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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · Small Molecule

What is Gensci-004?

Gensci-004 is a small molecule developed by GeneScience Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPEG rhGH, Gensci 004, PEG Somatropin
CompanyGeneScience Pharmaceuticals Co., Ltd.
Drug ClassSmall Molecule, Recombinant Proteins
Molecular TargetGHR,
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

Gensci-004 acts on 2 molecular targets:

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Gensci-004 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved

Related Research Articles

PubMedJournal of human lactation : official journal of International Lactation Consultant Association2026-11-11

The Effect of Breast Crawl on Breastfeeding Success and Maternal Feeding Attitudes: A Randomized Controlled Trial.

Çimen Coşkun Kevser K, İlçioğlu Kevser K

Breastfeeding difficulties often begin with the first feeding after birth. Although infant-led approaches that support newborns' instinctive feeding behaviors are considered beneficial, experimental evidence on their effectiveness and mechanisms is limited. This study aimed to evaluate the effect of the breast crawl intervention on breastfeeding success and maternal feeding attitudes, and to examine whether maternal attitudes and duration of the first breastfeeding episode mediate this relationship. This study used a randomized controlled trial design with 63 mother and infant dyads. Newborns in the intervention group initiated breastfeeding through breast crawl, while routine breastfeeding care was provided in the control group, and outcomes were analyzed using adjusted and mediation models. After adjusting for breastfeeding experience, the intervention group demonstrated significantly longer duration of the first breastfeeding episode (F = 83.89, p < .001), higher LATCH scores (F = 8.99, p = .004), and more positive IIFAS scores (F = 4.34, p = .041) compared to the control group. Parallel mediation analysis indicated that the intervention had a significant direct effect on breastfeeding success (LATCH), but this relationship was not mediated by maternal attitudes or breastfeeding duration (p > .05). Breast crawl is an effective, low-cost, and non-invasive intervention that supports early breastfeeding success through primarily direct mechanisms and can be integrated into routine postpartum care.

PMID 43010687
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PubMedArthroscopy, sports medicine, and rehabilitation2026-11-11

Female Sex Is Independently Associated With Greater Sagittal Tibial Tubercle-Trochlear Groove Distance and Patellar Tilt in High-Grade Trochlear Dysplasia.

Hartmann Martin M, Caliskan Berfin B, Ackermann Jakob J, Fucentese Sandro F SF

To assess sex-related differences in patellofemoral (PF) anatomy among patients with PF instability and high-grade trochlear dysplasia (Dejour types B-D). Consecutive patients with symptomatic PF instability and high-grade trochlear dysplasia (Dejour types B-D) who were scheduled for surgical treatment between January 2010 and December 2020 and had available preoperative radiographs and magnetic resonance imaging were retrospectively identified at a single center. Patients with normal trochlear morphology, type A dysplasia, missing preoperative magnetic resonance imaging, or prior osseous procedures were excluded. Standardized magnetic resonance imaging-based measurements were obtained for trochlear morphology, tibial tubercle position, and patellar geometry. Depending on data distribution, parametric or nonparametric tests were used to compare sexes. Multivariate linear mixed-effects models were performed to calculate regression coefficients (B) with 95% confidence intervals, adjusting for patient clustering, age, body height, supratrochlear spur height, Caton-Deschamps index, sulcus depth, and tibiofemoral rotation. A total of 301 knees from 278 patients were analyzed; 192 knees (63.8%) were from female patients. The mean age was 22.6 ± 8.1 years (range, 11-50 years), and the mean body mass index was 24.9 ± 5.5 (range, 16.4-48.1). Distribution according to the Dejour classification was 40.5% type B, 31.2% type C, and 28.2% type D. Female patients showed smaller patellar width (37.9 ± 3.4 mm vs 41.3 ± 4.1 mm; P < .001) and thickness (16.8 ± 2.0 mm vs 18.5 ± 2.6 mm; P < .001), as well as greater patellar tilt (29.3° ± 10.7° vs 25.0° ± 10.8°; P = .001) and sagittal tibial tubercle-trochlear groove (sTTTG) distance (9.9 ± 5.2 mm vs 8.4 ± 6.0 mm; P = .005). After adjustment for age and body height, differences in patellar width, patellar thickness, patellar tilt, and sTTTG remained significant. After additional adjustment for supratrochlear spur height, Caton-Deschamps index, sulcus depth, and tibiofemoral rotation, patellar tilt (B = 3.51°, P = .021) and sTTTG distance (B = 2.36 mm, P = .004) remained greater in female patients. Among patients with PF instability and high-grade trochlear dysplasia, female sex was associated with greater patellar tilt and sTTTG distance after adjustment for age, body height, and relevant anatomical covariates. Level III, prognostic retrospective comparative study.

PMID 43011600
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PubMedMedicine2026-11-11

Treatment outcomes and associated factors among acute coronary syndrome patients admitted to Jimma University Medical Centre, Jimma, Ethiopia: A 5-year retrospective study.

Tegene Elsah E, Bekele Gashahun G, Mecha Mohammed M, Godebo Tamirat T et al.

In developing countries, acute coronary syndrome (ACS) is becoming a more common cause of cardiovascular death. Although thrombolytic treatments and limited percutaneous coronary intervention have been introduced, in-hospital mortality from ACS is still high in sub-Saharan countries. This study aimed to evaluate the treatment outcome of ACS and its associated factors among patients attending Jimma University Medical Center, Jimma, Ethiopia. A retrospective hospital-based cross-sectional study was conducted among 300 ACS patients. Patient records from admissions between November 1st, 2017, and October 31st, 2022 were reviewed, with data collected between December 1st and 31st, 2022. Data were collected using a structured checklist, entered, and analyzed using Statistical Package for Social science version 26. Descriptive analysis was used to summarize baseline characteristics and determine treatment outcomes. Bivariable and multivariable regression analyses were employed to determine factors affecting poor treatment outcomes. The odds ratio with a 95% confidence interval was computed, and a P value < .05 was considered significant. Among the 300 ACS patients included in our study, 35.3% died during hospitalization. Hypertension was the most common risk factor, present in 88.3% of the patients. In addition, 20.3% were classified as Killip class III or IV. 20.7% had a left ventricular ejection fraction (LVEF) of less than or equal to 30%, and 79.3% had an LVEF > 30%. Regarding treatment, an aspirin loading dose, clopidogrel loading dose, beta-blockers, statins, morphine, and nitrates were given to 284 (94.7%), 286 (95.3%), 227 (75.7%), 283 (94.3%), 109 (36.3%), and 80 (26.7%) patients, respectively. Factors significantly associated with in-hospital mortality were older age (P ≤ .001), history of diabetes (P = .004), ST-segment elevation myocardial infarction diagnosis (P = .003), and Killip class III and IV (P ≤ .001), whereas LVEF > 30% was associated with significantly lower odds of in-hospital death (P < .001). The proportion of in-hospital mortality attributable to ACS was found to be high. As a result, timely evidence-based therapy should be included in the setup.

PMID 43012815
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PubMedMedicine2026-11-11

Smoking cessation outcomes with cytisine in Turkey: A retrospective cohort analysis of success rates and determinants.

Topuz Ayşe Nur AN, Özer Zeliha Yelda ZY, Özcan Sevgi S, Kurdak Hatice H et al.

This study aimed to investigate the success rates and factors associated with smoking cessation outcomes among patients treated with cytisine, which has recently been administered in Turkey. This retrospective cohort study evaluated data from patients who received free cytisine treatment under the national tobacco control program at two smoking cessation centers between May and December 2024. Binary logistic and Cox regression analyses were used. The mean age of the 236 patients was 42.13 ± 11.20 years, the mean Fagerström score was 8.64 ± 1.32, the mean smoking duration was 21.64 ± 11.61 years, the pack-year value was 28.84 ± 20.33, and the mean duration of cytisine treatment was 20.18 ± 8.19 days. At the six-month follow-up, the smoking cessation rate was 14.4%. Smoking duration (OR = 0.829, 95% CI: 0.691-0.996, P = .045), previous quit attempts (OR = 0.177, 95% CI: 0.034-0.934, P = .041), and cytisine treatment duration (OR = 1.207, 95% CI: 1.068-1.363, P = .002) were significantly associated with smoking cessation success. Using a cytisine value ≥ 25 as the reference category, participants with a value < 25 had a 71.9% lower hazard of smoking abstinence (HR = 0.281; 95% CI: 0.165-0.478; P < .001). Following adjustment for pack-year category, participants with a cytisine value < 25 had a 73.8% lower hazard of smoking abstinence than those with a value ≥ 25 (HR = 0.262; 95% CI: 0.154-0.448; P < .001). The overall effect of pack-year category was also statistically significant (P = .016). Compared with participants with 2-14 pack-years, the hazard of smoking abstinence was 34.1% lower among those with 15-35 pack-years (HR = 0.659; 95% CI: 0.442-0.984; P = .042) and 49.9% lower among those with > 35 pack-years (HR = 0.501; 95% CI: 0.312-0.806; P = .004). In this study, pack-years and duration of cytisine use were the primary factors associated with successful smoking cessation over six months. Additionally, the reported success rate for smoking cessation aligns with figures found in global literature, although it appears to be lower when compared to local studies. More research is needed to clarify the factors contributing to the significant variations in success rates reported across the literature.

PMID 43012842
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PubMedBMC medical education2026-11-11

AI literacy and AI anxiety in emergency and first aid students: a cross-sectional study.

Karabulut Mustafa M, Karabulut Derya D, Özpinar Saliha S

This study was conducted to determine Artificial Intelligence (AI) literacy and AI anxiety levels in students attending the First Aid and Emergency Program, to analyze the relationship between these variables, and to identify significant predictors of AI literacy and AI anxiety. This descriptive and cross-sectional study was conducted with 430 students enrolled in the Emergency and First Aid Program in Konya province. Data were collected using the Personal Information Form, Artificial Intelligence Literacy Scale (AILS), and Artificial Intelligence Anxiety Scale (AIAS). Descriptive statistics, independent samples t-test, Pearson correlation analysis, and multiple linear regression analysis were performed to analyze the data. The mean scores the participating students obtained from the overall AILS and AIAS were 3.96 ± 0.60 and 3.00 ± 0.76, respectively. There was a significant, weak, and negative correlation between the AILS and AIAS scores (r = - .24, p < .001). There was a negative correlation between the scores obtained from the overall AILS and the scores obtained from the learning anxiety (r = - .38, p < .001) and AI configuration anxiety (r = - .18, p = .004) dimensions of the AIAS. However, there was no significant correlation between the scores obtained from the AILS, and the scores obtained from the job replacement anxiety and sociotechnical blindness dimensions of the AIAS. The results of the multiple linear regression analysis demonstrated that of the participating students, those who did not follow AI-related news obtained lower scores from the AILS (β = - 0.19, p < .001). Variables such as being a Female (β = 0.22, p < .001), not following AI news (β = 0.11, p = .028), and not supporting the inclusion of AI courses in the curriculum (β = 0.10, p = .042) were associated with higher levels of AI anxiety. The weak negative correlation between AI literacy and AI anxiety suggests that higher levels of AI literacy may be associated with lower levels of AI anxiety. This finding suggests that strengthening content to support artificial intelligence literacy in the Emergency and First Aid Program curriculum could be considered. Specifically, it is considered that integrating educational content aimed at reducing learning anxiety in students and increasing their awareness of the functioning, limitations, and conscious use of AI systems into the curriculum might play a supportive role in managing students' anxiety levels. Therefore, further longitudinal and quasi-experimental studies should be conducted to understand the nature of this relationship and the potential effects of AI training better.

PMID 43009939
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PubMedFoot & ankle specialist2026-11-10

Functional Outcomes After Total Ankle Replacement: A Forgotten Joint Score-12 Analysis With Up to 10-Year Follow-up.

Shetty Chethan B CB, Wales Kathryn K, Shah Kalpesh K, Ramanathan Arun K AK

BackgroundTotal ankle replacement (TAR) offers pain relief and preservation of motion in patients with end-stage ankle arthritis. The Forgotten Joint Score-12 (FJS-12) is a validated patient-reported outcome measure (PROM) designed to assess joint awareness, but data in TAR remain limited.MethodsA retrospective study of all TARs performed at our institution between 2014 and 2023 was conducted. Patients with a minimum of 2 years of follow-up were contacted by telephone, and the FJS-12 was administered. Mean follow-up was 4.83 ± 2.48 years (range 2-10). Demographics, surgical details, and complications were recorded. Statistical analyses explored factors associated with FJS-12 scores. At the end of FJS-12 administration, patients graded their satisfaction on a 4-point Likert scale.ResultsOf 102 ankles screened, 81 patients were eligible (mean age 69.7 years; mean body mass index [BMI] 31.3). Female sex (P = .008), right-sided TAR (P = .004), and additional tendo-Achilles lengthening (P = .004) were associated with lower FJS-12 scores. Scores declined at 3 years post-surgery (P = .011). Other factors, including BMI, smoking, and hypertension, had no significant impact. Based on the score distribution and satisfaction analysis, the Patient Acceptable Symptom State (PASS) threshold corresponded to an FJS-12 of 43, and the forgotten-joint threshold to 85.ConclusionTotal ankle replacement provided favorable short- to mid-term functional outcomes, as measured by the FJS-12. The FJS-12 is a sensitive PROM that detects subtle differences in patient-reported outcomes and may be a useful adjunct in routine TAR follow-up. We propose preliminary TAR-specific PASS and forgotten-joint thresholds that closely match those reported for knee replacement and are lower than those for hip replacement. These thresholds provide clinically meaningful benchmarks for patient satisfaction and should be validated in larger, prospective, multicentre cohorts.Level of Evidence:Level III, retrospective cohort study.

PMID 43004672
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