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HE

Hep A-Vi (ViATIM / ViVAXIM)

✓ Approved

Sanofi S.A · Vaccine · Vaccine

What is Hep A-Vi?

Hep A-Vi is a vaccine developed by Sanofi S.A. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesViATIM, ViVAXIM
CompanySanofi S.A
Drug ClassVaccine, Large Molecules
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Sanofi S.A

Therapeutic Indications

Hep A-Vi is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsTyphoid fever✓ Approved
Surgical and medical proceduresAntiviral prophylaxis✓ Approved

Related Research Articles

PubMedVeterinary surgery : VS2026-09-19

Complete surgical excision of a type V-variant dermoid sinus (V/VI overlap) associated with spina bifida in a Shiba Inu dog: A case report.

Jeong Ji-Eun JE, Kim Sun-Young SY, Kim Jong-In JI

To describe the clinical, imaging, surgical, and histopathologic features of a type V/VI overlap dermoid sinus (DS), and highlight diagnostic and therapeutic considerations. Case report. A 16-month-old spayed female Shiba Inu dog. The Shiba Inu initially presented at 4 months of age with a dorsal thoracic hair tuft. Radiography and ultrasonography suggested a DS; contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) were declined. The dog presented 12 months later for malodor, erythema, pruritus, focal pain on palpation, intermittent discomfort, and decreased appetite, although neurologic status remained normal. CT and MRI revealed spina bifida at T12 and a sinus tract extending from the skin to the dorsal dura mater, with mild dorsal displacement of the dura. Surgical excision via dorsal laminectomy and partial durectomy allowed en bloc removal of the tract and fibrous dural attachment. Histopathology confirmed a keratin-filled dermoid cyst lined by adnexal epithelium with pyogranulomatous inflammation and a fibrous dural connection, consistent with a type V/VI overlap DS. Recovery was uneventful, with no recurrence or neurologic deficits at the 12-month follow-up. Dural attachment may lead to clinical discomfort, even if neurological deficits are not present. Intraoperative assessment, histopathology, and advanced diagnostic imaging modalities such as CT and MRI are essential for surgical planning and accurate classification. This is the first report of a Shiba Inu with a type V/VI overlap DS and thoracic spina bifida. Early surgical intervention based on an integrated approach can lead to a good long term patient outcome.

PMID 42760277
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PubMedbioRxiv : the preprint server for biology2026-09-19

Cryo-EM reveals patient- versus organ-specific structural diversity and bound ligands in λ6 light chain amyloids.

Huda Noorul N, Spencer Brian B, Hicks Chad W CW, Jayaraman Shobini S et al.

Immunoglobulin light chain (LC) amyloidosis is a debilitating multiorgan disease with limited treatment options. Sequence and structural variability make LC amyloids particularly challenging for therapeutic targeting. We report four cryo-EM structures of λ6-LC amyloid fibrils from four organs of two patients. Fibrils from different patients show different N-terminal conformations expanding known repertoire of λ6-LC amyloid folds. These folds contain a planar β-arch with a flexible linker containing the complementarity-determining region 2, flanked by N- and C-terminal segments in variable patient-specific conformations. The surface location of the structurally frustrated charged segment may contribute to the overrepresentation of the λ6-LC family in amyloidosis. These and other λ6-LC amyloid structures from different patients show different side chain packing. Conversely, cardiac, renal and splenic amyloids from the same patient exhibit similar structures with small peripheral organ-specific variations. Moreover, they show similar "orphan" densities, suggesting collagen-like triple helices bound to a tyrosine ladder along the fibril spine. Mass spectrometry detects collagen type-VI in tissue-extracted amyloids. Molecular dynamics simulations suggest amyloid binds collagen-VI triple helices via mixed interactions facilitated by the geometric complementarity between the layered amyloid structure and the triple helix. Similar interactions may drive formation of other amyloid-collagen complexes, influencing biological properties of amyloids.

PMID 42760916
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PubMedJournal of imaging informatics in medicine2026-09-19

Development and Validation of a Picture Archiving and Communication System-Integrated Artificial Intelligence for Predicting Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.

Shao Limin L, Qiu Yuxuan Y, He Bishi B, Chen Yuanjiao Y et al.

The objective of this study is to develop and validate a Picture Archiving and Communication System-integrated artificial intelligence (PACS-AI) tool for automated neck-level localization, three-dimensional (3D) segmentation, and metastasis risk prediction of cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). CT images from 710 patients with PTC, including 4942 LNs, were retrospectively collected from two medical centers and divided into training, internal test, and external test cohorts. The AI model consisted of a 3D TransUNet partition network, a Swin UNETR segmentation network, and a 3D U-Net classification network, all of which were integrated into the PACS. Additional data from 202 patients with PTC (including 202 LNs) were collected from the aforementioned two centers to evaluate the improvement in radiologists' diagnostic performance with PACS-AI assistance. In the internal and external test sets, the partition model achieved precision values of 0.919-0.990 and 0.848-1.000 across levels I-VI, respectively. The segmentation model showed mean Dice similarity coefficients (DSCs) of 0.674 and 0.633, with corresponding precision values of 0.832 and 0.722. The classification model achieved AUCs of 0.948 (internal) and 0.943 (external) for metastasis prediction. In the reader study, the classification model outperformed junior radiologists and significantly improved their diagnostic accuracy (all p < 0.05). The PACS-AI provides an integrated, visual, and clinically practical tool for the preoperative assessment of cervical LNs in patients with PTC, demonstrating the potential to enhance diagnostic accuracy among junior radiologists and to support broader clinical adoption.

PMID 42760456
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PubMedMedicine2026-09-19

Age- and sex-specific associations between thyroid function and diabetes in Korean adults: A nationwide cross-sectional study.

Choi Ji-Young JY, Yang Young-Mo YM

Thyroid dysfunction and diabetes mellitus (DM) are two common endocrine disorders that share overlapping metabolic pathways. While several studies have explored the association between thyroid function and DM, findings have been inconsistent. Specifically, both elevated and suppressed thyroid-stimulating hormone (TSH) have been variably reported as risk or protective factors for diabetes, and the contribution of thyroid autoimmunity (thyroid peroxides antibody, TPOAb) to diabetes risk remains particularly contested across study populations. This study aimed to evaluate the relationship between thyroid function markers-TSH, free thyroxine (free T4), and TPOAb - and the presence of diabetes in Korean adults. This cross-sectional study analyzed data from 4910 adults aged 19 years or older who participated in the Korea National Health and Nutrition Examination Survey (KNHANES VI) from 2013 to 2015. Serum levels of TSH, free T4, and TPOAb were measured, and DM was defined based on fasting glucose levels, use of antidiabetic medication, or self-reported diagnosis. As KNHANES does not classify diabetes by etiological subtype, the DM group predominantly reflects type 2 diabetes, consistent with its overwhelming predominance among Korean adults; type 1 diabetes could not be separately identified. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for diabetes across thyroid function categories, with subgroup analyses by age and sex. High TSH levels were significantly associated with an increased risk of diabetes (OR = 2.82; 95% CI: 1.26-6.32), especially in men under 65 years (OR = 5.10; 95% CI: 1.65-15.77). Low TSH levels were inversely associated with diabetes risk (OR = 0.35; 95% CI: 0.15-0.86). Low free T4 levels were also linked to an increased risk (OR = 2.08; 95% CI: 1.16-3.75), particularly in younger men. TPOAb positivity showed no significant overall association with diabetes, although a potential protective trend was observed in older men. Altered thyroid function, especially high TSH and low free T4 levels, is associated with increased diabetes risk in Korean adults. These findings suggest the clinical utility of thyroid function screening in diabetes risk assessment and highlight the need for further longitudinal research.

PMID 42760714
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PubMedSurgical case reports2026-09-19

Thoracoscopic Right S4 Segmentectomy for Pulmonary Arteriovenous Fistula Involving an Aberrant Bronchus: A Case Report.

Kato Hirohisa H, Abiko Masami M

Although pulmonary arteriovenous fistulas (PAVFs) have often been treated with embolization, surgical approaches including segmentectomy might also play a curative role. Furthermore, a near-infrared fluorescent (NIF) imaging has been widely used as an assisting tool during surgery and has been useful for identifying the intersegmental plane during pulmonary segmentectomy. We describe a thoracoscopic right S4 segmentectomy for a PAVF case involving a rare aberrant bronchus in the middle lobe bronchus using NIF imaging to identify the intersegmental plane and target the segmental bronchus. A 66-year-old woman presented with a PAVF consisting of dilated feeding and draining vessels (A4 and V4) in the right S4, the percutaneous oxygen saturation was 94%, and thoracoscopic right S4 segmentectomy was planned. Preoperatively, a bronchial CT simulation revealed a middle lobe bronchus involving a rare aberrant bronchus (B7a), and the target segmental bronchus (B4) was bronchoscopically marked with indocyanine green (ICG). Intraoperatively, the B4 was identified with NIF imaging and divided following division of the dilated vessels. The PAVF was completely removed with the dilated vessels, while the aberrant bronchus was preserved. Segmentectomy can contribute to a curative resection of PAVF, bronchial CT simulation helps to recognize the variant bronchus, and NIF imaging can identify not only the intersegmental plane but also the target segmental bronchus for division in PAVF cases with aberrant bronchus requiring thoracoscopic segmentectomy.

PMID 42760960
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PubMedOral and maxillofacial surgery2026-09-19

Transoral robotic reconstruction of a posterior palatal defect using an upper arm flap following polymorphous adenocarcinoma resection: a novel minimally invasive approach.

Wieker Henning H, Wagner Juliane J, Wiltfang Jörg J, Gülses Aydin A et al.

Surgical management of malignant tumors in the orofacial region frequently necessitates extensive resection, resulting in significant functional and aesthetic morbidity. In younger patients, these sequelae carry a substantial psychosocial burden, emphasizing the need for minimally invasive reconstructive strategies that preserve quality of life while maintaining oncological safety. A 36-year-old female patient presented with a small 1 × 1 cm swelling at the junction of the hard and soft palate on the left side. Incisional biopsy confirmed a malignant minor salivary gland tumor but did not permit definitive subtyping. The final diagnosis of a polymorphous adenocarcinoma (PAC), conventional subtype, was established only on the complete resection specimen. Following oncologically adequate resection, including partial hard palate and tuberosity removal, a 3 × 4 cm defect was reconstructed with a free upper arm flap. Supermicrovascular anastomoses to the superior labial and facial arteries (vessel diameter ~ 0.2 mm) were performed via a transoral approach using the Symani® robotic surgical system with 20× motion scaling. Venous anastomoses to the facial vein were completed end-to-end and end-to-side via the same intraoral access. Selective lymph node sampling of the four radiologically prominent ipsilateral level II lymph nodes through a minimal cervical incision showed no metastases, both on frozen section and on final histopathology (0/4). Final histopathology demonstrated a 15 mm low-grade PAC resected in sano, without lymphovascular invasion, without unequivocal perineural infiltration and without bone invasion, classified as pT1 pN0 (0/4) cM0, R0. Postoperative course was uneventful; functional rehabilitation including speech and swallowing therapy is ongoing. Robotic-assisted supermicrosurgery using the Symani® system enabled safe transoral free flap reconstruction of a posterior palatal defect with anastomoses at the sub 0.2 mm scale. This approach minimizes donor-site morbidity and demonstrates the feasibility of intraoral robotic supermicrosurgery as a novel reconstructive modality in head and neck oncology.

PMID 42760403
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