Drug Database
PT

PT-003

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-003?

PT-003 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-003 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedJournal of the American Geriatrics Society2026-09-19

Acute Care Group-Based Physical Therapy on an Inpatient Geriatrics Unit: Preliminary Data.

Crick James P JP, Hull Laura L, Maag Samuel S, Alain Gabriel N GN

Hospitalized older adults are at high risk for hospital-associated disability, but one-to-one physical therapy (PT) models often cannot meet demand for skilled mobility progression. Group-based PT is effective in outpatient and rehabilitation settings, but its feasibility in acute inpatient care is unknown. We conducted a single-site, prospective quality improvement implementation of acute care group-based PT (AC-GBPT) on a 39-bed medical-surgical geriatrics unit at an academic medical center. Sessions were offered weekly during routine clinical operations without additional staffing. Eligible patients were 60 years and older, had an active PT plan of care, were medically stable, and could transfer to a chair with human assistance. Feasibility outcomes included number of sessions delivered, participants per session, recruitment, reasons for non-participation, and adverse events. We also summarized participant characteristics and therapist productivity on days with versus without a group session. From March 19, 2025, through February 18, 2026, 37 sessions were delivered, with a mean of 4.22 participants per session (range 3-6). Across the period, 156 unique patient participations were recorded, and 69% of patients approached participated. At the time of participation, mean age was 77.9 years and mean time since admission was 8.6 days. No safety events occurred during or immediately after group sessions. Mean therapist productivity was notably higher on group days than on non-group days (1.59 vs. 1.31 patients/h; approximately 21% higher). A once-weekly AC-GBPT model for selected hospitalized older adults was feasible to deliver using existing resources and showed promising reach, safety, and operational performance, suggesting it may extend PT to more patients. Further work should assess patient acceptability, fully characterize staff time requirements, and assess patient-centered outcomes.

PMID 42760622
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PubMedMedicine2026-09-19

Exploring the association between gastroesophageal reflux disease and hyperlipidemia through bioinformatics and Mendelian randomization.

Sun Yongming Y, Wang Wenyan W, Xing Xiaodong X, Kang Wodele W et al.

Observational research has found a relationship between gastroesophageal reflux disease (GERD) and hyperlipidemia (HLP). This study explored the relationship between GERD and HLP using bioinformatics and Mendelian randomization (MR) methods. We first conducted bioinformatics analyses to identify differentially expressed genes (DEGs) from disease datasets and then performed a two-sample MR analysis with aggregated genome-wide association study (GWAS) data to investigate the relationship. 11 DEGs were shared between GERD and HLP. According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, cholesterol metabolism, renin secretion, and glycerolipid metabolism may represent common underlying mechanisms between the 2 diseases. The Inverse Variance Weighted (IVW) method identified P values of < .001 and .003 between GERD and HLP in the primary and replication MR analysis, respectively. The results were robust, as confirmed with the heterogeneity and pleiotropy tests. This study revealed the causal relationship between GERD and HLP through comprehensive approaches. The implicated shared genes and pathways offer valuable insights into potential therapeutic avenues and highlight the importance of addressing this link in clinical practice.

PMID 42760681
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PubMedFrontiers in medicine2026-09-19

Generational safety profiles of BTK inhibitors: adverse reaction signals and real-world evidence from the FAERS database.

Tu Jiachen J, Wang Zhe Z, Zhang Jingjing J, Xu Haojie H et al.

The development of Bruton's tyrosine kinase (BTK) inhibitors has revolutionized the management of B-cell malignancies and holds potential in autoimmune diseases. However, safety concerns remain regarding treatment-associated adverse events: first-generation ibrutinib has been associated with off-target adverse event profiles, second-generation agents (acalabrutinib and zanubrutinib) require further validation of long-term safety patterns, and the real-world safety characteristics of third-generation pirtobrutinib continue to be evaluated. This study aims to characterize differences in adverse event (AE) disproportionality reporting signal patterns among four BTK inhibitors using data from the FDA Adverse Event Reporting System (FAERS). This study analyzed AE reports for four BTK inhibitors from the FAERS database via disproportionality analysis with four distinct algorithms, complemented by a clinical prioritization scoring system. Disproportionality reporting signal patterns were characterized across System Organ Class (SOC), Preferred Term (PT), and temporal distribution dimensions. A standardized 2-year observation window was applied for sensitivity analysis, and AE-mortality associations were evaluated. A total of 77,014 AE reports were included in this study. The four BTK inhibitors showed positive disproportionality reporting signals in blood and lymphatic system disorders, cardiac disorders, and infections and infestations. However, distinct disproportionality signal patterns were observed at the PT level. Ibrutinib showed prominent cardiovascular-related disproportionality reporting signals, particularly for atrial fibrillation (ROR = 9.8). Acalabrutinib was characterized by a distinct headache signal. Zanubrutinib showed prominent signals for myelosuppression (ROR = 16.24) and haemorrhage subcutaneous (ROR = 146.81). Pirtobrutinib demonstrated the strongest signal for increased white blood cell count (ROR = 54.28). Descriptive analysis of reported time-to-onset distributions showed that pneumonia reports for ibrutinib represented a larger proportion among cases reported after longer treatment durations, whereas haemorrhage and decreased white blood cell count reports were more frequently observed within earlier reporting intervals. In terms of fatal outcomes, multiple PTs associated with ibrutinib showed statistically significant associations with reported death outcomes within the FAERS dataset. This descriptive pharmacovigilance study identified distinct disproportionality reporting signal patterns for four BTK inhibitors based on FAERS data, providing potential signals for post-marketing safety surveillance. These findings should be interpreted as differences in reporting patterns.

PMID 42760957
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PubMedNature water2026-09-19

Plasmon-enhanced reductive defluorination of PFAS in water under ambient conditions.

Durak Ozce O, Lee Seung Soo S SSS, Watt Lydia MacFarlane LM, Maisto Susanna K SK et al.

Photo-driven, plasmon-enhanced catalysis enables polyfluoroalkyl and perfluoroalkyl substance (PFAS) degradation in water under ambient conditions. Here we show that ultraviolet (UV) irradiation-induced localized surface plasmon resonance drives reductive defluorination of perfluorooctanoic acid and perfluorooctane sulfonic acid, two legacy contaminants. Stable, quantum-sized palladium and platinum nanocatalysts supported on aminated mesoporous silica nanoparticles (MSN-NH2-Pd and MSN-NH2-Pt) transform perfluorooctanoic acid and perfluorooctane sulfonic acid with stoichiometric, or near-stoichiometric, fluoride release under low-intensity UVC or UVA irradiation at room temperature. Time-resolved 19F nuclear magnetic resonance, high-resolution mass spectrometry and complementary analyses indicate a stepwise reductive hydrodefluorination pathway in which oxidized, short-chain products do not measurably accumulate under the conditions studied. Scavenger and control experiments are consistent with hydrated electrons and in situ hydrogen generation as key reactive species. Taken together, the results indicate that synergistic interfacial PFAS sorption, plasmon-induced hydrogen evolution and hydrated electron formation drive PFAS defluorination under mild reaction conditions.

PMID 42761012
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PubMedMedicine2026-09-19

Clinical efficacy of AI-navigated transperineal MRI-TRUS fusion biopsy for prostate cancer diagnosis: A retrospective cohort study.

Chen Jiangchuan J, Xu Qiao Q, Li Changlong C, Zhang Jiamo J

This study evaluates the clinical efficacy of transperineal 3D image registration combined with AI-electromagnetic navigation-guided mpMRI-TRUS fusion biopsy versus transrectal cognitive fusion biopsy for prostate cancer diagnosis. This retrospective cohort study analyzed 283 patients undergoing prostate biopsy at Yongchuan Hospital of Chongqing Medical University (January 2022 to December 2024). Participants were stratified into transrectal cognitive fusion (n = 146) and transperineal AI-navigated fusion (n = 137) groups. Detection rates of clinically significant prostate cancer (csPCa) and complication profiles were compared. Multivariable logistic regression identified independent predictors of csPCa detection. The transperineal AI-navigated fusion group demonstrated a significantly higher csPCa detection rate compared to the transrectal cognitive fusion group (55.5% vs 45.2%, P = .043). Multivariable logistic regression revealed that advanced age (OR = 1.05, 95% CI: 1.01-1.17), PI-RADS score > 3 (OR = 9.4, 95% CI: 3.95-16.74), and transperineal approach (OR = 3.65, 95% CI: 1.22-4.75) independently predicted csPCa detection. The AI-navigated group showed no hematochezia (0% vs 9.6%, P = .003), no sepsis (0% vs 2.1%, P = .246), and a significantly lower urinary tract infection rate (13.9% vs 28.8%, P = .035). However, urinary retention was significantly more frequent in the transperineal group (14.4% vs 7.3%, P = .012), although all cases resolved within 72 hours with conservative management. Transient perineal pain was also more frequent in the transperineal group (24.1% vs 8.9%, P = .017). AI-navigated transperineal fusion biopsy was associated with improved csPCa detection and a lower infectious complication rate compared to transrectal cognitive fusion biopsy, but with a significantly higher incidence of transient, self-limiting urinary retention. These findings support its potential as an effective diagnostic strategy, with the caveat that patients should be counseled regarding post-biopsy voiding function.

PMID 42760671
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PubMedMedicine2026-09-19

Estimated prevalence of osteoporosis in postmenopausal women in Saudi Arabia: A multicenter cross-sectional study.

Hakim Noor A NA, Hussein Khulood S KS

Although osteoporosis is a major public health concern, limited and outdated research in Saudi Arabia highlights the need to investigate its current prevalence and risk factors among postmenopausal women in Jeddah. This study aimed to determine the prevalence of osteoporosis in postmenopausal women in Saudi Arabia and identify factors associated with bone mineral density (BMD). A total of 450 healthy postmenopausal women aged ≥50 years were randomly chosen to participate in this cross-sectional study. The study collected demographic information and performed dual-energy X-ray absorptiometry scans of the lumbar spine and femoral neck. The overall prevalence of osteoporosis and osteopenia was 12.2% and 42.9%, respectively. Women with osteoporosis were older, had been menopausal for longer, and had a lower body mass index (BMI) than those with osteopenia or normal BMD (P < .001). Compared with those in the other 2 groups, women with osteoporosis also had fewer deliveries and a shorter breastfeeding duration (P = .01 and P = .003, respectively). Multiple linear regression analysis revealed that age, BMI, and duration of lactation were independent predictors of lumbar spine BMD (P = .007, P = .001, and P = .01, respectively), whereas menopausal duration and BMI were independent predictors of femoral neck BMD (P = .008 and P = .001, respectively). Osteoporosis and osteopenia are prevalent among postmenopausal women in Saudi Arabia. Older age and longer menopausal duration were associated with lower BMD, whereas higher BMI and longer lactation duration were positively associated with BMD. Given the cross-sectional design, these associations should not be interpreted as causal. Early identification and appropriate assessment of postmenopausal women according to their clinical and demographic risk factors may help support osteoporosis prevention.

PMID 42760690
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