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hydroquinone (Tanit)

✓ Approved

Vinas · Small Molecule · Small Molecule

What is hydroquinone?

hydroquinone is a small molecule developed by Vinas. It is approved for therapeutic indications.

Drug Profile

Brand NamesTanit
CompanyVinas
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Vinas

Therapeutic Indications

hydroquinone is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersSkin hyperpigmentation✓ Approved

Related Research Articles

PubMedDanish medical journal2026-10-22

First defaecation and use of laxatives after hip fracture surgery.

Christensen Sanne Høj SH, Matthiesen Laura Houstrup LH, Kristensen Nicolai Kjældgaard NK, Korsgaard Patrick P et al.

Patients undergoing hip fracture surgery are at risk of developing constipation post-operatively. This study investigated time to first defaecation after surgery. This retrospective cohort study included patients undergoing hip fracture surgery at a regional hospital from 1 May to 30 September 2024. Patients underwent a standardised hip fracture regimen, focusing on surgery within 24 hours of admission, early mobilisation, optimised medication including dual-drug laxatives, and daily geriatric post-operative rounds. Data were obtained from patient files after prospective data entry by the nursing staff, who were instructed on correct registration during the study period. We included 102 patients (64% women), with a median age of 83 years (IQR: 76-88 years). The mean time to defaecation after surgery was 2.7 days (SD: 1.5 days). In 24% of the patients, first defaecation occurred later than three days post-operatively. Time to defaecation correlated with length of hospital stay (r = 0.22; 95% CI: 0.04-1.5; p = 0.04). No difference in time to defaecation was observed between patients who were mobilised before or after post-operative day three (p = 0.91). Overall, 66 patients (65%) received laxatives beyond the standard regimen. Despite being treated with a contemporary, dedicated hip fracture regimen, post-operative delayed defaecation remains a frequent problem, and patients often require additional laxatives. This finding highlights a need to optimise post-operative constipation in hip fracture patients. None. Approved by the Central Denmark Region.

PMID 42902750
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PubMedPhysical chemistry chemical physics : PCCP2026-10-22

Dual-guest-metal control of stability and superconductivity in ambient-pressure B-C clathrates X0.5Y0.5B2C8.

Yang Yuting Y, Su Zhangmin Z, Chen Ruijie R, Guo Hongying H et al.

Phonon-mediated superconductivity in boron-carbon clathrates has become an active area of research, but how mixed guest-metal occupancy affects stability and superconductivity is still unclear. Using high-throughput first-principles calculations, we study quaternary X0.5Y0.5B2C8 clathrates (X, Y = Li, Na, K, Rb, Cs, Mg, Ca, Sr, and Ba) at ambient pressure. We identify 15 dynamically stable phases, all involving combinations of two large-radius guest metals. Fourteen of these phases are predicted to be superconducting: compounds with an average formal oxidation state at the metal sites of +1.5 and +1 show Tc of 34 to 42 K and 78 to 90 K, respectively, whereas the remaining +2 phase is semiconducting. The contrast in Tc fits a rigid-band picture in which lower guest formal oxidation states increase the B-C density of states at the Fermi level and enhance coupling to mid-frequency B-C phonons. Ab initio molecular dynamics at 300 K reveals no structural transformation, indicating that these dual-guest clathrates are viable candidates for further study.

PMID 42902693
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Predicting Clinical Outcome in Dengue Fever: A Retrospective Cohort Modeling Study.

Singh Santosh Kumar SK, Kumar Suman S, Vanajakumari Sreejith Prathapachandran SP, Khanuja Mehek M et al.

Dengue fever demonstrates a broad spectrum of clinical severity, ranging from self-limiting illness to life-threatening complications. Early identification of patients at risk of progression remains a clinical challenge, particularly in high-burden settings. Although platelet count and World Health Organization (WHO) dengue classification are routinely used in clinical practice, reliance on individual parameters may not adequately capture the multifactorial nature of disease severity. Development of multivariable predictive models integrating clinical and laboratory markers available at admission may improve early risk stratification and support evidence-based triage decisions. This retrospective predictive analysis included 667 consecutively hospitalized patients with laboratory-confirmed dengue infection. This retrospective cohort study was conducted in a tertiary care teaching hospital in Western Maharashtra over a 1.5-year period. Data were extracted from hospital records of patients evaluated during their admission period. An ordinal logistic regression model was developed to predict clinical outcome. Internal validation was performed using bootstrap resampling. Of 667 patients, 585 (87.7%) had uncomplicated recovery, 69 (10.3%) had complicated recovery, and 13 (1.9%) had adverse outcomes. WHO classification, platelet count, neutrophil-to-lymphocyte ratio (NLR), and warning sign count at admission independently predicted clinical outcome, with an optimism-corrected C-index of 0.820. Admission WHO classification, platelet count, NLR, and warning signs enable accurate early prediction of dengue severity and may assist in triage and monitoring decisions.

PMID 42902640
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-22

Electronic Asymmetry in Dual-Acceptor COFs Drives Site-Specific Cooperative 2e- ORR for Efficient H2O2 Photoproduction.

Zhou Meng-Yao MY, Wang Xiu X, Cui Wei-Rong WR

Covalent organic frameworks (COFs) hold promise for photocatalytic H2O2 production, yet the multistep 2e- oxygen reduction reaction (ORR) presents a fundamental contradiction: O2 activation demands a strongly electron-deficient site, while *OOH conversion requires a moderately electron-rich environment, a trade-off unresolvable in single-acceptor COFs. Herein, we report a dual-acceptor COF (BDZ-BFA-ETP) that integrates benzothiadiazole (BDZ) and pyridinium-based ETP units to create pronounced acceptor-side electronic asymmetry. This electronic reconstruction drives site-specific functional differentiation: the electron-deficient BDZ preferentially activates O2, while the relatively electron-rich ETP facilitates *OOH conversion and H2O2 release, cooperatively optimizing the entire 2e- ORR pathway. Consequently, BDZ-BFA-ETP achieves an exceptional H2O2 production rate of 7976.9 µmol g-1 h-1 in pure water under visible light without sacrificial agents, outperforming single-acceptor COFs by factors of 1.5 and 3.4, with an apparent quantum yield of 2.84% at 400 nm and robust stability across a wide pH range. Theoretical and in situ spectroscopic investigations confirm that this electronic asymmetry not only promotes charge separation but, crucially, enables the two distinct acceptor regions to perform separate elementary steps cooperatively. This work establishes a design concept linking electronic asymmetry, site-specific functional differentiation, and cooperative catalysis, offering a roadmap for efficient solar-driven H2O2 synthesis.

PMID 42902876
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PubMedFrontiers in immunology2026-10-22

Multimodal neuroimmune diagnostic profiling for pediatric lower urinary tract dysfunction associated with occult sacral nerve abnormalities.

Wang Dan D, Pei Jun J, Liao Hongyong H, Liu Yimeng Y et al.

Persistent pediatric lower urinary tract dysfunction (LUTD) may be associated with occult sacral neural impairment, a clinically challenging condition characterized by subtle sacral pathway dysfunction without overt spinal dysraphism. To develop, internally validate, and externally validate a multimodal diagnostic model integrating ultrasound, urodynamics, neuroelectrophysiology, and urinary biomarkers. The development dataset comprised 120 records (45 occult sacral neuropathy-related LUTD, 45 functional non-neurogenic LUTD, and 30 controls). The target-condition label followed a prespecified multidisciplinary composite reference standard based on clinical phenotype, neurological examination, spinal/pelvic MRI when available, conventional urodynamic interpretation, and longitudinal course; biomarker values and model probabilities were not components of that label. Preanalytical metadata included pre-catheterization collection, centrifugation at 3000 or 5000 x g for 10 minutes, 1.0- 1.5 mL aliquots, storage at -80 °C, limited freeze-thaw exposure, and creatinine normalization. We internally validated a six-predictor logistic model with 1,000 bootstrap repetitions. We assessed a separate 90-record, two-site dataset without refitting or threshold optimization. The locked model had an apparent AUC of 0.937 and Brier score of 0.099; optimism-corrected values were 0.920 and 0.116, respectively. The bootstrap mean calibration intercept was -0.065, and the slope was 1.032. In the external transportability analysis, the AUC was 0.928 (95% CI, 0.861-0.977), the Brier score was 0.098, the calibration intercept was -0.400, the calibration slope was 0.887, sensitivity was 80.0%, and specificity was 88.3%. Multimodal neuroimmune profiling demonstrated strong discrimination and acceptable calibration after optimism correction and external validation in an independent two-site cohort. Prospective multicenter validation is required before clinical implementation.

PMID 42903153
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PubMedInternational journal of MS care2026-10-22

Head Rotation Impairs Balance and Walking in People With Mild to Moderate Multiple Sclerosis: A Pilot Study.

Rösner Marianne M, Ramari Cintia C, Villa-Real Juan Ma Vecin JMV, Moumdjian Lousin L et al.

People with multiple sclerosis (MS) have an increased risk of falls, which are often associated with changes in movement direction and preceded by head rotation (HR). We aimed to investigate the effects of HR on postural control and gait temporal parameters in people with MS compared with controls (Cs) and to quantify the number of strides required to correct gait after HR. Eighteen people with MS (44.4 ± 9.9 years; 3.1 ± 1.5 Expanded Disability Scale Score) and 10 Cs (43.6 ± 10.3 years) participated. Postural control during a standing task on a force plate was assessed and quantified by center of pressure displacement. Gait was assessed by 2D sagittal video analysis and analyzed with Kinovea. After30 seconds of unperturbed walking on a treadmill, participants were instructed to turn their head to the left and walk on, followed by a right HR. The 10 strides after the HR were compared with the mean of normal walking strides. Inter- and intragroup comparisons were performed using a mixed model for repeated measurements. Hierarchical testing was used for stride analysis. While standing, people with MS performed worse in all conditions and increased center of pressure displacement after HR in comparison with Cs (P ≤ .05). While walking, both groups increased the relative stance phase after HR (P ≤ .05); however, people with MS reduced stride times (P ≤ .05), and Cs maintained them. After HR, people with MS needed 3 strides to normalize stride times back to baseline, versus 1 to none for Cs. People with MS have higher transient imbalance while walking and standing after an HR compared with Cs.

PMID 42903005
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