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miriplatin hydrate (miriplatin hydrate / SMP 11355 / Miripla)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is miriplatin hydrate?

miriplatin hydrate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via injectable (others) or intraarterial injection.

Drug Profile

Brand Namesmiriplatin hydrate, SMP 11355, Miripla
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteInjectable (Others), Intraarterial Injection
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

miriplatin hydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

Related Research Articles

PubMedFrontiers in pharmacology2026-07-25

Fibroblast growth factor 2 (FGF2) modulates the excitability of brain noradrenergic and serotonergic neurons: possible involvement of FGFR1 and FGFR4 receptors.

Paliokha Ruslan R, Racicky Matej M, Grinchii Daniil D, Khoury Talah T et al.

Fibroblast growth factor 2 (FGF2), in addition to its primary function in the connective tissue, plays also a role in the central nervous system (CNS). Thus, anxiolytic, antidepressant, and pro-addictive properties of this molecule have been reported. Our previous study showed that pro-alcohol consumption effect of FGF2 is mediated, at least in part, via its interaction with the central dopaminergic system. The present study aimed to test the hypothesis that pro-addictive and/or antidepressant-like effects of FGF2 can also be linked with FGF2-noradrenaline and FGF2-serotonin (5-HT) interactions. Adult male Wistar rats, weighing 250-350 g, were treated with the recombinant FGF2, selective inhibitors of FGFR1 (PD173074), FGFR2 (lirafugratinib), FGFR4 (BLU9931), or corresponding vehicle. The excitability of the noradrenergic neurons of the locus coeruleus (LC) and serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN) was assessed using the single-unit in vivo electrophysiology under chloral hydrate anesthesia. We found that FGF2 stimulated the burst firing of noradrenergic neurons and inhibited the burst firing of 5-HT neurons. PD173074 decreased the density of the spontaneously active noradrenergic neurons in the locus coeruleus, whereas BLU9931 had a stimulatory effect on the burst activity of 5-HT neurons. The psychoactive effects of the FGF2 might be mediated, at least in part, via its interaction with the central monoaminergic circuits. The FGF2-catecholaminergic interactions are putatively mediated via FGFR1, and FGF2-5-HT-crosstalk-via FGFR4. These two receptors can be thus potential targets for the future CNS drugs.

PMID 42499486
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PubMedACS omega2026-07-24

Hydrates-Based Separation of CH4/N2 Gas Using Copper Foam and Chemical Promoters.

Wang Lanyun L, Lv Zecheng Z, Mu Shifang S, Xu Yongliang Y et al.

Hydrate-based gas separation (HBGS) offers a safe and promising route for capturing low-concentration coalbed methane (CH4). Herein, the formation behavior of CH4 hydrates promoted by 1,3-dioxolane (1,3-DIOX) and porous copper foam (CF) was systematically investigated. Experimental results demonstrated that the combined use of CF (60 PPI) and 5.56 mol % 1,3-DIOX under a coupled spraying-stirring mode markedly accelerates hydrate formation, yielding a maximum gas storage capacity of 0.1733 mol CH4 per mole H2O at 3.0 MPa, which is 10.1 times higher than that of the static pure water system. At 4.0 MPa, the maximum capacity is 0.1244 mol CH4/mol H2O, which is 3.7 times higher than that of the static pure water system. Furthermore, due to the higher thermodynamic driving force, the induction time for the 10% CH4 system is shorter than that of the 5% system. Specifically, the induction time with 0.3 wt % l-leucine was 21.31%-40.38% shorter than that of the combined CF and 1,3-DIOX system. After single-stage separation, the CH4 content was effectively enriched from 5% to 8.0%-10.25% and from 10% to 17.9%-21.7%. Compared to l-leucine, the system containing sodium lignosulfonate demonstrated a higher CH4 concentration in the hydrate phase, indicating superior selectivity. The CH4 recovery rates for the feeding gas systems with 10% and 5% CH4 were approximately 40% and 50%, respectively. Comparing to the reported results in smaller reactors of 58-1000 mL, the comparable CH4 recovery here is realized in a much larger scale reactor of 3927 mL, which is really a great improvement. These findings confirm that the proposed CF/1,3-DIOX system is an effective strategy for the enrichment of low-concentration CBM, providing a viable technical route for multistage industrial separation processes.

PMID 42495277
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PubMedEFSA journal. European Food Safety Authority2026-07-24

Assessment of the feed additive consisting of zinc chelate of amino acids hydrate (3b606) for all animal species for the renewal of its authorisation (Zinpro Animal Nutrition (Europe), Inc.).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo RE, Azimonti Giovanna G, Bonos Eleftherios E et al.

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of zinc chelate of amino acids hydrate as a feed additive for all animal species. The applicant has provided data demonstrating that the additive currently in the market complies with the conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the FEEDAP Panel concludes that the additive remains safe for the target species and consumers. Regarding user safety, the additive is an eye irritant. It is also considered a skin and respiratory sensitiser. Exposure of users by any route is considered a risk and should be minimised. The FEEDAP Panel is not in a position to conclude on the environmental safety of the additive. The conclusions of the forthcoming opinion on the environmental risk assessment of trace elements are expected to be directly applicable to the present assessment and will inform the final evaluation. There is no need to assess the efficacy of the additive in the context of the renewal of the authorisation.

PMID 42494835
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PubMedFrontiers in nutrition2026-07-23

Machine learning-assisted optimization of ultrasound-ohmic processing of hawthorn vinegar: antidiabetic activity, phenolic profiling, and molecular docking insights.

Dülger Altıner Dilek D, Şimşek Mehmet Ali MA, Yalçınkaya Mehmet Ali MA, Yıkmış Seydi S et al.

Hawthorn vinegar is a fermented product with functional properties, containing phenolic compounds and bioactive ingredients that could promote health. In this study, ultrasound-ohmic (USOH) processing conditions were optimized using a hybrid machine-learning-based approach to maximize the α-glucosidase and α-amylase and inhibitory activities of hawthorn vinegar. A Box-Behnken experimental design with 27 runs was used, including four independent variables: ultrasound amplitude (40-80%), ultrasound duration (2-6 min), ohmic field strength (20-40 V/cm), and ohmic heating time (2-6 min). Thirteen machine learning algorithms were comparatively evaluated using systematic hyperparameter optimization with GridSearchCV and 5-fold cross-validation. The Lasso Poly2 model showed the highest predictive performance for both α-glucosidase and α-amylase inhibition, with CV R 2 values of 0.9301 and 0.9299, respectively, and low MAPE values (<1%). Metaheuristic optimization algorithms, including Particle Swarm Optimization (PSO), Differential Evolution (DE), and Gray Wolf Optimization (GWO), converged to similar optimum processing conditions, indicating the robustness of the optimized process region. Under the combined optimal conditions, the experimental α-amylase and α-glucosidase inhibition activities were 39.27 ± 1.36% and 37.54 ± 0.53%, respectively. In addition, USOH treatment significantly enhanced the phenolic profile of hawthorn vinegar compared to thermally pasteurized and untreated samples. In particular, the contents of chlorogenic acid, catechin hydrate, caffeic acid, rutin, naringin, resveratrol, and quercetin were markedly increased after treatment. Additionally, five phenolic compounds were evaluated by molecular docking analysis against α-amylase and α-glucosidase, and the strongest binding affinities were observed for naringin (-7.40 kcal/mol) and chlorogenic acid (-7.17 kcal/mol), respectively. These findings demonstrate that machine learning-assisted ultrasound-ohmic processing can effectively improve the antidiabetic and functional properties of hawthorn vinegar.

PMID 42488216
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PubMedIranian journal of pharmaceutical research : IJPR2026-07-22

Pharmacologic Sedation-Related Respiratory Complications in Pediatric Dentistry: A Decade-Long Scoping Review.

Mohammadpour-Belvirdy Leila L, Sadati Elham E, Hassanzad Maryam M, Valinejadi Ali A

Procedural sedation is widely used in pediatric dentistry to facilitate dental care in uncooperative children. From a pharmacological perspective, sedative agents differ substantially in their mechanisms of action, routes of administration, and safety profiles. Among the reported adverse effects, respiratory complications remain the most clinically significant and potentially life-threatening. Despite extensive clinical use, a comprehensive synthesis of respiratory adverse events (RAEs) associated with commonly used sedative drugs in pediatric dental settings is lacking. This scoping review aimed to map the existing evidence on respiratory complications associated with pharmacological sedation in pediatric dentistry. A scoping review was conducted in accordance with established methodological frameworks. Electronic databases were systematically searched for studies reporting the use of sedative or anesthetic agents in pediatric dental procedures. Eligible studies included clinical trials, cohort studies, case series, and retrospective analyses that documented respiratory outcomes. Data were extracted on patient characteristics, sedative agents and combinations, dosages, routes of administration, monitoring methods, and reported respiratory complications. The included studies showed substantial variability in sedation protocols. The most frequently reported agents were benzodiazepines, chloral hydrate, ketamine, propofol, dexmedetomidine, and opioid combinations. For clarity, respiratory complications in this review are categorized as mild (e.g., transient oxygen desaturation, partial airway obstruction), moderate (e.g., hypoventilation requiring intervention), and severe (e.g., laryngospasm, apnea requiring advanced airway management). RAEs ranged from mild, transient events (e.g., oxygen desaturation and airway obstruction) to more serious conditions, including laryngospasm and apnea. Most complications were managed successfully with basic airway maneuvers, supplemental oxygen, or brief positive-pressure ventilation. Severe outcomes requiring advanced airway intervention were rare. Continuous respiratory monitoring, particularly pulse oximetry and capnography to facilitate earlier detection of ventilatory compromise, was consistently associated with prompt management of adverse events. Pharmacological sedation in pediatric dentistry is generally safe when appropriate drug selection, dosing, and monitoring are used. Respiratory complications are relatively common but are typically mild and reversible. From a pharmacological perspective, careful consideration of sedative combinations, cumulative respiratory depressant effects, and vigilant monitoring is essential to optimize patient safety. Further high-quality studies are needed to refine evidence-based sedation protocols and minimize respiratory risks.

PMID 42483082
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PubMedJournal of fluorescence2026-07-21

A Dual-Responsive Julolidine-Barbituric Acid Platform for Environmental Hydrazine Detection.

Manivannan Ramalingam R, Jayasudha Palanisamy P, Choi Yoon Woo YW, Son Young-A YA

Hydrazine is a highly toxic and carcinogenic compound widely used in industrial, agricultural, and pharmaceutical applications, necessitating rapid, sensitive, and selective detection methods for environmental and safety monitoring. In this study, we report the design and synthesis of a novel Julolidine-barbituric acid-based fluorescent chemosensor (JB) via a simple Knoevenagel condensation reaction for the selective detection of hydrazine hydrate. The probe exhibits high selectivity toward hydrazine over competing analytes, accompanied by a distinct colorimetric change from orange to colorless under visible light and a fluorescence shift from yellow to blue with significant enhancement in emission intensity under UV irradiation. The sensor showed a linear response over the concentration range of 0-2.0 × 10- 5 M, with limits of detection of 7.78 × 10- 6 M from UV-visible spectroscopy and 508 nM from fluorescence measurements, indicating high sensitivity for trace-level detection. The sensing mechanism was investigated using 1H-NMR and HRMS spectroscopic techniques, confirming hydrazine-induced nucleophilic cleavage of the conjugated system. Additionally, the sensor demonstrated practical applicability through JB-coated paper strips for rapid, on-site detection, as well as successful detection of hydrazine in real soil samples. These results highlight JB as a cost-effective, portable, and efficient platform for real-time monitoring of hydrazine hydrate in environmental systems.

PMID 42479294
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