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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · therapeutic agent

What is Purethal Mites?

Purethal Mites is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPurethal Mites
CompanyHAL Allergy Group
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

Purethal Mites is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

Related Research Articles

PubMedBMC veterinary research2026-05-23

Knowledge, attitudes, and practices related to traditional and conventional ectoparasite control in domestic ruminants: a cross-sectional survey conducted in Hawassa City, Ethiopia.

Gemechu Kabech Gedeno KG, Ali Wosenyelesh Kebede WK, Zewde Mihiret Genene MG

Ruminant livestock is an integral component of agricultural production in Ethiopia. However, productivity is constrained by ectoparasites such as ticks, lice, fleas, and mites, which cause economic losses and transmit pathogens. In this study, traditional methods refer to ethnoveterinary remedies based on indigenous knowledge, whereas conventional methods refer to commercially manufactured ectoparasiticides. This study aimed to assess community knowledge, attitudes, and practices (KAP) regarding traditional and conventional ectoparasite control methods in domestic ruminants, identify associated risk factors, and document treatments known in Hawassa City, Ethiopia. A cross-sectional questionnaire-based survey was conducted from January to June 2025. Data were collected through face-to-face interviews using Kobo Toolbox from 423 randomly selected participants. Data were analyzed using STATA version 17, and binary logistic regression was used to identify factors associated with KAP scores. Of the 423 participants, 167 (40.0%, 95% CI: 34.8-44.3) were aware of both traditional and conventional treatments, 107 (25.0%, 95% CI: 21.2-29.7) knew only traditional treatments, 48 (11.0%, 95% CI: 8.5-14.8) knew only conventional treatments, and 101 (24.0%, 95% CI: 19.9-28.2) had no knowledge of any treatments. Regarding traditional treatments, 35.5%, 38.1%, and 40.4% of respondents demonstrated good knowledge, positive attitudes, and good practices, respectively. For conventional treatments, the corresponding proportions were 73.8%, 21.0%, and 53.4%, respectively. Logistic regression analysis indicated that age, education level, occupation, religion, farming system, and farming experience were significantly associated with KAP scores for traditional treatments (P < 0.05). For conventional treatments, age, sex, religion, marital status, and farming experience were significant predictors. Additionally, the study identified ten reasons for the use of traditional treatments, fourteen types of traditional remedies, and seven types of conventional treatments. Knowledge, attitudes, and practices regarding traditional ectoparasite control methods were generally low, whereas knowledge and practices related to conventional methods were higher, although attitudes remained low. These findings highlight the need for targeted community awareness programs to promote the safe and informed use of both traditional and conventional ectoparasite control methods.

PMID 42174594
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PubMedScientific data2026-05-22

Chromosomal-level genome assembly of minute pirate bug Orius nagaii Yasunaga, 1993 (Hemiptera: Anthocoridae).

Yin Zhenjuan Z, Wang Chengxing C, Li Dingyin D, Wang Ruijuan R et al.

Species of the genus Orius, diminutive predatory insects that act as natural enemies of other arthropods, are frequently employed in agricultural pest management for controlling various pests, such as thrips, mites, aphids, whiteflies, etc. However, the scarcity of high-quality genomic resources for these predators hinders our comprehension of their population evolution and predation ecology. Consequently, we assembled and annotated a chromosomal-scale genome of Orius nagaii by collating PacBio and Illumina sequencing and Hi-C genomic analysis techniques. The final genome assembly size 152.62 Mb, with scaffold and contig N50 lengths of 11.53 and 2.39 Mb, respectively. It is organized into 12 pairs of autosomes and a pair of XY sex chromosomes. The quality assessment of the genomic data with BUSCO revealed a completeness of 98.5% (n = 1,367). Also, 11,917 protein-coding genes were discovered, with 94.28% of them having functional annotations. The high-quality genome of O. nagaii produced serves as a valuable resource for comprehending the interactions between predatory natural enemies and hosts, along with their evolutionary trajectories.

PMID 42168233
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PubMedBulletin of entomological research2026-05-22

Detection of spider mite infestation via hyperspectral imaging and deep neural networks with spatial-spectral attention.

Xie Hongyu H, Jiang Yankui Y, Li Jiguo J, Jiang Sijia S et al.

Early detection of spider mite emergence is highly challenging due to the lack of visible symptoms and subtle physiological changes. To address the rapid monitoring of pest mite damage, this study provided a method based on hyperspectral imaging combined with a joint spatial-spectral attention (SSA) mechanism in a deep convolutional neural network (DCNN) for automated detection of pest mite infections. Leaves infested with varying degrees of spider mites Tetranychus urticae Koch (Acari: Tetranychidae) were captured daily to obtain multi-band spectral information of hyperspectral images. After data preprocessing, the joint SSA mechanism was applied to weigh and optimise the spatial and spectral features of the images, focusing specifically on infested regions. Furthermore, the super-pixel principal component analysis method (SPCA) dimensionality reduction method was applied to reduce model complexity and enhance classification accuracy. The spatial attention module automatically adjusted the weights of critical regions in the image, ensuring the network concentrated on the infected areas, while the spectral attention module improved sensitivity to the unique spectral features of infected regions. The proposed method can significantly enhance the accuracy of identifying mite infected areas, particularly in detecting mild infections of the leaves. Compared with traditional approaches, our proposed SPCA + DCNN + SSA model achieved notable improvements in classification accuracy and robustness, yielding the highest OA (up to 99.1% for specific severity levels) and Kappa coefficient (0.989). Importantly, it drastically reduced misclassification in the highly challenging mild infection stages.

PMID 42169607
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PubMedPloS one2026-05-22

The effect of Demodex-associated Bacillus oleronius proteins and hyperosmolarity on a human conjunctival epithelial cell line.

Sharma Nikhil N, Martin Eilidh E, Pearce Edward Ian EI, Hagan Suzanne S

Demodex mites act as a carrier vector for the bacterium Bacillus oleronius. Antigenic proteins from this bacterium are capable of producing an inflammatory response. This study investigated the potential effects of Demodex spp.-associated Bacillus oleronius proteins and dry eye-induced hyperosmolarity on an immortalised human conjunctival epithelial (Chang) cell line. The Wong Kilbourne derivative of the Chang (WKD) HeLa-modified conjunctiva-derived epithelial cell line was cultured in a series of NaCl-hyperosmolar conditions with various concentrations ranging from 350mOsm/L to 550mOsm/L. Chang cells were then exposed to semi-purified B.oleronius proteins at 2 µg and 6 µg either alone or in conjunction with dry eye-induced hyperosmolar (HO) stress at 2 µg + HO500 mOsm/L and 6 µg + HO500 mOsm/L. The cell viability was assessed with the RealTime-Glo MT cell viability assay. Compared to controls, the cell viability appeared to decrease in a dose-dependent manner. B. oleronius concentration at 6 µg showed significantly lower cell viability than both controls (p < 0.001) and 2 µg (p < 0.001). When 500mOsm/L was added to the 2 µg and 6 µg concentrations, the lowest cell viability was observed (p < 0.001). At 24 hours, the B.oleronius 2 μg combined with HO500 resulted in 38% viable cells, compared to 81% viability in B.oleronius 2 μg alone (p < 0.001). Similarly, the B.oleronius 6 μg combined with HO500 showed only 23% metabolising cells compared to 60% viability cells in B.oleronius 6 μg alone (p < 0.001). The results suggest that the presence of bacterial proteins and hyperosmolarity have a dose and time-dependent effect on cellular viability. These experiments suggest that patients affected with the comorbidity of dry eye disease and Demodex blepharitis could experience more severe signs than those with Demodex-associated blepharitis alone.

PMID 42172274
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PubMedJournal of inflammation research2026-05-22

Deacetyl Ophiopojaponin A ameliorates Asthma by Inhibiting L-Type Calcium Channel Cav2.3 to Reduce Calcium Load in Airway Epithelial Cells.

Li Huan H, Jiang Lingxue L, Qian Jing J, Bao Wenping W et al.

The in-house preparation Qingre Runzao formula (QRRZF) has been used for decades in our hospital to treat asthma with good efficacy, but its underlying mechanisms and key components remain unclear. This study aims to elucidate the potential mechanisms and key components by which the QRRZF ameliorates asthma. UPLC-MS/MS was employed to identify the components of the QRRZF; therapeutic targets were predicted with SwissTargetPrediction and Super-Pred. Asthma transcriptomic data were obtained from GEO and differentially expressed genes were identified (GSE43696 and GSE147878). Venn analysis yielded potential targets of the QRRZF against asthma. GO and KEGG enrichment analyses with Metascape identified key pathways; the pathway-associated proteins served as receptors for molecular docking to rank drug-receptor affinities, thereby identifying key anti-asthma components. CETSA was performed on 16HBE cells cultured in vitro to verify docking results. CCK-8 and ELISA assessed the anti-asthma effects of the key components in vitro, and an HDM-induced asthma mouse model evaluated its efficacy in vivo. A total of 21 components and 827 predicted targets were obtained; 1250 asthma-related targets were extracted from GEO, yielding 76 potential therapeutic targets. Enrichment analysis suggested calcium signaling pathway as the main pathway; molecular docking showed Deacetyl Ophiopojaponin A (DOA) bound most tightly to Cav2.3, confirmed by CETSA. In vitro experiments demonstrated that DOA protected 16HBE cells from damage induced by house dust mites, reducing the levels of inflammatory cytokines and alleviating airway inflammation, such IL-6, IL-13, and TNF-α. In vivo experiments showed that DOA reduced inflammatory cell infiltration and airway inflammation in the lung bronchioles, protecting the epithelial barrier and demonstrating significant therapeutic efficacy. These results indicate that DOA exerts potent anti-asthma effects by inhibiting the Cav2.3 calcium channel. This study reveals that calcium signaling pathway is the principal mechanism by which QRRZF improves asthma, and DOA is the key therapeutic component, which alleviates asthma-induced airway inflammation by inhibiting Cav2.3 expression and reducing calcium load in airway epithelial cells.

PMID 42169749
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PubMedScientific reports2026-05-21

Growth-promoting rhizobacteria amend the defense of strawberry plants against sequentially attacking herbivores.

Hosseini Afsane A, Hosseini Mojtaba M, Schausberger Peter P

Plant defense systems such as induced resistance (IR; induced by herbivores) and induced systemic resistance (ISR; induced by beneficial rhizobacteria) are modulated by overlapping signaling pathways within plants. Both ISR and IR are systemic and may involve the production of toxic, antifeedant and/or repellent compounds, and/or reduce nutrient availability, which may in consequence affect plant usability and palatability for later arriving herbivores. The combined effects of ISR and IR on different herbivores sharing the same plant and plant performance have been rarely addressed. Here, we assessed the effects of three plant-growth-promoting rhizobacteria (PGPR), Azotobacter chroococcum, Azospirillum brasilense and Pseudomonas brassicacearum, on the defense response and physiology of strawberry plants upon sequential attack by two herbivores with different feeding modes, two-spotted spider mites Tetranychus urticae and cotton aphids Aphis gossypii. Attack of strawberry plants by spider mites and aphids adversely affected the abundance of the later arriving herbivore, mediated by the host plant's defense system. First-attacking spider mites exerted much stronger adverse effects on later attacking aphids than first-attacking aphids on later attacking spider mites. In absence of PGPR inoculation, the herbivores, especially first-attacking spider mites, severely impaired host plant physiology and productivity. PGPR inoculation increased the plant`s capacity to mount a stronger phenolic response upon attack by spider mites and aphids, indicating a priming-like enhancement of inducible defense. In consequence, the abundances of both herbivores were lower on PGPR-inoculated plants compared to chemically fertilized and control plants. Overall, our study suggests that PGPR inoculation ameliorates the plant damage caused by sequentially attacking herbivores. Additionally, the PGPRs improve the physiology and productivity, and favorably balance the nutritional state, of strawberry plants.

PMID 42162162
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