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alternaria allergen SLIT

✓ Approved

HAL Allergy Group · therapeutic agent

What is alternaria allergen SLIT?

alternaria allergen SLIT is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via oral (po) or sublingual (sl)/oral transmucosal.

Drug Profile

CompanyHAL Allergy Group
RouteOral (PO), Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

alternaria allergen SLIT is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedAllergologie select2026-11-11

Rare allergen sources are clinically relevant sensitizers in Central Europe.

Wöhrl Julia J, Hemmer Wolfgang W, Lang Roland R, Moritz Katharina K et al.

In recent times, diagnosing allergies apart from house dust mite (HDM), birch tree, and grass pollen has become increasingly difficult because allergen manufacturers have withdrawn many commercial skin prick test (SPT) solutions for rare allergen sources. A cohort of 5,857 patients (mean age 35.9 ± 20.3 years, 60.5% female) was tested with standardized SPT panels comprising 46 inhalant and food allergens at a large allergy outpatient clinic in Vienna. Cases with positive tests and allergen-specific history were judged as "relevant", those without as "latent". In the patient cohort, 48.8% presented with a history of allergic rhinoconjunctivitis (ARC), 16.7% with bronchial asthma (BA), 13.2% with atopic dermatitis (AD), and 28.9% with food allergy (FA). Of 113,893 SPTs, 7.0% were relevant, 5.3% were latent, and 87.7% remained negative. The 3 most frequent allergen sources - grass, birch, and HDM - showed the highest ratio of 22.2% relevant compared to 7.1% latent SPTs. The 6 other non-rare allergen sources - European ash tree, mugwort, ragweed, Alternaria alternata, cat, and dog - yielded 9.5% positive and 7.4% latent SPT results. The other 34 rare allergen sources resulted in 1.8% positive and 3.9% latent tests. Plantain, horse, hazelnut (food), soymilk, peanut, plane tree, and nettle ranked top among the rare allergens. Among rare allergens, relevant SPTs to horse/rabbit, Alternaria alternata, oat flour, and rye flour were associated with an increased risk for BA including work-related asthma. 15.4% (1,230/7,985) of all relevant SPTs were observed in "rare allergens". This demonstrates the necessity of including rare allergens in standard allergy workups.

PMID 43011841
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PubMedThe Journal of school health2026-11-11

Managing Food Allergies and Intolerances in the Tasmanian School Lunch Project, Australia.

Masila Nicodemus N, Smith Kylie K, Waddingham Suzanne S, Cleland Verity V et al.

The Tasmanian School Lunch Project is the first government-funded school lunch program in Australia. This study explored: (1) how the needs of students with food allergies/intolerances were addressed enabling them to safely eat school meals and (2) stakeholder perspectives on food allergy management. A developmental evaluation approach with qualitative data collection in 2022-2024 included review of project documentation, open-ended survey responses (229 parents, 123 school staff), and interviews/focus groups (42 parents, 65 school staff, 27 implementation and advisory team members). Thematic analysis of all qualitative data identified six themes: allergen risk assessment and management, limited allergen awareness, cross-sectoral collaboration and communication, infrastructure and resource support to schools, inclusivity and equitable access, and building trust among stakeholders. Accurate student allergy information, allergy/anaphylaxis policy adherence and implementation of targeted food allergen pilot enabled provision of modified meals. Strategic collaboration, coordination and stakeholder capacity building supported successful implementation. Future school lunch programs need to ensure inclusion of students with allergies is a core consideration during planning and develop policies and procedures that support safe food provision at scale. A coordinated approach to implementation and trust between parents and schools enabled students with allergies to participate in the School Lunch Project.

PMID 43010154
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PubMedeMicrobe2026-11-11

Isolation and Antibacterial Characterization of Endophytic Fungi from Rotheca myricoides (Hochst.) Steane & Mabb and their Secondary Metabolites.

Murithi Kiburi Alex KA, Mang'era Clarence Maikuri CM, Matasyoh Josphat Clement JC, Irungu Beatrice Njeri BN

Endophytic fungi were isolated from healthy tissues of Rotheca myricoides. Antibacterial activity was screened using dual-culture and disc-diffusion assays against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli. Active isolates were identified through morphological characterization and molecular sequence analysis. Six antibacterial-active isolates were selected from 62 culturable endophytic fungi and were assigned to genus, species complex, or species based on ITS or beta-tubulin sequences: Fusarium incarnatum agg., Fusarium solani agg., Fusarium equiseti agg., Alternaria arborescens agg., Purpureocillium sp., and Colletotrichum acutatum. C. acutatum produced the largest inhibition zones in dual culture, followed by A. arborescens agg. Bioassay-guided purification yielded five metabolites from C. acutatum, namely N-acetyltyramine (1), tyrosol (2), N-(2-phenylethyl)acetamide (3), N-acetyltryptamine (4) and indole-3-acetic acid (5). One compound, alternariol monomethyl ether (AME) (6) was obtained from A. arborescens agg. AME (6) exhibited the strongest antibacterial activity, with Minimum inhibitory concentration (MIC) values of 31.25 μg/mL against S. aureus (ATCC 29203) and 62.5 μg/mL against K. pneumoniae (DCM 132), P. aeruginosa (ATCC 10145), and E. coli (ATCC 25922). Although the isolated compounds do not represent novel antibiotic classes and generally exhibited only moderate antibacterial activity, they expand current knowledge of the chemical diversity of Kenyan fungal endophytes and provide a basis for future studies aimed at elucidating their mechanisms of action, structure-activity relationships, and pharmacological relevance.

PMID 43011580
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PubMedAllergologie select2026-11-11

Allergology 2030 - 75 years of the DGAKI: Early detection, more effective prevention, better treatment : DGAKI Position Paper on Preventive, Evidence-Based, Precision-Oriented, and Integrated Allergology in Germany.

Hamelmann Eckard E, Lommatzsch Marek M, Pfützner Wolfgang W, Wagenmann Martin M et al.

Allergic diseases are among the most common chronic conditions in Germany and may affect patients throughout the life course, often with multimorbidity and, in some cases, life-threatening manifestations. Despite substantial advances in immunology, molecular diagnostics, allergen immunotherapy and targeted therapies, allergology in Germany faces structural deficits in education and training, academic infrastructure, regional access to specialized care, interdisciplinary coordination, and the implementation of scientific innovation into routine care. This position paper of the German Society for Allergology and Clinical Immunology (DGAKI), published on the occasion of its 75th anniversary, outlines a vision for "Allergology 2030". Allergology should evolve from a predominantly reactive discipline towards a more preventive, evidence-based, precise and coordinated approach. This requires stronger academic structures, reliably secured allergological expertise, tiered and integrated care pathways, and robust infrastructures for translation, data and implementation. Because these challenges extend beyond individual specialties, institutions and sectors of care, the DGAKI calls for the development of a National Action Plan for Allergology in Germany. Together with relevant partners and stakeholders, such a plan should translate scientific evidence and identified unmet needs into shared priorities, measurable objectives, implementation mechanisms and evaluation. The overarching goal is to create the conditions for allergic diseases to be detected earlier, prevented more effectively and treated better.

PMID 43011802
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PubMedCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026-11-11

Transventricular and Transseptal Closure of Left Ventricular Outflow Tract Pseudoaneurysms After Mechanical Aortic Valve Replacement: Access-Related and Technical Considerations.

Ealick William W, Clark Daniel E DE, Kipps Alaina K AK, McElhinney Doff B DB

Pseudoaneurysms of the left ventricular outflow tract (LVOT) are a life-threatening entity, typically developing as a complication of infective endocarditis or prior cardiac surgery. They should be repaired to reduce the risk of systemic embolization and the catastrophic risks of rupture. Surgical resection has been the gold standard; however, percutaneous transcatheter closure has emerged as an alternative for patients deemed to be at prohibitive surgical risk. The procedural access routes and technical methods for closure remain variable and patient specific. This study aims to describe unique cases of percutaneous LVOT pseudoaneurysm closure in patients with mechanical valves. From 2023 to 2026, 4 patients underwent percutaneous transcatheter closure of LVOT pseudoaneurysms at our center after prior mechanical aortic valve or root replacement (AVR). Case 1 highlights an antegrade transseptal approach to pack a wide-necked post-endocarditis pseudoaneurysm with coils. Case 2 demonstrates the ability of a microcatheter to engage a slit-like orifice and utilization of coil embolization without device closure of the orifice due to proximity to the aortic valve ring. Case 3 illustrates a combined approach using devices to close 2 separate orifices and coils to pack a large aneurysm sac. Case 4 represents the first reported case of an excluded LVOT pseudoaneurysm accessed via a percutaneous, transthoracic puncture of the RV free wall and subsequent traversal of the interventricular septum. In our experience, percutaneous transcatheter closure is a feasible option in most cases and should be considered prior to operative revision unless there is an unstable valve, active endocarditis, or other complicating circumstance that mandate prosthetic valve removal or a surgical approach for other reasons.

PMID 43010587
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PubMedERJ open research2026-11-11

Discordant associations between type 2 biomarkers and severity of asthma and COPD.

Janson Christer C, Malinovschi Andrei A, Borres Magnus M, Faner Rosa R et al.

Allergic and type 2 (T2) inflammatory biomarkers are increasingly used to predict outcomes and guide treatment in asthma and COPD. The objective of this cross-sectional study was to determine the prevalence of allergic sensitisation and T2 biomarkers and their clinical associations among patients with diagnoses of asthma and/or COPD in NOVELTY, a large multinational, observational study. Participants were enrolled from primary/specialist care, stratified by physician-assigned diagnosis and severity. We assessed fractional exhaled nitric oxide (≥25 ppb), blood eosinophils (≥300 cells·µL-1) and allergen-specific IgE sensitisation (≥0.35 kU·L-1 to any of 11 aeroallergens). Associations between biomarkers and clinical outcomes were examined using descriptive statistics and multivariable regression models adjusted for age, sex, body mass index and smoking status. Data for all biomarkers were available for 4352 participants (asthma: n=2194; asthma+COPD: n=633; COPD: n=1525). Overall, 63% participants had at least one positive biomarker (asthma: 77%; asthma+COPD: 60%; COPD: 45%); only 8%, 4% and 1% of participants, respectively, were positive for all three biomarkers. Women and current smokers were more likely to be triple-negative. Among participants with asthma, having more positive biomarkers was associated with more severe physician-assessed disease, lower lung function and exacerbations. By contrast, in COPD, having no positive biomarkers was associated with more severe physician-assessed disease and lower lung function. Allergic and T2 biomarkers are highly prevalent in asthma and asthma+COPD but less frequent in COPD. Their patterns show distinct associations, sometimes with opposite trends, across diagnostic groups, suggesting distinct underlying mechanisms that differ.

PMID 43011565
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