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ceftriaxone sodium + tazobactam sodium (Citrafen)

✓ Approved

Bharat Serums and Vaccines Limited · Small Molecule · Small Molecule

What is ceftriaxone sodium + tazobactam sodium?

ceftriaxone sodium + tazobactam sodium is a small molecule developed by Bharat Serums and Vaccines Limited. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesCitrafen
CompanyBharat Serums and Vaccines Limited
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Bharat Serums and Vaccines Limited

Therapeutic Indications

ceftriaxone sodium + tazobactam sodium is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsStreptococcal infection✓ Approved

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Structural optimization and freeze-thaw stabilization of carnauba wax and beta-sitosterol bigels via peanut protein and sodium alginate complexation.

Hu Chun C, Li Chunyu C, Zhang Weinong W, He Junbo J et al.

This study investigated the influence of peanut protein/sodium alginate (PP/SA) complex and oleogel-to-hydrogel ratio on the structure, mechanical properties and stability of carnauba wax/β-sitosterol-based bigels. The results indicated adding SA increased PP mean particle size from 88.1 to 395.2 and 729.6 nm, and absolute zeta-potential from 38.5 to 53.0 and 60.5 mV, and improved its surface hydrophobicity. Additionally, at 40% and 50% oleogel, SA addition was shown to improve the performance of PP bigels in water holding capacity, elastic modulus (G'), viscous modulus (G″), textural properties (hardness, springiness, chewiness and gumminess), as well as physical and freeze-thaw stability. Notably, the bigels with 50% oleogel exhibited the most compact structure and optimal functional properties. However, at 60% oleogel, the PP bigels declined in texture parameters, rheological properties and stability, making the positive effects of SA negligible. These findings provide a theoretical foundation for utilizing PP/SA bigels as potential spreadable sauce substitutes.

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PubMedLaboratory medicine2026-09-20

Effect of sodium citrate and magnesium sulphate anticoagulation on platelet parameters measured on the Alinity hq analyzer.

Betzer Cristine C, McGrail Rie R

EDTA-dependent pseudothrombocytopenia (PTP) may cause spuriously low platelet counts and can be prevented by using alternative anticoagulants, such as sodium citrate (citrate) and magnesium sulphate (MgSO4). However, these anticoagulants may affect platelet parameters depending on the analytical platform. Their effect on platelet measurements using the Abbott Alinity hq hematology analyzer has not previously been evaluated. Blood samples from 40 outpatients without known PTP were collected in K2-EDTA, citrate, and MgSO4 tubes. Platelet count, mean platelet volume, and reticulated platelet fraction were measured on an Alinity hq analyzer. Paired comparisons were performed using Friedman repeated-measures analysis with the Dunn multiple comparisons test. Compared with EDTA, median platelet counts were statistically significantly lower in citrate (-21.1%) and MgSO4 (-31.7%) than in EDTA (P < .05). Mean platelet volume was also statistically significantly reduced in citrate (-3.2%) and MgSO4 (-4.7%) (P < .05). Median reticulated platelet fraction was slightly higher in both anticoagulants, but only MgSO4 differed substantially from EDTA. On the Alinity hq analyzer, citrate and MgSO4 result in statistically significantly lower platelet count than EDTA in samples from individuals without known PTP. Platelet parameters are therefore influenced by anticoagulant choice and should not be interpreted interchangeably.

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Beyond the Usual Pathogens: Community-Acquired Meningoencephalitis Caused by Streptococcus equi in an Immunocompetent Adult.

Hammadi Hicham H, Elbouti Anas A, Chikhi Brahim B, Aarjouni Youssef Y et al.

Streptococcus equi is a rare zoonotic pathogen that only occasionally causes invasive central nervous system infections in humans. We report the case of a previously healthy 50-year-old man who presented with fever and altered mental status in the setting of recent animal exposure. Cerebrospinal fluid analysis was consistent with acute bacterial meningitis, while direct microscopy and multiplex polymerase chain reaction identified S. equi. Antimicrobial susceptibility testing confirmed susceptibility to ceftriaxone. Despite early initiation of intravenous ceftriaxone and adjunctive dexamethasone, the patient's course was complicated by generalized status epilepticus requiring intensive care support. He subsequently showed progressive neurological recovery with a favorable outcome. This case underscores the importance of considering S. equi as a potential cause of community-acquired bacterial meningoencephalitis in patients with relevant zoonotic exposure and highlights the value of rapid molecular diagnostics for early pathogen identification and targeted antimicrobial therapy.

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Comparative analysis of vitamin C derivatives on ATP homeostasis across diverse cell types.

Goc Anna A, Sumera Waldemar W, Niedzwiecki Aleksandra A

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High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis.

He Zhenting Z, Deng Ziling Z, Zhang Huan H, Xiang Yiming Y et al.

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by a complex interplay of genetic, environmental, and immunological factors. Neutrophils, as a key component of the innate immune system, play a critical role in IBD pathogenesis due to their dysregulated infiltration, impaired apoptosis, and resultant epithelial damage during the disease process. Conventional approaches aimed at suppressing neutrophil activity have achieved only modest clinical efficacy and highlight the need for strategies that recalibrate neutrophil responses without compromising their essential antimicrobial functions. In this study, we employed high-throughput chemical screening using neutrophil-specific transgenic zebrafish larvae to identify compounds capable of modulating neutrophil homeostasis, and subsequently evaluating their efficacy in a dextran sodium sulfate (DSS)-induced IBD model. We identified epothilone B (Epo B), a traditional chemotherapeutic drug, as a potential therapeutic candidate for IBD. Our findings demonstrate that Epo B protects against IBD by promoting intestinal epithelial recovery, alleviating inflammatory responses, and rebalancing the gut microbiota. Mechanistically, Epo B selectively stimulates neutrophil apoptosis by targeting and enhancing Caspase-3 cleavage, thereby inhibiting neutrophilic inflammation. This study underscores the utility of in vivo high-throughput drug screening in IBD and highlights Epo B as a promising candidate for drug repurposing in IBD treatment, offering a novel therapeutic strategy by targeting neutrophil apoptosis.

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