Drug Database
IB

ibrutinib

✓ Approved

Johnson & Johnson Services, Inc. · Companion diagnostic · Companion diagnostic

What is ibrutinib?

ibrutinib is a companion diagnostic developed by Johnson & Johnson Services, Inc.. It is approved for therapeutic indications via others.

Drug Profile

CompanyJohnson & Johnson Services, Inc.
Drug ClassCompanion diagnostic
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Johnson & Johnson Services, Inc.

Therapeutic Indications

ibrutinib is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

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PubMedDose-response : a publication of International Hormesis Society2026-07-25

Integrating Network Pharmacology and Experimental Validation Reveals EGFR/PI3K/Akt Axis Mediates Ibrutinib-Induced Cardiotoxicity.

Guan Yingxia Y, Mei Jiaqi J, He Yuanqiao Y, Lu Mei M et al.

This study aims to systematically explore the molecular mechanism underlying ibrutinib-induced cardiotoxicity. Network toxicology was applied using DrugBank, PharmMapper, GeneCards, OMIM, and TTD databases to identify overlapping targets between ibrutinib and myocardial injury, followed by PPI network construction (STRING; confidence ≥0.7) and GO/KEGG enrichment analyses (Metascape). Molecular docking (AutoDock Vina) verified ibrutinib's binding affinity to core targets. In vitro, H9C2 cardiomyocytes were exposed to ibrutinib (0, 10, 20, 40, and 80 μM) for 24 h; CCK-8, DCFH-DA, EdU, and Calcein-AM/PI assays were performed to assess cell viability, ROS levels, proliferation, and cell death, respectively. Western blot analyzed phosphorylation of EGFR/PI3K/Akt/mTOR pathway proteins. A total of 42 overlapping targets were screened from 337 ibrutinib-related targets and 471 myocardial injury-related genes. PPI network analysis identified EGFR, AKT1, SRC, ESR1, and CASP3 as hub genes, and KEGG enrichment analysis identified the PI3K-Akt pathway as the most significantly enriched cascade. Molecular docking confirmed that ibrutinib stably bound BTK and EGFR with a binding energy of -30.2 kcal/mol and formed multiple hydrogen bonds and salt bridges (2.2-3.2 Å). In H9C2 cells, ibrutinib dose-dependently reduced viability (IC50 = 119.49 μM), increased ROS production (40 and 80 μM), inhibited proliferation (10 and 20 μM), and promoted cell death (5 and 10 μM). Western blot confirmed that ibrutinib significantly downregulated phosphorylation of PI3K p85, Akt (Ser473), mTOR (Ser2448), and p70S6K (Thr389) without altering total protein expression. Ibrutinib induces cardiotoxicity by targeting BTK/EGFR and inhibiting the downstream EGFR/PI3K/Akt/mTOR pathway, providing a mechanistic framework for clinical safety management of BTK inhibitors.

PMID 42500305
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PubMedVeterinary medicine and science2026-07-25

Green Tea Extract, Keratin Hydrolysate and Vitamin C Exert Anti-Ageing Effects Through the Hippo Signalling Pathway in Feline and Canine Mammary Gland Cells.

Gao Yi Y, Sun Xue X, Ma Yan Y, Li Jiaxi J et al.

Ageing is a progressive decline in organ function and tissue integrity caused by genetic, environmental and physiological factors. With the increasing lifespan of companion animals, effective anti-ageing interventions for elderly felines and canines have attracted growing attention in veterinary medicine. This study aimed to investigate the anti-ageing effects of green tea extract, keratin hydrolysate and vitamin C in feline and canine mammary gland cells and to explore the underlying molecular mechanisms. Feline and canine mammary gland cells were treated with green tea extract, keratin hydrolysate and vitamin C in vitro. Cell proliferation, oxidative stress responses and ageing-associated protein expression induced by actinomycin D were evaluated. The involvement of the Hippo signalling pathway was further analysed to determine the molecular mechanisms underlying the anti-ageing effects. Green tea extract, keratin hydrolysate and vitamin C significantly promoted the proliferation of feline and canine mammary gland cells. These treatments effectively restored the abnormal expression of ageing-related proteins induced by actinomycin D and exhibited protective effects against oxidative damage. Mechanistically, the anti-ageing effects were associated with regulation of the Hippo signalling pathway. Green tea extract, keratin hydrolysate and vitamin C exhibit significant anti-ageing effects in feline and canine mammary gland cells through modulation of the Hippo pathway. These findings suggest their potential as safe and effective anti-ageing interventions for improving health and alleviating geriatric syndromes in ageing companion animals.

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PubMedGalen medical journal2026-07-25

Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions: A Systematic Review : Short title: Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions.

Al-Hakami Hadi H

Accurate diagnosis of head and neck lesions relies heavily on image-guided biopsy techniques, which facilitate targeted sampling and enable radiologic-pathologic correlation. Increasing use of CT-guided fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) necessitates updated evaluation of their diagnostic performance and safety. To systematically identify, appraise, and synthesize published evidence on the diagnostic accuracy, tissue adequacy, and radio-pathologic concordance of image-guided biopsy for head and neck lesions. This review followed PRISMA 2020 guidelines and a protocol registered in PROSPERO (CRD420251181567). Searches were conducted across PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, and Google Scholar (January 2018-September 2025). Eligible studies included human subjects undergoing image-guided FNAC or CNB with reported diagnostic outcomes. Two reviewers independently screened, extracted data, and assessed quality using QUADAS-2. Due to methodological and clinical heterogeneity, meta-analysis was not performed. From 345 records, eight studies met inclusion criteria. Most were retrospective (8/10), evaluating CT-guided FNAC, CNB, or percutaneous needle biopsy across cervical, suprahyoid, salivary, lymphatic, thyroid, and skull base lesions. Diagnostic sensitivities ranged from 85-95%, specificities from 92-97%, and overall accuracies from 90-96%. Diagnostic yield was high (85-100%), and radio-pathologic concordance consistently exceeded 87%. Complications were uncommon and generally minor, except for hilar lymph node biopsies, which showed higher pneumothorax rates. Image-guided biopsy of head and neck lesions demonstrates high diagnostic accuracy and excellent radio-pathologic concordance across diverse anatomic regions, supporting its role as a reliable, minimally invasive diagnostic tool. Despite strong performance in deep and complex spaces, procedure-specific complication risks-particularly in hilar lymph node sampling-should inform clinical decision-making.

PMID 42499369
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PubMedThe Medical clinics of North America2026-07-25

Diagnostic Tools in Sleep Medicine.

Yuan Nathaniel N, Avidan Alon Y AY

This article presents a structured, clinically grounded approach to the diagnosis of sleep disorders. Key conceptual distinctions are clarified to support accurate symptom characterization and avoid diagnostic misclassification. Validated screening instruments are reviewed. Objective diagnostic modalities are discussed. The role of the physical examination and targeted biomarkers is emphasized as a means of enhancing diagnostic precision in selected patients. Through integration of clinical data, subjective assessments, and objective measures, the experienced clinician can accurately diagnose and manage common sleep disorders including insomnia, hypersomnolence disorders, obstructive sleep apnea, and circadian rhythm sleep-wake disorders while delivering individualized, patient-centered care.

PMID 42498433
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PubMedJournal of molecular biology2026-07-25

Alcohol dehydrogenase D from Pyrococcus furiosus is a thermostable rare earth element binding enzyme: Metal/cofactor interactions modulate the apparent reaction equilibrium constant.

Gokulu Ipek Simay IS, Abeyrathna Sameera S, Banta Scott S

Metals are frequently exploited in the active sites of enzymes; however, the involvement of rare earth elements (REEs) in biocatalysis has been less commonly observed. Here, we show that the alcohol dehydrogenase D (AdhD) from Pyrococcus furiosus can bind REE ions, and the forward activity (alcohol oxidation) is accelerated by the addition of REEs, while, unexpectedly, the reverse reaction is inhibited. In the companion paper, we discovered a REE binding site in the AdhD structure that is distal to the active site. Here, we identified a second REE binding interaction that is only observed in the presence of bound cofactor. The addition of REEs affects the observed equilibrium constant of the reaction, and the binding of the REEs by the enzyme/cofactor complex depends on the redox state of the cofactor. Comparable REE-dependent modulation of catalysis was also observed with human aldose reductase (hAR), suggesting a conserved mechanism of REE interaction among aldo-keto reductase (AKR) family enzymes. REE interactions attenuate the formation of the enzyme cofactor/complexes, which explains the differential impact on the reaction rates and the variable effective reaction equilibrium constant. Together, these results establish a mechanism by which REEs tune catalytic directionality and apparent thermodynamic set points through cofactor-dependent binding and linkage effects, rather than through classical active-site metal catalysis.

PMID 42497915
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PubMedWorld journal of otorhinolaryngology - head and neck surgery2026-07-25

Research Progress on Upper Airway Cough Syndrome.

Huang Wan-Ting WT, Chen Jia J

Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and treatment. The utilization of nasal and laryngeal endoscopy is crucial in the diagnostic process, and the implementation of a multidisciplinary collaborative approach can markedly enhance diagnostic accuracy and treatment outcomes. This article provides a comprehensive review of the clinical characteristics, diagnostic and therapeutic approaches, and pathophysiological mechanisms associated with UACS, aiming to equip clinicians with a deeper understanding for improved management of this condition.

PMID 42500107
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