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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · therapeutic agent

What is Purethal Mites?

Purethal Mites is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPurethal Mites
CompanyHAL Allergy Group
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

Purethal Mites is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

Related Research Articles

PubMedJournal of insect physiology2026-09-18

Microbial diversity and cytoplasmic incompatibility in Tetranychus urticae Spanish populations.

Cabedo-López Marc M, Cruz-Miralles Joaquín J, Pina Tatiana T, Ibañez-Gual M Victoria MV et al.

The two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is a worldwide important citrus pest. Global populations of T. urticae harbour Wolbachia and other bacterial species, some of which are considered endosymbionts. The genus Wolbachia encompasses strict intracellular bacteria that cause several types of reproductive distortions in their hosts, such as male feminization, thelytokous parthenogenesis, cytoplasmic incompatibility, or male death. The presence of different Wolbachia strains can affect the mite's reproductive parameters, which can have important implications for its management. In this study, we explored the microbiota composition of a T. urticae Spanish population and its effect on reproduction after antibiotic treatment. Firstly, we conducted a microbiota characterization using 16S deep sequencing. In a second step, we evaluated reproductive parameters through different crosses between treated and untreated mites (T- and U- mites respectively). Following antibiotic treatment, the marked reduction in Wolbachia dominance revealed a more even bacterial community composed of several previously low-abundance taxa. This mite microbiota was hidden by the great contribution of Wolbachia to the total number of OTUs. Whereas the antibiotic treatment unveiled the presence of other reproductive distorter bacterial species, not previously identified in the Spanish mite populations surveillance with species-specific primers. We determined that the tetracycline treatment primarily removed Wolbachia from the mite microbiota. The results from the crosses, which showed an altered offspring sex ratio, unveiled an induced cytoplasmic incompatibility (CI) between treated and untreated lines. Our results identify Wolbachia as the most likely endosymbiont associated with the observed cytoplasmic incompatibility.

PMID 42759928
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PubMedCureus2026-09-18

Forgotten but Not Gone: Pediatric Scrub Typhus in an Urbanizing Tropical Region.

Nguyen Dac Cuong DC, Giang Hai Trieu HT, Vu Dinh Mai DM, Nguyen Viet Van VV

Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi, transmitted to humans through the bite of infected larval trombiculid mites. Its nonspecific clinical presentation often leads to delayed diagnosis and treatment, increasing the risk of severe complications. As urbanization progresses and awareness declines, clinicians may overlook this diagnosis, particularly when characteristic findings such as an eschar are absent or have been resolved. We report the case of an 11-year-old boy from Vietnam who was admitted with recurrent fever persisting for two weeks, occasionally accompanied by abdominal distension. Further history revealed a previous insect bite that had resolved before admission and recent cases of scrub typhus among individuals living in the same neighborhood. Given the epidemiological context, targeted investigations were performed, leading to the identification of Orientia tsutsugamushi infection and confirmation of scrub typhus. Appropriate antibiotics resulted in significant clinical improvement. Thorough assessment of epidemiological exposure and early diagnostic testing are essential for timely diagnosis and treatment, thereby reducing morbidity and preventing potentially life-threatening complications.

PMID 42757256
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PubMedJournal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi2026-09-18

Advances in the role of house dust mite allergen components in the pathogenesis of allergic diseases.

Guo Chao-Fan CF, Wang Yan Y, Wang Yi-Nuo YN, Zhang Meng M et al.

House dust mites (HDMs) represent one of the most prevalent indoor aeroallergens globally and are closely associated with type 2 immune-mediated conditions, including allergic asthma, allergic rhinitis, and atopic dermatitis. To date, over 30 HDM allergenic components have been identified and are classified into proteases, lipid-binding proteins, structural proteins, and proteins with uncharacterized functions based on their structural and biological features. Among these, allergens from group 1, 2, and 23 exhibit robust immunoglobulin E(IgE)-binding activity and play pivotal roles in allergic sensitization and inflammatory cascades. HDM allergens disrupt epithelial barrier integrity, activate cell surface receptors, and promote the maturation of dendritic cells via Toll-like receptors, thereby driving type 2 immune responses. Furthermore, recent studies indicate that HDM allergens modulate the homeostasis of the immune microenvironment by affecting metabolic pathways, such as glycolysis, lipid metabolism, and ferroptosis. Traditional diagnostics and treatments heavily rely on crude mite extracts, which are limited by their complex composition, batch-to-batch variability, and a heightened risk of adverse reactions. Conversely, component-resolved diagnosis (CRD) and allergen immunotherapy (AIT) present novel avenues for precision medicine. This review systematically delineates the classification, structural characteristics, and immunopathogenic mechanisms of HDM allergen components in allergic diseases. It further summarizes recent advances in precision diagnostics and targeted interventions, aiming to provide a theoretical foundation for the individualized clinical management of allergic diseases.

PMID 42760190
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PubMedInsect science2026-09-17

A horizontally transferred bacterial gene for pantothenic acid biosynthesis regulates diapause and reproduction in the spider mite Amphitetranychus viennensis.

Liu Meibin M, Wang Yifei Y, Ren Yikang Y, Yang Fan F et al.

Horizontal gene transfer (HGT) has contributed substantially to the evolution of arthropod genomes, yet the functional significance of many horizontally acquired genes remains poorly understood. The hawthorn spider mite, Amphitetranychus viennensis, is a devastating agricultural pest whose high fecundity and overwintering diapause afford its exceptional ecological resilience. Through a genome-wide screen, we identified 37 high-confidence horizontally transferred genes (HTGs) in A. viennensis. Among these candidates, we prioritized AvPBL, a gene encoding pantothenate-β-alanine ligase, for functional characterization because it controls the rate-limiting step of a distinctly non-metazoan pantothenic acid (vitamin B5) biosynthesis pathway. RNAi-mediated suppression of AvPBL significantly reduced transcript abundance and endogenous pantothenic acid levels, triggering a 23.7% reduction in cumulative fecundity and severely compromising the mites' ability to enter winter diapause. Importantly, exogenous pantothenic acid supplementation rescued these reproductive and diapause defects, directly linking the observed phenotypes to the disruption of pantothenic acid biosynthesis. Our results demonstrate that the horizontally transferred bacterial gene AvPBL has been functionally integrated into the endogenous metabolic network of A. viennensis, playing a critical role in vitamin B5 biosynthesis, reproduction, and diapause regulation. These findings provide direct evidence that horizontally acquired metabolic genes can shape key life-history traits and drive adaptive evolution in arthropods.

PMID 42750349
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PubMedZoonoses and public health2026-09-17

Minor Risk to Contract Metazoan Parasites via the Consumption of Edible Snails, Born and Reared in France.

Gerard Claudia C, Ansart Armelle A

In a context of food security of animal consumption and diversification of protein sources, we have studied the risks to contract metazoan parasites through the consumption of 'gros-gris' snails (Cornu aspersum maximum) sampled in 12 French farms. The dissection of 361 adult snails, born and reared in France, revealed a very low parasite prevalence of 0.55% [Confidence interval: 0.15%-2.00%]. Each of the two parasitized snails harboured a single larva of the trematode Brachylaima at the metacercarial stage in its kidney. For its development, Brachylaima requires the presence of both terrestrial gastropods (first and second intermediate hosts) and vertebrates (definitive hosts) such as rodents and birds which faeces contain parasite' eggs. As for these vertebrate hosts, humans can be infected through the ingestion of parasitized snails and then harboured the parasite at an adult stage in the intestine, which could lead to digestive pathology. Our preliminary results suggest however very limited parasitological risks of the consumption of snails if they are born and reared in France, contrarily to wild snails from the subspecies C. aspersum aspersum ('petit-gris'), frequently found infected not only by Brachylaima, but also by nematodes and mites. In order to avoid snail contamination in helicicultures as much as possible, we recommend preventing intrusion of vertebrates, potentially parasitized, in the parks.

PMID 42750228
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PubMedClinical biochemistry2026-09-17

IgE allergy testing utilization: next steps from a provincial quality improvement initiative.

Parker Michelle L ML, Higgins Victoria V, Proctor Dustin T DT, Vander Leek Timothy K TK et al.

Appropriate utilization of allergen specific IgE (sIgE) testing is essential for optimizing identification of clinically relevant allergens. A provincial quality improvement sIgE utilization project in Alberta, Canada was recently implemented, including discontinuation of allergen screens and panels. Herein, we performed in-depth analyses of sIgE testing patterns and results after the utilization changes to identify opportunities for further improvement. Two years of provincial sIgE data were analyzed to assess positivity by number of orders per encounter, frequency of individual sIgE orders by allergy specialists and non-allergy specialists, distribution of result values by provider group and patient age, and degree of overlap for similar allergens ordered together. Non-allergy specialists are not substantially more likely to get at least one positive result when up to five allergens are ordered per patient encounter. Non-allergy specialists ordered more eggs, dairy and grains sIgE than allergy specialists for the same number of encounters and were more likely to receive quantitatively lower results. The frequency of detectable sIgE was much lower for adults as compared to pediatrics across all food categories except for crustaceans. For salmonid fish, crustaceans, and house dust mites, a single test per category would identify 95% or more of cases with at least one detectable sIgE. Discontinuing allergen screens and panels is an important first step in the quest for improved sIgE utilization, but restricting the number of tests ordered per patient encounter and curating the list of available sIgE to non-allergy specialists may further optimize sIgE testing appropriateness.

PMID 42753888
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