Drug Database
PT

PT-003

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-003?

PT-003 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-003 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

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PubMedAdvances in colloid and interface science2026-05-24

Advances in surface functionalization of porous titanium as novel orthopedic implants - a review.

Jiang Xiaodan X, He Guandi G, Guo Jiabao J, Bao Yuanqi Y et al.

Porous titanium (PT) and its alloys are widely used in orthopedic applications due to their interconnected porosity, favorable mechanical properties, biocompatibility, and low elastic modulus that alleviates stress shielding. However, the long-term clinical success of PT implants is largely determined by their surface characteristics. In recent years, surface functionalization has emerged as a promising strategy for tailoring the physicochemical and biological properties of PT. By constructing bioactive coatings or functional interfaces with controlled composition and microstructure, these approaches can significantly enhance corrosion and wear resistance, often reducing corrosion current density by one to two orders of magnitude. They also exhibit high antibacterial performance, commonly exceeding 90% efficacy against representative bacterial strains, and promote osteogenic responses, with cell adhesion, proliferation, and differentiation generally enhanced compared to unmodified controls, thereby facilitating osseointegration. This review systematically summarizes recent advances in PT surface functionalization, encompassing in-situ modification, coating-based, and pore-filling strategies, with a focus on their mechanisms, applications, and comparative advantages. Furthermore, emerging trends and innovative approaches are discussed, highlighting their potential for developing multifunctional and clinically translatable PT implants. Overall, this review provides an overview of recent progress and remaining challenges, offering guidance for the rational design of next-generation PT implants with enhanced biological performance and clinical applicability.

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PubMedColloids and surfaces. B, Biointerfaces2026-05-24

Tyrosine-based melanin-like multifunctional nanocomplexes for combined photothermal/photodynamic therapy of tumors.

Fu Kang K, Pan Lingfeng L, Zhang Xian X, Li Xianan X et al.

Photothermal therapy (PTT) and photodynamic therapy (PDT) have shown great potential for tumor treatment owing to their high spatiotemporal selectivity and minimally invasive characteristics; however, conventional inorganic photothermal agents often suffer from limited biocompatibility, and PDT efficacy is severely compromised by tumor hypoxia. To overcome these challenges, we developed a multifunctional nanocomposite (MNP@TCPP/Pt) for synergistic PTT/PDT. Melanin-like nanoparticles (MNP) were synthesized via tyrosinase-catalyzed oxidation of L-tyrosine, followed by surface grafting of the photosensitizer tetrakis (4-carboxyphenyl) porphyrin (TCPP) and in situ reduced of platinum nanoparticles. MNP@TCPP/Pt exhibited a uniform particle size of ∼180 nm with a near-neutral zeta potential (-10 mV). Upon laser irradiation, the MNP component efficiently converted light energy into heat, resulting in a temperature increase of approximately 28 °C within 300 s to enable effective PTT. Meanwhile, TCPP generated abundant reactive oxygen species (ROS) under light activation to achieve PDT. Notably, the surface-decorated Pt nanoparticles displayed catalase-like activity, continuously decomposing hydrogen peroxide to generate oxygen, with an oxygen production level of 6 mg L-1, thereby alleviating tumor hypoxia and enhancing PDT efficacy. In vitro experiments demonstrated that MNP@TCPP/Pt under laser irradiation significantly induced apoptosis in CT26 cells and maintained high ROS generation under hypoxic conditions, accompanied by a pronounced downregulation of HIF-1α expression. Furthermore, in vivo studies confirmed effective tumor growth inhibition after laser treatment without noticeable systemic toxicity. Overall, MNP@TCPP/Pt provides a promising and biocompatible platform for synergistic PTT/PDT in hypoxic tumor therapy.

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PubMedAmerican journal of clinical pathology2026-05-24

Hilar fat invasion is a poorly defined and inconsistently interpreted lung carcinoma staging parameter.

Butnor Kelly J KJ, Westcom Alayna M AM

Hilar fat invasion raises the T category of otherwise pT1 lung carcinomas to pT2a. Pathologists were surveyed to better understand their awareness and interpretation of hilar fat invasion. Pathologists interested in pulmonary pathology were invited to participate in an online survey of hilar fat invasion assessment. Of 80 respondents, 58% considered hilar fat any fat that is outside the lung but inside the pleural reflection, 32% considered it to be fat inside the pleural reflection near hilar lymph nodes around the main bronchus, and 10% were uncertain or had a different definition. When asked which pT designation is most appropriate for a lobectomy specimen with a pT1-sized invasive carcinoma that directly invades the fat around the lobar bronchus but does not involve the lobar bronchus margin, 69% indicated pT1c, 23% chose pT2a, and 8% were unsure/other. For a pneumonectomy specimen with a pT1-sized invasive carcinoma that directly invades the fat around both the lobar and main bronchus but does not extend beyond the pleural reflection or involve the main bronchus margin, 48% assigned pT2a, 39% chose pT1c, and 13% were unsure/other. There is a lack of consensus among pathologists as to what constitutes hilar fat invasion, resulting in considerable interobserver variability in pT categorization. Making hilar fat invasion a standard pT designation could improve awareness, and defining the anatomic boundaries of hilar fat could result in greater consistency in assigning a pT category to tumors that extend into fat outside the lung.

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PubMedBiosensors & bioelectronics2026-05-24

Machine vision-integrated portable colorimetric biosensing platform with triple-layered (Pt@ZIF-8)3@PDA nanozymes for multiplexed ultrasensitive detection of pathogenic bacteria.

Wen Yuhao Y, Hao Xingkai X, Yang Peiji P, Gao Chi C et al.

Simple and in-field detection of multiple pathogenic bacteria is urgently needed. In this work, a biosensor using a nanozyme-based colorimetric immunoassay was developed for sensitive detection of multiple pathogenic bacteria. Firstly, a nanocomposite (Pt@ZIF-8)3@PDA-Ab was synthesized based on nanozyme coated with multiple layers of metal-organic frameworks to recognize and probe target bacteria. Additionally, leveraging the catalytic properties of Pt nanoparticles with different substrates (TMB, OPD, AEC, and ABTS), a multicolor sensor array, a portable imaging device, and an in-house coded machine vision algorithm were developed for colorimetric detecting multiple pathogenic bacteria. For single target pathogen detection, this approach exhibits a favorable linear relationship within the range of 10-106 CFU/mL, with a detection limit (LOD) as low as 2 CFU/mL for Salmonella Typhimurium. Furthermore, the (Pt@ZIF-8)3@PDA-Ab-based biosensor exhibited excellent selectivity and ambient storage stability for as long as 60 days. The colorimetric biosensing platform demonstrates excellent detection capabilities of multiple pathogens bacteria, showing a favorable linear relationship within the range of 10-106 CFU/mL, with LOD as low as 10, 7, 5, and 3 CFU/mL for Staphylococcus aureus, Salmonella Typhimurium, Escherichia coli, and Vibrio parahaemolyticus, respectively. The proposed sensor exhibits excellent anti-interference capability (RSD<5.8%). When applied in detecting carrot, lake water and artificial saliva samples, the method demonstrated satisfactory accuracy (RSD<5.8%) for four types of bacteria. This work highlights the synergistic integration of a structurally engineered ambient-stable nanozyme, a multicolor sensor array, and a machine vision-enabled portable device, offering a promising and generalizable strategy for point-of-need pathogen detection in food safety, environmental monitoring, and clinical diagnostics.

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PubMedChemSusChem2026-05-24

Green Hydrogen Generation Utilizing Efficient Phthalocyanine-Based Electrocatalyst.

Itagi Mahesh M, Yaseen Mohammed M, Imadadulla Mohammed M, Manjuraj T T et al.

Energy production and use must be in balance with the ecosystem since it is a necessary part of life. Among the many renewable and non-renewable energy sources, hydrogen is considered a sustainable and green energy source. Sustainable hydrogen production will be required for the hydrogen economy, and this can be accomplished by electrochemically splitting water with efficient electrocatalysts. Because of their significant catalytic activity, low overpotential, and low energy consumption, platinum (Pt) and Pt-based catalysts are utilized. The hydrogen evolution reaction (HER), which uses pricey Pt catalysts to electrocatalytically reduce water to molecular hydrogen, has the potential to be a sustainable energy source; however, its limited availability and high cost limit its practical applicability. As a result, a simple, low-cost, stable, and environmentally friendly thiol-substituted cobalt phthalocyanine (MTCoPc) was utilized as an electrocatalyst for HER activity. MTCoPc/SP (SP: super-p) hybrid composite electrocatalyst demonstrated good HER catalytic performance in 1 M KOH, with overpotentials of 110 and 169 mV at current densities of 10 and 50 mA cm-2, respectively. The MTCoPc/SP hybrid composite's remarkable activity toward HER and long-term stability make it a potential electrocatalyst for real-time application.

PMID 42177629
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PubMedMetabolomics : Official journal of the Metabolomic Society2026-05-24

Association of age-related macular degeneration with exposome related metabolomics.

Lains Ines I, Bhat Roshni R, Mendez Kevin K, Gil Joao J et al.

Age-related macular degeneration (AMD) is a multifactorial disease, but it remains unclear how external exposures - the exposome - promote its development. Metabolomics can provide insights to better understand AMD pathophysiology. Previous work to date has focused primarily on associations between endogenous metabolites and AMD. This study aimed for the first time to investigate associations of exogenous metabolites in plasma and urine and AMD. Cross-sectional study including patients with AMD and a control group (> 50 years) from Boston, US and Coimbra, Portugal (PT). Color fundus photographs (CFP) of all participants were used for AMD staging. Fasting plasma and urine samples were used for metabolomic profiling using Ultrahigh Performance Liquid Chromatography - Mass Spectrometry (Metabolon, Inc). Multivariate and ordinal logistic mixed-effect regression models were computed for each cohort and then combined by meta-analysis. Primary outcome was association of metabolites with AMD (vs. no AMD). False discovery rate (FDR) was used to account for multiple comparisons and significant q-values are reported. We included 1023 eyes (823 from the US and 580 from PT). Meta-analysis revealed significant associations of tartronate, thioproline and 2-methoxyhydroquinone sulfate levels with both presence and staging of AMD (q < 0.005 for all). Similar trends were seen in urine. To the best of our knowledge, this is the first study to identify associations between exogenous metabolites and AMD. These findings are crucial for identifying possible targets for preventive strategies for this blinding disease.

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