Drug Database
OX

Oxalyt-C

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Oxalyt-C?

Oxalyt-C is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications.

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Oxalyt-C is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedFood chemistry: X2026-07-25

Effects of supercooling, sub-freezing, and deep-freezing pre-cooling on freshness, flavor, water-holding capacity, and microstructure of beef during EPS-based distribution.

Tang Yuqing Y, Mu Baide B, Sun Depeng D, Li Qian Q et al.

This study examined how pre-cooling temperature affects beef quality and temperature fluctuations during expanded polystyrene (EPS)-based distribution, simulated as 48 h at 25 °C followed by chilled storage at 4 °C. Beef steaks were pre-cooled to -0.5 °C (supercooling), -5 °C (sub-freezing), or -18 °C (deep-freezing) and compared with a 4 °C refrigerated control. Quality was evaluated by freshness indicators (total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), total viable count (TVC)), water-holding capacity, flavor (electronic tongue, electronic nose, gas chromatography-ion mobility spectrometry), and microstructure. Pre-cooling temperature markedly affected thermal behavior, temperature fluctuation, and quality changes during EPS-based distribution. Deep-freezing (-18 °C) was associated with the largest temperature rise (∼16 °C) and more pronounced indicators of freeze-thaw damage. Sub-freezing (-5 °C) resulted in microstructural features indicative of freezing-related structural disruption and greater drip loss. Supercooling (-0.5 °C) showed the smallest temperature increase (∼4 °C), better preserved microstructure, and maintained relatively higher freshness, flavor, and water-holding capacity. At the end of the 48 h distribution simulation, all pre-cooled groups remained below 15 mg/100 g TVB-N, while the -18 °C group had the highest TBARS and purge loss. During subsequent chilled storage, the -0.5 °C group reached the spoilage limit (20 mg/100 g TVB-N) after 96 h, compared with 72 h for the -5 °C and -18 °C groups. Overall, supercooling at -0.5 °C provided the best beef quality preservation during short-term EPS-based distribution, highlighting the importance of appropriate pre-cooling state selection for e-commerce logistics.

PMID 42500043
Read full article →
PubMedACS central science2026-07-25

Catalytically Promiscuous PLP-Dependent Aminotransferases Are Biocatalysts for C-C Bond Formation.

Kim Alexander T AT, Howard James R JR, Cuba Cáceres Andrés G AG, Chong Kyle I KI et al.

Access to noncanonical amino acids is increasingly important in natural products synthesis and drug discovery. Enzymatic synthesis has emerged as an efficient strategy for simplifying approaches toward these molecules. Pyridoxal-5'-phosphate (PLP)-dependent enzymes have been extensively studied for the biocatalytic functionalization of α-amino acids. However, the high substrate specificity of these enzymes has limited the substrate scope of PLP-mediated biocatalysis. Efforts to identify generalist catalysts may be enabled by catalytic promiscuity, a property well-known in the PLP-dependent enzyme family. In pursuit of PLP-catalyzed C-C bond formation, we leverage a cofactor-centric approach with PLP-dependent enzymes not previously known to mediate C-C bond formation to access key nucleophilic intermediates. In this work, we show that aminotransferases Aro8 and TyrB can mediate C-C bond formation, the first such activity reported for aminotransferases. Further, this non-native function can be improved by the addition of a sacrificial ketoacid. Interestingly, Aro8 and TyrB exhibit distinct conformational dynamics that impact the diastereoselectivity of the reaction. These results indicate that aminotransferases are an untapped resource for the discovery of new biocatalysts for C-C bond formation and demonstrate the value of cofactor-guided reaction discovery.

PMID 42500034
Read full article →
PubMedAnalytical and bioanalytical chemistry2026-07-25

Caribbean ciguatoxin (C-CTX) reference materials: feasibility studies for calibration solutions and fish tissue matrix materials.

Mudge Elizabeth M EM, Garrido Bruno C BC, Murphy A Elizabeth AE, Robertson Alison A et al.

Ciguatera poisoning (CP) is the most prevalent marine toxin illness globally and disproportionately affects tropical and subtropical regions that rely on fish as a major food source. It is a global concern due to fish importation, tourism in endemic regions, and changes to ocean temperatures leading to the spread of the causative microorganisms into non-endemic regions. CP is caused by the consumption of fish contaminated with ciguatoxins, a class of lipophilic, ladder-framed polyether marine toxins that cause a combination of gastrointestinal, neurological, and cardiovascular symptoms. A major constraint in ciguatoxin analysis is the lack of reference materials (RMs), especially for Caribbean ciguatoxins. Caribbean ciguatoxin-5 (C-CTX5) was isolated from Gambierdiscus silvae and quantitated by qNMR. The purified C-CTX5 was accurately diluted and used to prepare a small batch calibration solution RM at a concentration of 0.5 µg/mL. The solution was shown to be homogeneous and demonstrated good stability over 28 days at temperatures up to 23 °C. A matrix reference material was prepared using fish tissue (Sphyraena barracuda) naturally incurred with C-CTX1, with concentrations estimated using the C-CTX5 calibration solution. The fish matrix RM was homogeneous, and C-CTX1 remained stable at temperatures up to 4 °C for 28 days. At temperatures above 4 °C, a time-dependent decrease in measured C-CTX1 concentration was observed. Addition of antibiotics and an antioxidant stabilizer was shown to improve both the stability of the fish matrix and measured C-CTX1 content. These successful feasibility studies establish processes for the development of large-scale C-CTX reference materials, which are essential to ensure accurate measurements for both research and regulatory frameworks.

PMID 42498790
Read full article →
PubMedHLA2026-07-25

Identification of the Novel HLA-C*16:248 Allele Using Next-Generation Sequencing.

Somuncu Makbule Nihan MN

HLA-C*16:248 differs from HLA-C*16:02:01:01 by a non-synonymous substitution in exon 4.

PMID 42500830
Read full article →
PubMedJournal of breath research2026-07-25

A novel approach to non-invasive lung cancer screening via exhaled breath analysis using proton transfer reaction time-of-flight mass spectrometry.

Hernández Camarillo Maribel M, Campos-González Joshua J, Vera-Nuñez Fernando F, Hernández-López Enrique E et al.

Lung cancer (LC) remains a global public health problem. To minimize late diagnosis, new detection techniques are needed. The analysis of volatile organic compounds (VOCs) in human breath (the volatilome) represents a non-invasive alternative to current methods for the early detection of LC. In this study, VOCs were determined in the breath of individuals with LC (N=22) and without LC (non-LC, N=21) using proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS). Orthogonal partial least squares discriminant analysis (oPLS-DA) and hierarchical cluster analysis (HCA) were conducted on a subset of 54 VOC ions (out of 180). Twenty-one of the 54 VOC ions were detected in exhaled breath. CH₄O₃H⁺ and C₈H₇NH⁺ were found only in participants without cancer. Among the 19 common ions present in both cohorts, the intensities of 8 ions were statistically different. The LC/non-LC ratios were observed for C₄H₈O₂H⁺, followed by C₃H₄OH⁺, C₂H₂OH⁺, C₂H₃ONH⁺, C₃H₄H⁺, C₃H₂H⁺, C₄H₈H⁺, and C₆H₈H⁺. Spearman correlation analysis could be used to differentiate metabolic processes or pathways between cohorts. Diagnostic ratio is a potential tool to classify individuals with or without lung cancer. This study provides exploratory evidence for exhaled VOCs as potential LC biomarkers and positions them as a complement to current diagnostic pathways, with a potential role in supporting early triage and clinical decision-making.

PMID 42497886
Read full article →
PubMedACS physical chemistry Au2026-07-25

Hydrogen Transfer to Internal Alkynes Using Secondary Amines on Carbon-Supported Noble Metals.

Konieczny Katharina K, Qiu Tianyin T, Menzel Jan Paul JP, Maslack Jacqueline J et al.

The catalytic hydrogen transfer of internal alkynes using carbon-supported noble metals (Pd/C, Pt/C) was systematically studied with various secondary amines, such as indoline (Ind), tetrahydroquinoline (Thq), diisopropylamine ((iPr)2NH)), and, for comparison, diisopropylethylamine ((iPr)2NEt)) as hydrogen donors. The reactions proceeded sequentially, forming (Z)- and (E)-olefins as interim products, having (Z) as a major olefin product, which were sequentially hydrogenated to alkanes. The presence of (E)-alkene isomers was also observed as minor products. Among the tested systems, Pt/C-Ind, Pd/C-Ind, Pt/C-Thq, and Pd/C-Thq exhibited the highest activity and selectivity. Initial reaction rates and activation parameters (activation energy, E a; enthalpy of activation, ΔH ‡; and entropy of activation, ΔS ‡) were determined for these systems. To further elucidate the reaction mechanism, density functional theory (DFT) calculations were performed. The computational results revealed that the balance between adsorption strength and binding energy of reactants and intermediates governs the observed selectivity trends. Notably, the strongly negative activation entropies suggest a rigid, highly ordered transition state, independent of the metal catalyst.

PMID 42500219
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about Oxalyt-C