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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · Small Molecule

What is Gensci-004?

Gensci-004 is a small molecule developed by GeneScience Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPEG rhGH, Gensci 004, PEG Somatropin
CompanyGeneScience Pharmaceuticals Co., Ltd.
Drug ClassSmall Molecule, Recombinant Proteins
Molecular TargetGHR,
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

Gensci-004 acts on 2 molecular targets:

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Gensci-004 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved

Related Research Articles

PubMedArthroscopy, sports medicine, and rehabilitation2026-07-25

Influence of Psychiatric Comorbidities on Postoperative Outcomes Following Pediatric Medial Patellofemoral Ligament Reconstruction.

Arif Haad A HA, Lane Pearce P, Elliott Shamar T ST, Momaya Amit A et al.

To compare postoperative complications, rehabilitation outcomes, and health care utilization in children undergoing primary medial patellofemoral ligament reconstruction for patellofemoral instability with and without a pre-existing mental illness. The TriNetX U.S. Collaborative Network was queried to identify patients younger than 18 years old undergoing medial patellofemoral ligament reconstruction for patellar instability in the United States between 2000 and 2020. Patients were then separated into those with a pre-existing mental illness (PMI Group) and those without (Control Group). After propensity score matching for patient demographics, chronic pain, and obesity, postoperative complication rates, rehabilitation outcomes, and health care utilization of both groups were compared across 1 year. After propensity score matching, each group consisted of 223 patients for a total cohort of 446 patients. The PMI Group showed significantly greater rates of postoperative knee pain (51.5% vs 41.0%, P = .004, risk ratios (RR): 1.40), opioid analgesic use (42.2% vs 31.4%, P = .018, RR: 1.34), nonopioid analgesic use (34.5% vs 22.0%, P = .006, RR: 1.27), emergency department visits (22.0% vs 4.9%, P < .001, RR: 4.46), and physical therapy treatment sessions (61.4% vs 51.1%, P = .028, RR: 1.20). Children with pre-existing mental illness exhibit significantly greater rates of persistent knee pain, higher opioid consumption, and increased health care utilization following medial patellofemoral ligament reconstruction. Level III, retrospective comparative study.

PMID 42500160
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PubMedNutrition research (New York, N.Y.)2026-07-25

Skin carotenoid scores are a valid approximation of fruit and vegetable intake among adults with obesity.

Jilcott Pitts Stephanie B SB, Wu Qiang Q, Gates Elizabeth E, Laska Melissa N MN et al.

Skin carotenoid score (SCS) as measured using pressure-mediated reflection spectroscopy has been validated among adults with normal and overweight body mass index, with little validation research among adults with obesity. Therefore, the purpose of this exploratory study was to examine the validity of SCS as an approximation of fruit and vegetable intake among adults with obesity. We used samples from adults with obesity from three prior studies: The first study examined the validity of SCS among 213 adults, 34 with obesity; the second, examined sensitivity of SCS to a β-carotene-rich juice intervention among 162 adults, 14 with obesity; the third examined changes in inflammatory markers in a 3-week lycopene-rich juice intervention, among 25 participants with obesity. Correlations between SCS and plasma carotenoids, and between SCS and self-reported FV and carotenoid intake were calculated using SAS 9.4. There was a positive association between SCS and plasma carotenoids (r = 0.30, P = .009), and between SCS and self-reported FV (r = 0.33, P = .004) and total carotenoid (r = 0.44, P < .001) intake in adults with obesity. In this small, secondary data analysis, the association between SCS and self-reported total FV intake among adults with obesity was similar to that among normal- and overweight adults in prior studies. The correlation between SCS and total plasma carotenoid concentrations among adults with obesity was weaker than that among normal- and overweight adults in prior studies. More work is needed to understand the associations between SCS and plasma carotenoid concentrations among adults with obesity.

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PubMedMedicine2026-07-25

Risk factors of cerebrospinal fluid leakage following posterior lumbar interbody fusion for lumbar degenerative disease: A retrospective observational study of 684 patients.

Wang Hongwei H, Yuan Hong H, Zheng Bin B, Wang Xiaoying X et al.

This study holds the primary objective of confirming the risk factors for cerebrospinal fluid leakage (CSFL) following posterior lumbar interbody fusion for lumbar degenerative disease. The 684 patients who received posterior lumbar interbody fusion for lumbar degenerative disease at our hospital from 2017 to 2023 fell into the CSFL group (n = 115) or the control group (n = 569). We retrospectively recorded demographic, surgical, and radiographic data for the examination of the independent risk factors related to CSFL. Univariate and multivariate logistic regression analyses were conducted to more thoroughly measure their significance. The incidence of CSFL was 16.8% (115/684 patients). According to multivariate analysis, elderly individuals (age ≥ 60 years; odds ratio [OR], 1.601; 95% confidence interval [CI], 1.004-2.554; P = .048), patients with fusion levels ≥ 4 (OR, 3.665; 95% CI, 1.523-8.818; P = .004), patients with scoliosis (OR, 5.213; 95% CI, 1.380-19.698; P = .015), patients with spondylolisthesis (OR, 2.229; 95% CI, 1.382-3.595; P = .001), and patients with a duration of operation ≥ 250 minutes (OR, 8.586; 95% CI, 1.114-66.172; P = .039) could independently indicate the risk of CSFL. For patients with CSFL, obvious increases in postoperative drainage, lengths of stay, hospitalization costs, and frequency of blood transfusions, all with P < .001, were detected. Elderly age (≥60 years), fusion level ≥ 4, scoliosis, spondylolisthesis, and operative duration ≥ 250 minutes were identified as independent predictive factors for the risk of CSFL. CSFL patients had significantly more postoperative drainage, longer lengths of stay, higher hospitalization costs, and more frequent blood transfusions.

PMID 42499087
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PubMedMedicine2026-07-25

The effect of family integrated care based on Swanson theory of caring on premature infants: A non-randomized cohort study.

Chen Lili L, Zhu Huijie H

Preterm birth significantly impacts neonatal growth and development, and the family integrated care (FICare) nursing model offers several benefits. This study investigated the impact of FICare on preterm infants, based on Swanson caring theory. This theory includes 5 core processes (knowing, being with, doing for, enabling, and maintaining belief) that guide person-centered care. A non-randomized cohort study was conducted. A total of 52 preterm infants (28-36 weeks of gestation) were enrolled, 33 in the intervention group (FICare nursing model based on Swanson caring theory) and 19 in the control group (traditional care). The primary outcomes were the length, weight, and head circumference of preterm infants at corrected ages of 1, 3, and 6 months. Additionally, parental anxiety levels and the Parenting Sense of Competence scale were assessed. The intervention group demonstrated a shorter transitional feeding period (P = .015), a higher breastfeeding rate (P = .007), and a significantly lower rate of unplanned rehospitalization (P = .004). Infants in the intervention group had significantly greater body length (P = .041) and weight (P = .002) at corrected ages. Parental state and trait anxiety decreased, and Parenting Sense of Competence scores were increased (P < .001). No significant differences were observed in the duration of oxygen therapy, total enteral feeding period, length of hospital stay, or weight at discharge from hospital. FICare based on Swanson caring theory was associated with improved feeding transition, reduces unplanned readmissions, promotes growth within 6 months corrected age, alleviates parental anxiety, and enhances parenting competence. The findings are limited by the non-randomized design and baseline imbalance in birth weight.

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PubMedJournal of cancer policy2026-07-25

Motorized Travel Time to Access Childhood Cancer Care in India: A Multi-Center Geospatial Analysis.

Sra Manraj Singh MS, Aksithanand K J KJ, Ganguly Shuvadeep S, Radhakrishnan Venkatraman V et al.

Delays in diagnosis and treatment, driven in part by limited geographic access to specialized care, continue to hinder childhood cancer outcomes. In this study, we aimed to evaluate motorized travel times for children seeking care at three referral childhood cancer centers in India. This multi-center retrospective study analyzed individual-patient level data for children (aged ≤19 years) diagnosed with cancer between 2005-2019 at three tertiary hospitals in India: All India Institute of Medical Sciences (AIIMS) and Rajiv Gandhi Cancer Institute (RGCI) in New Delhi, and Women's Indian Association (WIA) Cancer Institute in Chennai. Patient residential addresses were geocoded, and travel times were estimated using Malaria Atlas Project friction surface rasters and Dijkstra's algorithm. An exploratory logistic regression analysis was performed to identify factors associated with prolonged motorized travel time (>60minutes). A total of 22,328 patients with a median age of 10 years (IQR 4-15), 32·5% (n=7,261) female, and 54·2% (n=12,093) with solid malignancies were included. The median motorized travel time was 161minutes (IQR 27-430), with 73·5% of patients traveling >60minutes. Male sex (aOR 1·23, 95% CI: 1·15-1·31; p<0·001) and solid malignancies (aOR 1·09, 95% CI: 1·03-1·16; p=0·004) were associated with prolonged travel time. Compared with AIIMS, WIA had higher odds (aOR 2·79, 95% CI: 2·58-3·03) and RGCI had lower odds (aOR 0·69, 95% CI: 0·65-0·74) of prolonged travel time (p<0·001). Children with cancer in India face a substantial travel time burden to access cancer care, highlighting the need for expansion of pediatric oncology services. There is a need for policies that expand pediatric oncology capacity beyond major urban referral centers, strengthen regional treatment networks, and improve referral systems to reduce delays and disparities in diagnosis and treatment and improve childhood cancer outcomes.

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PubMedMedicine2026-07-25

Predictive value of right ventricular functional indices for bronchopulmonary dysplasia in preterm infants: A systematic review and meta-analysis.

Wan Enyu E, Liu Qian Q, He Yuanxia Y, He Yun Y

To comprehensively determine whether echocardiographic measures of right-sided cardiac performance can identify premature neonates at risk of developing bronchopulmonary dysplasia. We systematically queried 4 electronic databases - PubMed, Embase, the Cochrane Library, and Web of Science - from their respective launch dates through April 2025 to retrieve eligible studies examining whether echocardiographic markers of right-sided cardiac performance could anticipate bronchopulmonary dysplasia in premature neonates. Study rigor was evaluated with the Newcastle-Ottawa Scale, while the review was designed and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance and the Cochrane Handbook. Pooled effect estimates were calculated in RevMan 5.3, whereas sensitivity analyses and Egger regression test were performed with Stata/SE 15.1. Twelve studies were incorporated, involving 1316 preterm infants, with 414 of them diagnosed with bronchopulmonary dysplasia (BPD). Meta-analysis indicated that tricuspid annular plane systolic excursion (TAPSE) (weighted mean difference [WMD] = -0.08, 95% confidence interval [CI] -0.12 to -0.04, P = .0002), myocardial performance index (MPI) (WMD = 0.05, 95% CI 0.02-0.08, P = .004), fractional area change (FAC) (WMD = -3.51, 95% CI -6.68 to -0.33, P = .03), pulmonary artery acceleration time (PAAT) (WMD = -6.54, 95% CI -10.71 to -2.37, P = .002), and PAAT to right ventricular ejection time ratio (PAAT/RVET) (WMD = -0.04, 95% CI -0.07 to -0.01, P = .005) can aid BPD prediction. Subgroup analyses showed that measurements obtained before 36 weeks' postmenstrual age (PMA) had better predictive performance for TAPSE, MPI, and FAC than measurements obtained at 36 weeks' PMA. PAAT/RVET remained predictive of BPD both before 36 weeks' PMA and at 36 weeks' PMA. Among infants with birth weight ≥1000 g, MPI demonstrated better predictive performance for BPD. Sensitivity analyses (leave-one-out) showed that exclusion of individual studies had no meaningful effect on the summary estimates, supporting the stability of the results. TAPSE, MPI, FAC, PAAT, and PAAT/RVET have predictive value for BPD in preterm infants.

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