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meningococcus B & C vaccine

✓ Approved

Abivax · Vaccine · Vaccine

What is meningococcus B & C vaccine?

meningococcus B & C vaccine is a vaccine developed by Abivax. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

CompanyAbivax
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Abivax

Therapeutic Indications

meningococcus B & C vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeningococcal bacteraemia✓ Approved

Related Research Articles

PubMedMedicine2026-09-19

The safety and efficacy of different anti-tuberculosis regimens containing Lzd for RR/MDR/Pre-XDR-TB patients in China.

Tang Xian-Zhen XZ, Ma Yao Y, Tang Shen-Jie SJ, Chen Qing Q et al.

China remains a high-burden country for rifampicin-resistant tuberculosis. The treatment of drug-resistant tuberculosis is expensive, with many adverse drug reactions and greater difficulty to cure. Searching for appropriate treatment regimens is urgent. A retrospective study was conducted on HIV-negative patients aged 18 to 60 years with rifampicin- or multidrug- or pre-extensively drug-resistant tuberculosis (RR/MDR/Pre-XDR-TB) at the Public Health Clinical Center of Chengdu, China from May 1, 2018 to July 31, 2022. Patients were divided into 3 groups: linezolid (Lzd) + bedaquiline (Bdq) containing group (regimen A), Lzd + delamanid (Dlm) containing group (regimen B), and Lzd + other drugs containing group (regimen C, not containing Bdq or Dlm). A total of 142 RR/MDR/Pre-XDR-TB patients were included (63 in regimen A, 34 in regimen B, and 45 in regimen C). At 2 months of treatment, 1 patient was lost to follow-up in regimen A and regimen C, respectively. At 6 months of treatment, 3 patients were lost to follow-up in regimen A and regimen C, respectively, and 2 patients were lost to follow-up in regimen B. The sputum culture conversion rates of RR/MDR/Pre-XDR-TB patients in regimen A, B, and C at the end of 2 and 6 months were (72.6% [45/62] vs 64.7% [22/34] vs 18.2% [8/44]) and (95.0% [57/60] vs 90.6% [29/32] vs 81.0% [34/42]), respectively (P < .05). 88.2% (30/34) of the Dlm group used Lzd-Dlm-clofazimine (Cfz)-cycloserine (Cs) containing regimens. 7.9% (5/63) of patients stopped using Bdq due to corrected QT interval by Fredericia >500 ms. 2.9% (1/34) of patients with corrected QT interval by Fredericia prolongation and an increase of 88 ms from baseline stopped Dlm. No patient experienced any malignant heart disease events. Due to related adverse events of Lzd, 14.1% (20/142) reduced Lzd dosage and 6.3% (9/142) had permanent discontinuation of Lzd. 6-month Lzd + (Bdq or Dlm) containing regimens were associated with favorable early culture conversion and showed good safety among HIV-negative patients aged 18 to 60 years with RR/MDR/Pre-XDR-TB. Lzd-Dlm-Cfz-Cs containing regimens may serve as promising candidate regimens for future research on rifampicin-resistant tuberculosis. Multicenter prospective studies with longer follow-up and definitive treatment outcomes are needed to establish comparative effectiveness or treatment superiority of these regimens.

PMID 42760708
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PubMedAAPS PharmSciTech2026-09-19

Comprehensive Stability Assessment of Squalene in a Nanoemulsion Adjuvant and the SpiN-Tec Vaccine: HPLC Quantification, Stress Testing, and Stability Studies.

Gomes Isabela Pereira IP, Rivelli Graziella Gomes GG, Bagno Flávia Fonseca FF, Hojo-Souza Natália Satchiko NS et al.

Squalene-based nanoemulsions are widely used as adjuvants in vaccine formulations, but their stability can be affected by environmental factors such as pH, oxidative stress, temperature, and light. We have produced a squalene nanoemulsion (CTVad1) to support the clinical development of new vaccines. This study aimed to develop and validate an HPLC method for squalene quantification in SpiN-Tec, a recombinant protein vaccine against COVID-19. We also aimed to evaluate the stability of the CTVad1 adjuvant and SpiN-Tec under controlled storage conditions. A reversed-phase HPLC method was developed and validated, and comprehensive forced degradation studies were performed on the raw material and SpiN-Tec under acidic, basic, oxidative, thermal, and photolytic conditions to demonstrate the stability-indicating capability of the method. Physicochemical, morphological, and biological characteristics were assessed, and stability studies of both the vaccine and the CTVad1 adjuvant were performed under accelerated and long-term conditions. The HPLC method was selective, precise, accurate, linear, and robust. Squalene raw material degraded under all tested conditions, whereas formulation in nano-sized globules improved its stability, with degradation observed only under hydrogen peroxide and light exposure. CTVad1 remained stable over time, exhibiting only minor, non-critical changes within the specification limits in both accelerated and long-term stability studies, regardless of the glass packaging used (clear or amber). In addition, the SpiN-Tec vaccine maintained its physicochemical and biological integrity under all tested conditions, with all evaluated parameters remaining within the established specification ranges. Our findings demonstrate that proper formulation, packaging, and storage conditions can preserve squalene stability in nanoemulsion-based vaccines, ensuring the quality, safety, and efficacy of the SpiN-Tec vaccine and its adjuvant throughout shelf life.

PMID 42760453
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PubMedOcular immunology and inflammation2026-09-19

Bilateral Maculopathy in an Infant Following Measles, Mumps, Rubella, and Varicella-Zoster (MMRV) Vaccination.

Ben-Avi Ravid R, Amer Radgonde R

To report on the long-term clinical outcome of a healthy infant who presented with posterior uveitis following the administration of the combined measles, mumps, rubella, and varicella (MMRV) vaccine. Descriptive case report. A 13-month-old infant presented with bilateral visual loss two weeks after receiving the MMRV vaccine. Ophthalmic examination revealed bilateral retinitis and retinal vasculitis with exudative retinal detachment. Extensive infectious work-up was conducted including serologic exams and PCR testing of blood, aqueous humor, cerebrospinal fluid and urine. Serological tests for measles yielded positive IgM and IgG titers. PCR testing for measles in the aqueous humor and urine was negative. Neurologic assessment and neuroimaging were unremarkable, excluding central nervous system involvement. Empiric systemic antiviral and corticosteroid therapy was initiated. Gradual resolution of posterior uveitis ensued, culminating in bilateral macular scars. Over a six-year follow-up period, the patient demonstrated stable ocular findings with no evidence of recurrent inflammation or systemic autoimmune disease. Final visual acuity was 6/9 in each eye. This case represents a rare occurrence of non-necrotizing retinitis following MMRV vaccination. To our knowledge, this is the first report describing the sequential OCT characteristics of presumed measles vaccine-associated retinitis. The prolonged follow-up period supports the absence of an alternative etiology and provides valuable insight into the long-term course and visual prognosis of vaccine-associated retinopathy.

PMID 42760840
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PubMedMedicine2026-09-19

Association of blood parameters and ratios with aseptic loosening after total knee arthroplasty: A retrospective cohort study.

Kurt Mehmet M, Yilmaz Selcuk S, Dulgeroglu Turan Cihan TC, Kartal Emre Mucahit EM

This study aimed to evaluate the association of blood parameters and ratios with knee prosthesis loosening in patients after knee arthroplasty. A total of 221 patient files having knee prosthesis attempting to our clinic between 2018 and 2022 were retrospectively examined. Patients were divided into 2 groups as loosening (n = 108; 48.9%) and not loosening (n = 113; 51.1%) groups. Monocyte/high-density lipoprotein (HDL) ratio monocyte-to-HDL ratio (MHR), Neutrophil/lymphocyte ratio, Albumin/ C-reactive protein (CRP) ratio, albumin-to-C-reactive protein ratio (ACR), Eosinophile-to- lymphocyte ratio, mean platelet volume /PLT ratio mean platelet volume-to-platelet ratio, Monocyte -to-lymphocyte ratio, Platelet/lymphocyte ratio (PLR) and Hemoglobin/Platelet ratio (HPR) parameters of patients were evaluated. HDL, albumin, hemoglobin, ACR, PLR and HPR levels were significantly higher in loosening patients (P < .05). CRP, neutrophile, lymphocyte, monocyte and MHR means were significantly higher in no-loosening patients (P < .05). Loosening was significantly correlated with gender (R = 0.141; P < .05), HDL (R = 0.474; P < .01), albumin (R = 0.349; P < .01), CRP (r = -0.466; P < .01), neutrophile (r = -0.167; P < .05), lymphocyte (r = -0.240; P < .01), monocyte (r = -0.380; P < .01), hemoglobin (R = 0.254; P < .01), MHR (r = -0.513; P < .01), ACR (R = 0.496; P < .01), PLR (R = 0.142; P < .05) and HPR (R = 0.204; P < .01). Binary logistic regression analysis showed that MHR (B = -0.415; P < .01), ACR (B = 0.048; P < .01), and HPR (B = 30.640; P < .05) were significantly associated with knee prosthesis loosening at the multivariate level. ROC analysis demonstrated statistically significant discriminative performance for MHR, area under the curve ([AUC] = 0.798; P < .01), ACR (AUC = 0.786; P < .01), and HPR (AUC = 0.618; P < .01). For MHR 6.2481 cutoff level, sensitivity was 72.2% and specificity was 10.6%. For ACR 8.6380 cutoff level, sensitivity was 84.3% and specificity was 59.3%. For HPR 0.0506 cutoff level, sensitivity was 63.9% and specificity was 54.0%. MHR, ACR, and HPR were significantly associated with aseptic loosening after total knee arthroplasty and may be considered potential associated markers rather than definitive predictors.

PMID 42760748
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PubMedF1000Research2026-09-19

Depression and Suicidal Ideation Among Men who have sex with men and Transgender Women in Chiang Mai, Thailand.

Lynn Kyaw Sein KS, Aurpibul Linda L, Chotirosniramit Nuntisa N, Kosashunhanan Natthapol N et al.

Depression and suicidal ideation are common among men who have sex with men (MSM) and transgender women (TGW). Pre-exposure prophylaxis (PrEP) has become an important component of HIV prevention, but its relationship with mental health remains incompletely understood. This study compared depression and suicidal ideation/risk between PrEP users and non-users among MSM and TGW attending HIV prevention services, and identified factors associated with depression. A cross-sectional study was conducted among 150 MSM and TGW (75 PrEP users and 75 non-users) recruited from two HIV prevention clinics in Chiang Mai, Thailand Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and suicidal ideation/risk was assessed using the Columbia-Suicide Severity Rating Scale (C-SSRS). Group differences were compared using χ 2 tests, Fisher's exact test, or independent-samples t-tests as appropriate. Multivariable linear regression was performed to identify factors associated with depression. PrEP users had significantly lower mean depression scores than non-users (3.80±3.46 vs. 5.96±3.76; mean difference 2.16, 95% CI: 0.99-3.33; p <0.001). Suicidal ideation/risk was reported by 5 (6.7%) PrEP users and three (4.0%) non-users, with no significant difference between groups (Fisher's exact test, p = 0.719). In the adjusted linear regression model, PrEP use was independently associated with lower depression scores (B = -1.77, 95% CI: -3.07 to -0.47; p = 0.008), whereas experience of discrimination was independently associated with higher depression scores (B = -1.32, 95% CI: -2.59 to -0.06; p = 0.040). Among MSM and TGW attending HIV prevention services in Chiang Mai, PrEP use was independently associated with lower depression scores, whereas suicidal ideation/risk did not differ significantly between PrEP users and non-users. Experience of discrimination was associated with higher depression scores. Although causal inferences cannot be made, the findings highlight the importance of considering mental health alongside HIV prevention services for key populations.

PMID 42760901
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PubMedParasite immunology2026-09-19

Egg Deposition-Associated Immune Transition and Tfh-Like Humoral Features During Schistosoma japonicum Infection in Mice.

Tang Zhen Z, Zhou Tingyu T, Luo Wanping W, Shui Mingyi M et al.

Schistosoma japonicum infection causes egg-induced hepatic granulomatous inflammation together with extensive remodelling of host immunity. Although infection is known to progress from early Th1-associated immunity to egg-driven type 2 responses, the temporal relationships among egg-induced pathology, CD4+ T-cell polarization, T follicular helper (Tfh)-like phenotypes and parasite-specific humoral immunity remain incompletely defined. We therefore infected BALB/c mice with S. japonicum and examined them at serial time points after infection, assessing hepatic histopathology, serum ALT and AST activities, T-cell frequencies, cytokine-producing CD4+ T cells, helper-lineage transcription factors, PD-1 and ICOS expression on T cells, PD-L1 and ICOSL expression on B cells, CXCR5+ICOS+ phenotypic Tfh-like cells and serum SEA-specific IgG, with five biologically independent mice at each time point. Egg-associated hepatic granulomas first became apparent at week 5, enlarged during the middle stage of infection and regressed at later time points. Early infection was characterized by increased IFN-γ-producing CD4+ T cells and elevated Tbx21 expression; following egg deposition, IL-4-, IL-17A- and IL-21-producing CD4+ T cells and Gata3, Rorc and Bcl6 expression increased, and PD-1 and ICOS on CD4+ T cells together with PD-L1 and ICOSL on B cells changed dynamically over the course of infection. By week 8, CXCR5+ICOS+ Tfh-like cells were increased in the spleen, mesenteric lymph nodes and peripheral blood, and SEA-specific IgG had risen markedly after egg deposition and correlated positively with the frequency of splenic CXCR5+ICOS+ CD4+ T cells (rs = 0.3979, p < 0.001). Egg deposition thus represents a temporal immunological transition point in S. japonicum infection: the onset of egg-induced hepatic pathology coincides with the shift from early Th1-associated features to Th2-, Th17-, Tfh-like and SEA-specific humoral responses.

PMID 42760867
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