Drug Database
SC

SC-001 (SP009 / SC001)

✓ Approved

Declion Pharmaceuticals · · Polypeptide

What is SC-001?

SC-001 is a polypeptide developed by Declion Pharmaceuticals. It is approved for therapeutic indications via injectable (others) or intradermal injection.

Drug Profile

Brand NamesSP009, SC001
CompanyDeclion Pharmaceuticals
Drug ClassPolypeptide
RouteInjectable (Others), Intradermal Injection
StatusApproved
Sources: ClinicalTrials.gov, Declion Pharmaceuticals

Mechanism of Action

Molecular Targets

SC-001 acts on 1 molecular target:

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Therapeutic Indications

SC-001 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresBotulinum toxin injection✓ Approved

Related Research Articles

PubMedDrug and alcohol dependence reports2026-09-20

Community-level determinants of buprenorphine provider availability: A ZCTA-level (zip code tabulation area) analysis.

Jehan Sadia S, Seay Kristen D KD

Equitable access to medications for opioid use disorder (MOUD) remains a global challenge. Little is known about community geographic, demographic, and socioeconomic characteristics associated with buprenorphine provider availability following removal of the X-waiver. This study examined these associations across U.S. Zip Code Tabulation Areas (ZCTAs). We analyzed 32,667 ZCTAs from SAMHSA, the U.S. Census, CDC WONDER, and the Missouri Census Data Center. Outcomes were provider availability (≥1 provider/ZCTA) and provider count. Independent variables included dichotomized measures of urban/rural, racial composition, median household income, educational attainment, unemployment, health insurance coverage, and continuous opioid overdose mortality. Multivariable logistic and negative binomial models were estimated. 30.2% of ZCTAs had at least one provider. Rural ZCTAs had lower provider availability (AOR=0.074, p < .001) and provider counts (IRR=0.070, p < .001). Majority non-White ZCTAs were not significantly associated with either provider availability (AOR=1.1, p = .17) or counts (IRR=1.1, p = .35). Communities with majority less than a bachelor's degree had lower provider availability (AOR=0.50, p < .001) and counts (IRR=0.53, p < .001). Higher unemployment (AOR=1.5; IRR=1.4, both p < .001), lower health insurance coverage (AOR=1.3; IRR=1.2, p < .001), and higher opioid overdose mortality (AOR=1.3; IRR=1.3, both p < .001) were associated with greater provider availability and counts. Low median household income was not associated with provider availability (AOR=1.0, p = .65) but was associated with higher provider counts (IRR=1.2, p < .001). Despite the removal of X-waiver, the availability of buprenorphine providers remains limited and uneven. Policies should prioritize equitable distribution of providers to better align treatment capacity with community need, particularly in rural areas.

PMID 42763521
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PubMedEsophagus : official journal of the Japan Esophageal Society2026-09-20

Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms.

Suzuki Yugo Y, Oda Minoru M, Tanaka Junji J, Kikuchi Daisuke D et al.

Extensive mucosal resection following endoscopic submucosal dissection (ESD) for hypopharyngeal neoplasms can result in scar contracture and pharyngeal deformity, potentially increasing the risk of aspiration pneumonia. This study aimed to evaluate the efficacy and safety of local triamcinolone acetonide (TA) injection for preventing post-ESD pharyngeal deformity. This retrospective cohort study included 388 patients who underwent ESD for hypopharyngeal neoplasms between 2011 and 2026. Patients were divided into those who received local TA injection after ESD (TA group, n = 65) and those who did not (control group, n = 323). Post-ESD pharyngeal deformity was classified into four grades based on endoscopic findings. The piriform sinus was subdivided into three subfields according to the extent of the mucosal defect. The TA group had a significantly lower deformity severity and fewer grade ≥ 2 deformities than the control group (both p < .001). Significant preventive effects were observed only in the piriform sinus (both p < .001). Among mucosal defects involving multiple piriform sinus subfields, both outcomes were significantly lower in the TA group for mucosal defects involving two (p < .001 and p = .046, respectively) and three (both p < .001) subfields. Similar findings were observed after propensity score matching. No adverse events related to TA injection were observed. Local TA injection may be an effective and safe strategy for preventing post-ESD pharyngeal deformity, particularly in mucosal defects involving multiple piriform sinus subfields.

PMID 42763380
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PubMedLaterality2026-09-20

Does script format matter for language lateralisation? A functional transcranial Doppler study of Chinese verbal fluency.

Abdelsattar Hager Ahmed HA, Khan Sumbul Asad SA

Although language production is generally dominated by the left hemisphere, it remains uncertain whether the script format influences the degree of this lateralization. To examine this issue, verbal fluency was assessed in 96 right-handed native Chinese speakers using functional transcranial Doppler sonography (fTCD). The subjects were asked to perform four overt word-generation tasks with four combinations of cue format and fluency type: Pinyin phonological fluency, character phonological fluency, Pinyin semantic fluency, and character semantic fluency. Laterality indices were calculated as the mean left-minus-right middle cerebral artery blood-flow velocity difference across the complete prespecified period of interest from 4 to 14 s after cue onset. All four conditions showed significant left lateralization, with mean LIs of 3.05, 2.60, 2.76, and 2.26 for Pinyin phonological, character phonological, Pinyin semantic, and character semantic fluency, respectively; all ps < .001. Pinyin-cued tasks yielded greater lateralization than character-cued tasks, F(1, 95) = 117.61, p < .001, ηp² = .553, and phonological fluency yielded greater lateralization than semantic fluency, F(1, 95) = 32.81, p < .001, ηp² = .257. The results indicate that verbal fluency is left-dominant in Mandarin, while the script format modulates the degree of hemispheric dominance during lexical retrieval.

PMID 42763425
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PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-09-20

Fundamentals of Arthroscopic Surgery Training Program Shows Transfer Validity Through Enhanced Operative Arthroscopic Performance.

Nicandri Gregg G, Davis Eric E, Meyer Alex A, Brady Jacqueline J et al.

To evaluate the content, construct, concurrent, and transfer validity of the Fundamentals of Arthroscopic Surgery Training (FAST) program and to determine whether FAST testing performance correlated with arthroscopic performance in the operating room. Participants were postgraduate years 1 to 3 (PGY1-3) orthopaedic residents from 7 programs who completed a 2-day FAST Training and Surgical Skills Assessment Course at the Orthopaedic Learning Center in February 2020. Residents underwent pre/postcourse surgical skills assessment in the operating room to determine baseline skills and measure transfer validity. Performance on surgical cases was measured using the Arthroscopic Surgical Skill Evaluation Tool, American Board of Orthopaedic Surgery's Operative Performance Score (O-Score), and the Procedure-Specific Checklist Tool (P-Tool). Baseline, training, and postcourse FAST testing was completed. Construct, concurrent, and content validity were assessed. Thirty-four (100%) participants completed the curriculum; 100% of residents and faculty agreed that FAST training improved arthroscopic skills (content validity). Expert-novice comparisons showed significant performance differences for 5 of 6 modules (construct validity). Post-training pass rates improved across all modules except the maze. Each FAST module passed correlated with a 1.24-point increase in Arthroscopic Surgical Skill Evaluation Tool score for simulated cadaveric arthroscopy (P < .001) and improved VirtaMed knee and shoulder simulator metrics (concurrent validity). Each FAST module passed correlated with a 3.86 (P < .001) Arthroscopic Surgical Skill Evaluation Tool (0-33 scale) improvement, a 4.52 (P < .001) American Board of Orthopaedic Surgery's O-Score (8-40 scale) improvement, and a 1.29 (P < .001) American Board of Orthopaedic Surgery's Procedure-Specific Tool (1-5 scale) improvement in the operating room (transfer validity). Performance on the FAST testing was significantly associated with improved arthroscopic performance on cadaveric, simulated, and live surgical assessments, showing content, construct, concurrent, and transfer validity within this cohort. The FAST program provides a structured, measurable method for developing fundamental arthroscopic skills early in orthopaedic residency, offering programs an evidence-based option for standardized assessment and targeted skills training.

PMID 42763781
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PubMedmicroPublication biology2026-09-20

Against All Odds: Computational Screening Via Machine Learning Ranking and Generation of Antibody Candidates for Creutzfeldt-Jakob Disease.

Tiruvellore Vinayan V, Koegle Mike M

Creutzfeldt-Jakob disease (CJD) is a fatal prion disorder with no approved treatments. This study developed a machine learning pipeline trained on 21 literature-curated PrP-targeting CDR sequences to rank 29,574 original and mutation-generated candidate sequences using neutralization, selectivity, and literature-based blood-brain barrier (BBB) proxy scores. The models showed internal performance (neutralization AUC = 0.9239; selectivity AUC = 0.7759), identified 10 high-percentile candidates, and generated 7,309 novel variants. These findings support hypothesis-generating sequence-level prioritization of PrP-targeting candidates, but do not establish native PrP Sc -specific binding, full-antibody efficacy, exact PrP epitope recognition, or in vivo BBB penetration and require further experimental validation and testing.

PMID 42763563
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PubMedFrontiers in public health2026-09-20

Component- and dimension-level network associations between sleep quality and health-related quality of life in older adults with hypertension.

Sun Xinyuan X, Guo Yanan Y, Ding Baoyang B, Hu Jun J

Older adults with hypertension commonly experience poor sleep quality and reduced health-related quality of life (HRQoL). Previous studies have mainly examined these associations using total scores, providing limited insight into interactions between specific symptom dimensions. This study aimed to construct a component- and dimension-level network linking sleep quality and HRQoL and to compare network differences across depressive-symptom status. This study included 2,257 older adults. Sleep quality, HRQoL, and depressive symptoms were assessed using the B-PSQI, EQ-5D-5L, and PHQ-9, respectively. We estimated a component- and dimension-level network based on the EBICGlasso-regularized Gaussian graph model, calculated centrality and bridge centrality metrics, validated stability using the bootstrap method, and compared network differences between the depressive and non-depressive-symptom groups. The final network included 10 nodes and 32 non-zero edges among 45 possible edges, with a density of 0.711. The strongest associations were between sleep efficiency and sleep duration (SE-ST, 0.793), sleep interruption and subjective sleep quality (SW-SQ, 0.583), and self-care and usual activities (SC-UA, 0.560). Usual activities (UA) showed the highest strength centrality and expected influence, followed by subjective sleep quality (SQ), self-care (SC), and sleep efficiency (SE). Sleep efficiency had the highest bridge expected influence, followed by subjective sleep quality. Centrality indices demonstrated good stability (CS = 0.75). No significant differences were found in network structure (M = 0.224, P > 0.05) or global strength (S = 0.119, P > 0.05); repeated 1:1 subsampling broadly supported these findings. Sleep components and HRQoL dimensions formed a closely connected network in older adults with hypertension. Usual activities showed the highest centrality, while sleep efficiency and subjective sleep quality showed prominent cross-community. These domains may be useful for screening or hypothesis generation but should not be interpreted as confirmed intervention targets.

PMID 42763455
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