Drug Database
SC

SC-001 (SP009 / SC001)

✓ Approved

Declion Pharmaceuticals · · Polypeptide

What is SC-001?

SC-001 is a polypeptide developed by Declion Pharmaceuticals. It is approved for therapeutic indications via injectable (others) or intradermal injection.

Drug Profile

Brand NamesSP009, SC001
CompanyDeclion Pharmaceuticals
Drug ClassPolypeptide
RouteInjectable (Others), Intradermal Injection
StatusApproved
Sources: ClinicalTrials.gov, Declion Pharmaceuticals

Mechanism of Action

Molecular Targets

SC-001 acts on 1 molecular target:

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Therapeutic Indications

SC-001 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresBotulinum toxin injection✓ Approved

Related Research Articles

PubMedProgress in neuro-psychopharmacology & biological psychiatry2026-07-25

Structure-function coupling abnormalities in adolescent obsessive-compulsive disorder and their molecular correlates.

Li Mingming M, Yuan Xiaochi X, Zhang Chenchen C, Li Rui R et al.

Obsessive-compulsive disorder (OCD) frequently emerges during adolescence, a critical period of brain network maturation. Although altered functional and structural connectivity have been reported separately in adolescent OCD, structural-functional connectivity (SC-FC) coupling, which reflects how white matter architecture shapes functional organization, remains unexplored. Fifty adolescents with OCD and 53 healthy control participants underwent multimodal neuroimaging. SC-FC coupling was quantified across 246 brain regions and large-scale networks. Group differences were examined using general linear models, and associations with symptom severity were assessed using partial correlations. Machine learning evaluated prediction of diagnosis and symptom severity. Spatial correlation analyses linked coupling alterations to neurotransmitter systems and transcriptional signatures. Adolescents with OCD exhibited elevated SC-FC coupling, most prominently within the default mode network (DMN, t = 3.563, p < 0.001). DMN coupling was positively associated with compulsive symptom severity (ρ = 0.436, p = 0.002). SC-FC coupling discriminated patients from controls with 66.0% accuracy (area under the curve = 0.691, p = 0.003) and predicted symptom severity (r = 0.426, p = 0.002). Spatial association analyses linked SC-FC coupling alterations to normative dopaminergic and cholinergic molecular architectures. Transcriptomic analyses identified genes enriched for synaptic, neurodevelopmental, and signaling-related processes, with preferential expression in excitatory and inhibitory neurons. These findings demonstrate that adolescent OCD is characterized by SC-FC coupling alterations embedded within specific neurochemical and transcriptional architectures, suggesting that SC-FC coupling may serve as a systems-level marker linking brain organization, molecular substrates, and clinical manifestations.

PMID 42498116
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PubMedMagnetic resonance in medicine2026-07-25

1D Pre-Acquisition Navigator Correcting Respiratory-Induced Field Fluctuations in Multi-Echo Gradient-Echo Imaging of the Thoracic Spinal Cord.

Cronin Alicia E AE, D'Astous Alexandre A, Williams Nathan N, Guénette Antoine A et al.

In the spinal cord (SC), multi-echo gradient echo (ME-GRE) increases gray (GM) and white matter (WM) contrast and improves sensitivity to lesions in people with multiple sclerosis (pwMS). However, SC ME-GRE is susceptible to breathing-induced field fluctuations, causing ghosting artifacts and signal loss. Recent work introduced a 1D phase navigator following the last echo to measure field variations; however, susceptibility to phase wrapping increases at longer echo times. We propose a 1D phase navigator preceding the first echo, reducing phase accumulation and eliminating the need for respiratory monitoring. ME-GRE data covering the lower (T9-T12 vertebrae) and upper (T4-T8 vertebrae) thoracic SC were acquired in 20 healthy volunteers and 3 pwMS at 3T. Standard and navigator-corrected images were acquired in the same acquisition. To evaluate image quality, WM and GM signal-to-noise ratio (SNR), WM/GM contrast-to-noise ratio (CNR), and background ghosting signals were measured and compared between the two reconstructions. Both were blindly assessed for artifacts, structural delineation, and diagnostic confidence in pwMS. Navigator correction significantly increased GM and WM SNR and CNR, reduced posterior ghosting across both thoracic regions, and significantly reduced artifacts while increasing structural delineation. Preliminary evaluation in three pwMS showed consistent improvements in artifact mitigation, structural delineation, and lesion conspicuity with navigator correction, providing proof-of-concept for potential clinical application. A 1D navigator prior to the first echo reduces ghosting and improves thoracic SC image quality without respiratory monitoring. This approach could improve the diagnostic value and enhance the reliability of thoracic SC ME-GRE.

PMID 42499019
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PubMedJournal of environmental management2026-07-25

Radiation-vegetation regulation of water-soil ecosystem services in coastal transition zone based on high-resolution remote sensing diagnosis.

Ji Jiahui J, Xu Min M, Wang Shaohua S, Li Zishen Z et al.

Understanding the regulatory mechanisms of water-soil ecosystem services is essential for managing ecologically fragile coastal transition zones. From a short-term exploratory perspective, this study focused on Dongying City in the Yellow River Delta and assessed the dynamics of water retention (WR) and soil conservation (SC) from 2020 to 2024. Their synergy and trade-off patterns were identified using hotspot analysis, and a Radiation-Vegetation-Ecosystem Services structural equation model was developed to explore the potential pathways through which net radiation and vegetation regulate these services across different ecosystem types. The results showed that both WR and SC declined markedly in 2023. Potential synergy dominated the WR-SC relationship, while potential trade-offs occurred locally. Although synergy and trade-off hotspots were largely spatially separated, both were observed along the two banks of the Yellow River in northeastern Dongying. Net radiation was negatively associated with WR, whereas vegetation played a key mediating role in regulating both WR and SC. The dominant pathways varied among ecosystem types: wetlands were more strongly constrained by radiation, forests were primarily regulated by vegetation, and grasslands were influenced by both factors. This study provides a fine-resolution diagnostic framework for exploring short-term water-soil ecosystem service dynamics and offers new insights into the coupled regulation of these services by physical energy input and vegetation, thereby supporting targeted ecological management in fragile coastal regions.

PMID 42497740
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PubMedBiochimica et biophysica acta. Molecular basis of disease2026-07-25

RRx-001 induces apoptosis through reactive oxygen and endoplasmic reticulum stress in Burkitt lymphoma cells by acting as CD47 and c-Myc regulator.

Xu Linyan L, Lu Tianyi T, Deng Ling L, Zhang Meina M et al.

Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma with a poor prognosis in refractory and recurrent patients. RRx-001 is a promising anticancer agent currently under investigation in hematological malignancies; however, its therapeutic effects on BL are not clear. In this study, RRx-001 was found to inhibit the proliferation of BL cells and induce a DNA damage response. RRx-001 can induce apoptosis through caspase cascades with increasing cleavage of Caspases 8, 9, and 3. RRx-001 can also upregulate the expression of DR4, DR5, Bax, and cytochrome C and decrease the expression of Bcl-2, Mcl-1, and XIAP. RRx-001 promotes the accumulation of reactive oxygen species and triggers endoplasmic reticulum (ER) stress in BL cells, both these alterations contribute to RRx-001-induced apoptosis. Additionally, RRx-001 regulates MAPK pathways, and JNK/p38 MAPK signaling functions as a critical hub linking ER stress and oxidative DNA damage. Importantly, RRx-001 also functions as a regulator of CD47 and c-Myc, strongly inhibiting them both in vitro and in a BL cell tumor-bearing mouse model. The overexpression of CD47 increases the proliferation and partially inhibits the apoptosis of BL cells induced by RRx-001. Hence, the findings of this study provided new evidence that RRx-001 may serve as a therapeutic drug for treating BL.

PMID 42498053
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PubMedThe American surgeon2026-07-25

The Components Separation Technique Increases 30-Day Adverse Outcomes in Patients Undergoing Anterior Abdominal Hernia Repair With Medium to Large Defects.

Bosch Katherine R KR, Davenport Daniel L DL, Roth J Scott JS

BackgroundComponents separation techniques (CST) for anterior abdominal hernia repair (AAHR) are utilized to facilitate midline closure, reduce hernia recurrences, and avoid bridging mesh. New CPT® codes for AAHR allow differentiation of the impact of CST on AAHR outcomes, accounting for defect size.MethodsWe selected electively performed >3 cm AAHRs from the 2023 ACS NSQIP files. We examined the influence on NSQIP 30-day outcomes of CST (CPT 15734) with and without adjustment for defect size and NSQIP risk variables.ResultsIn 24 478 elective >3 cm defect AAHRs, 2227 patients (9.1%) underwent CST. CST is more common in open approach [5.4% vs 13.2% (P < .001)], large defects [3.6% vs 26.4% (P < .001)], recurrent hernias [.4% vs 17.3% (P < .001)], and incarcerated repairs [7.3% to 11.5% (P < .001)]. CST increased AAHR-adjusted operative time by 75 min in laparoscopic and 68 min in open procedures (P < .001). Major morbidity increased from 4.4% to 11.8% (P < .001) in CST patients, and SSI increased from 2.5% to 6.0% (P < .001). With risk adjustment, CST odds ratio for morbidity was 1.38 [95% CI 1.16-1.63, P < .001] and SSI was 1.22 [95% CI 0.97-1.53, P = .083]. The use of CST increased reoperation from 1.6% to 2.8% (P < .001), readmission from 3.5% to 7.0% (P < .001), and 30-day mortality from 0.2% to 0.5% (P = .003). Hospital stay increased by 1.2 days (P < .001).ConclusionVentral hernia repair with CST is associated with significantly increased 30-day adverse outcomes compared to repairs without CST in hernias of all sizes.

PMID 42498985
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PubMedNucleic acids research2026-07-25

Robust and generalizable CNV detection for single-cell sequencing assays.

Moore Travis W TW, Mohammed Hisham H, Adey Andrew C AC, Yardımcı Galip Gürkan GG

Copy number variations (CNVs) are genomic structural variants that are strongly linked to cancer progression and genetic disorders. CNVs can be highly heterogeneous at population and tissue scale; thus, single-cell resolution detection holds great promise for studying clonal evolution and CNV-driven changes. Despite advanced sc-RNA-seq CNV detection methods, accurate methods for epigenomic single-cell modalities lag behind. We developed RIDDLER; a robust, unsupervised method that uses outlier-aware statistical modeling to detect CNVs across multiple single-cell modalities and assays. RIDDLER utilizes a robust regression framework to model the expected distribution of reads genome-wide by accounting for assay-specific biases, identifying CNVs as outliers from that distribution. This versatile framing allows deployment of RIDDLER in multiple modalities with appropriate bias features. We demonstrate the accuracy of RIDDLER in calling single-cell CNVs and dissecting clonal heterogeneity in sc-ATAC-seq and sc-methylation. RIDDLER is more accurate and more robust to data sparsity than competing methods. We illustrate useful applications of RIDDLER for dissection of clonal structure, identification of subclonal accessibility peaks, and multimodal integration from CNV structure. RIDDLER stands out as a scalable, generalizable multi-modal method for accurate CNV detection, empowering studies aiming to link CNV dynamics to epigenetic alterations within the same cell.

PMID 42500822
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