Drug Database
GR

granulocyte colony stimulating factor (Hebervital)

✓ Approved

Heber Biotec · CSF3 · Recombinant Proteins

What is granulocyte colony stimulating factor?

granulocyte colony stimulating factor is a recombinant proteins developed by Heber Biotec. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesHebervital
CompanyHeber Biotec
Drug ClassRecombinant Proteins
Molecular TargetCSF3
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Heber Biotec

Mechanism of Action

Molecular Targets

granulocyte colony stimulating factor acts on 1 molecular target:

CSF3colony stimulating factor 3 (GCSF, CSF3OS)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

granulocyte colony stimulating factor is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersNeutropenia✓ Approved
Blood and lymphatic system disordersBone marrow disorder✓ Approved

Related Research Articles

PubMedCureus2026-09-20

Thyroid Hormone Levels and Its Co-relation With Human Chorionic Gonadotropin in Patients With Molar Pregnancy.

Singh Priyadarsini P, Behera Swayamprava S, Patra Lipsa L, Behuria Sasmita S et al.

Introduction Gestational trophoblastic disease (GTD) is characterized by abnormal trophoblastic proliferation, with hydatidiform mole being its most common form. Markedly elevated serum human chorionic gonadotropin (hCG) concentrations in molar pregnancy can stimulate thyroid-stimulating hormone receptors, resulting in thyroid dysfunction. This study aimed to evaluate thyroid hormone levels and their correlation with serum β-human chorionic gonadotropin (β-hCG) concentrations in patients with molar pregnancy and to compare thyroid function between complete and partial hydatidiform mole. Materials and methods This prospective observational study was conducted in the Department of Obstetrics and Gynaecology, Srirama Chandra Bhanja (SCB) Medical College and Hospital, Cuttack, Odisha, India, from January 2022 to December 2023. Eighty-eight women with histopathologically confirmed hydatidiform mole were included after excluding 26 patients who had received initial treatment elsewhere and were referred exclusively for oncological management. Serum β-hCG, thyroid-stimulating hormone (TSH), free triiodothyronine (free T3), free thyroxine (free T4), total triiodothyronine (total T3), and total thyroxine (total T4) were measured before uterine evacuation. Thyroid hormone profiles were compared between complete and partial mole, and correlations between serum β-hCG and thyroid hormone parameters were analyzed using Pearson's correlation coefficient. Results Among 15,844 deliveries, 88 women with histopathologically confirmed hydatidiform mole were analyzed, yielding a hospital-based frequency of 5.5 per 1,000 deliveries. Complete mole constituted 57 (64.8%) cases and partial mole 31 (35.2%). Patients with complete mole had significantly lower TSH (0.82±0.71 vs. 1.96±0.82 µIU/mL; p<0.001) and significantly higher free T3, free T4, total T3, total T4, and β-hCG levels than those with partial mole (all p<0.001). Serum β-hCG demonstrated a significant negative correlation with TSH (r=-0.61; p<0.001) and positive correlations with free T3 (r=0.73), free T4 (r=0.69), total T3 (r=0.65), and total T4 (r=0.67) (all p<0.001). Conclusion Complete hydatidiform mole was associated with significantly higher serum β-hCG concentrations and more pronounced thyroid dysfunction than partial hydatidiform mole. Serum β-hCG concentrations demonstrated a significant negative correlation with TSH and positive correlations with free and total T3 and T4 levels, supporting a close association between trophoblastic activity and thyroid function. These findings suggest that thyroid dysfunction may be particularly relevant in women with complete hydatidiform mole or markedly elevated serum β-hCG concentrations; however, larger multicentric studies with adjustment for potential confounding factors and longitudinal follow-up are warranted to clarify the clinical significance of these associations.

PMID 42763703
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PubMedOdontology2026-09-20

Effects of clear aligner cleaning agents on Streptococcus mutans biofilms and thermoplastic surface integrity: an in vitro study.

Nalbantoglu Eser Rengin ER, Harzivartyan Sevan S, Topcuoglu Nursen N, Yilmaz Hanife Nuray HN et al.

Clear aligners are increasingly used in paediatric and adolescent orthodontics, but prolonged wear and suboptimal hygiene may promote cariogenic biofilm accumulation. This study aimed to compare the antibacterial efficacy of commonly used commercial and household clear aligner cleaning agents against Streptococcus mutans biofilms and to examine their effects on aligner surface integrity. Biofilms were grown on 48 clear aligner discs; 42 (n = 7 per group across four experimental and two control groups) were used for biofilm quantification, and 6 (n = 1 per group) for SEM analysis. After biofilm formation, discs were treated with Invisalign® Cleaning Crystals, Corega® Proguard and Retainer tablets, Invisalign® Aligner Cleaning Spray, or white vinegar diluted to a final acetic acid concentration of 0.5%. Viable bacteria were quantified as colony-forming units per millilitre (CFU/mL), and surface morphology was assessed by SEM. Data were analysed using the Kruskal-Wallis test followed by Dunn-Holm post hoc comparisons (p < 0.05). Commercial agents significantly reduced CFU counts compared with the negative control, whereas white vinegar did not. Median CFU values were lowest for the commercial agents (1.2-2.5 × 10³ CFU/mL), with no significant difference among them, and Invisalign® Cleaning Crystals and Corega® tablets were more effective than white vinegar (p ≤ 0.04). SEM corroborated the microbiological findings, showing substantial biofilm removal without apparent surface deterioration after commercial treatment. These findings support the use of commercial products in evidence-based clear aligner hygiene protocols because of their greater antibiofilm efficacy and preservation of thermoplastic surface integrity.

PMID 42763375
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PubMedGenes & diseases2026-09-20

ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming.

Yu Sen S, Ke Mingxin M, Ma Muyuan M, Jiang Tingting T et al.

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death with limited treatment options, and there is an urgent need to develop effective therapeutic strategies. The zonula occludens-2 (ZO-2) protein is a member of the tight junction protein family, and its function and underlying mechanisms of action in PDAC are unknown. Gene expression and its association with the clinicopathologic characteristics of patients with PDAC were analyzed using immunohistochemistry and bioinformatics and functionally validated by using in vitro and in vivo mouse models. Protein expression and protein regulation were measured by using gain- and loss-of-function assays and molecular biology methods. The expression level of ZO-2 decreased in PDAC and was highly correlated with aggressive pathological features and the prognosis of patients. Increased expression of ZO-2 inhibited the proliferation, migration and colony formation of PDAC cells in vitro and inhibited PDAC tumor growth and liver metastasis in vivo. Mechanistically, ZO-2 bound to the mitochondrial membrane protein phosphoglycerate mutase 5 (PGAM5) and trapped it in the cytosol. Reduced expression of ZO-2 caused increased mitochondrial localization of PGAM5, leading to activated mitochondrial function and increased intracellular reactive oxygen species and ATP levels, thereby promoting PDAC malignancy, whereas increased ZO-2 expression did the opposite. ZO-2 expression also correlated directly with immune cell infiltration and immune signaling in PDAC. Downregulation of ZO-2 caused increased localization of PGAM5 to the mitochondrial membrane and promoted PDAC malignancy through metabolic reprogramming. ZO-2 is associated with the PDAC immune microenvironment. The ZO-2-PGAM5 axis could serve as a potential therapeutic target in PDAC.

PMID 42763477
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PubMedFrontiers in public health2026-09-20

Factors and a configurational pathway associated with lower turnover intention among high-level medical professionals in county-level hospitals in China: a multicenter cross-sectional study.

Dong Shuxin S, Tai Qiuyuan Q, Yao Yiming Y, Shen Junlong J et al.

This study developed a context-specific framework of perceived conditions related to lower turnover intention among high-level medical professionals in county-level hospitals and examined the configurational pattern associated with a high retention-oriented score. A multicenter cross-sectional study combined three Delphi rounds, psychometric evaluation, and fuzzy-set qualitative comparative analysis (fsQCA). The Delphi process progressed from 33 items in round 1-37 in round 2 and 34 assessed in round 3, with 33 retained for the survey. From July 2024 to February 2025, online and paper questionnaires were distributed in 10 county-level public hospitals in Jiangsu Province. Of 635 questionnaires distributed, 611 were returned and 579 were valid. The sample was randomly split for exploratory factor analysis (EFA; n = 289) and confirmatory factor analysis (CFA; n = 290). fsQCA used the full sample, a frequency threshold of 10, consistency of 0.85, and proportional reduction in inconsistency (PRI) of 0.70. Thirty experts participated in Delphi round 1 and 29 in rounds 2 and 3 after one expert retired. The final 31 condition items showed high internal consistency (alpha = 0.971), suggesting both reliability and possible redundancy. Parallel analysis in the EFA half-sample suggested two factors, whereas a theory-constrained five-factor solution remained interpretable. In the CFA half-sample, the correlated five-factor model fit was marginal (Satorra-Bentler chi-square = 1350.48, df = 424, CFI = 0.903, TLI = 0.893, RMSEA = 0.087, 90% CI 0.082-0.092, SRMR = 0.042) and was similar to the second-order and bifactor models. No condition met the 0.90 necessity threshold. The corrected truth-table analysis identified one high-score configuration, PD*IES*CIS*OIE (consistency = 0.953; PRI = 0.917; coverage = 0.631). PD and CIS were core present conditions; IES and OIE were peripheral present conditions; IEPS was not included. A single sufficient configuration combined favorable perceptions of personal development, institutional/environmental support, compensation/incentive support, and organizational/interpersonal empowerment. The result does not support multiple substitutable pathways. Because the outcome was a retention-oriented score derived from a turnover-intention measure, the findings concern lower turnover intention rather than directly observed retention. The cross-sectional, individual-level results indicate associations and should not be interpreted causally or at the hospital level.

PMID 42763469
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PubMedInternational journal of endocrinology and metabolism2026-09-20

Large-Scale Brain Network Connectivity Mediates the Association Between Metabolic Risk Factors and Cognition: An fMRI Study of the Human Connectome Project.

Soleymani Yunus Y, Batouli Seyed Amirhossein SA, Khalagi Kazem K, Pourabbasi Ata A

Subclinical metabolic disturbances have been associated with functional brain changes; however, the neural pathways mediating their cognitive effects remain unclear. This study investigated whether large-scale brain network connectivity mediates associations between metabolic risk factors and cognition in healthy young adults. Data were obtained from 676 participants (22 - 37 years) in the Human Connectome Project. Metabolic indices (body mass index (BMI), glycated hemoglobin, thyroid-stimulating hormone (TSH), systolic/diastolic blood pressure, and hematocrit) were assessed alongside the National Institutes of Health (NIH) Toolbox Cognition Battery scores, the Mini-Mental State Examination, and fluid intelligence measures. Resting-state fMRI data underwent group independent component analysis to identify 14 intrinsic connectivity networks. Partial correlations were computed between network time series, and multiple regression models were adjusted for age, sex, race, and education. Mediation analyses with bootstrapped confidence intervals were conducted to test whether network connectivity explained the metabolic-cognition relationships. We found that large-scale resting-state networks significantly mediated the associations between specific metabolic risk factors and cognitive performance. Specifically, BMI, hematocrit, and TSH showed significant associations with both cognition and network connectivity (all P < 0.05). BMI-related reductions in vocabulary performance were fully mediated by altered connectivity in the frontoparietal-language, sensorimotor-frontoparietal, primary visual-auditory, and default mode-executive attention networks and partially mediated (compensatory effect) by salience-sensorimotor connectivity (indirect effects: -0.0238, -0.0115, -0.0110, -0.0096, and 0.0068, respectively; 95% CIs: [-0.0421, -0.0085], [-0.0239, -0.0030], [-0.0237, -0.00016], [-0.0206, -0.0014], and [0.0001, 0.0165], respectively). Hematocrit's positive association with vocabulary performance was partially mediated by the primary visual-auditory, salience-auditory, and language-dorsal attention networks, with primary visual-ventral attention connectivity exerting a suppressive effect (indirect effects: 0.0094, 0.0149, 0.0074, and -0.0113, respectively; 95% CIs: [0.0007, 0.0215], [0.0032, 0.0319], [0.0001, 0.0197], and [-0.0249, -0.0012], respectively). TSH was positively associated with fluid intelligence via a direct pathway (P = 0.010), without mediation by resting-state connectivity. These findings highlight large-scale brain networks as potential intermediate phenotypes that link metabolic health to cognition, suggesting that targeted neuromodulation of vulnerable circuits, combined with metabolic interventions, may offer novel strategies for preserving cognition in at-risk populations.

PMID 42763643
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PubMedJournal of research in nursing : JRN2026-09-20

Psychometric properties of the Persian version of Pressure Ulcer Management Self-Efficacy Scale for nurses.

Mohammadzade Sarhadi Sajjad S, Najafi Fereshteh F, Fendereski Afsaneh A, Sharifi Simin S

Pressure ulcers remain a major clinical challenge, and nurses' self-efficacy is essential for their prevention and management. The Pressure Ulcer Management Self-Efficacy Scale (PUM-SES) for nurses was developed to assess this competency. This study aimed to translate, culturally adapt and validate the Persian version of the PUM-SES (PUM-SES-P) among Iranian nurses. This three-phase study began with forward and back translation. In phase two, face and content validity were evaluated by 10 nurses and 15 experts, respectively, and construct validity and reliability were assessed among 200 and 30 nurses. In phase three, criterion-related and convergent validity were evaluated among 100 nurses. Content validity indices were favourable (content validity index = 0.97, content validity ratio = 0.90), and factor analysis supported a four-factor structure. The scale showed high internal consistency (α = 0.91) and acceptable test-retest reliability (r = 0.89). Correlations with General Self-Efficacy Scale (r = 0.88) and Attitude towards Pressure Ulcer Prevention instrument (r = 0.77, p < 0.001) supported validity. The PUM-SES-P appears to be a valid, reliable instrument for assessing pressure ulcer self-efficacy among Iranian nurses in this sample, offering a potentially useful resource for nurse educators and unit managers. Further validation in larger, more diverse samples is recommended before broader clinical application.

PMID 42763473
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