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hydroquinone (pigmentasa / pigmentasa)

✓ Approved

Vinas · Small Molecule · Small Molecule

What is hydroquinone?

hydroquinone is a small molecule developed by Vinas. It is approved for therapeutic indications via topical.

Drug Profile

Brand Namespigmentasa, pigmentasa
CompanyVinas
Drug ClassSmall Molecule
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, Vinas

Therapeutic Indications

hydroquinone is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersChloasma✓ Approved
Skin and subcutaneous tissue disordersSkin hyperpigmentation✓ Approved

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PubMedJournal of child neurology2026-05-24

Farber Lipogranulomatosis With Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy: Expanding the Phenotypic Spectrum.

Saini Lokesh L, Gunasekaran Pradeep Kumar PK, Kumar Ashna A, Manjunathan Sujatha S et al.

BackgroundFarber lipogranulomatosis with spinal muscular atrophy with progressive myoclonic epilepsy (FL-SMA-PME) is inherited in an autosomal recessive manner because of pathogenic variations in the ASAH1 gene. We report a series of 4 children from 3 different families with genetically proven FL-SMA-PME.CasesA 5-year-old girl born of a second-degree consanguineous marriage presented with progressive myoclonic epilepsy for 4 years, neuroregression, and skeletal deformities. A 6-year-old girl born of a non-consanguineous marriage presented with milestones regression, cognitive decline, myoclonic jerks, and joint pain from the age of 2 years. Her elder sibling had similar complaints. A 3-year-old girl born to second-degree consanguineously married parents presented with developmental delay and myoclonic jerks. The common features noted were frontal bossing, central hypotonia, contractures, and flexion deformity of the wrist and fingers, flat feet with flexion deformity and contractures, fasciculations, generalized osteopenia, and swelling at multiple joints.ResultsAll 4 children had developmental regression and PME. Central hypotonia was noted in 4 of 4 children (100%). Three of 4 children (75%) had corneal clouding, 2 of 4 (50%) had nystagmus, and 2 of 4 (50%) had cherry-red spots. Nerve conduction study showed axonal motor type polyneuropathy in 4 of 4 patients (100%). Genetic testing in patient 1 revealed c.553T>C(p.Trp185Arg) in exon 8, patients 2 and 3 revealed c.553T>C(p.Trp185Arg) in exon 8 and deletion c.(126+1_127-1)_(351+1_352-1) in exons 2 to 4, and patient 4 revealed c.505T>C(p.Trp169Arg) in exon 8 and c.314T>C(p.Leu105Pro) in exon 5 of ASAH1 gene.ConclusionASAH1-related disorders are multifaceted, representing an amalgamation of storage disorder, neurodegeneration, and peripheral nervous system involvement. Misdiagnosis can be common because of the multitude of presentations.

PMID 42175818
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PubMedEmerging microbes & infections2026-05-24

Cross-border importation-initiated limited local transmission of dengue virus serotype 4 genotype I in the China, Myanmar, and Laos border region, 2024.

Zhou Yang Y, Li Man M, Liu Libo L, Wang Peigang P et al.

AbstractDengue virus serotype 4 (DENV-4) has rarely been reported in the China-Myanmar-Laos (CML) border region since 2013, where serotypes 1, 2, and 3 have predominated. In 2024, after a nine-year absence of DENV-4 in this region, 17 DENV-4 cases were identified from 2,417 dengue patients through the surveillance network in Jinghong City, China. Over half of the patients presented with dengue fever with warning signs, accompanied by hepatic dysfunction and coagulopathy. Nine complete envelope gene sequences were obtained, and phylogenetic analysis classified the strains into DENV-4 genotype I lineages I_A.3 and I_A.3.2. Integration of epidemiological and phylogenetic data demonstrated that importation of I_A.3.2 from Myanmar initiated limited local transmission in China, whereas I_A.3 importation occurred later and was not associated with local spread. The 2024 I_A.3.2 strains formed a distinct subcluster characterized by the I351 V substitution in envelope protein domain III. Multiple nonsynonymous mutations were identified across the envelope protein, several of which differed from current tetravalent vaccine reference strains, highlighting potential implications for vaccine efficacy. This study documents the importation-initiated limited local transmission of DENV-4 genotype I in the CML border region in 2024 and reveals the accumulation of critical envelope protein mutations. The findings fill important gaps in understanding DENV-4 evolution in this region and underscore the urgency of sustained genomic surveillance in high-risk border areas to inform regional dengue prevention and control strategies.

PMID 42175801
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PubMedEuropean journal of medicinal chemistry2026-05-24

Targeted degradation of SETDB1 by an Aptamer-CRBNL PROTAC as a novel therapeutic strategy for breast cancer.

Huang Shuyu S, Lv Yingge Y, Wang Yuting Y, Duan Yang Y et al.

PROteolysis TArgeting Chimeras (PROTACs) represent a novel therapeutic strategy that leverages the ubiquitin-proteasome system for targeted protein degradation. Aptamers, with their high specificity and binding affinity, have recently been explored as alternative recognition elements in PROTAC design. Here, we developed an aptamer-based PROTAC targeting SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), an epigenetic regulator implicated in breast cancer progression. The SETDB1-specific aptamer identified in our previous work was conjugated to a CRBN E3 ligase ligand via click chemistry, generating a serum-stable PROTAC, designated as P-SETDB1-4. P-SETDB1-4 effectively recruits CRBN to SETDB1, inducing proteasome-dependent degradation of SETDB1 in breast cancer cells. Consequently, P-SETDB1-4 significantly inhibits the proliferation and migration of breast cancer cells. Moreover, P-SETDB1-4 enhances the CD8+ T cells cytotoxicity against breast cancer cells and suppresses tumor growth in vivo. RNA sequencing analysis elucidates the molecular mechanism underlying P-SETDB1-4-mediated tumor suppression and promotion of CD8+ T cell-mediated killing. This study provides a promising therapeutic strategy for breast cancer and highlights the potential of aptamer-CRBNL PROTACs for targeting other challenging oncogenic proteins.

PMID 42176657
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-05-24

4-Methylpyridine-Mediated Homogenization of Wide-Bandgap Perovskite Films for Efficient All-Perovskite Tandem Solar Cells.

Wang Jianan J, Zheng Shijie S, Zhu He H, Miao Tianyin T et al.

Mixed-halide wide-bandgap (WBG) perovskites are promising top‑cell materials for multi-junction photovoltaics owing to their tunable bandgap and excellent photoelectronic properties. However, their solution processing often suffers from mismatched crystallization kinetics between iodine and bromine species, leading to compositional inhomogeneity and limited device performance. Herein, we report a solvent engineering strategy by introducing 4-methylpyridine (4-MePy) as a coordinating modulator. 4-MePy possesses strong coordinating ability and a moderate boiling point. It selectively retards the rapid crystallization of bromine-rich components by interacting more strongly with lead bromide, thereby homogenizing the halide distribution. The resulting perovskite films exhibit low defect density, reduced lattice strain, and uniform composition and morphology. These improvements suppress carrier recombination and increase the halide migration barrier. Consequently, single-junction WBG cells with a bandgap of 1.77 eV achieve a champion power conversion efficiency (PCE) of 20.68% and a high open‑circuit voltage (VOC) of 1.35 V. When integrated into all-perovskite tandem solar cells, this strategy delivers PCEs of 29.70% (certified 29.17%) on 0.05 cm2 and 29.00% on 1 cm2 devices.

PMID 42176244
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PubMedMicrobial cell factories2026-05-24

Expanding the substrate spectrum in engineered Pseudomonas taiwanensis for efficient production of 4-coumarate from lignocellulosic sugars.

Wynands Benedikt B, Feltes Sophia S, Teófilo da Silva Nadine N, Polen Tino T et al.

Aromatics are important building blocks for polymers, pharmaceuticals, and advanced materials, but their current production relies on petrochemical processes. Biotechnological de novo production from renewable bio-based feedstocks with microbial cell factories provides a sustainable alternative. In this study, we enhanced 4-coumarate production in Pseudomonas taiwanensis from glucose and glycerol compared to previously published producers. This was achieved through heterologous expression of tyrosine ammonia-lyase (TAL) from Rivularia sp. PCC7116, which debottlenecked the specific deamination of tyrosine. Moreover, deletion of the phosphoenolpyruvate carboxylase-encoding gene ppc further increased the production. Subsequently, the substrate spectrum for efficient aromatics production was expanded to include the abundant pentoses, xylose and arabinose. Heterologous non-oxidative assimilation pathways were integrated into P. taiwanensis GRC3 chassis strains and growth on xylose and arabinose was improved through adaptive laboratory evolution, whole-genome sequencing, and reverse engineering. Optimized catabolic modules were then transferred to producer strains to enhance or enable 4-coumarate production from xylose and arabinose. Notably, the product yield on xylose increased approximately 3.5-fold with the non-oxidative xylose isomerase pathway compared to the oxidative native Weimberg pathway, without compromising yields on glucose. For the final strain, P. taiwanensis GRC3Δ6-TYR2Δppc-REXA-attTn7::P14f-RpcTAL, product yields were significantly higher on xylose (38.2% (Cmol/Cmol)) and arabinose (39.7% (Cmol/Cmol)) than on glucose (26.0% (Cmol/Cmol)). 4-Coumarate production was characterized on mixtures of glucose, xylose, and arabinose to mimic lignocellulosic hydrolysate feedstocks, with the best reverse-engineered xylose- and arabinose-metabolizing 4-coumarate producer significantly outperforming the reference strain.

PMID 42177502
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PubMedBiomacromolecules2026-05-24

Understanding Solid-State Structural Transitions and Stability of Silk Fibroin from a Bound Water Perspective.

Qi Zhenzhen Z, Hu Zhen Z, Tan Guohongfang G, Chen Yanai Y et al.

In this study, the crystalline structure of silk fibroin was regulated by controlling water molecule states under precise temperature and humidity. Low-field NMR revealed that strong bound water remained stable at 5-6%, while weak bound water varied significantly with environmental conditions. Thermal analysis showed that glass transition and crystallization temperatures decreased as weak bound water increased. X-ray diffraction indicated that weak bound water critically influences crystallization: at 4-60 °C, exceeding 4% weak bound water induced transformation to Silk I; below this threshold, the amorphous state remained. Above 70 °C, weak bound water dropped below 4%, leading to Silk II formation. Crystallization kinetics and molecular dynamics simulations confirmed that water molecules enhance chain segment mobility, accelerating structural transformation. This work provides a theoretical basis for regulating the processing, storage, and structural stability of protein-based biomaterials under nonphysiological conditions.

PMID 42175893
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