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Oxalyt-C

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Oxalyt-C?

Oxalyt-C is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications.

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Oxalyt-C is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedAngewandte Chemie (International ed. in English)2026-05-24

Nitrate-Stabilized Cuδ+ Sites Promote Selective CO2 Electroreduction to Ethanol for Tandem Acetamide Electrosynthesis.

Guo Chengying C, Yang Rong R, Meng Nannan N, Shao Jiang J et al.

Electrosynthesis of acetamide, a multicarbon nitrogenous compound containing C─C─N bonds, from abundant CO2 and nitrate is important for low-carbon industry. However, the simultaneous electroreduction construction of C─C and C─N bonds is challenging. Herein, we propose a strategy to construct C─C and C─N bonds in tandem at the cathode and anode, respectively. At the cathode, a nitrate-induced dynamic Cuδ+ site is designed to promote C─C coupling activity from CO2 reduction to ethanol, which is accompanied by the generation of ammonia from nitrate reduction, with a total Faradaic efficiency of 88.6%. The generated ethanol and ammonia serve as feedstocks for the tandem construction of C─N bonds at the anodic region via a possible nucleophilic attack pathway. We achieve the synthesis of acetamide with a Faradaic efficiency of 71.4% and a yield rate of 0.13 mmol h-1 cm-2. The carbon footprint analysis of this tandem strategy revealed net-zero emissions at a carbon intensity of 0.23 kgCO2e kWh-1, indicating its sustainable nature from the viewpoint of carbon neutrality.

PMID 42175817
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PubMedJournal of the American Chemical Society2026-05-24

Electrosynthesis of Ethylene Glycol from Methanol via Oxidative C-C Coupling.

Wang Xi X, Zhang Chunyu C, Zhan Leshu L, Liu Yuanbo Y et al.

Ethylene glycol (EG) is a commodity chemical, but its industrial production heavily relies on fossil-based feedstocks (that are, oil-based ethylene and coal-based syngas) and faces high carbon footprint. Herein, we report one-step electrosynthesis of EG from an important C1 platform molecule─methanol (MeOH), via oxidative C-C coupling at the anode. Over a boron-doped diamond (BDD) electrode, EG was produced with a Faradaic efficiency of 34.3% and a selectivity of 48.7% at a current density of 100 mA cm-2, delivering a productivity of 639 μmol cm-2 h-1. Mechanistic studies revealed that the reaction proceeded via a radical-mediated pathway, wherein H2O was first oxidized to the hydroxyl radical (•OH) on the BDD electrode, which mediated C-H bond activation of MeOH to deliver the •CH2OH intermediate, following C-C coupling to generate EG. To enhance EG selectivity, a paired-electrolysis strategy was designed that couples MeOH-to-EG at the anode and reduction of the byproduct formaldehyde to MeOH at the cathode. In a membrane-free flow cell, EG selectivity was increased from 48.7% to 72.1% with cycling stability over 80 h. This work demonstrates the opportunity to synthesize carbon-chain-propagated chemicals from basic C1 feedstock via radical-type C-C coupling by electrocatalysis.

PMID 42177674
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PubMedBiochemical and biophysical research communications2026-05-24

Deficiency of C/EBPβ in pancreatic acinar cells exacerbates inflammation in the early phase of acute pancreatitis.

Horitani Susumu S, Tsujimae Masahiro M, Masuda Atsuhiro A, Gonda Masanori M et al.

Acute pancreatitis is a common gastrointestinal emergency with no specific therapeutic targets. CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that regulates inflammatory gene expression through cooperation with NF-κB and STAT3 signaling pathways, but its role in acute pancreatitis remains unknown. Thus, we employed complementary experimental approaches to investigate C/EBPβ function in acute pancreatitis. In AR42J pancreatic acinar cells, C/EBPβ was knocked down by RNA interference followed by caerulein stimulation. In parallel, pancreas-specific C/EBPβ knockout mice (Cebpbflox/flox; Pdx1-Cre) were subjected to caerulein-induced acute pancreatitis model and evaluated by histological scoring, serum enzyme measurement, and RNA sequencing. Primary acinar cells isolated from knockout and control mice were also stimulated ex vivo. C/EBPβ expression was transiently induced in AR42J cells following caerulein stimulation. Knockdown of C/EBPβ significantly increased IL-6 mRNA expression after stimulation. Pancreas-specific C/EBPβ knockout mice exhibited significantly greater interstitial edema, leukocyte infiltration, and subsequent acinar cell necrosis compared with control mice. Gene set enrichment analysis revealed upregulated activation of IL-6/JAK/STAT3 signaling pathways in knockout mice. Furthermore, primary acinar cells from knockout mice showed significantly elevated Il6 expression upon caerulein stimulation. C/EBPβ plays a protective role in the early phase of acute pancreatitis by suppressing IL-6-driven inflammatory responses in pancreatic acinar cells, identifying C/EBPβ as a potential regulatory factor in acute pancreatitis pathogenesis.

PMID 42176384
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PubMedOrganic letters2026-05-24

Dual Gold/Silver Catalysis: 3-Alkynylpyrroles via a Tandem C(sp2)-H Alkynylation/N-Alkynylation.

Shen Peng P, Li Peifeng P, Liu Mengyu M, Qin Rui R et al.

A dual gold/silver-catalyzed cascade C(sp2)-H alkynylation/N-alkynylation of enamines with hypervalent iodine(III) reagents for the synthesis of 3-alkynylpyrroles is reported. This cooperative Au/Ag catalytic system enables the one-step construction of multisubstituted pyrrole frameworks under mild conditions. Mechanistic studies allowed the capture of the initially formed Au(I) species and support a pathway involving an alkynyl Au(III) intermediate together with a silver-assisted C-H activation process. The cascade sequence efficiently forges C-C and C-N bonds, providing 3-alkynylpyrroles in good yields with broad functional group tolerance. Gram-scale synthesis and further derivatization of the products highlight the practicality and synthetic utility of this transformation.

PMID 42175961
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PubMedACS nano2026-05-24

Customizable Interfacial Solvation via Hydrogel Mediation for Enhanced C-C Coupling in CO2 Electroreduction.

Wang Meiling M, Fang Mingwei M, Huang Zihao Z, Feng Xiaochen X et al.

Interfacial water structure critically influences CO2 electroreduction pathway and product selectivity, yet molecular-level strategies to precisely regulate interfacial solvation and quantitatively correlate it with C-C coupling remain limited. Here, we report a hydrogel-mediated, customizable interfacial solvation strategy by integrating an ultrathin, ion-cross-linked, water-retentive hydrogel layer on Cu (Cu-IWH), formed via coordination between chitosan and divalent metal cations. The resulting charged and hydrated interface enables controlled modulation of the interfacial electrostatics, ion hydration, and local chemical environment, thereby steering CO2 electroreduction toward C2+ products. In situ Raman spectroscopy reveals that solvated K+(H2O)n species interact with adsorbed hydroxyl groups (OHad), leading to a reorganization of the interfacial hydration structure and the formation of Cu·OHad·K+(H2O)n* interfacial complexes. By tuning the hydrogel cross-linking density, an optimal balance between OHad coverage and cation accessibility is achieved, maximizing the population of these complexes, which shows a quantitative correlation with enhanced C2+ selectivity. Density functional theory calculations further show that these complexes induce interfacial charge redistribution, stabilize *CO adsorption in configurations favorable for C-C coupling, and lower the kinetic barrier for *CO-*CO dimerization. Meanwhile, the hydrogel matrix enriches interfacial OH-, creating a locally alkaline microenvironment that promotes *COL/*COB coadsorption and facilitates C-C coupling. As a result, the optimized Cu-IWHM catalyst delivers a C2+ Faradaic efficiency of 87.5% at -1.2 A cm-2 and a single-pass carbon efficiency of 94.3% at -1.0 A cm-2, while sustaining stable operation for over 800 h at 800 mA in a 4 cm2 MEA electrolyzer. When scaling to a 100 cm2 MEA, the system achieves 81.5% C2+ selectivity with a C2+ energy efficiency of 34.0% at 40 A and operates stably for 82 h at 20 A. This work establishes hydrogel-mediated interfacial solvation engineering as a tunable approach for regulating interfacial environments and promoting C-C coupling in CO2 electrocatalysis.

PMID 42175958
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PubMedJournal of child neurology2026-05-24

Farber Lipogranulomatosis With Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy: Expanding the Phenotypic Spectrum.

Saini Lokesh L, Gunasekaran Pradeep Kumar PK, Kumar Ashna A, Manjunathan Sujatha S et al.

BackgroundFarber lipogranulomatosis with spinal muscular atrophy with progressive myoclonic epilepsy (FL-SMA-PME) is inherited in an autosomal recessive manner because of pathogenic variations in the ASAH1 gene. We report a series of 4 children from 3 different families with genetically proven FL-SMA-PME.CasesA 5-year-old girl born of a second-degree consanguineous marriage presented with progressive myoclonic epilepsy for 4 years, neuroregression, and skeletal deformities. A 6-year-old girl born of a non-consanguineous marriage presented with milestones regression, cognitive decline, myoclonic jerks, and joint pain from the age of 2 years. Her elder sibling had similar complaints. A 3-year-old girl born to second-degree consanguineously married parents presented with developmental delay and myoclonic jerks. The common features noted were frontal bossing, central hypotonia, contractures, and flexion deformity of the wrist and fingers, flat feet with flexion deformity and contractures, fasciculations, generalized osteopenia, and swelling at multiple joints.ResultsAll 4 children had developmental regression and PME. Central hypotonia was noted in 4 of 4 children (100%). Three of 4 children (75%) had corneal clouding, 2 of 4 (50%) had nystagmus, and 2 of 4 (50%) had cherry-red spots. Nerve conduction study showed axonal motor type polyneuropathy in 4 of 4 patients (100%). Genetic testing in patient 1 revealed c.553T>C(p.Trp185Arg) in exon 8, patients 2 and 3 revealed c.553T>C(p.Trp185Arg) in exon 8 and deletion c.(126+1_127-1)_(351+1_352-1) in exons 2 to 4, and patient 4 revealed c.505T>C(p.Trp169Arg) in exon 8 and c.314T>C(p.Leu105Pro) in exon 5 of ASAH1 gene.ConclusionASAH1-related disorders are multifaceted, representing an amalgamation of storage disorder, neurodegeneration, and peripheral nervous system involvement. Misdiagnosis can be common because of the multitude of presentations.

PMID 42175818
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