Drug Database
ME

mesoglycan sulfate (mesoglycan / Perclar / Mesuglican)

✓ Approved

Mediolanum Farmaceutici Spa · F2

What is mesoglycan sulfate?

mesoglycan sulfate is a therapeutic agent developed by Mediolanum Farmaceutici Spa. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Namesmesoglycan, Perclar, Mesuglican
CompanyMediolanum Farmaceutici Spa
Molecular TargetF2
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

mesoglycan sulfate acts on 1 molecular target:

F2coagulation factor II, thrombin (THPH1, PT)
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Therapeutic Indications

mesoglycan sulfate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersPeripheral vascular disorder✓ Approved

Related Research Articles

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Yang Zhengqiu Z, Fang Jie J, Zhao Yongqiang Y, Zhang Yaobin Y et al.

Longwall mining disrupts overlying strata and creates goafs, altering groundwater conditions and the chemical composition of affected aquifer systems. In arid and semiarid regions, understanding how deep coal extraction influences sulfate biogeochemistry is essential for assessing mining-related groundwater degradation and protecting scarce groundwater resources. This study combined major-ion chemistry, water isotopes (δD and δ18Owater), sulfate isotopes (δ34S and δ18OSO4), δ13CDIC, and Bayesian isotope mixing analysis to investigate sulfate sources and transformation in the multiaquifer system and goaf of the Jinjie Coal Mine, China. The results reveal a marked contrast between sulfate generation in the goaf and its subsequent transformation in the Jurassic aquifers. Pyrite oxidation and associated carbonate dissolution dominate sulfate and dissolved inorganic carbon (DIC) production in goaf water, whereas Bayesian source apportionment identifies pyrite oxidation as the principal sulfate source in most goaf-water samples. The spatial variation in source contributions is consistent with differences in the thickness and continuity of the Baode aquitard. Mining-induced fracturing, locally extending to the surface, facilitates the exposure of pyrite-bearing strata to oxygenated water and air, promoting sulfate generation in the goaf. The resulting sulfate subsequently enters the Jurassic aquifers, where relatively confined and reducing conditions favor bacterial sulfate reduction. Sulfate depletion, enrichment of residual sulfate in heavy sulfur and oxygen isotopes, and relatively depleted δ13CDIC values provide complementary evidence for this transformation. These findings provide a process-based framework for understanding sulfate evolution in mining-affected groundwater systems.

PubMedSmall methods2026-11-11

Modulated Laser-Assisted Nanopore Fabrication With Ammonium Sulfate for Single-Molecule Sensing.

Matsuda Kyosuke K, Hirano Taichi T, Takahashi Shu S, Hagiwara Hidetaka H et al.

Nanopore sensing provides a label-free platform for single-molecule analysis. To achieve reliable solid-state nanopore sensing, however, it is essential to optimize appropriate nanopore fabrication methods, as variations in pore diameter, geometry, surface state, and fabrication residues can affect molecular discrimination capability. Here, we report a temporally modulated CW laser-assisted dielectric breakdown method for facilitating in-situ fabrication of nanopores in silicon nitride membranes, coupled with ammonium sulfate electrolytes to improve sensing performance. Systematic characterization revealed that temporally modulated CW laser minimizes contamination/debris formation during pore fabrication and yields improved nanopore sensing. Streaming-potential measurements and interfacial ion-transport simulations suggest that ammonium-containing electrolytes modify the SiN nanopore interface by promoting NH4 + adsorption on the inner pore surface as well as SO4 2- ions, thereby enhancing DNA-pore interactions. This effect slowed a subset of DNA translocation events, enabling longer dwell-time observations and differentiation between poly(dA) and poly(dC) blockade populations. Furthermore, aptamer-assisted detection enabled detection of Scp1-bound aptamer complexes under conditions where the protein alone tended to clog the pore. The Scp1-aptamer complex showed prolonged dwell times compared with those of free aptamers, even under 0.14 M KCl. Together, these results demonstrate that integrating our approach provides an improved approach for high-performance single-molecule nanopore detection.

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Gout is a widespread inflammatory arthritis whose current treatments focus mainly on symptom relief and urate lowering. Recent work suggests that circulating metabolites and inflammatory proteins interact in complex ways to influence disease risk, with fibroblast growth factor 19 (FGF19) standing out as a potential regulatory node linking metabolism and inflammation. We performed bidirectional 2-sample Mendelian randomization using genome-wide association study summary statistics for 1440 serum metabolites and 91 inflammatory proteins, with gout outcomes drawn from FinnGen R12. Mediation analyses were then applied to examine whether FGF19 acts as an intermediary in selected metabolite-gout pathways. Genetically predicted levels of vanillactate and histidine betaine were associated with higher gout risk, whereas sphingomyelin species and taurolithocholate 3-sulfate showed protective effects. Among inflammatory proteins, FGF19, adenosine deaminase and FGF5 appeared protective, while cluster of differentiation 244 increased risk. Bidirectional analyses revealed reciprocal relationships, including a negative causal effect of propionylcarnitine on FGF19. Mediation testing further showed that FGF19 explained 7.88% of the total effect of lipid-related metabolites on gout via glycodeoxycholate 3-sulfate and 9.58% via cis-3,4-methyleneheptanoylglycine. These findings indicate that FGF19 may exert protective effects against gout partly by modulating bile acid and fatty acid metabolism. The results offer genetic evidence for metabolic-immune crosstalk in gout pathogenesis and highlight FGF19-related pathways as possible targets for more precise therapeutic strategies.

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Azelaic Acid Mediates the Protective Effect of Lactiplantibacillus plantarum F1m against Colitis via PPARγ Activation.

Jia Dan D, Han Yuan Y, Li Zhi Z, Zhang Xueyong X et al.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a high recurrence risk. Although probiotics show promise for UC treatment, the underlying mechanisms remain incompletely understood. Herein, we found that Lactiplantibacillus plantarum F1m, isolated from yak yogurt, alleviated dextran sulfate sodium (DSS)-induced colitis in mice, improving symptoms, restoring intestinal barrier function, and alleviating gut microbiota dysbiosis. F1m reversed DSS-induced phylum-level changes by increasing Bacteroidota and decreasing Bacillota, and enriched Faecalibaculum and Akkermansia at the genus level. Mechanistically, F1m suppressed the NF-κB and ERK/MAPK pathways while activating PPARγ signaling. Metabolomics revealed elevated azelaic acid (AzA) levels in F1m-treated mice, positively correlated with the abundances of Bifidobacterium bifidum, Bifidobacterium pluvialisilvae, and Methanobrevibacter smithii. Furthermore, AzA was identified as a microbiota-derived PPARγ ligand, and exogenous AzA alleviated colitis in a PPARγ-dependent manner. Collectively, these findings indicate that F1m enhances AzA production by modulating gut microbiota, thereby protecting against colitis via PPARγ activation.

PubMedJournal of applied biomaterials & functional materials2026-11-11

The impact of supercritical carbon dioxide on the biological and biomechanical properties of decellularised heart valve root.

Aslam Sahirah S, Desai Amisha A, Edwards Jennifer H JH, Jennings Louise M LM et al.

Decellularised heart valves are a promising option for right ventricular outflow tract reconstruction, such as during the Ross procedure. A terminal sterilisation method is required to enhance the clinical translation of these biological scaffolds and ensure patient safety. This study therefore evaluated the feasibility of using supercritical carbon dioxide (scCO2) supplemented with oxidising agents, as a potential sterilisation approach for low-concentration sodium dodecyl sulfate-decellularised porcine pulmonary heart valve (dPHV) roots. The findings demonstrated that scCO2 sterilisation preserved the histoarchitecture and microscopic structure of the dPHV roots, with no observable reduction in collagen or glycosaminoglycan content, and no cytotoxic effects, confirming biocompatibility. A reduction in collagen thermal stability was observed, although matrix composition remained largely unchanged. Several significant differences in biomechanical properties were observed post-scCO2 treatment, mainly within elastin-phase behaviour, whereas collagen-phase parameters were largely preserved. Overall, structural integrity was maintained, supporting scCO2 as a feasible sterilisation strategy for dPHV roots.

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Yan Xiuhua X, Hu Lidan L, Li Zhiyuan Z

While fine particulate matter (PM2.5) is a recognized environmental hazard, the specific contribution of its chemical components to arthritis risk remains poorly characterized. To address this critical gap, this study leverages a large, nationally representative longitudinal cohort of middle-aged and older Chinese adults (14,935 individuals) to provide novel insights into the distinct contributions of specific PM2.5 components to arthritis risk, and to identify the most hazardous components and vulnerable populations. Using advanced statistical models (mixed-effects logistic regression and quantile g-computation), we demonstrate for the first time the distinct toxicities of key PM2.5 components-organic matter (OM), black carbon (BC), sulfate (SO4 2-), nitrate (NO3 -), and ammonium (NH4 +)-on arthritis prevalence. Our results confirm that both short- and long-term exposure to PM2.5 mass and specific components (OM, BC, SO4 2-, and NH4 +) significantly increase arthritis risk. Furthermore, with unprecedented granularity, we identified that males and individuals with overweight/obesity are particularly vulnerable. These findings provide a crucial advancement in environmental epidemiology, moving beyond total PM2.5 mass to pinpoint the most harmful components. They underscore the dual public health strategy of targeting emission sources of PM2.5 chemical components in China.

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