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telmisartan + amlodipine (Micamlo BP / Onduarp / Micamlo AP)

✓ Approved

Astellas Pharma · AGTR1 · Small Molecule

What is telmisartan + amlodipine?

telmisartan + amlodipine is a small molecule developed by Astellas Pharma. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMicamlo BP, Onduarp, Micamlo AP
CompanyAstellas Pharma
Drug ClassSmall Molecule
Molecular TargetAGTR1, CACNA1C
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

telmisartan + amlodipine acts on 2 molecular targets:

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

telmisartan + amlodipine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedMedical physics2026-05-24

Improving textural realism in breast phantom images.

Omena Luana de M LM, de Oliveira Guilherme M GM, do Rêgo Thaís G TG, Barbosa Yuri de A M YAM et al.

Breast phantom images can lack textural realism, limiting their utility for imaging research. Achieving realism across all BI-RADS breast densities is essential for representative, unbiased datasets. This study validated simplex noise for improving realism and density fidelity in simulated mammary parenchyma across BI-RADS categories. Two reader trials were conducted with eight students from the Artificial Intelligence Applications Laboratory (ARIA) at the Federal University of Paraíba, Brazil. In the first trial, participants compared paired images with and without simplex noise for overall realism in BI-RADS A (fatty) and BI-RADS D (dense) patterns using 2-AFC. During the second trial, optimized parameters were tested across all four BI-RADS categories. Readers selected the most realistic image in each pair and rated confidence levels. In Trial 1, the simplex enhanced reconstruction was judged as more realistic in 96% of BI-RADS D evaluations, compared to 58.6% for BI-RADS A. Trial 2 achieved a high realism consensus for simplex enhanced reconstructions (1,288 vs. 312 selections), with category improvements: BI-RADS A (92.5%), B (92.25%), C (81%), and D (57.75%). ROC analysis confirmed high discriminative performance, with AUC values of 0.95 (A), 0.74 (B), 0.85 (C), and 0.93 (D). Results indicate density dependent effects, with more pronounced improvements in lower density categories. The introduction of simplex noise enhances the textural realism of simulated mammographic images, particularly representing variability across BI-RADS categories. These simulations provide a resource for testing and validation without patient data.

PubMedCardiovascular intervention and therapeutics2026-05-24

Acute bi-ventricular haemodynamic changes after transcatheter aortic valve implantation for severe aortic stenosis assessed using invasive pressure-volume loops.

Androshchuk Vitaliy V, Long Edouard E, Chehab Omar O, Wilcox Joshua J et al.

Transcatheter aortic valve implantation (TAVI) aims to relieve the increased left ventricular (LV) afterload imposed by aortic stenosis (AS). However, the early haemodynamic impact of TAVI on bi-ventricular performance remains poorly characterised. This prospective study quantified the acute bi-ventricular response following TAVI for severe symptomatic AS using gold-standard invasive pressure-volume loop (PVL) assessment. Left and right ventricular (RV) PVLs were recorded using a conductance catheter pre- and immediately post-TAVI. Indices of contractile function, ventriculo-arterial coupling and energetics were derived. In total, 12 patients (84.1 years [interquartile range: 77.1, 87.2]; female 25%) were included. TAVI resulted in significant bi-ventricular reductions in afterload, measured by effective arterial elastance (LV: 2.1 [1.8, 2.3] to 1.4 [1.3, 1.7] mmHg/mL, p < 0.001; RV: 0.5 [0.4, 0.6] to 0.4 [0.3, 0.4] mmHg/mL, p = 0.006). Despite an acute decline in LV contractility, measured by end-systolic elastance (p = 0.021), there was a significant net improvement in ventriculo-arterial coupling in both the LV (p = 0.003) and RV (p = 0.006). Both the LV and RV demonstrated significant reductions in stroke work (SW) (LV-SW: 11,915.0 [9,727.5, 15,288.7] to 7,360.5 [6,937.0, 9,113.1] mmHg/mL, p < 0.001; RV-SW: 1,506.9 [1,420.5, 1,676.2] to 1,418.1 [1,250.8, 1,510.3] mmHg/mL, p = 0.020) and pressure volume area (PVA) (LV-PVA: 16,188.5 [13,171.5, 18,726.5] to 9,674.2 [9,185.9, 11,872.2] mmHg/mL, p < 0.001; RV-PVA 2,176.1 [2,046.3, 2,885.1] to 1,960.2 [1,835.6, 2,269.0] mmHg/mL, p = 0.002), with stable SW/PVA ratios. The acute haemodynamic effects of TAVI for severe symptomatic AS extend beyond the LV. Patients experienced bi-ventricular unloading, improved ventriculo-arterial coupling and reduced myocardial metabolic demand.

PubMedScientific reports2026-05-24

Nonlinear electronic streaming instability in lunar plasmas.

Deka Partha Pratim PP, Karmakar Pralay Kumar PK, Atteya Ahmed A

The nonlinear dynamics of bi-electronic streaming instability (BSI) is investigated in lunar plasma environments using the nonlinear WKB method. It is seen that the considered instability saturation is governed by a standard form of the Korteweg-de Vries (KdV) equation. It has a unique set of multiparametric nonlinear convective and linear dispersive coefficients. We semi-analytically reveal the instability saturation, principally in diverse solitary wave forms, alongside their basic conservation laws, in a broader perspective horizon. The sensitive frame velocity-dependency of the derived rarefactive solitary structures is illustrated, alongside the streaming velocity effects. It is interestingly found that such wave-spectral patterns completely disappear for a particular value of the relative streaming velocity (frame-flow equalisation). This study fairly maps the investigated nonlinear BSI saturation amongst the Kaguya-observed electrostatic solitary waves (ESWs) observationally reported elsewhere.

PubMedKidney international2026-05-23

Distinct proteomic signatures of urinary extracellular vesicles link to albuminuria and treatment responses in diabetic kidney disease.

van Heugten Martijn H MH, Beckmann Sebastian B SB, Salib Madonna M, Curovic Viktor Rotbain VR et al.

Urinary extracellular vesicles (uEVs) offer a non-invasive approach to gain pathophysiological insight into kidney disease and treatment effects. Our study aimed to investigate the impact of albuminuria and anti-albuminuric therapies on the uEV proteome in diabetic kidney disease. uEVs were isolated from urine samples of 20 patients with diabetes and albuminuria (age 64 years, estimated glomerular filtration rate 85 ml/min per 1.73 m2, urinary albumin creatinine ratio 130 mg/g) who participated in a crossover trial. Participants received telmisartan, empagliflozin, linagliptin, and baricitinib in random order across four 4-week treatment periods. Quantitative proteomics was performed using liquid chromatography-tandem mass spectrometry. Results were compared with two datasets (one single-nucleus, one single-cell) analyzing the effects of proteinuria and sodium-glucose cotransporter 2 inhibition (SGLT2i) on the kidney transcriptome. A total of 2,441 proteins were identified in uEVs, of which 355 were significantly associated with albuminuria. Treatment with telmisartan, empagliflozin, linagliptin, and baricitinib resulted in, respectively, 86, 313, 80, and 47 differentially abundant uEV proteins with minimal overlap between treatments. Of the albuminuria-associated uEV proteins, 100 were significantly altered by at least one treatment. The overall proteomic signature was characterized by enrichment of podocyte-associated proteins, complement proteins, serpins, galectins, G-protein coupled receptors, lysosomal proteins, solute carriers, tubular injury proteins, and EV-related proteins such as Rab GTPases and tetraspanins. Comparison with the transcriptomic datasets showed that 15% of the albuminuria-associated uEV proteins and 62% of the sodium-glucose transport protein 2 inhibitor-responsive uEV proteins also exhibited changes at the transcript level in kidney cells, usually in a concordant manner. Our study identified distinct uEV proteomic signatures linked to albuminuria and treatment responses in diabetic kidney disease, with minimal overlap across drugs and substantial concordance with kidney transcriptomic changes. These findings highlight the potential of uEVs as carriers of biomarkers for kidney injury and therapeutic effects.

PubMedScience bulletin2026-05-23

The (bi)carbonate precipitation challenge in electrocatalytic CO2 reduction reaction: a cross-scale perspective.

Tian Di D, Wang Qiang Q, Zhang Guobin G, Qu Zhiguo Z et al.

PubMedFood chemistry2026-05-23

Machine learning - optimized molecularly imprinted electrochemical sensor based on Bi-rich BiOBr/BC@AuNPs for trace determination of sulfachlorpyrazine sodium in food.

Zeng Qian Q, Liu Peng P, Chen Yihui Y, Li Yingnan Y et al.

A highly sensitive and selective molecularly imprinted electrochemical sensor was developed for the detection of sulfachloropyrazine sodium (SPZ), assisted by machine learening (ML) optimization. The sensing platform was fabricated using novel Bi-rich BiOBr/BC@AuNPs nanocomposite, where the synergistic combination of Bi-rich BiOBr, conductive biochar, and gold nanoparticles markedly enhanced electron transfer and provided abundant electroactive sites. Critical imprinting parameters, including the functional monomer-to-template ratio, electropolymerization cycles, elution time, and incubation time, were optimized using a central composite design coupled with ML algorithms like support vector regression. Under optimal conditions, the sensor displayed a wide linear range of 0.031-61.34 ng/mL, with a low detection limit of 0.0025 ng/mL and a quantification limit of 0.0077 ng/mL. The sensor exhibited excellent selectivity, effectively distinguishing SPZ from structurally analogous sulfonamide. Successful application to spiked chicken, milk, and honey samples yielded satisfactory recoveries and reproducibility, confirming its strong potential for practical food safety.

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