venezia Giulia "Do Not Crush" list, the Italian Medicines Agency (AIFA) database for Summary of Product Characteristics (SmPC), AIFA Law 648/96 off-label use lists, and the Stabilis database for oral liquid formulation stability. Two representative drugs, propranolol hydrochloride and imatinib mesylate, were analyzed. For each drug, the model generated a structured output including crushability, regulatory information, off-label status, and extemporaneous formulation data. The same queries were manually performed by an experienced hospital pharmacist. Primary outcome was information retrieval time; secondary outcomes included completeness and accuracy. The LLM-assisted workflow reduced retrieval time to less than 2 minutes per drug (mean 1 minute 45 seconds), compared with a mean of 20 minutes (range 15-25 minutes) for the manual process, plus an additional 5 to 10 minutes for transcription. Output completeness was 100%, with all predefined fields correctly populated. The model accurately classified drug crushability and correctly identified Law 648/96 regulatory status. For propranolol, the system identified crushability, pediatric off-label authorization, and SyrSpend-based formulations with stability data of up to 146 days at room temperature. For imatinib, the model highlighted cytotoxic handling precautions, identified the absence of SyrSpend formulations, and retrieved alternative formulation stability data (30 days refrigerated). A properly configured LLM can function as an effective decision-support tool in hospital compounding pharmacy, improving efficiency while maintaining high standards of completeness, accuracy, and regulatory compliance. These preliminary results support further investigation into the integration of the LLM system into routine pediatric galenical preparation practice.

PMID 42500259
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PubMedGalen medical journal2026-07-25

Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions: A Systematic Review : Short title: Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions.

Al-Hakami Hadi H

Accurate diagnosis of head and neck lesions relies heavily on image-guided biopsy techniques, which facilitate targeted sampling and enable radiologic-pathologic correlation. Increasing use of CT-guided fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) necessitates updated evaluation of their diagnostic performance and safety. To systematically identify, appraise, and synthesize published evidence on the diagnostic accuracy, tissue adequacy, and radio-pathologic concordance of image-guided biopsy for head and neck lesions. This review followed PRISMA 2020 guidelines and a protocol registered in PROSPERO (CRD420251181567). Searches were conducted across PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, and Google Scholar (January 2018-September 2025). Eligible studies included human subjects undergoing image-guided FNAC or CNB with reported diagnostic outcomes. Two reviewers independently screened, extracted data, and assessed quality using QUADAS-2. Due to methodological and clinical heterogeneity, meta-analysis was not performed. From 345 records, eight studies met inclusion criteria. Most were retrospective (8/10), evaluating CT-guided FNAC, CNB, or percutaneous needle biopsy across cervical, suprahyoid, salivary, lymphatic, thyroid, and skull base lesions. Diagnostic sensitivities ranged from 85-95%, specificities from 92-97%, and overall accuracies from 90-96%. Diagnostic yield was high (85-100%), and radio-pathologic concordance consistently exceeded 87%. Complications were uncommon and generally minor, except for hilar lymph node biopsies, which showed higher pneumothorax rates. Image-guided biopsy of head and neck lesions demonstrates high diagnostic accuracy and excellent radio-pathologic concordance across diverse anatomic regions, supporting its role as a reliable, minimally invasive diagnostic tool. Despite strong performance in deep and complex spaces, procedure-specific complication risks-particularly in hilar lymph node sampling-should inform clinical decision-making.

PMID 42499369
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PubMedThe Medical clinics of North America2026-07-25

Diagnostic Tools in Sleep Medicine.

Yuan Nathaniel N, Avidan Alon Y AY

This article presents a structured, clinically grounded approach to the diagnosis of sleep disorders. Key conceptual distinctions are clarified to support accurate symptom characterization and avoid diagnostic misclassification. Validated screening instruments are reviewed. Objective diagnostic modalities are discussed. The role of the physical examination and targeted biomarkers is emphasized as a means of enhancing diagnostic precision in selected patients. Through integration of clinical data, subjective assessments, and objective measures, the experienced clinician can accurately diagnose and manage common sleep disorders including insomnia, hypersomnolence disorders, obstructive sleep apnea, and circadian rhythm sleep-wake disorders while delivering individualized, patient-centered care.

PMID 42498433
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