Drug Database
OX

Oxalyt-C

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Oxalyt-C?

Oxalyt-C is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications.

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Oxalyt-C is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedNature ecology & evolution2026-09-19

Afforestation and reforestation support coupled gains in soil life and carbon storage worldwide.

Meng Zexin Z, Wu Yiping Y, Eisenhauer Nico N, Cui Yongxing Y et al.

Forest planting is widely promoted as a nature-based climate solution for mitigating anthropogenic carbon (C) emissions. Whether different planting strategies lead to similar trajectories in C storage and how these affect soil microbial growth are poorly understood. Here we compile data on 1,158 paired afforestation/reforestation and reference sites across six continents. We find that afforestation has the potential to support greater soil microbial biomass and larger topsoil C storage across stand development spanning up to a century. Reforestation is associated with substantial recovery of soil C storage and soil microbial biomass, with both approaching original forest levels during the first three decades, but these gains are not sustained in older stands. Soil C and microbial biomass responses are generally coupled across prior land uses, climatic zones and planted tree species, with greater gains on degraded lands. Overall, our work provides evidence that afforestation and reforestation could contribute to soil C storage and support soil microbial growth under global change, offering critical insights for refining nature-based climate solutions.

PMID 42760318
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PubMedJournal of assisted reproduction and genetics2026-09-19

Novel and recurrent TUBB8 variants cause irreversible meiotic spindle defects and refractory ART failure in Chinese women with oocyte maturation arrest.

Zhuang Xin-Jie XJ, Li Yue Y, Lian Ying Y, Qiu Xin X et al.

Oocyte maturation arrest (OMA) is a major monogenic cause of unexplained female infertility and recurrent assisted reproductive technology (ART) failure. TUBB8, which encodes an oocyte-specific β-tubulin isoform essential for acentrosomal spindle assembly, represents the most common genetic etiology of metaphase I (MI) arrest. This study aimed to identify pathogenic TUBB8 variants and characterize their clinical phenotypes and molecular mechanisms in Chinese women with unexplained recurrent OMA. Six unrelated Chinese women with primary infertility and persistent OMA were enrolled. Whole-exome sequencing and Sanger sequencing were performed to identify and validate TUBB8 variants. Inheritance patterns, oocyte morphology, spindle integrity, and clinical ART outcomes were systematically evaluated. Three-dimensional structural modeling was used to predict the functional impact of the identified variants. Five heterozygous missense variants were identified: c.292G > A (p.Gly98Arg), c.731G > A (p.Gly244Asp), c.735G > C (p.Gln245His), c.845G > C (p.Arg282Pro), and c.880 T > C (p.Phe294Leu). All variants mapped to evolutionarily conserved, functionally essential domains and were predicted to be deleterious. All patients exhibited normal ovarian reserve and endocrine profiles but uniform, irreversible MI arrest: 85.4% of retrieved oocytes arrested at MI, with only 5.7% reaching metaphase II. Polarization microscopy revealed absent or severely disorganized spindles. Despite ICSI combined with artificial oocyte activation, the fertilization rate was only 6.3%, with no blastocyst formation or clinical pregnancy. Structural modeling suggested that these variants may interfere with GTP hydrolysis, lateral protofilament interactions, and C-terminal hydrophobic networks, thereby exerting dominant-negative effects on spindle assembly. This study expands the pathogenic mutational spectrum of TUBB8 and confirms that novel and recurrent TUBB8 missense variants cause irreversible MI arrest and complete ART refractoriness in Chinese women. Our findings support routine TUBB8 genetic screening as a valuable diagnostic tool for unexplained recurrent OMA, facilitating early diagnosis, avoidance of futile ART cycles, and personalized reproductive counseling.

PMID 42760497
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PubMedFrontiers in nutrition2026-09-19

Intravenous vitamin C as micronutrient therapy in patients with sepsis or septic shock: an updated systematic review and meta-analysis of randomized controlled trials.

Cai Binrong B, Xiao Qian Q, Xia Yiqin Y, Yu Xian X et al.

The adjunctive therapeutic value of vitamin C in sepsis or septic shock patients remains controversial. This study aimed to evaluate the therapeutic efficacy and safety of intravenous administration of vitamin C in sepsis or septic shock patients through meta-analysis. Relevant literature was searched in PubMed, Embase, and Scopus databases and other related databases. The primary outcome was 28-day mortality. Secondary outcomes included duration and total dose of vasopressors, change in sequential organ failure assessment (SOFA) scores from baseline to the earliest reported time point between 72 and 96 h (ΔSOFA), hospital length of stay, intensive care unit length of stay, urine output in the 24-h, and incidence of adverse events. Fourteen randomized controlled trials enrolling 1,958 patients were eligible for assessment. Meta-analysis demonstrated that intravenous vitamin C reduced 28-day mortality in sepsis or septic shock patients compared to the control group (RR 0.70; 95% CI 0.53 to 0.93; P = 0.02; I 2 = 52%), based on low quality of evidence, and subgroup analysis showed the benefit was driven by single-center studies, not observed in multicenter trials. Vitamin C shortened the duration of vasopressor use (SMD = -0.42, 95% CI -0.77 to -0.08, P = 0.02) and was associated with a greater reduction in SOFA score (MD = -1.04, 95% CI -1.83 to -0.25, P = 0.01), but did not reduce vasopressor dose, length of stay, or 24-h urine output. No significant adverse events were reported. This meta-analysis suggests that intravenous vitamin C might be associated with reduced mortality in sepsis, but the benefit was not confirmed in low-risk-of-bias multicenter trials and was primarily driven by single-center studies. Intravenous vitamin C appeared safe. Given the exploratory nature of these subgroup analyses and the data-driven thresholds used, high-quality, multicenter RCTs are warranted. http://www.crd.york.ac.uk/PROSPERO/view/CRD4204261367808, identifier CRD4204261367808.

PMID 42761050
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PubMedMedicine2026-09-19

Mediation of the association between sedentary behavior and complex multimorbidity by the hs-CRP/HDL-C ratio: Findings from NHANES 2015-2020.

Sun Hongcun H, Hu Jiandao J, Qian Aijuan A, Jiang Wenbo W

This study aimed to investigate the association between sedentary behavior and complex multimorbidity among American adults, verify the mediating role of the high-sensitivity C-reactive protein/high-density lipoprotein cholesterol (hs-CRP/HDL-C) ratio in this relationship, and provide a theoretical basis for the prevention and control of chronic diseases. A total of 8246 adults aged ≥20 years from the National Health and Nutrition Examination Survey 2015 to 2020 were enrolled as study participants. Sedentary time was collected via questionnaire surveys, while hs-CRP and HDL-C levels were obtained through laboratory tests. Complex multimorbidity (defined as the coexistence of ≥3 chronic diseases) was determined based on clinical diagnoses. Logistic regression analysis was used to examine the association between sedentary behavior and complex multimorbidity. A mediation effect model was applied to quantify the mediating effect of the hs-CRP/HDL-C ratio, and subgroup analyses were conducted to explore population heterogeneity. The prevalence of complex multimorbidity in the study population was 25.72%, with a mean daily sedentary time of 5.87 hours. After adjusting for potential confounding factors, each 1-hour increase in daily sedentary time was associated with a 3.46% higher risk of complex multimorbidity (odds ratio = 1.03, 95% confidence interval: 1.02-1.05, P < .001). Restricted cubic spline analysis revealed a linear association between sedentary time and complex multimorbidity. Mediation effect analysis indicated that the hs-CRP/HDL-C ratio exerted a partial mediating effect on the association, accounting for 5.17% of the total effect (95% confidence interval: 0.0001-0.0004, P < .001). Subgroup analyses demonstrated that this mediating effect was more pronounced in individuals aged 45 to 64 years and in males, with mediating proportions of 2.67% and 5.86%, respectively (both P < .05). Sedentary behavior may be positively associated with the risk of complex multimorbidity among American adults, and the hs-CRP/HDL-C ratio partially explain this association.

PMID 42760689
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PubMedThe Journal of school health2026-09-19

Object-Control Skills and Cortisol Response During Physical Education Lessons in Primary School Children.

Silvestri Fioretta F, Curzi Davide D, Zimatore Giovanna G, Bonavolontà Valerio V et al.

Object-control (OC) skills are fundamental movement skills acquired during primary school that may act as either stressors or engagement factors during physical education (PE). This study examined the acute impact of OC exercises on children's stress levels across grade levels. 124 primary school children (Grades 3-5) participated in two PE lessons, one including OC exercises and one without. Salivary cortisol (C) was measured before and after each lesson. Fourth-grade children showed lower C concentrations than fifth-grade students (p = 0.02). Following PE without OC, third-grade C levels decreased (p = 0.045), fourth-grade increased (p < 0.01), and fifth-grade showed no change. Following PE with OC, C decreased only in fifth-grade children (p = 0.03). Because stress-related effects of OC exercises differ by grade level, PE curricula should introduce OC tasks progressively. Primary school children exhibit distinct, grade-dependent neuroendocrine responses after physical activity. High cognitive loads in complex OC tasks may buffer typical cortisol reductions in younger children, whereas mature cohorts find OC activities stress-regulating. Evaluating motor skill development alongside hormonal adaptations can help optimize school health policies and stress management strategies.

PMID 42760851
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PubMedJournal of general internal medicine2026-09-19

Untangling the Web of Hepatitis C Risk in Rural Communities.

Sami Muhammad Mohsin MM, Amjad Muhammad Waqar MW, Latif Muhammad Bilal MB

PMID 42760463
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