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telmisartan + amlodipine (Micamlo BP / Onduarp / Micamlo AP)

✓ Approved

Astellas Pharma · AGTR1 · Small Molecule

What is telmisartan + amlodipine?

telmisartan + amlodipine is a small molecule developed by Astellas Pharma. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMicamlo BP, Onduarp, Micamlo AP
CompanyAstellas Pharma
Drug ClassSmall Molecule
Molecular TargetAGTR1, CACNA1C
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Astellas Pharma

Mechanism of Action

Molecular Targets

telmisartan + amlodipine acts on 2 molecular targets:

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

telmisartan + amlodipine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedTurkish journal of medical sciences2026-07-25

Reliability and validity of the Turkish version of the Barthel Index-dyspnea in patients with pulmonary hypertension.

Merç Pınar P, Demir Rengin R, Zeren Melih M, Durdu Habibe H et al.

The Barthel Index-dyspnea (BI-d) is a respiratory disease-specific tool developed on the basis of the Barthel Index (BI), which provides a simple and quick way to measure the degree of dyspnea in activities of daily living (ADL). Dyspnea is one of the most common symptoms of pulmonary hypertension (PH). The objective of this study was to explore the reliability and validity of the Turkish version of the BI-d in patients with PH. A total of 73 PH patients were included in the study. Criterion validity was explored using the modified Medical Research Council (mMRC) dyspnea scale, 6-min walk test (6MWT), and London Chest Activities of Daily Living (LCADL) scale, while divergent validity was examined through correlations between the BI-d and BI. The BI-d demonstrated strong correlations with the LCADL (r = 0.801) and mMRC (r = 0.775), and a moderately negative correlation with the 6MWD (r = -0.510), supporting criterion-related validity. A weak negative correlation with the BI (r = -0.289) supported divergent validity. The BI-d scores differed significantly across the mMRC grades and PH functional classes, confirming known-group validity. Reliability analyses showed good internal consistency (Cronbach's α = 0.85) and excellent test-retest reliability (intraclass correlation coefficient = 0.94). The Turkish version of the BI-d demonstrates high reliability and validity in PH. As a tool that integrates respiratory burden with activity-related functional performance, it provides a practical assessment of dyspnea-related impairment during ADL.

PMID 42499427
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PubMedMedicine2026-07-25

Effect of curcumin compared to chlorhexidine on clinical variables of periodontal health: A systematic review and meta-analysis of randomized controlled trials.

Jiang Linxin L, Li Simin S, Reissmann Daniel R DR, Schmalz Gerhard G et al.

Chlorhexidine is effective in managing periodontal diseases but has side effects. Curcumin is a natural alternative with anti-inflammatory properties. This meta-analysis aimed to compare the efficacy of curcumin and chlorhexidine on clinical variables in periodontal diseases. This study included only randomized controlled trials. The primary outcomes were differences in mean plaque index (PI) and gingival index (GI); the secondary outcomes were differences in probing depth (PD), attachment loss (AL), and bleeding index (BI). Data were analyzed by Stata software. Twenty-six randomized controlled trials comprising 1266 subjects were included. Twenty-four studies had a high risk of bias, and 2 studies had some concerns. The pooled data revealed comparable efficacy of curcumin and chlorhexidine in reducing PI (I2 = 83.3%; standardized mean difference [SMD]: -0.041, 95% confidence interval [CI, -0.245-0.163], P = .692), GI (I2 = 87.8%; SMD: 0.033, 95% CI [-0.216-0.281], P = .797), and BI (I2 = 77.7%; SMD: -0.044, 95% CI [-0.208-0.295], P = .735). However, the efficacy of chlorhexidine was found to be superior to curcumin in reducing PD (I2 = 93.7%; SMD: 0.883, 95% CI [0.419-1.347], P < .001) and AL (I2 = 90.1%; SMD: 0.539, 95% CI [0.019-1.058], P = .042). As for the subgroup analyses of follow-up term, there was a nonsignificant difference between curcumin and chlorhexidine in PI, GI, and BI. As for PD and AL, the subgroup analyses of follow-up term showed different results from the overall pooled analysis: the short term (≤ 1 month) showed the superior efficacy of chlorhexidine over curcumin; however, the long term (> 1 month) showed similar efficacy. Curcumin could be an alternative to chlorhexidine and adjunctively used in reducing clinical variables of periodontal diseases, especially with regard to plaque accumulation and gingival inflammation.

PMID 42499105
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PubMedJournal of Ayurveda and integrative medicine2026-07-25

Antidiabetic potential of a novel hydroxyphenyl-bi-benzopyran-hexol compound from Cassia fistula as an α-amylase inhibitor: Integrated in silico screening and in vitro validation using a nonlinear regression model.

Baskar Rajamanickam R, Harini Manoharan M, Selvapriya Sikkal Selvaraaju SS, Hemadevi Thangarasu T et al.

Diabetes mellitus is a critically important metabolic disease, causing persistent hyperglycemia. Blood glucose levels can be effectively maintained by inhibiting the activity of α-amylase. α-amylase inhibitors manage postprandial hyperglycemia by delaying carbohydrate digestion. Identification of a potent α-amylase inhibitor from 915 bioactive compounds of Madhumukthi Kudineer Chooranum (MKC) by combining siddha knowledge with computational and experimental methods. Molecular docking of bioactive compounds present in MKC with α-amylase was performed, and the top ten compounds that exhibited binding affinities better than the standard inhibitor acarbose were evaluated for Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties, followed by Molecular Dynamics Simulations (MDS). An in vitro enzyme inhibition assay was performed for the top lead for validation of the in silico findings. Lead 2, Hydroxyphenyl-bi-benzopyran-hexol from Cassia fistula demonstrated the stable protein-ligand interaction with a binding energy of -69.70 ± 3.93 kJ/mol. The crude Cassia fistula stem bark extract containing Lead 2 showed 57% inhibition of α-amylase. The IC50 values were calculated using a nonlinear regression approach based on a 4-parameter logistic (4 PL) model, yielding a lower IC50 value of 237.25 μg/ml for the extract, compared to the IC50 value of 264.59 μg/ml for acarbose. By integrating traditional siddha knowledge with advanced computational screening and in vitro validation, this study proposed a novel Hydroxyphenyl-bi-benzopyran-hexol compound from Cassia fistula as a promising natural α-amylase inhibitor. However, these findings are to be validated using animal studies before clinical research leading to a novel drug.

PMID 42497787
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PubMedPalliative care and social practice2026-07-25

Healthcare professionals' experiences of telehealth adoption in palliative care: A cross-sectional survey.

Kirby Ann A, Griffin Donal D, Heavin Ciara C, Kiely Fiona F et al.

Research has revealed a dramatic rise in the adoption of telehealth by healthcare professionals (HCPs). Limited evidence exists focusing solely on HCPs' adoption and use of telehealth in palliative care and lacks nuance about when and how telehealth is clinically appropriate. The aim is to deepen understanding of HCPs' behavioural intention (BI) regarding the adoption and use of telehealth in palliative care, and to examine their current patterns of telehealth use. Cross-sectional data were collected from HCPs working in palliative care between July 27th and September 22nd, 2023. A probit analysis examined the difference between users and non-users of telehealth in palliative care, while a multiple linear regression assessed the association between a HCPs' BI of using telehealth and Performance Expectancy, Effort Expectancy, Facilitating Conditions, and Social Influence. Perceived benefits to clinical performance were associated with increased willingness to adopt telehealth. Workplace culture, experience, opportunity to use telehealth, and peer encouragement were highlighted as important contributors to a supportive environment. However, despite positive BIs, many previous users reported infrequent use in practice, suggesting a gap between intention and routine clinical integration. HCPs recognised the benefits of telehealth, but concerns remained regarding treating and managing physical symptoms in palliative care. Telephone-based services were still primarily used, though hybrid models were recognised as needed at times in some clinical situations. Patterns of use suggested distinct user groups, indicating that telehealth implementation requires tailored training, organisational supports, and clear escalation pathways for transitioning from virtual to in-person care. Addressing these factors may support more sustainable and clinically appropriate telehealth delivery in palliative care, with potential benefits for patient outcomes and experiences.

PMID 42499755
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PubMedArab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology2026-07-25

Molecular subtyping and therapeutic drug prediction in esophageal squamous cell carcinoma based on manganese-metabolism-related genes.

Li Long L, Zhang Ying Y, Li Qi Q, Wu Yanli Y et al.

Immunotherapy offers promising prospects for esophageal squamous cell carcinoma (ESCC), a highly fatal malignant tumor. Given the association between manganese metabolism and tumor immunity, this study explored the prognostic value and role of manganese-metabolism-related genes (MMRGs) in the ESCC immune microenvironment to uncover their clinical potential. Transcriptomic and clinical data of ESCC were retrieved from TCGA and the GEO as training and validation cohorts, respectively. Patients were clustered and subtyped based on MMRGs, with survival compared. A prognostic risk model was constructed using differential analysis, PPI network, and Cox regression; its relationship with immune characteristics, immunotherapy response, and drug sensitivity was evaluated. SLC40A1 was knocked down in vitro, and its effects on cellular function and drug sensitivity were assessed via qRT-PCR, Western blot, colony formation, Transwell, and CCK-8 assays. ESCC patients were stratified into two MMRG-defined subtypes. Cluster 2 showed significantly worse overall survival (OS) than Cluster 1. An 8-gene prognostic model was established and patients were assigned to RiskScorehigh and RiskScorelow groups. The high-risk group, characterized by worse OS, displayed an immunosuppressive microenvironment with abundant M2 macrophages and high immune-checkpoint expression (PDCD1, CTLA4, TIGIT), along with a lower TIDE score, suggesting potentially greater benefit from immune-checkpoint blockade. The RiskScorehigh group was more sensitive to Gemcitabine and Oxaliplatin, whereas the RiskScorelow group responded better to BI-2536 and NU7441. Cellular functional assays confirmed high expression of SLC40A1 in ESCC cells. SLC40A1 knockdown significantly inhibited cell proliferation, migration, and invasion. Additionally, cells exhibited greater sensitivity to Gemcitabine than to BI-2536. MMRG-based subtyping and the reliable prognostic risk score model provide novel insights for predicting prognosis and developing personalized therapy in ESCC.

PMID 42498557
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PubMedSmart molecules : open access2026-07-25

Data-driven elemental descriptors for rational design of high-sensitivity extreme ultraviolet photoresists.

Liu Jiyuan J, Wei Jialiang J, Zhu Huie H, Peng Xiaojun X

The rational design of high-sensitivity photoresists for extreme ultraviolet (EUV) lithography is hindered by the lack of quantitative, predictive descriptors that link material composition to EUV absorption. Here, we develop a density-free, data-driven approach that quantifies both elemental sensitivity and impact. We introduce elemental sensitivity descriptors, μ n and A n , to estimate how elemental doping alters the linear attenuation coefficient and absorbance without requiring density information of the target material. Furthermore, we define elemental impact Δϕ i to evaluate whether an element acts as a positive or negative contributor when embedded in high-absorption compounds. We identify I, Te, In, Sn, Sb, Cs, and Bi as top candidates for EUV photoresists, while revealing the detrimental role of H and C as matrix components. This work provides a generalizable strategy for EUV photoresist design.

PMID 42500729
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