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unspecified allergy vaccine (Staloral)

✓ Approved

Stallergenes · therapeutic agent

What is unspecified allergy vaccine?

unspecified allergy vaccine is a therapeutic agent developed by Stallergenes. It is approved for therapeutic indications via injectable (others) or oral (po) or subcutaneous injection or sublingual (sl)/oral transmucosal.

Drug Profile

Brand NamesStaloral
CompanyStallergenes
RouteInjectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, Stallergenes

Therapeutic Indications

unspecified allergy vaccine is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedAllergologie select2026-11-11

National and regional allergy and asthma programs: A comparative analysis and lessons for a German National Action Plan For Allergology.

Köhler Charlotte C, Kalb Birgit B, Becker Sven S, Klimek Ludger L et al.

Allergic diseases impose a substantial public health burden, yet Germany lacks a sustained national framework coordinating allergy-related care, prevention, education, research, and evaluation. We analyzed international allergy and asthma programs to identify principles relevant to a German National Action Plan (NAP) for Allergology. A structured literature and policy review identified national and regional allergy and asthma initiatives through scientific databases, grey literature, and policy documents. Of 13 identified initiatives, 8 were included in the primary comparative analysis. Program characteristics and reported outcomes were descriptively assessed, and structural components were compared across nine analytical domains. The programs differed in scope, implementation, governance, and evaluation. Recurring components included defined priorities, governance and accountability, multidisciplinary stakeholder involvement, integration of evidence-based care, professional and patient education, research and data infrastructure, monitoring, and sustainable resources. Several established programs reported favorable changes in healthcare utilization, disease management, patient quality of life, and healthcare costs. Predominantly observational evaluations, however, limited causal attribution. Eight interrelated strategic objectives were derived for consideration in the development of a German NAP. International programs cannot be directly transferred to Germany. Their recurring structural and implementation principles may nevertheless inform a coordinated national strategy linking unmet needs to measurable objectives, implementation responsibilities, resources, and prospective evaluation. The proposed framework requires further prioritization, operationalization, and stakeholder consensus.

PMID 43011508
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PubMedThe Journal of school health2026-11-11

Managing Food Allergies and Intolerances in the Tasmanian School Lunch Project, Australia.

Masila Nicodemus N, Smith Kylie K, Waddingham Suzanne S, Cleland Verity V et al.

The Tasmanian School Lunch Project is the first government-funded school lunch program in Australia. This study explored: (1) how the needs of students with food allergies/intolerances were addressed enabling them to safely eat school meals and (2) stakeholder perspectives on food allergy management. A developmental evaluation approach with qualitative data collection in 2022-2024 included review of project documentation, open-ended survey responses (229 parents, 123 school staff), and interviews/focus groups (42 parents, 65 school staff, 27 implementation and advisory team members). Thematic analysis of all qualitative data identified six themes: allergen risk assessment and management, limited allergen awareness, cross-sectoral collaboration and communication, infrastructure and resource support to schools, inclusivity and equitable access, and building trust among stakeholders. Accurate student allergy information, allergy/anaphylaxis policy adherence and implementation of targeted food allergen pilot enabled provision of modified meals. Strategic collaboration, coordination and stakeholder capacity building supported successful implementation. Future school lunch programs need to ensure inclusion of students with allergies is a core consideration during planning and develop policies and procedures that support safe food provision at scale. A coordinated approach to implementation and trust between parents and schools enabled students with allergies to participate in the School Lunch Project.

PMID 43010154
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PubMedAllergologie select2026-11-11

Rare allergen sources are clinically relevant sensitizers in Central Europe.

Wöhrl Julia J, Hemmer Wolfgang W, Lang Roland R, Moritz Katharina K et al.

In recent times, diagnosing allergies apart from house dust mite (HDM), birch tree, and grass pollen has become increasingly difficult because allergen manufacturers have withdrawn many commercial skin prick test (SPT) solutions for rare allergen sources. A cohort of 5,857 patients (mean age 35.9 ± 20.3 years, 60.5% female) was tested with standardized SPT panels comprising 46 inhalant and food allergens at a large allergy outpatient clinic in Vienna. Cases with positive tests and allergen-specific history were judged as "relevant", those without as "latent". In the patient cohort, 48.8% presented with a history of allergic rhinoconjunctivitis (ARC), 16.7% with bronchial asthma (BA), 13.2% with atopic dermatitis (AD), and 28.9% with food allergy (FA). Of 113,893 SPTs, 7.0% were relevant, 5.3% were latent, and 87.7% remained negative. The 3 most frequent allergen sources - grass, birch, and HDM - showed the highest ratio of 22.2% relevant compared to 7.1% latent SPTs. The 6 other non-rare allergen sources - European ash tree, mugwort, ragweed, Alternaria alternata, cat, and dog - yielded 9.5% positive and 7.4% latent SPT results. The other 34 rare allergen sources resulted in 1.8% positive and 3.9% latent tests. Plantain, horse, hazelnut (food), soymilk, peanut, plane tree, and nettle ranked top among the rare allergens. Among rare allergens, relevant SPTs to horse/rabbit, Alternaria alternata, oat flour, and rye flour were associated with an increased risk for BA including work-related asthma. 15.4% (1,230/7,985) of all relevant SPTs were observed in "rare allergens". This demonstrates the necessity of including rare allergens in standard allergy workups.

PMID 43011841
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PubMedJournal of agricultural and food chemistry2026-11-11

Review on the Potential of Bioactive Peptides in Modulating Allergic Responses via Dendritic Cells.

Zhao Qing Q, Mu Guangqing G, Zhu Xuemei X, Wu Xiaomeng X et al.

Food allergy can lead to dietary restrictions, nutritional deficiencies, and, in severe cases, systemic allergic reactions such as anaphylaxis. Dendritic cells (DCs) play a crucial role in the immune response, presenting antigens to T-cells and initiating adaptive immunity. Bioactive peptides have shown potential in alleviating allergic reactions, but their effects on DCs require further investigation. Current direct and indirect evidence suggests that bioactive peptides may modulate allergic reactions by influencing DC activation, maturation, antigen presentation, and subsequent immune responses. This review explores the role of DCs in immune regulation and maturation, focusing on their dual function in promoting immune tolerance and reducing allergic reactions. Bioactive peptides may modulate allergic responses by influencing DCs at various stages of maturation. Furthermore, this review discusses the potential involvement of gut microbiota and microbial metabolites in bioactive peptide-associated regulation of DC activity. These findings provide a mechanistic framework for further evaluation of the potential of bioactive peptides in allergy-related immune regulation.

PMID 43012721
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PubMedNPJ vaccines2026-11-11

A structure-guided trivalent subunit vaccine confers maternal protection to neonatal piglets against PEDV and PDCoV.

Liu Jia J, Chen Longping L, Li Dan D, Wang Zhuo Z et al.

Antigenic divergence among porcine epidemic diarrhea virus (PEDV) genotypes and porcine deltacoronavirus (PDCoV) limits the cross-protection provided by current commercial vaccines. Here, employing a structure-guided antigen design strategy, we developed a trivalent subunit vaccine concurrently targeting PEDV G2a, PEDV G2b, and PDCoV. The vaccine antigen set comprises optimized spike ectodomain antigens, featuring stabilizing mutations, a heptad repeat 2 (HR2) deletion, a fused neutralizing epitope, and a flagellin adjuvant fused to the N-terminus. Formulated with MF59+CpG adjuvants, this trivalent vaccine elicited robust PEDV- and PDCoV-specific neutralizing antibody responses and Th1/Th2-associated cellular immune responses characterized by IFN-γ, IL-2, and IL-4 production in mice. Immunization of pregnant sows with 300 μg dose induced high-titer IgG, IgA, and colostral secretory IgA (SIgA) against all three target viruses. Although neutralizing antibody titers were comparable between the 100 μg and 300 μg dose groups, the 300 μg group showed higher and more persistent levels of colostral binding IgG and SIgA. Following maternal immunization, piglets that acquired maternal antibodies through colostrum exhibited reduced clinical diarrhea, lower fecal viral RNA shedding, and less severe intestinal lesions after challenge with PEDV G2a, PEDV G2b, or PDCoV. These findings support this structure-guided trivalent subunit vaccine as a promising candidate for maternal immunization against co-circulating porcine enteric coronaviruses.

PMID 43009510
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PubMedHealth communication2026-11-11

Spiritual Health Locus of Control and COVID-19 Booster Intentions Among Hispanic Americans: A Culturally Grounded Extension of the Extended Parallel Process Model.

Kim Joon J, Jun Jungmi J, Zambrano Rodriguez Viviana Carolina VC

Declining uptake of COVID-19 boosters poses significant public health concerns. Hispanic Americans, who have experienced disproportionate pandemic impacts, report lower uptake of updated boosters than non-Hispanic White adults, partly attributable to vaccine hesitancy. Although religiosity plays a central role in Hispanic communities, little is known about how spiritually grounded beliefs shape cognitive and emotional responses to vaccination. This study integrates the extended parallel process model (EPPM) with spiritual health locus of control (SHLOC) to examine how exposure to faith-based and governmental vaccine information influences booster intention through spiritually grounded efficacy appraisals. Using an online survey of Hispanic American adults (N = 349), we tested a structural equation model linking SHLOC, perceived threat, efficacy beliefs, fear, and vaccination intentions. Results indicated that active SHLOC, reflecting beliefs in divine partnership in health, increased response efficacy and indirectly promoted booster intention and vaccine advocacy, whereas passive SHLOC, reflecting divine determinism, reduced self-efficacy and indirectly discouraged booster intention. Perceived threat was positively associated with fear, and efficacy beliefs emerged as the strongest predictors of booster intention. Mediation analyses supported serial pathways from message exposure to SHLOC to efficacy to intention, identifying spiritually grounded control beliefs as a culturally embedded mechanism in vaccine decision making. Findings suggest that faith-based engagement can function as either a protective or risk communication channel, depending on whether messages reinforce divine partnership or determinism. The study advances EPPM by identifying SHLOC as a culturally grounded antecedent to efficacy appraisal and offers implications for culturally responsive vaccine communication in Hispanic communities.

PMID 43012739
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