Drug Database
PU

Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · therapeutic agent

What is Purethal Mites?

Purethal Mites is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPurethal Mites
CompanyHAL Allergy Group
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

Purethal Mites is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

Related Research Articles

PubMedParasites & vectors2026-11-11

Mitogenomic insights into Sarcoptes scabiei in American black bears (Ursus americanus): COI utility for regional surveillance and mite genetic structure.

Francisco Raquel R, Grunert Ryan K A RKA, Rivera Reyes Jomari J, Broadhurst Jillian R JR et al.

Sarcoptic mange is a skin disease caused by the parasitic mite Sarcoptes scabiei that affects humans and over 150 species of domestic animals and wildlife worldwide. For the American black bear (Ursus americanus), sarcoptic mange is considered a significant emerging disease and case numbers have increased dramatically over the past four decades. While molecular techniques, such as DNA sequencing, are commonly used for diagnosis of clinical cases, they remain underutilized for studying cross-species transmission and regional mite variation. We captured complete mitochondrial genomes from S. scabiei mites (n = 17) collected from infested black bears in the Eastern United States (U.S.) using custom-designed oligonucleotide baits. These full mitogenomes were then used to refine primers targeting the cytochrome c oxidase subunit I (COI) gene. We then amplified and analyzed 285 COI sequences from S. scabiei collected across multiple North American wildlife hosts to assess their utility in inferring regional diversity and host-associated genetic structure. Full mitogenome comparisons with sequences from the U.S., Japan, and Australia revealed three major global S. scabiei clades, with two circulating among North American black bears. The COI haplotype networks showed regional clustering rather than host-specific patterns, suggesting that ecological or geographic factors influence transmission dynamics. Our findings confirm the presence of multiple S. scabiei lineages in American black bears and other U.S. wildlife and support the use of the COI gene for large-scale, cost-effective screening of genetic variation and shared haplotypes across host species. The integration of mitogenome and COI data offers a scalable model for investigating S. scabiei diversity in wildlife and domestic hosts.

PMID 43010067
Read full article →
PubMedThe Journal of infectious diseases2026-11-10

Orientia tsutsugamushi genotypes associated with severe scrub typhus in South India.

Schmidt Wolf-Peter WP, Alexander Neal N, Makepeace Benjamin L BL, Castaneda Sastre Erika E et al.

Orientia tsutsugamushi is an obligate intracellular bacterium with a complex genome, causing mite-borne scrub typhus in many parts of Asia. We determined O. tsutsugamushi genotypes in chigger mites, small mammal hosts and human fever cases to explore genotype-specific virulence. We enrolled scrub typhus patients from two hospitals in Tamil Nadu, India. Chigger mites were collected from small mammals trapped in 25 rural villages located within the catchment areas of the hospitals. Samples underwent screening for Orientia with real-time PCR followed by nested PCR of the partial tsa56 gene and Sanger sequencing. Phylogenetic trees were used to group sequences into clades, labelled according to the nearest reference genotypes. We determined 138 tsa56 sequences from 1165 blood samples from human fever cases, 63 sequences from 762 chigger pools, and 58 sequences from 874 small mammals. Sequences were grouped into nine genotypes. The two most common genotypes in chiggers and small mammals were never found in human scrub typhus cases, while genotypes common in humans were rare in chiggers. There was a positive relationship between the human-to-chigger genotype prevalence ratio and the genotype-specific proportions of human infections that were severe (r= 0.87, p= 0.011). Two genotypes, labelled Kato-Vellore and TA763-Vellore, caused 72% of infections involving shock and all five observed deaths. The genotype-specific risk of shock was closely associated with the prevalence of eschar skin lesions (r= 0.84, p= 0.017). O. tsutsugamushi genotypes differed strongly between chiggers and human fever patients and showed marked variation in clinical severity.

PMID 43006856
Read full article →
PubMedJournal of chemical ecology2026-11-10

Disentangling Chemical Defence and Prey Composition of Oophaga sylvatica.

Tartara Arianna A, Neira-Salamea Karla K, Keller Alexander A, Rödel Mark-Oliver MO et al.

Poison frogs acquire alkaloids from arthropod prey, yet linking diet to chemical defence remains challenging due to methodological and ecological complexity. We investigated this relationship in 23 adult Oophaga sylvatica from an early-stage cacao regeneration plot in the Ecuadorian Chocó. Using non-destructive alkaloid sampling and GC-MS profiling, combined with stomach flushing, morphological prey identification, and DNA metabarcoding, we characterised individual alkaloid richness and abundance (total alkaloid quantity), described prey diversity, and tested whether diet similarity correlated with alkaloid similarity. We also compared metabarcoding and morphological identification for stomach content analysis.We detected 130 alkaloids spanning 16 structural classes and found substantial inter-individual variation in richness and abundance. Most alkaloids occurred in low quantities, whereas a few classes dominated chemical profiles. Total alkaloid quantity increased with alkaloid richness. Diet analysis recovered 280 prey taxa across 22 orders, with ants, flies, beetles, and mites contributing most to richness. Metabarcoding recovered more diversity, improved taxonomic resolution, and detected highly digested and soft-bodied prey. Morphological identification recovered fewer taxa overall but performed better for small, sclerotized groups, particularly mites.Prey composition could not be correlated with alkaloid profiles, likely reflecting temporal mismatches between short-term diet data and long-term toxin accumulation, limited knowledge of alkaloid sources, and methodological constraints. Using available literature, only 15% of detected alkaloids could be linked to known arthropod sources among the recovered prey. We demonstrate that combining morphological prey identification with DNA metabarcoding provides a more comprehensive understanding of poison frog diets while highlighting existing knowledge gaps regarding alkaloid sources and the need for more complete DNA barcode reference databases.

PMID 43007349
Read full article →
PubMedExperimental & applied acarology2026-11-09

RNA interference targeting host physiological pathways enhances Beauveria bassiana efficacy against the tomato red spider mite Tetranychus evansi.

Cao Zhangguang Z, Smagghe Guy G, Lan Xinlin X, Li Zhuo Z et al.

The tomato red spider mite Tetranychus evansi is a major pest of Solanaceous crops and is increasingly difficult to control due to rapid development of resistance to acaricides. Entomopathogenic fungi such as Beauveria bassiana provide environmentally compatible alternatives, but their relatively slow action and variable efficacy limit field performance. This study investigated whether RNA interference (RNAi)-mediated disruption of key physiological pathways in T. evansi could enhance fungal pathogenicity. Spray bioassays revealed stage-specific susceptibility to B. bassiana strain HGS-1, with adult females being the most susceptible stage; however, mortality reached only 54% after 9 days at 1 × 109 spores/mL. To identify molecular targets, genes associated with housekeeping, immune, and cuticle-related functions were screened using RNAi. The result showed that silencing of genes TeATP, TeRPL13, TeRPS18, TeMyd88, TePGRP, TeCPR25, TeHex1, and TeHex2 significantly induced death of adult mites. The fungal infection​ following RNAi showed​ that silencing of these genes increased mitesusceptibility​ to B. bassiana. Co-application of dsRNA and B. bassiana further enhanced control efficacy. In particular, dsTeRPL13 and dsTeNox increased cumulative mortality by 18-19%, while dsTeCHS and dsTeHex1 reduced median lethal time, indicating faster disease progression. These results demonstrate that RNAi-mediated targeting of host physiological pathways can improve the performance of fungal biocontrol. By weakening metabolic capacity, immune defense, and cuticle integrity, this approach offers a promising, biosafe strategy for managing spider mites and addressing acaricide resistance within integrated pest management (IPM) programs.

PMID 43002318
Read full article →
PubMedInternational immunopharmacology2026-11-09

Fumarate hydratase attenuates HDM/LPS-induced asthmatic airway inflammation by inhibiting Drp1-mediated mitochondrial fission in airway epithelial cells.

Liu Minrong M, Hu Jiannan J, Wang Decai D, Liu Chao C et al.

Mitochondrial structural and functional dysfunction in airway epithelial cells is recognized as a central driver in the progression of severe asthma. However, the current understanding of the mechanisms underlying damage to the mitochondria remains insufficient, and effective therapeutic strategies for its repair are lacking. Fumarate hydratase (FH) is a pivotal metabolic enzyme in the tricarboxylic acid cycle. It exhibits anti-inflammatory and tissue-repairing effects in immune-related diseases, but its contribution to asthma has not been previously reported. We examined the role of FH in severe asthma utilizing human transcriptomic datasets and in vitro (airway epithelial cells) and in vivo (mouse) models induced by lipopolysaccharide (LPS) in combination with house dust mites (HDM), in conjunction with FH overexpression and pharmacological inhibition interventions. Mitochondrial function, mitochondrial dynamics, and inflammatory responses were assessed, together with Drp1 overexpression rescue and NRF2 inhibition experiments. Analysis of human severe asthma datasets, together with HDM/LPS-induced cellular and mouse models, consistently revealed reduced FH expression. Restoration of FH expression improved mitochondrial function, suppressed Drp1-associated mitochondrial fission, and reduced airway inflammation, whereas Drp1 overexpression partially reversed the mitochondrial protective effects of FH. FH also reduced Keap1 expression, promoted NRF2 nuclear translocation and HO-1 expression, and NRF2 inhibition attenuated the anti-inflammatory effects of FH. These findings identify FH as a previously unrecognized metabolic regulator with protective effects in airway inflammation and support a role for mitochondrial fission-fusion dynamics in FH-mediated protection of airway epithelial cells.

PMID 43002910
Read full article →
PubMedbioRxiv : the preprint server for biology2026-11-08

RNA-seq analysis of Triatoma gerstaeckeri during mite infestation reveals increased metabolic demand and lower reproductive investment.

Cemal Alina A, Bryant Jacob J, Kondragunta Alekhya A, Hoque Syeda Farjana SF et al.

Triatomine insects, also known as kissing bugs, serve as vectors for the Trypanosoma cruzi parasite, which can cause American trypanosomiasis, also known as Chagas disease. Triatomines are known to be parasitized by mites in natural and colony settings, where mites feed on the arthropod to obtain nutrients and resources for reproduction. This feeding, while necessary for the mite's survival, likely occurs at the expense of their insect host. We examined the transcriptional response of Triatoma gerstaeckeri infested with mites ( Pimeliaphilus spp.) and an uninfested group using Illumina-based RNA-seq, followed by targeted measurement of nutritional reserves in both groups. Our results show increased expression of factors involved in protein translation, but decreased expression of processes associated with cell development. These results are supported by declines in protein levels in mite-infested T. gerstaeckeri and lower expression of reproductive factors, suggesting a distinct reduction in nutrient reserves and reproductive output. These studies provide critical information on the interaction of mites and triatomines while considering the utility of mites as biological control of triatomines in nature or for husbandry protocols to minimize issues with mite infestations of colony individuals.

PMID 42999231
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about Purethal Mites