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prednisolone farnesil (Farnezone / Farnesone / Farnerate)

✓ Approved

SK · NR3C1 · Small Molecule

What is prednisolone farnesil?

prednisolone farnesil is a small molecule developed by SK. It is approved for therapeutic indications via topical.

Drug Profile

Brand NamesFarnezone, Farnesone, Farnerate
CompanySK
Drug ClassSmall Molecule
Molecular TargetNR3C1
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, SK

Mechanism of Action

Molecular Targets

prednisolone farnesil acts on 1 molecular target:

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

prednisolone farnesil is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersRheumatoid arthritis✓ Approved

Related Research Articles

PubMedMedicine2026-11-11

Intravascular large B-cell lymphoma presenting as unilateral lymphedema in a patient with rheumatoid arthritis and sarcoidosis: A case report.

Kimura Masatoshi M, Sasaki Haruka H, Kudo Risa R, Murai Masayuki M et al.

Intravascular large B-cell lymphoma (IVLBCL) is an uncommon subtype of diffuse large B-cell lymphoma, typically presenting with nonspecific symptoms and lacking lymphadenopathy or visible tumor lesions, which makes early diagnosis challenging. A 66-year-old female developed progressive unilateral lymphedema despite ongoing treatment for rheumatoid arthritis and sarcoidosis. Sarcoidosis-related lymph node lesions were also considered as a potential cause, and the prednisolone dose was increased. Despite these measures, the edema worsened, and a fever of around 38°C developed. At the initial evaluation, the serum soluble interleukin-2 receptor level was already elevated at 9985 U/mL. Initial investigations, including imaging, bone marrow aspiration, and random skin biopsies, failed to reveal malignancy. Subsequent monitoring revealed that the serum level of serum soluble interleukin-2 receptor had risen further to 19,835 U/mL and that thrombocytopenia was present, prompting a repeat random skin biopsy that ultimately confirmed IVLBCL through the identification of intravascular cluster of differentiation 20-positive lymphoma cells. Chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone was initiated. However, the patient developed peripheral neuropathy, suspected to be an adverse drug reaction. Consequently, the regimen was switched to polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisolone. After completing 8 courses, the patient achieved remission. The left lower-limb lymphedema improved significantly. This case highlights several clinically significant points: first, IVLBCL can present solely as unilateral lymphedema without detectable lymph node enlargement or tumorous lesions, underscoring the diagnostic difficulty. Second, repeated random skin biopsies, including adipose-rich vascular tissue, are crucial in establishing a definitive diagnosis when initial biopsies are inconclusive. Third, patients with underlying autoimmune conditions such as rheumatoid arthritis and sarcoidosis, particularly those receiving immunosuppressive therapies, may have an increased susceptibility to lymphoma, suggesting that systemic immune dysregulation could contribute to disease onset.

PMID 43012796
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PubMedCase reports in oncological medicine2026-11-11

Orbital Diffuse Large B-Cell Lymphoma Masquerading as Periorbital Cellulitis in a Paediatric Patient With Ataxia-Telangiectasia: A Case Report.

Alabdulrazzaq Fajer F, Alkanderi Arwa A, AlHazeem Bashayer B, Alenezi Abdullah A

Ataxia-telangiectasia (A-T) is a rare autosomal recessive disorder characterised by cerebellar ataxia, combined immunodeficiency and elevated predisposition to lymphoid malignancy, rendering orbital malignancy clinically and radiologically indistinguishable from infection. We report a 7-year-old female with A-T presenting with left periorbital cellulitis unresponsive to prolonged antimicrobial therapy, surgical drainage and antifungal escalation. Incisional biopsy of a persistent periorbital mass revealed diffuse large B-cell lymphoma (DLBCL), confirmed on immunohistochemistry. Staging indicated Lugano-modified Ann Arbour Stage IV disease, with a primary orbital mass and non-contiguous mediastinal and abdominal disease on cross-sectional imaging. Bone marrow assessment showed no morphological involvement, although flow cytometry detected a light chain-restricted B-cell population. The pulmonary lesions could not be radiologically distinguished from necrotising infection. She received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) with cyclophosphamide and vincristine reduced to approximately 50% of standard doses but died approximately 2 months after diagnosis, following a severe necrotising pulmonary infection after the second treatment cycle. This case underscores the importance of early malignancy consideration in immunocompromised A-T patients with refractory orbital disease, the critical role of timely tissue biopsy and the diagnostic difficulty of distinguishing lymphomatous involvement from infection on imaging alone in this population.

PMID 43011227
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PubMedClinical case reports2026-11-11

Chronic Calcific Pancreatitis as the Probable Initial Manifestation of Systemic Lupus Erythematosus With Mixed Connective Tissue Disease Overlap: A Case Report.

Sazal Rashid Shahriar RS, Faisal Abdullah Al AA, Sikder Sabiha S, Ahmed Moontasir M et al.

Chronic calcific pancreatitis as the presenting manifestation of systemic lupus erythematosus (SLE) is exceedingly rare, particularly in tropical regions where it may be misattributed to tropical chronic pancreatitis (TCP). A 22-year-old Bangladeshi male farmer presented with a one-year history of recurrent postprandial epigastric pain and steatorrhea. Three months before admission, he developed inflammatory polyarthritis, a photosensitive malar rash, oral ulcers, Raynaud phenomenon, and progressive proximal muscle weakness. Investigations revealed normocytic anemia (hemoglobin 9.2 g/dL), thrombocytopenia (50 × 109/L), a positive direct Coombs test, and a broad autoantibody profile including strongly positive antinuclear antibodies, anti-dsDNA, anti-U1-RNP, anti-nucleosome, anti-Ku, and anti-ribosomal P antibodies. Computed tomography and magnetic resonance cholangiopancreatography showed chronic calcific pancreatitis with beaded main pancreatic duct dilatation (10-11 mm), diffuse intraductal calculi, and parenchymal atrophy, without features of autoimmune pancreatitis. He fulfilled the 2019 EULAR/ACR classification criteria for SLE (score 22) and the Sharp criteria for mixed connective tissue disease (MCTD) overlap. Alcohol use, gallstone disease, hypercalcemia, hypertriglyceridemia, pancreatotoxic drugs, and cassava exposure were absent, but genetic testing and serum IgG4 were unavailable. Hydroxychloroquine, prednisolone, mycophenolate mofetil, and pancreatic enzyme replacement were followed by improvement of the systemic features, including platelet normalization. On the available evidence, the pancreatic disease is most plausibly an early manifestation of SLE-MCTD overlap, although a hereditary or tropical contribution cannot be formally excluded. This case expands the spectrum of SLE-associated pancreatic disease and underscores the need for systematic autoimmune evaluation in young patients from tropical regions with unexplained chronic calcific pancreatitis.

PMID 43011214
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PubMedJournal of medical case reports2026-11-11

Diagnostic dilemma in the management of a cervical spinal cord lesion: neuromyelitis optica spectrum disorder: a case report.

Azode Kelechi Michael KM, Balogun Simon Adewale SA, Komolafe Morenikeji Adeyoyin MA, Olasode Babatunde Josiah BJ et al.

Neuromyelitis optica spectrum disorder, known eponymously as Devic's disease, is a condition in which antibodies are elaborated against aquaporin water channels in the end foot processes of astrocytes due to autoimmune dysregulation thereby initiating a cascade of neuroinflammatory events that culminates in astrocytic injury, dysfunctional axonal blebs and demyelination of the central nervous system neurons. Its cervical spine symptoms may sometimes mimic a similar presentation of a cervical spine lesion. This is further validated by its core clinical magnetic resonance image feature of longitudinally extensive transverse myelitis bearing radiologic similarities with an intramedullary spinal cord lesion thereby resonating the need to maintain a high index of suspicion when evaluating patients with either condition. It is pertinent to highlight that while surgery may confer a potential benefit in patients with acute exacerbations of symptoms attributable to cervical spine compressive myelopathy due to the disease, the mainstay of treatment involves the use of steroids, immunosuppressive therapy and plasmapharesis. We report a case of a 50-year-old Nigerian female of Yoruba ethnicity who presented with progressive weakness involving all limbs of 2 weeks' duration. She had associated history of photophobia and a 1-week history of fever with sore throat a month prior to presentation. Cranial and cervical spine T2-weighted magnetic resonance imaging showed increase signal intensity within the right optic nerve and bulbous expansion with signal intensity noted in the C3-C7 segments of the spinal cord, respectively. She had C3-C6 cervical decompression surgery to relieve her symptom of progressive weakness of all her limbs with associated worsening difficulty with breathing. Laboratory investigations parameters were in keeping with neuromyelitis optica spectrum disorder and histological analysis of resected tissue specimen revealed features of neuroinflammation. She was placed among other medications, prednisolone, tenofovir, and azathioprine. She died on postoperative day 27 following development of sudden-onset respiratory distress. This article highlights the need to suspect a diagnosis of Devic's disease when evaluating patients with cervical spine lesions. It underscores the need for early diagnosis, the need for intensive ventilatory support, and the potential role of immunosuppressive therapy in improving outcomes.

PMID 43010088
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PubMedLeukemia & lymphoma2026-11-10

Dasatinib, prednisolone, and vincristine as a 'chemo-lite' induction approach for Philadelphia chromosome-positive acute lymphoblastic leukemia.

Endo Toshihide T, Takahashi Hiromichi H, Namiki Takahiro T, Hayashi Yoshiyuki Y et al.

PMID 43004503
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PubMedTransplantation direct2026-11-10

Spleen as an Ectopic Site for Human Stem Cell-derived Hepatocyte and Islet Transplantation in an Operational Immunodeficient Pig Model.

Enosawa Shin S, Noguchi Hirofumi H, Umezawa Akihiro A, Miyamoto Yoshitaka Y et al.

Extensive efforts in cell transplantation have focused on identifying effective transplantation sites, including autologous and ectopic options. Intraportal transplantation of pancreatic islets into the liver has produced favorable outcomes. We examined whether the spleen, which possesses a sinusoidal vascular structure similar to that of the liver, could serve as an alternative transplantation site for human progenitor cell-derived hepatocyte- or islet-like cells, using the same clinically relevant transplantation procedure. The operational immunodeficient pig (OIDP) model has been used for transplantation of human stem cell-derived cells. In accordance with the OIDP protocol, recipients underwent thymectomy and received tacrolimus, mycophenolate mofetil, and prednisolone via a gastric tube, while the spleen was not removed. Instead, splenic immune cells were inactivated by perfusing mitomycin C using a temporal extracorporeal circuit that isolated the spleen from systemic circulation. After thorough rinsing, human-induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs) or induced tissue progenitor cell-derived islets (iTPC-derived islets) were transplanted into the spleen through this route. Administration of tacrolimus, mycophenolate mofetil, and prednisolone reduced concanavalin A-induced lymphocyte activation. Splenic lymphocytes treated with mitomycin C under extracorporeal circulation similarly reduced activation in response to concanavalin A. Human albumin was detectable in pig serum 2 wk after iPSC-HLC transplantation. After harvesting the spleen at 4-wk posttransplantation, colonies of cells positive for human albumin and vimentin were identified. Similarly, after transplantation of quantum-dot-labeled human iTPC-derived islets, human C-peptide was detected in the serum after a glucose tolerance test. Histological analysis confirmed differentiation of pancreatic progenitor cells into insulin-producing cells in the spleen. This exploratory study using pigs demonstrated the feasibility of intrasplenic cell transplantation via the splenic artery.

PMID 43006082
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