Drug Database
TH

theophylline (Teonova syrup / Theodur Sprinkle / Theolan suspension)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · ADORA1 · Small Molecule

What is theophylline?

theophylline is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTeonova syrup, Theodur Sprinkle, Theolan suspension
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
Molecular TargetADORA1, ADORA2A
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

theophylline acts on 2 molecular targets:

ADORA1adenosine A1 receptor (RDC7)
ADORA2Aadenosine A2a receptor (A2aR, RDC8)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

theophylline is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersRespiratory disorder✓ Approved

Related Research Articles

PubMedFrontiers in public health2026-05-21

Beyond "Taiji Diagram": how multimodal metaphor deciphers Yin Xu and Yang Xu through Traditional Chinese Medicine science communication short videos.

Wang Shaoci S, Wang Musi M, Ng Lay Shi LS, Shaari Azianura Hani AH

This study investigates how multimodal metaphors convey two core Traditional Chinese Medicine (TCM) concepts- "Yin Xu" (Yin deficiency) and "Yang Xu" (Yang deficiency)-in short science communication videos on Douyin. Drawing on Conceptual Metaphor Theory, Multimodal Metaphor Theory, and Visual Grammar Theory, this research examines the effectiveness of multimodal representation of TCM concepts in digital health communication. This study adopts a quantitative multimodal discourse analysis approach to analyze 15 short videos on Yin Xu and Yang Xu published on Douyin between 2023 and 2024. Using ELAN software, 89 metaphorical units were annotated across four semiotic modes (written signs, pictorial signs, sound, and gesture) to evaluate their performance, distribution, and cross-modal coordination. Findings indicate that 43.8% of metaphorical mappings exhibit source-target domain inconsistencies, accompanied by insufficient cross-modal coordination and minimal dynamic narrative elements. Written text overwhelmingly dominates the modal distribution at 67.4%, while visual elements remain notably underrepresented at 21.3%. These findings suggest that multimodal inconsistency and visual underutilization may compromise the conceptual coherence of TCM metaphorical communication. In response to these identified shortcomings, this paper presents optimization strategies focused on color-based coding systems, dynamic narrative construction, and enhanced cross-modal integration. By developing a systematic framework for enhancing the precision and coherence of TCM metaphor representation in digital media, this research contributes to the convergence of semiotic analysis, science communication, and cognitive linguistics.

PubMedFrontiers in psychology2026-05-21

A methodological protocol for multimodal profiling of conversational abilities in mandarin-speaking children with and without developmental language disorder.

Wang Cai C, Xu Jiamin J, Yao Mengmeng M, Wang Jingyu J et al.

Developmental Language Disorder (DLD) is a common neurodevelopmental condition that affects both the structural and pragmatic aspects of language. Conversational abilities-including topic initiation, maintenance, repair, turn-taking, and the integration of non-verbal behaviors-are essential for social communication and peer relationships. While a substantial body of research has described conversational difficulties in DLD among English-speaking populations, there is limited evidence on how these impairments manifest in Mandarin-speaking children. There is a critical need for culturally adapted assessment approaches; thus, this protocol primarily aims to evaluate the feasibility of a multimodal framework tailored specifically to the Mandarin-speaking context. This protocol describes an age-stratified cross-sectional observational study with two phases. In Phase 1, an adapted multimodal profiling framework will be developed and piloted through semi-structured free conversation and role-play tasks, recorded with audio-video equipment. Transcription will follow Codes for the Human Analysis of Transcripts (CHAT) conventions within European Distributed Corpora (EUDICO) Linguistic Annotator (ELAN), with word segmentation supported by Jieba and manual correction. Annotation tiers will capture utterance-level features, communicative acts (Inventory of Communicative Acts-Abridged [INCA-A]), repairs, turn-taking, and gesture-speech alignment (stroke apex ±500 ms). Feasibility (session completion, recording length, and utterance yield) and reliability (Cohen's κ, ICC, and drift checks) will be evaluated to refine the coding manual. In Phase 2, the finalized protocol will be applied to 90 children with DLD and 90 typically developing (TD) peers (aged 4-6, matched for age and sex). Data analysis will quantify primary outcome measures (topic maintenance ratio, successful repair rate, gesture-speech synchrony index) and secondary outcome measures (lexical diversity, initiation-maintenance balance, and turn-taking productivity), with exploratory analyses of demographic and home-environment moderators. This protocol advances methodological research by providing a transparent and reproducible framework for multimodal profiling of pragmatic language in Mandarin-speaking preschoolers. Its strengths include multimodal data integration and explicit feasibility benchmarks. Limitations include the cross-sectional design and a modest sample size. Future research may extend the protocol to longitudinal studies, contributing to the establishment of standardized procedural benchmarks and improved data comparability within this specific linguistic environment.

PubMedPCN reports : psychiatry and clinical neurosciences2026-05-21

Electroconvulsive therapy in an older patient with recurrent major depressive disorder and a permanent pacemaker: A case report.

Omori Wataru W, Kodaka Narumi N, Oga Kenichi K, Masuda Yoshikazu Y et al.

Electroconvulsive therapy (ECT) is highly effective for severe or treatment-resistant major depressive disorder, including in older adults. In patients with permanent pacemakers, however, ECT may be avoided because of concern about device malfunction or arrhythmia. We report a man in his 80s with recurrent major depressive disorder and a dual-chamber pacemaker for complete atrioventricular block. During the approximately 2 years before admission, the depressive episode achieved only partial remission despite mirtazapine 30 mg/day and trials of duloxetine 60 mg/day and venlafaxine 150 mg/day, then worsened acutely. Vortioxetine was introduced after admission, but severe symptoms persisted. Pre-ECT interrogation confirmed pacemaker dependence with only minimal intrinsic ventricular activity. After multidisciplinary preparation, approximately twice-weekly ECT was initiated using a Thymatron System IV device with initial bitemporal placement; stimulus dosing initially followed the half-age method, beginning at 40% (202 mC) with a brief-pulse stimulus. As seizure induction became difficult, augmentation included hyperventilation, theophylline premedication, switching to right unilateral placement, and ketamine anesthesia. Continuous monitoring and peri-ECT device checks showed stable function; no magnet application or reprogramming was required. The patient received 20 treatments. The 21-item GRID Hamilton Depression Rating Scale (GRID-HAM-D) score improved from 32 before ECT to 2 after the acute course. Mood, anxiety, appetite, and physical strength improved early, followed by more gradual improvement in psychomotor retardation. No clinically significant arrhythmias, pacemaker malfunction, oversensing, pacing inhibition, or serious hemodynamic complications occurred. This case supports the feasibility of carefully planned ECT in selected older patients with permanent pacemakers, provided that multidisciplinary planning and practical device precautions are in place.

PubMedElectrophoresis2026-05-14

A Simulation Study of Inhibition Assay With Theophylline on the Enzymatic Hydrolysis of p-Nitrophenyl Phosphate With Alkaline Phosphatase in a Continuous Mode of Electrophoretically Mediated Microanalysis.

Takayanagi Toshio T, Nomoto Asuka A, Mizuguchi Hitoshi H

Inhibition assays in a continuous mode of electrophoretically mediated microanalysis (EMMA) were simulated using a MATLAB matrix. The enzymatic hydrolysis of p-nitrophenyl phosphate (NPP) with alkaline phosphatase (ALP) was adopted as a model enzymatic reaction, where theophylline (THE) was used as a model inhibitor. In the simulation, the substrate NPP and the inhibitor THE were tandemly injected into a separation capillary filled with a separation buffer containing ALP. The formation rate of the product p-nitrophenol (NP) was calculated using a Michaelis-Menten constant, the inhibition constant, and the reagent concentrations. A plateau response of the product was reproduced in the simulation based on the continuous enzymatic reaction and the continuous resolution of the product in EMMA. In addition to the plateau response of the product, a depressed plateau was also simulated as a consequence of the inhibition reaction. This depressed plateau was caused by the overlapping between the injected zones of the substrate and the inhibitor. The simulated electropherograms including the inhibition-induced depression were consistent with the experimental data. The Michaelis-Menten constant, the inhibition constant, and the inhibition type were also reproduced from the simulated plateau responses. Factors affecting the plateau depression were further investigated through simulations by varying the injected zone lengths and experimental conditions. This study successfully demonstrated the utility of the simulation approach for designing inhibition assays of enzymatic reactions in a continuous mode of EMMA.

PubMedInternational journal of molecular sciences2026-05-13

Betaine Alters the Interplay of the Adenosine and NO Systems in the Control of Renal Regional Haemodynamics and Excretion in Diabetic Female Rats.

Dobrowolski Leszek L, Monchakivska Anna Volodymyrivna AV, Rogozińska Małgorzata M, Kowalski Konrad K et al.

We showed recently that the adenosine system and nitric oxide (NO) can interact differently in the control of renal function in normoglycaemia (NG) versus streptozotocin-induced diabetes (DM). Herein, we investigated if this relationship is modulated by dietary betaine (Bet, food compound possessing antioxidant and anti-inflammatory properties), to examine if adenosine receptor signalling in NG and DM females is altered by chronic Bet supplementation. The effects of intravenous infusion of theophylline, non-selective adenosine receptor antagonist, were examined in anaesthetised Sprague-Dawley female rats, pretreated for 2 weeks with Bet alone or combined with 4-day NO synthesis blockade with L-NAME (Bet + L-NAME). Renal blood flow (RBF, ultrasound artery probe), perfusion of the cortex, outer (OM-BF) and inner medulla (IM-BF; laser-Doppler technique), and tissue NO signal (selective electrode) were determined along with renal excretion. Bet and Bet + L-NAME decreased baseline RBF irrespective of glycaemia, whereas Bet lowered (NG) or elevated (DM) basal OM-BF; Bet + L-NAME treatment abolished these effects. Baseline sodium excretion decreased after Bet and Bet + L-NAME in NG only. Bet modified theophylline effects: IM-BF was lowered in DM rats, while tissue NO changes shown in the control were modified: NO increased in NG and decreased in DM. In NG, these effects were abolished by Bet + L-NAME. Bet pretreatment did not alter diuresis, natriuresis and kaliuresis, but after Bet + L-NAME these parameters increased (NG) or decreased (DM). Dietary Bet has the potential to affect renal medullary blood circulation; however, the eventual effect depends on glycaemia. Bet can modify renal functional changes induced by the interplay of the adenosine and NO systems, both in rats with normoglycaemia and streptozotocin diabetes.

PubMedInternational journal of language & communication disorders2026-05-12

Verbal and Behavioral Communication Strategies in Chinese Parent-Child Interactions: Distinctions Between Autism Spectrum Disorder and Typical Development.

Feng Jing J, Lee Jaehoon J, Song Woonyoung W, Chu Shin Ying SY et al.

This study examined the characteristics and differences in the verbal and behavioral strategies employed by Chinese-speaking parents of children with Autism Spectrum Disorders (ASDs) and parents of typically developing (TD) children. Ten-minute video recordings of parent-child interactions were analyzed, involving 34 children with ASD (Mage = 4.77 years, SD = 1.46; 29 boys) and 31 TD children (Mage = 4.84 years, SD = 1.43; 15 boys) alongside their parents. Verbal and behavioral samples were transcribed, coded, and analyzed using EUDICO Linguistic Annotator (ELAN) and Computerized Language Analysis (CLAN) software to evaluate grammatical, syntactic, pragmatic, semantic, and non-verbal functions. The Mann-Whitney U test was utilized to compare the interactive strategies between the two parental groups. Parents in the ASD group demonstrated a significantly shorter mean length of utterance (MLU), greater reliance on gestures and labeling, and a higher frequency of behavioral directives compared to parents in the TD group (all ps < 0.01). In contrast, parents of TD children exhibited a significantly higher frequency of expansions, general responses, and questions, facilitating richer language input and reciprocal conversational engagement. These findings suggest that parent-mediated interventions for Chinese-speaking children with ASD should prioritize balancing developmentally appropriate simplified input with responsive interaction strategies rather than merely increasing linguistic complexity to better support child-initiated communication and joint engagement. What is already known on this subject Previous research has established that parent-child interaction plays a central role in early language intervention for children with Autism Spectrum Disorder (ASD). Parents tend to adapt their communication to children's reduced responsiveness by using shorter utterances and more directive strategies. Responsive parental behaviors, such as expansions and contingent responses, are consistently associated with better language outcomes. However, most evidence comes from Western language contexts, and parental communication strategies in Chinese-speaking families remain under explored. What this study adds to existing knowledge This study extends existing evidence by characterising the structure of parental communication strategies in Chinese-speaking parent-child interactions involving children with ASD. It demonstrates that, despite comparable amounts of overall linguistic input, parents of children with ASD show a systematic imbalance between adaptive scaffolding (shorter utterances, gestures and labeling) and responsive strategies (expansions, questions and imitations). The findings further identify a culturally specific pattern of increased gesture use in Chinese-speaking ASD families, highlighting language- and culture-dependent adaptations not captured in Western-focused research. What are the potential or actual clinical implications of this work? The findings have direct implications for speech and language therapy practice with Chinese-speaking families. Intervention should focus on calibrating parental interaction patterns rather than increasing the quantity of language input. Speech-language therapists should support caregivers in maintaining developmentally appropriate scaffolding, such as simplified utterances, gestures, and labeling, while reducing excessive behavioral directives and strengthening responsive strategies, including expansions, imitations, and child-led questioning. These results inform culturally responsive caregiver coaching and support the integration of parent-mediated approaches into routine clinical service delivery.

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