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HE

Hep A-Vi (ViATIM / ViVAXIM)

✓ Approved

Sanofi S.A · Vaccine · Vaccine

What is Hep A-Vi?

Hep A-Vi is a vaccine developed by Sanofi S.A. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesViATIM, ViVAXIM
CompanySanofi S.A
Drug ClassVaccine, Large Molecules
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved

Therapeutic Indications

Hep A-Vi is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsTyphoid fever✓ Approved
Surgical and medical proceduresAntiviral prophylaxis✓ Approved

Related Research Articles

PubMedJournal of environmental sciences (China)2026-07-25

WTAP upregulates HK2 expression via m6A methylation to reprogram cell glycolysis and stemness under Cr(VI) exposure.

Xie Yunxia Y, Wang Lin L, Zhang Ruike R, Ran Wenwen W et al.

Epidemiological investigations indicate that hexavalent chromium (Cr(VI)) exposure induces lung carcinogenesis, but the underlying epigenetic mechanisms of Cr(VI)-induced carcinogenesis remain to be further investigated. In this study, we used a Cr(VI)-exposed mouse model to demonstrate elevated m6A modification levels in lung tissues, and further used Cr(VI) transformed cell model (CrT) to identify that Cr(VI) induced the expression of Wilms' tumor 1-associated protein (WTAP), a key localization gene for m6A RNA methylation modification, in a time and concentration-dependent manner, and proved that WTAP enhanced cell proliferation and was involved in the maintenance of cellular stemness through up-regulating CD133 expression. Additionally, WTAP upregulated the expression of hexokinase 2 (HK2), a rate-limiting glycolytic enzyme, while knocking down HK2 significantly reduced WTAP's ability to promote CD133 expression. Furthermore, we identified m6A modification site on HK2 mRNA bound to the WTAP-VIRMA complex by molecular docking model and m6A MeRIP-qPCR assay. Notably, both WTAP and HK2 were significantly high expression in blood samples from chromium-exposed occupational workers, and their expressions were significantly positively correlated. We also demonstrated that WTAP was significantly overexpressed in lung cancer cell, and found that the overall survival rate of lung squamous cell carcinoma patients with high expression of WTAP was significantly reduced. Collectively, our study demonstrated that WTAP is a novel mechanism of Cr(VI)-induced malignant transformation of cells, and further revealed that WTAP mediates the Cr(VI)-induced glycolytic remodeling and enhances the cellular stemness via HK2. WTAP and HK2 represent promising biomarkers for chromium-exposed populations.

PubMedTurkish journal of biology = Turk biyoloji dergisi2026-07-25

Context-dependent regulation of SIX1 by ETS1 within EMT-associated transcriptional networks.

Yalim Camci İrem İ

Epithelial-mesenchymal transition (EMT) is a fundamental process driving tumor plasticity, metastasis, and therapy resistance. Although E26 transformation-specific transcription factor 1 (ETS1) and Sine oculis homeobox homolog 1 (SIX1) are individually implicated in EMT-related transcriptional programs, the regulatory interplay and functional coordination of these proteins across tumor states remain unclear. Hence, this study aimed to investigate the mechanistic and clinical behavior of the ETS1-SIX1 axis, with a focus on hepatocellular carcinoma (HCC) and aggressive endothelial-like cancer phenotypes. ETS1-SIX1 expression patterns were analyzed using real-time quantitative polymerase chain reaction in HCC-derived cell lines and the endothelial-like SK-HEP-1 cell line, whereas chromatin immunoprecipitation (ChIP) assays were performed in SK-HEP-1 cells to assess ETS1 binding to the SIX1 promoter. Clinical relevance was assessed using The Cancer Genome Atlas (TCGA) RNA-sequencing (RNA-seq) datasets (breast invasive carcinoma, colon adenocarcinoma, liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma) with correlation and survival analyses, and validated using tumor cDNA panels and public transcriptomic data. ChIP assays confirmed ETS1 binding to the SIX1 promoter. Expression analyses indicated an inverse relationship between ETS1 and SIX1 in HCC-derived cell lines, the endothelial-like SK-HEP-1 cell line, and tumor cDNA panels. Pan-cancer analyses showed decreased ETS1 and increased SIX1 expression in tumors, with stage-dependent heterogeneity. Elevated SIX1, but not ETS1, was associated with poorer overall survival, particularly in LIHC. Gene set enrichment analysis linked high-risk profiles to EMT, cell cycle, and immune-related pathways, while ETS1 expression decreased with increasing tumor grade. This study supported a model in which ETS1 negatively regulates SIX1 expression within liver cancer-associated contexts. Integrating mechanistic and clinical analyses, the findings suggest that the ETS1-SIX1 axis contributes to EMT-driven tumor plasticity and aggressive tumor behavior, with potential relevance for future therapeutic investigation.

PubMedEnvironmental research2026-07-25

Fabrication of a Tripolyphosphate-Modified Chitosan-Sodium Alginate Composite for Highly Efficient Uranium Adsorption from Water.

Zhong Xingyu X, Yang Fang F, Lu Lihong L, Zhang Wenqing W et al.

The preparation of composite materials with excellent adsorption capacity for uranium in water remains a topic of great interest. In this work, a novel composite adsorbent, tripolyphosphate-modified chitosan-sodium alginate (PCSSA), was successfully prepared by incorporating sodium alginate into tripolyphosphate-modified chitosan via chemical cross-linking. The resulting material exhibited excellent adsorption capacity for U(VI) in aqueous solutions. Within the chitosan matrix, amino, alkyl, and phosphate groups act synergistically to form amino-alkyl phosphate ligands (NH2-CH2-PO43-) with chelating functionality, providing abundant adsorption sites for efficient U(VI) removal. SEM and EDS characterization revealed a rugged, plate-like surface morphology, loaded with functional groups such as phosphate and carboxyl/hydroxyl groups. Systematic adsorption experiments indicated that the U(VI) adsorption behavior of PCSSA follows the Langmuir isotherm and the Elovich kinetic model. Under optimal conditions (pH = 3, 298.15 K, adsorbent dose = 30 mg), the maximum adsorption capacity reached 561.86 mg·g-1. In real water samples with a low U(VI) concentration (30 mg·L-1), the removal efficiency was as high as 88%, outperforming many similar bio-based adsorbents. FTIR and XPS analyses suggested that the phosphate groups interact with UO22+ through multiple mechanisms, including electrostatic attraction, ligand exchange, and complexation. The PCSSA composite is environmentally friendly and straightforward to prepare, showing promising potential for application in water pollution control.

PubMedJournal of environmental sciences (China)2026-07-25

Waste-treating-waste: A compressible shrimp-shell-derived chitin/polyethyleneimine aerogel for efficient adsorption of Cr(VI) and Congo red from simulated wastewater.

Mohammed Yusof A Y A YAYA, Jančář J J

Given the need to achieve the Global Sustainable Development Goals (SDGs), water and wastewater treatment, alongside waste valorization, are recognized as some of the most critical objectives. Thus, wastewater treatment via sustainable and environmentally friendly adsorbents is imperative. Herein, compressible hierarchical shrimp-shell-derived chitin (Ch)/polyethyleneimine (PEI) hybrid aerogels (denoted as ChP) were developed. The prepared hybrid bio-based aerogel exhibited excellent reversible compressibility with abundant water-transport pathways to accelerate Cr(VI) and Congo red adsorption. The Langmuir monolayer maximum adsorption capacities of ChP1@1 at 298 K were found to be 329.97 mg/g for Cr(VI) at pH 3 and 1495.31 mg/g for CR at pH 5. Interestingly, the incorporation of PEI not only enhanced the adsorption capacity but also tailored the network of the aerogels. Kinetic and thermodynamic studies revealed that the process followed the pseudo-second-order and Elovich kinetic models, with a spontaneous and endothermic adsorption behavior. Additionally, the fabricated aerogel demonstrated exceptional selectivity and removal efficiency even in the presence of various interfering elements, with stable performance of up to 5 cycles. Mechanistic insights elucidated by FTIR and XPS demonstrate that Cr(VI) initially adsorbed through electrostatic interaction followed by partial reduction, whereas CR is mainly captured by electrostatic interaction and hydrogen bonding. Overall, this eco-friendly aerogel offers promising potential for sustainable wastewater remediation and circular waste reutilization.

PubMedPrecision radiation oncology2026-07-25

Refining the boundaries of the nodal CTV in the middle neck for nasopharyngeal carcinoma.

Deng Yue Y, Liu Yi Y, Wang Dan D, Zhao Yue Y et al.

In our previous research, we found that the subcompartments formed by the cervical fascia in the supraclavicular region (levels IV, Vb, and lower VI) effectively define the boundaries of the nodal clinical target volume (CTV) for nasopharyngeal carcinoma (NPC). This study aimed to determine whether the same anatomical approach could be applied to the middle neck region (levels III, Va, and upper VI). We enrolled 100 patients with NPC who had positive lymph nodes throughout the neck, including the supraclavicular region. Their pretreatment images were systematically reviewed. We analyzed lymph node distribution patterns in relation to both the 2013 International Consensus node-level definitions and the cervical fascia-based subcompartments proposed in our previous study. Based on our findings, we recommend several modifications to the 2018 international CTV consensus guidelines. Our analysis confirmed that the cervical fascial subcompartments effectively define nodal CTV borders. Based on the observed lymph node distribution patterns, we propose several specific optimizations for the middle neck. The lateral border of level Va can be retracted from the skin and platysma to the line connecting the posterior margin of the sternocleidomastoid muscle (SCM) and the anterior margin of the trapezius muscle (TM). Medially, the border can be safely retracted to an anterior-posterior line bisecting the center of the common carotid artery (CCA), as the space medial to this line is consistently devoid of nodes. In addition, the anterior boundary of the CTV may be defined by the lymph nodes located anterior to the carotid sheath; otherwise, the carotid sheath itself serves as the boundary. Cervical fascial anatomy provides valuable insight into the distribution patterns of lymph nodes in the middle neck region in patients with NPC. Based on these anatomical considerations, appropriate modifications to the nodal CTV defined by the 2018 consensus can be implemented for the middle neck region.

PubMedBMJ open2026-07-25

From diagnosis to daily life: a qualitative investigation into patients' lived experiences of pre-diabetes diagnosis and care in a primary care setting in Singapore.

Asharani P V PV, Kumarasan Roystonn R, Ramu Madhumitha M, Yeow Wee Brian Tan BT et al.

The prevalence of pre-diabetes mellitus (pre-diabetes, pre-DM) is increasing globally, with 5%-10% of adults with pre-DM progressing to type 2 DM (T2DM) annually. Despite the availability of national screening programmes and lifestyle interventions, uptake remains suboptimal and the lived experiences of individuals navigating pre-DM diagnosis and care in Singapore remain poorly understood. Understanding these experiences is critical, as patient perspectives can reveal gaps in care delivery, particularly in a multiethnic population where cultural, social and systemic factors intersect in complex ways. The current study explores the barriers and facilitators in detecting and managing pre-DM in Singapore's multiethnic population. This qualitative study employed purposive sampling and a phenomenological approach to capture the experiences of those living with pre-DM (n=13). Participants were recruited from National Healthcare Group polyclinics through clinician referrals and through self-referrals. Eligible participants were aged 21 and above, Singapore citizens or permanent residents, diagnosed with pre-DM and conversant in at least one local language, while those with T2DM or type 1 DM were excluded. One-to-one in-depth interviews were conducted between August 2023 and February 2024, which were audio-recorded, transcribed verbatim and analysed through reflexive thematic analysis. Six overarching themes were identified: a) pathways to pre-DM diagnosis (detection during management of chronic conditions, self-initiated detection through health screening (HS)), b) dealing with diagnosis: navigating shock, acceptance and worry about the future, c) life before diagnosis: living in comfort and the absence of consequences (dietary habits and lifestyle choices before diagnosis, when not knowing felt safer: the reasons for not doing HS), d) life after diagnosis: reconfiguring daily life (lifestyle changes: renegotiating diet and exercise habits, alternative therapies: integrating traditional approaches), e) pre-DM care (challenges and enablers of pre-DM management) and f) reimagining care: suggestions for improving pre-DM care. The main barriers were i) personal factors: the struggle to sustain behavioural changes (such as lack of awareness, difficulty with dietary and physical activity changes, lack of self-discipline), ii) navigating social and environmental barriers to lifestyle change, iii) the financial burden of lifestyle changes, iv) work-related factors: competing priorities and time constraints,v) feeling unheard: the healthcare team-related barriers to care and vi) gaps in the systems: structural barriers to care (such as long waiting times, clinician rotation, short consultations). Enablers included i) fear to action: personal drivers of pre-DM self-management (such as personal factors including fear of developing T2DM), ii) family, peers and domestic help as daily support, iii) feeling heard and cared for: healthcare team-related factors, iv) seamless care through operational excellence and v) knowledge about pre-DM: sources and information seeking. Our findings suggest the need for multilevel collaboration to promote effective strategies to manage pre-DM in the community. This requires interventions to promote early screening, healthcare reforms to reduce waiting times and clinician rotation, and sustaining lifestyle modifications. Interventions should leverage the enablers identified in the study while addressing the barriers to ensure healthcare reforms. The insights derived from this study can directly inform locally contextualised interventions and policy reforms to strengthen pre-DM care delivery within a multiethnic healthcare setting.

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