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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · therapeutic agent

What is Purethal Mites?

Purethal Mites is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPurethal Mites
CompanyHAL Allergy Group
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

Purethal Mites is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

Related Research Articles

PubMedCurrent protocols2026-07-08

Application of Microbial and Parasitology Techniques for Diagnosis in Laboratory Rodents.

Rapaport Debora D, Arama Maya Levin ML, Harlev Michael M

Pathogen diagnosis in rodents through effective health monitoring programs is essential for maintaining high welfare and standards in laboratory animal facilities. Although many animal facilities are increasingly adopting real-time polymerase chain reaction testing of environmental or filter samples for pathogen detection, thereby reducing the need for sentinel animals, classical methods such as microbiological assays and microscopic examination for parasites, remain essential and relevant tools in laboratory animal diagnostics. This article describes protocols for the identification of bacterial, viral, and parasitic agents in mice and rats in accordance with the recommendations of the Federation of European Laboratory Animal Science Associations. The methodologies presented detailed procedures for sample collection from mice and rats and for screening these samples using bacterial, parasitological, and viral panels. In addition, we describe bacterial culture techniques and the use of selective and differential media for pathogen isolation, as well as step-by-step protocols for the detection of pinworms, mites, and parasite eggs. These protocols provide a practical foundation for establishing a basic diagnostic laboratory to support standardized animal husbandry and health monitoring quality. © 2026 The Author(s). Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Gathering rodent samples for pathogen screening Basic Protocol 2: Inoculation and screening of bacterial cultures from rodent samples Support Protocol 1: Identification of bacteria using differential media Basic Protocol 3: Identification of Helicobacter by PCR targeting the 16S rRNA gene Basic Protocol 4: Pinworm screening by microscopy Support Protocol 2: Confirmation and specification of parasites (pinworms and mites) by PCR Basic Protocol 5: Mite screening by microscopy Basic Protocol 6: Virus identification by serology.

PMID 42418478
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PubMedArchives of insect biochemistry and physiology2026-07-08

Behavioral Resistance in Varroa destructor: First Evidence in Response to Acaricide?

Missud Théa T, Watkins Max M, Mielgo Paulo Damian PD, Papachristoforou Alexandros A et al.

The ectoparasite Varroa destructor (Mesostigmata: Varroidae) poses a major threat to honey bee colonies due to its role as a viral vector and its capacity to develop resistance to treatments. While physiological resistance and target-site mutations are well documented, behavioral mechanisms remain largely unexplored. This study investigated the potential existence of behavioral resistance in V. destructor, defined as a modification of behavior in response to an acaricidal molecule. Using Y-maze olfactometric assays, we evaluated mite responses to three acaricides-amitraz, tau-fluvalinate, and oxalic acid-across five French populations with distinct treatment histories. Forty groups of five mites were exposed to "acaricide/solvent" pairs, and choices were recorded after 18 h. Results revealed marked heterogeneity among populations. Two population exhibited significant avoidance of tau-fluvalinate, providing the first case of avoidance behavior in V. destructor, but no coinciding phenotypic resistance. No avoidance was detected for amitraz and oxalic acid. These findings suggest that behavioral resistance may exists in France but is not systematic. Identifying this phenomenon opens new perspectives on the parasite's adaptation to treatments and underscores the need to integrate behavioral aspects into control strategies.

PMID 42418445
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PubMedPloS one2026-07-08

Geographic and Orientia infection status influence on the bacterial microbiome of free-living chiggers in North Carolina, USA.

Chen Kaiying K, Travanty Nicholas V NV, Garshong Reuben A RA, Wasserberg Gideon G et al.

Chiggers (larval Trombiculid mites) serve as vectors for Orientia species that cause scrub typhus, a potentially serious illness in humans with a broadening global distribution. To date, there is limited research on the chigger microbiome in the United States (US) compared to some other parts of the world. Investigating chigger bacterial communities is essential for understanding the potential role they play in pathogen transmission dynamics within these arthropods. This study investigated the bacterial communities of free-living chiggers collected from sites across the three ecoregions in North Carolina using 16S rDNA gene targeted next-generation sequencing. Molecular identification of the chigger revealed three species: Eutrombicula splendens, Eutrombicula tinami, and Pseudoschoengastia sp. All three trombiculid mite species occurred at least once in the Mountains and Piedmont, except for E. tinami, which was absent from the Coastal Plain ecoregion. Microbiome analysis revealed significant differences in alpha and beta diversity among the collection sites for E. splendens. No significant differences in overall microbiome diversity were observed between E. splendens and Pseudoschoengastia sp., the two dominant chigger species. However, the microbiome of E. splendens alone exhibited significant differences in both Shannon diversity and beta diversity between Orientia-infected and uninfected individuals. Within E. splendens, genera like Brevibacillus and Telluria were more abundant in Orientia-positive chiggers, while Methylobacterium was more abundant in Orientia-negative chiggers. We also found potentially pathogenic bacterial genera, including Rickettsia, Listeria, Legionella, Staphylococcus, and Streptococcus sequences. These findings suggest that geography and Orientia infection influence chigger-associated bacterial communities, potentially affecting their vector competence.

PMID 42418460
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PubMedZootaxa2026-07-07

Catalogue of oribatid mites (Acari: Oribatida) from Continental Southeast Asia-Addendum (2021-2025).

Ermilov Sergey G SG

The Addendum (2021-2025) to the Catalogue of oribatid mites (Acari: Oribatida) from Continental Southeast Asia (CSEA) is based on 48 published papers. It includes 694 species/subspecies, belonging to 229 genera, 83 families, 35 superfamilies, and five infraorders, recorded from Vietnam, Thailand, and Cambodia. Among these, first records were established for Vietnam (133 species, three subspecies, 19 genera, eight subgenera, and six families), Thailand (26 species, one subspecies, nine genera, two families, and one superfamily), and Cambodia (two species, one genus, and one family). Currently, 984 species/subspecies of oribatid mites, representing 342 genera, 103 families, 37 superfamilies, and five infraorders of the Suborder Oribatida, are known in the CSEA. Given that oribatid mites in the region remain poorly studied (particularly in Laos, Cambodia, Myanmar, and Thailand), a significant increase in the number of taxa is expected in the future.

PMID 42408007
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PubMedZootaxa2026-07-07

Crossing 5,000 km: A new species of Litarachna (Acari: Hydrachnidia) and the molecular connectivity of marine mites across the Indian Ocean.

Pešić Vladimir V, Smit Harry H, Bańkowska Aleksandra A, Górecka Ewa E et al.

Pontarachnidae, the only family of Hydrachnidia inhabiting marine environments, utilize diverse dispersal mechanisms to inhabit broad geographic ranges. Recent molecular studies in semi-enclosed basins, such as the Mediterranean and Red Seas, have challenged the dispersal capabilities of species like Litarachna communis and Pontarachna punctulum, which were previously assumed to be widely distributed. In this study, we employed an integrative taxonomic approach to examine pontarachnid mites from the Indian Ocean. We describe a new species, Litarachna almirisp. nov., identified from both Mauritius and Thailand. This disjunct distribution, spanning nearly 5,500 km, demonstrates that mites within the Indian Ocean, a fully integrated component of the global ocean system, can achieve significant long-distance dispersal. Additionally, we provide the first molecular confirmations for Litarachna denhami (Kenya), L. triangularis (Thailand), and Pontarachna cf. australis (Kenya). These findings emphasize the necessity of further taxonomic clarification and molecular analysis of type-locality material to resolve the distribution patterns of marine mites accurately.

PMID 42408035
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PubMedZootaxa2026-07-07

Ontogeny and morphological diversity in immature mites (Part IX) (Title page).

Zhang Zhi-Qiang ZQ, Pfingstl Tobias T

PMID 42407815
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