Drug Database
NI

NIK-127

✓ Approved

Kowa · Small Molecule · Small Molecule

What is NIK-127?

NIK-127 is a small molecule developed by Kowa. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Therapeutic Indications

NIK-127 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDiarrhoea✓ Approved

Related Research Articles

PubMedInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026-11-11

Three-year survival rate and prognostic factors among women with vulvar cancer treated at Ocean Road Cancer Institute in Tanzania: A retrospective cohort study.

Almada Noela J NJ, Oneko Olola O, Masenga Gileard G, Mmbaga Blandina T BT et al.

Vulvar cancer accounts for approximately 5% of gynecologic malignancies worldwide. Global incidence remains low (0.85 per 100 000 women). Vulvar cancer is under-reported in low- and middle-income countries, and survival data from sub-Saharan Africa remain limited. This study evaluates the 3-year survival rate and associated prognostic factors among women diagnosed with vulvar cancer at Ocean Road Cancer Institute in Tanzania. A retrospective cohort study of 127 women with histologically confirmed vulvar cancer diagnosed between January 2019 and December 2021 was conducted. Overall survival was estimated using the Kaplan-Meier method. Cox proportional hazards regression identified mortality predictors. Analyses were performed using STATA 17. Among 127 patients, 61.4% were aged >45 years and 62.2% were HIV-positive. Squamous cell carcinoma (SCC) was the predominant histological subtype (89%). The 1-, 2-, and 3-year survival rates were 76.0%, 51.3%, and 39.1%, respectively. In the univariate analysis, factors associated with mortality were age greater than 45 years (P = 0.047), lymph node involvement (P = 0.046), advanced FIGO (the International Federation of Gynecology & Obstetrics) stage (P < 0.001), lack of surgical treatment (P = 0.010), and suboptimal treatment (P = 0.004) In multivariate analysis, advanced stage (adjusted hazard ratio, aHR = 2.93, P < 0.001) and suboptimal treatment (aHR = 1.91, P = 0.031) were independent predictors of mortality, with age greater than 45 years showing marginal significance (aHR = 1.62, P = 0.054). Three-year survival among women with vulvar cancer at Ocean Road Cancer Institute was poor (39.1%). SCC was the predominant histology. Advanced FIGO stage, older age, and suboptimal treatment independently predicted mortality.

PMID 43012128
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PubMedCambridge prisms. Extinction2026-11-11

Inherently at risk: Low floral morphological variability predicts conservation risk.

Tremblay Raymond L RL, Leon-Rodríguez Alex A, Colon Miranda Jose J, Meléndez Hebib Valeria V

Extinction risk should, in theory, be shaped not only by extrinsic pressures but also by intrinsic biological traits, including intraspecific floral morphological variability, which may influence ecological flexibility and pollination success. We evaluated whether reduced floral morphological dispersion, measured as species-level coefficients of variation (CVs) for seven floral dimensions, is associated with elevated conservation risk in Caribbean orchids. Class-weighted logistic regressions were fitted across multiple imputations, with exhaustive Bayesian Information Criterion selection across 127 candidate models. Single-trait models were favoured, petal-length CV best supported, followed by sepal-width and labellum-length. Sign-direction analyses confirmed that five perianth traits were predominantly negatively associated with risk (lower CV → higher risk), whereas column-length CV was robustly positive. Discrimination of Threatened from Not-Threatened species was modest but consistently above chance; under a precautionary threshold penalising missed detections, nearly all Threatened species were flagged. Because threat status was phylogenetically clustered (Fritz and Purvis D = 0.62), the full model set was refitted using phylogenetic logistic regression and taxonomic and phylogenetic mixed models; effect signs, magnitudes and rankings were preserved. Species at higher risk therefore tend to exhibit reduced intraspecific floral variation, and the model offers a biologically interpretable triage tool for prioritizing unassessed Caribbean orchids.

PMID 43011661
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PubMedBMC gastroenterology2026-11-10

Recompensation of decompensated autoimmune hepatitis cirrhosis: a multi-center retrospective analysis.

Kulkarni Anand V AV, Kumar Karan K, Roy Akash A, Priya Padma P et al.

Recompensation is well known in patients with alcohol-associated liver disease (ALD) and viral hepatitis. While there is limited data on patients with autoimmune hepatitis (AIH). The primary objective was to assess the rate of recompensation in AIH-related decompensated cirrhosis; the secondary objectives were to determine predictors of recompensation per Baveno VII criteria, re-decompensation, and further decompensation rates. In this multicentre retrospective study from India, we included patients with biopsy-proven AIH-related decompensated cirrhosis from January 2019 to December 2024. Among 127 patients (aged 48.9±12.8 years; women: 72.4%, Child B: 51.2%; Child C: 48.8%), 77.2% (98/127) patients received immunosuppressive therapy, and 64.3% (63/98) had achieved complete biochemical remission. Forty-four of 127 patients (34.6%, 95% CI, 26.4-43.6) achieved recompensation after a median follow-up of 18 months (0.2-94 months). On competing risk regression analysis, Child Pugh score (sHR, 0.832 [95%CI, 0.7-0.979]; P = 0.02) was the only predictor of recompensation. Of the patients who recompensated, 20.4% (9/44) re-decompensated, and 44.4% (4/9) recompensated again. Of the 83 patients who had not recompensated, 9.6% (8/83) experienced further decompensation; of these, 37.5% (3/8) recompensated later. The transplant-free survival rate among recompensated patients was 97.7% (95% CI, 87.9-99.9) compared with 63.8% (95% CI, 52.5-74.1) among those who did not achieve recompensation (P < 0.001). Twenty-five per cent of patients with AIH-primary biliary cholangitis recompensated, while none with AIH-primary sclerosing cholangitis recompensated. One-third of patients with AIH-related decompensated cirrhosis recompensate and one in five of such patients re-decompensate again.

PMID 43004210
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PubMedWei sheng yan jiu = Journal of hygiene research2026-11-10

[Pathway analysis of characteristics and related factors of school bullying victimization among primary and secondary school students in Hunan Province in 2022].

Luo Miyang M, Wan Jialin J, Huang Zhihang Z, Liu Zhuoning Z et al.

To describe the characteristics of school bullying victimization among primary and secondary school students in Hunan Province and to explore the possible pathways of associated factors. From September to December 2022, a multistage stratified cluster random sampling method was used to recruit 209 096 students (from grade 4 of primary school to grade 3 of senior high school) across 14 prefectures and cities in Hunan Province. A self-administered questionnaire, developed by the Chinese Center for Disease Control and Prevention, was employed to collect data on bullying victimization, personal characteristics, unhealthy lifestyle habits, injuryrelated behaviors, and domestic violence. Anthropometric measurements (height and weight) were also taken. A total of 200 735 valid questionnaires were returned (response rate 96.0%). Structural equation modeling was applied to examine the pathways between various factors and bullying victimization, with model fit assessed by root mean square error of approximation (RMSEA), comparative fit index (CFI), Tucker-Lewis index (TLI), and incremental fit index (IFI). Among the 200 735 participants, 52.0% (n=104 327) were boys and 48.0% (n=96 408) were girls; 36.4% (n=73 117) were from primary schools and 63.6% (n=127 618) from secondary schools; 36.7% (n=73 651) resided in urban areas and 63.3% (n=127 084) in suburban county areas; 81.5% (n=163 644) were of Han ethnicity and 18.5% (n=37 091) were ethnic minorities; and 32.3% (n=64 888) were boarders. The overall prevalence of bullying victimization was 5.6% (n=1152), with verbal bullying being the most common (4.1%, n=8226), followed by physical bullying (2.6%, n=5304) and relational bullying (1.7%, n=3388). The structural equation model demonstrated a good fit (RMSEA=0.06, CFI=0.93, TLI=0.91, IFI=0.93). The standardized direct effects were as follows: injury-related behaviors had the largest coefficient (0.77, P<0.001), followed by unhealthy lifestyle habits (0.19, P<0.001), personal characteristics (-0.11, P<0.001), and domestic violence (0.05, P<0.001). In addition, the indirect effect of personal characteristics on bullying victimization through injury-related behaviors was 0.11. The detection rate of school bullying victimization among primary and secondary school students in Hunan Province is relatively high, with verbal bullying being the most common form. Personal characteristics, unhealthy lifestyle habits, injury-related behaviors, and domestic violence are major associated factors.

PMID 43004789
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PubMedThe Journal of clinical investigation2026-11-10

ATRX loss predicts poor outcomes and sensitizes to TEAD inhibition in soft tissue sarcomas.

Denu Ryan A RA, Singh Anand K AK, Jiang Yingda Y, Zheng Zhao Z et al.

ATRX is one of the most frequently altered genes in sarcoma and encodes an ATP-dependent chromatin remodeler implicated in maintaining heterochromatin. However, ATRX alterations have not been leveraged for sarcoma treatment. We observed loss of ATRX protein in 14% of soft tissue leiomyosarcoma (STLMS, n =127), 53% of uterine leiomyosarcoma (ULMS, n = 95), 37% of undifferentiated pleomorphic sarcoma (UPS, n = 82), and 8% of dedifferentiated liposarcoma (DDLPS, n = 84). ATRX loss was associated with significantly worse outcomes in ULMS, UPS, and DDLPS. ATRX knockout in sarcoma cells increased proliferation in cooperation with TP53 deletion, chromatin remodeling, and enrichment of PRDM4 and NFIX transcription factor motifs. PRDM4 and NFIX knockdown in ATRX-mutant sarcoma lines resulted in reduced proliferation and invasion, suggesting an epistatic relationship. Consistent with the known and re-demonstrated functional relationship between PRMD4 and YAP1, ATRX loss activated YAP1-TEAD signaling, and ATRX-deficient cells and sarcoma xenografts were more sensitive to the TEAD inhibitors VT103 and IAG933. Overall, our results identify ATRX loss as a prognostic factor of worse outcomes, implicate the ATRX-PRDM4-YAP1-TEAD axis as an underlying mechanism, and suggest use of TEAD inhibition as a potential therapeutic strategy for ATRX-deficient sarcomas.

PMID 43007728
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PubMedPloS one2026-11-10

Integrated network toxicology and experimental validation identify VCAM1 as a candidate molecular link between pyrethroid exposure and keloid.

Wang Zun Z, Yang Chen C, Wang Wencai W, Zhang Zijian Z et al.

Keloids are fibroproliferative skin lesions characterized by excessive extracellular matrix deposition. The potential molecular links between pyrethroid exposure and keloid-associated alterations remain unclear. We integrated network toxicology, machine learning, single-cell transcriptomics, virtual gene perturbation, molecular docking, molecular dynamics simulation, external transcriptomic validation, and qRT-PCR to investigate candidate molecular links between pyrethroid exposure and keloid. A total of 127 shared candidate targets between pyrethroid insecticides and keloid were identified, mainly enriched in MAPK, PI3K-Akt, and FoxO signaling pathways. Three machine-learning algorithms prioritized VCAM1 and FGFR1. In GSE145725, both genes showed significant differential expression and high dataset-level discriminatory performance. In the integrated external validation cohort generated from GSE90051 and GSE158395, VCAM1 remained significantly upregulated and showed good discriminatory performance (AUC = 0.869), whereas FGFR1 showed weaker external support (AUC = 0.677) without significant differential expression. Molecular docking and 100-ns molecular dynamics simulation supported the structural plausibility of selected pyrethroid-target interactions, particularly theta-cypermethrin with VCAM1. Single-cell analysis characterized the cell-type-specific distribution of candidate genes, while virtual gene perturbation suggested a putative VCAM1-SOCS3 regulatory relationship. qRT-PCR further showed that 20 μM cypermethrin exposure for 24 h significantly increased VCAM1 mRNA expression in KEL FIB cells. VCAM1 emerged as the most consistently supported candidate linking cypermethrin exposure with keloid-associated molecular alterations, while the predicted VCAM1-SOCS3 relationship requires further mechanistic validation.

PMID 43008012
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