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miriplatin hydrate (miriplatin hydrate / SMP 11355 / Miripla)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is miriplatin hydrate?

miriplatin hydrate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via injectable (others) or intraarterial injection.

Drug Profile

Brand Namesmiriplatin hydrate, SMP 11355, Miripla
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteInjectable (Others), Intraarterial Injection
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

miriplatin hydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

Related Research Articles

PubMedThe Review of scientific instruments2026-11-11

A novel integrated multi-physics parameter testing system for monitoring the deformation and failure characteristics of hydrate-bearing sediments.

Zhai Siyu S, Bu Qingtao Q, Liu Xiaoli X, Wang Xiujuan X et al.

Natural gas hydrates mostly exist in marine sediments as cemented or load-bearing structures, with stability highly susceptible to temperature-pressure variations. Hydrate-production-driven reservoir deformation and failure can trigger submarine geohazards such as submarine landslides, whereas methane leakage aggravates global warming and marine ecological degradation. Hence, clarifying the deformation-failure mechanisms of hydrate-bearing sediments (HBS) is critically essential. Existing studies have adopted acoustic and mechanical tests for HBS characterization, yet internal damage evolution during deformation remains poorly understood. Most previous studies adopt single-source data and conventional mechanical parameters, lacking in situ multi-physics monitoring for internal damage, which prevents quantitative links between micro-scale sediment damage and macro-scale specimen failure. This study develops an integrated testing system to synchronously acquire multi-physics signals (acoustic and mechanical) over the full deformation-failure course of HBS. This unified platform realizes automated multi-dimensional data collection, in situ hydrate formation, and triaxial shear measurements. Validation tests are performed on homogeneous sandy HBS specimens. Combined analyses of acoustic-emission and ultrasonic-velocity multi-source data overcome single-method limitations, advance mechanistic understanding, and uncover HBS deformation-failure patterns. This work supplies systematic multi-source data for geological-hazard prevention in hydrate exploitation.

PMID 43012636
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-11-11

Scalable Hydrogel-Programmed Porous Photonic Cement for Passive Daytime Cooling.

Xie Dong D, Wang Yu Y, Zhao Yasong Y, Feng Shuangjiang S et al.

Cement is among the most widely produced materials on Earth, yet its strong solar absorption causes building envelopes to act as heat sources, increasing cooling energy demand. Here, we structurally program cement hydration to transform conventional cementitious materials into passive cooling interfaces. Through hydrogel-confined mineralization of cement clinker, we construct a robust, hierarchically porous calcium-silicate-hydrate (C-S-H) network that integrates broadband light scattering, vapor transport and thermal insulation. By regulating the composition and crystallinity of the hydrates, the material achieves ∼95% solar reflectance and ∼98% infrared emissivity without the use of additional photonic fillers. The hygroscopic nature of the network further enables sustained evaporative cooling under humid or cloudy conditions where radiative cooling alone becomes inefficient. Life-cycle analysis indicates that this strategy provides a pathway to transform high-emission cement into carbon-mitigating materials integrated within opaque building envelopes, enabling the scalable deployment of daytime radiative cooling across the built environment.

PMID 43010573
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PubMedAnalytical chemistry2026-11-11

Deposition-Separation First, Then Response: A Bifunctional Magnetic Nanozyme Enables Anti-Interference Uranyl Sensing.

Zhan Zhou Z, Bu Zhijian Z, Wang Linjie L, Yin Xiangbiao X et al.

Although nanozymes have been demonstrated as a promising sensing element to achieve sensitive detection of uranyl (UO22+) thanks to their catalytic signal amplification feature, it is still challenging to achieve a reliable analysis of the target in real complex matrices because some coexisting constituents can perturb nanozyme catalysis, consume reactive species, or directly alter catalytic products. To address this deficiency, here, we proposed a "deposition-separation first, then response" strategy for anti-interference uranyl sensing via designing a bifunctional magnetic Fe3O4/CoOx nanozyme that coupled target conversion, matrix cleanup, and catalytic response together. In the presence of H2O2, UO22+ was first converted into uranyl peroxide hydrate that deposited on the surface of Fe3O4/CoOx. Structural and spectroscopic analyses indicated that this deposition could enrich oxygen vacancy sites to promote H2O2 activation and accelerate the production of hydroxyl radicals for enhanced oxidation of 3,3',5,5'-tetramethylbenzidine. The UO22+-deposited Fe3O4/CoOx was then collected magnetically and resuspended before nanozyme response; thus, potential interference from coexisting species in samples was avoided, with no appreciable compromise of the uranyl-dependent signal. Consequently, the proposed strategy enabled the sensitive detection of uranyl in the range of 0.1-20 μM, demonstrating excellent resistance to matrix effects during real water analysis. By isolating unknown backgrounds from chromogenic transduction while retaining the analyte-activated catalytic interface, our work offers a reliable route for uranyl sensing in diverse matrices.

PMID 43010437
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PubMedFrontiers in medicine2026-11-11

Efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome: an updated meta-analysis based on disease severity and treatment strategy subgroups.

Haibier Abduwupuer A, Ma Jiawei J, Wang Yuanyuan Y, Wu Tong T

Sivelestat sodium hydrate is a selective neutrophil elastase inhibitor that attenuates neutrophil-mediated alveolar-capillary injury and is used in some East Asian countries for acute lung injury/ARDS. We evaluated the efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome (ARDS) and explored whether disease severity, baseline mortality risk, and treatment background modify the mortality effect. We searched PubMed/MEDLINE, Embase, Cochrane CENTRAL, Web of Science, CNKI, Wanfang, and ClinicalTrials.gov from database inception to August 27, 2026. Eligible studies were adult studies of sepsis-induced ARDS comparing a sivelestat-containing regimen with an otherwise comparable regimen without sivelestat. COVID-19-only cohorts, non-septic ARDS, mixed-etiology studies without a separable sepsis subgroup, and comparisons in which both groups received sivelestat were excluded. The primary outcome was all-cause mortality; secondary outcomes included P/F ratio, duration of mechanical ventilation, ICU length of stay, organ-function scores, inflammatory markers, and adverse events. Mortality was pooled as odds ratios (ORs) using a random-effects model with restricted maximum likelihood; Hartung-Knapp intervals were used for the primary and study-design analyses. This review was prospectively registered in PROSPERO. Fourteen studies were eligible for qualitative synthesis, and 10 studies (943 patients) provided extractable 2 × 2 mortality data. Deaths occurred in 73/431 patients receiving sivelestat and 125/512 controls. Sivelestat was associated with lower mortality (OR=0.55, 95% CI 0.36-0.84; I2 = 0%). The signal persisted in randomized trials (OR=0.37, 95% CI 0.16-0.86; I2 = 0%). Study-level point estimates appeared more favorable in cohorts with baseline P/F < 100 mmHg and control mortality >30%; however, interaction tests were not statistically significant and severity analyses were ecological. Leave-one-out analyses were stable. Egger testing did not detect significant small-study asymmetry (P = 0.197), although power was limited. Baseline-stratified treatment effects by IL-6, PCT, CRP, or neutrophil elastase were unavailable for quantitative effect-modification analyses. In an updated and etiologically strict evidence synthesis, sivelestat was associated with lower mortality in sepsis-induced ARDS, including in randomized trials. Severe hypoxemia and high baseline risk remain plausible enrichment factors, but current aggregate evidence is insufficient to support a validated phenotype-guided prescribing rule. Co-intervention reporting was sparse, and residual confounding by prone positioning, sedation, neuromuscular blockade, and steroid background cannot be excluded. PROSPERO CRD420261541158.

PMID 43011073
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PubMedLangmuir : the ACS journal of surfaces and colloids2026-11-10

Pore-Scale Gas Invasion and Residual Liquid Trapping in a Hydrophilic Microfluidic Network.

Tian Xinyu X, Li Dongliang D, Lu Jingsheng J, Liang Deqing D et al.

Gas invasion into liquid-saturated hydrophilic porous media is governed by interfacial, wetting, viscous, and pore-scale effects that control pathway selection and residual liquid trapping. However, how liquid composition influences gas-pathway establishment, postbreakthrough redistribution, and final liquid retention remains insufficiently understood. Here, nitrogen displacement was visualized in a hydrophilic glass microfluidic network initially saturated with 12 liquid systems, including water, 3.5 wt % NaCl brine, and formulations containing ethanol, polyethylene glycol (PEG), sodium dodecyl sulfate (SDS), or sodium dodecylbenzenesulfonate (SDBS). Breakthrough time, liquid-saturation evolution, final residual liquid saturation, stabilization time, and final gas morphology were quantified. Three invasion modes were identified: preferential-channel flow, dendritic expansion, and network-like expansion. Breakthrough times ranged from 1 to 67 s, showing that rapid formation of a spanning gas pathway did not necessarily correspond to extensive liquid removal. PEG system W5 showed the highest final residual liquid saturation (∼0.42), whereas SDBS system W11 showed the lowest (∼0.07), corresponding to a final gas occupancy of ∼0.93. SDS system W8 and SDBS system W10 both exhibited high final gas occupancy together with relatively short stabilization times. Lower measured air-liquid surface tension was associated with broader branched invasion in some systems, while final liquid removal likely reflected coupled effects of viscosity, wettability, and pore-structure heterogeneity. Film-like residual liquid and locally isolated gas regions further showed that extensive gas occupation did not necessarily ensure complete connectivity among the optically resolved gas-filled regions. These results reveal a decoupling between breakthrough dynamics and final liquid removal and provide mechanistic pore-scale insight relevant to evaluating water-block mitigation in hydrate-bearing sediments.

PMID 43007153
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PubMedInorganic chemistry2026-11-09

Synthesis and Structural Characterization of Three Lithium Dithiophosphates: Li3PO2S2·11H2O, Li3PO2S2·H2O, and Li3PO2S2.

Bouaouina Jamal J, Sassoye Capucine C, Avdeev Maxim M, Rousse Gwenaëlle G et al.

Solid-state batteries require electrolytes with high Li-ion conductivity, together with good interfacial and chemical stability. Oxythiophosphate-type solid electrolytes appear to achieve such a balance, but their chemistry remains little investigated. Here, we report the low-temperature aqueous synthesis of lithium dithiophosphate undecahydrate, Li3PO2S2·11H2O, and its dehydration pathway to the monohydrate Li3PO2S2·H2O and to the anhydrous phase Li3PO2S2. Li3PO2S2·11H2O crystallizes in the P212121 space group, isostructural to the parent compound Na3PO2S2·11H2O. Upon annealing at 100 °C, a monohydrate forms with a C2cm structure solved ab initio from XRPD and PND data. Further dehydration at 200 °C yields anhydrous Li3PO2S2, which adopts a Pbca structure isostructural to the Na analog. Solid-state NMR spectroscopy confirms dominant (PO2S2) units in the hydrate and reveals partial transformation to (PO3S)/(PO4) units upon annealing. Li3PO2S2·11H2O exhibits a room-temperature ionic conductivity of ∼10-5 S cm-1. The ionic conductivities of Li3PO2S2·H2O and Li3PO2S2 are lower: σ = 8.7 × 10-8 S·cm-1 and 2.6 × 10-8 S·cm-1 (at 110 °C), with activation energies of ∼0.70 and ∼0.69 eV, respectively. These findings expand the oxythiophosphate structural family with new hydrated and anhydrous phases, providing a basis for tuning O/S composition and Li-ion transport through targeted cation substitution.

PMID 43001980
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