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S-amlodipine gentisate (Nexad / Nexad TAb)

✓ Approved

SK Chemicals · CACNA1C · Small Molecule

What is S-amlodipine gentisate?

S-amlodipine gentisate is a small molecule developed by SK Chemicals. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesNexad, Nexad TAb
CompanySK Chemicals
Drug ClassSmall Molecule
Molecular TargetCACNA1C
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, SK Chemicals

Mechanism of Action

Molecular Targets

S-amlodipine gentisate acts on 1 molecular target:

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

S-amlodipine gentisate is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedJournal of environmental sciences (China)2026-07-25

High-efficiency 4-CP removal by CuFe₂S₃/H₂O₂ Fenton-like system: Unraveling the role of sulfur vacancies in H₂O₂ activation.

Wang Likai L, Liu Donglin D

The degradation of persistent organic pollutants like 4-chlorophenol (4-CP) remains a critical challenge in wastewater treatment. Transition-metal sulfides have emerged as promising Fenton-like catalysts owing to their tunable electronic structures and abundant redox-active sites. Herein, we report a highly efficient Fenton-like system using ternary copper-iron sulfide (CuxFeySz) nanocatalysts for 4-CP degradation. Three CuxFeySz phases-CuFe₂S₃, CuFeS₂, and Cu₅FeS₄-were synthesized and systematically evaluated, with CuFe₂S₃ demonstrating superior catalytic activity, achieving complete degradation of 20 mg/L 4-CP within 7 min using 5 mmol/L H₂O₂. Mechanistic studies reveal that sulfur vacancies in CuFe₂S₃ serve as key features, enhancing H₂O₂ adsorption and activation, as evidenced by in situ Raman spectroscopy. Comparative studies with CuFe₂S₃ analogues (0.7-CuFe₂S₃, 0.9-CuFe₂S₃, Fe₃S₄, and Cu₈S₅) confirm the unique catalytic efficiency of stoichiometric CuFe₂S₃, attributed to its optimal electronic structure and vacancy density. This work not only presents CuFe₂S₃ as a cost-effective and high-performance Fenton-like catalyst but also lays a solid foundation for the application of naturally occurring copper-iron sulfide minerals in wastewater treatment.

PMID 42498368
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PubMedArchives of virology2026-07-25

HBV PreS/S gene mutations in patients with chronic hepatitis B.

Çakal Bülent B, Çavuş Bilger B, Atasoy Alp A, Bulakçı Mesut M et al.

Variants in the hepatitis B virus (HBV) PreS/S gene have been suggested to contribute to the development of progressive liver disease. This study aimed to evaluate the association between HBV PreS/S variations and liver histopathology in patients with chronic hepatitis B. A total of 109 patients under clinical follow-up for chronic hepatitis B were included. The HBV PreS/S gene was amplified by PCR and sequenced using the Sanger method. Amino acid substitutions, nonsense mutations, and deletions were analyzed in relation to liver fibrosis stage. Overall, 58 of 389 amino acid sites (14.9%) in the HBV PreS/S gene showed substitutions, with the highest mutation rate observed in the PreS2 region (27.27%). Mutations L54P (PreS1), F130L/S (PreS2), and S207R/N/I/T and I208T (S gene) were significantly more frequent in patients with advanced fibrosis (F ≥ 3) (p < 0.05). Multivariable analysis identified S207R/N/I/T as an independent risk factor for liver fibrosis. Patients with PreS2 mutations had higher fibrosis scores (p < 0.05). The S207R/N/I/T mutation in the C-terminal region of the HBV S protein is independently associated with liver fibrosis, while PreS2 mutations may contribute to fibrosis progression in chronic hepatitis B.

PMID 42498832
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PubMedSurgical endoscopy2026-07-25

Does preoperative grit predict improved outcomes after bariatric surgery?

Fuller Josephine J, LaFontaine Elizabeth E, Nikbakht Amirreza A, Heidel Eric E et al.

The Grit-S test is an eight-item questionnaire that is used preoperatively to identify patients' level of determination and ability to work towards long term goals. It has been previously found that a higher preoperative Grit-S score is associated with greater postoperative success in orthopedic surgery and neurosurgical populations, but not with weight loss success after laparoscopic sleeve gastrectomy. The purpose of this study is to examine if there is an association between Grit-S score and outcomes for patients undergoing either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy. A retrospective analysis of patients who completed the Grit-S questionnaire prior to undergoing either RYGB or sleeve gastrectomy between June 2022 and August 2024 was completed. The relationship between preoperative Grit-S score and weight loss at one year, readmission rates, and improvement of comorbidities was analyzed. Successful weight loss was defined as 20% total body weight loss. A total of 165 patients met inclusion criteria (RYGB 82.4%, sleeve gastrectomy 17.6%). Successful weight loss was achieved by 80% of the cohort. There was no significant difference between the average Grit-S score for patients with unsuccessful weight loss with a median of 3.67 (IQR 3.42-4.17) compared to patients with successful weight loss with a median of 4 (IQR 3.58-4.33) at one year postoperatively (p = 0.11). In addition, no relationship was found between Grit-S score and readmission rates (p = 0.70). Grit-S scores did not predict who no longer needed medications for diabetes, hyperlipidemia, or hypertension postoperatively compared to those who did (p < 0.05 for all comparisons). The Grit-S test may not be an accurate predictor of postoperative weight loss success after bariatric surgery. However, more research is necessary. Future efforts should focus on studying Grit-S score alongside other aspects of the preoperative psychiatric clearance process.

PMID 42498864
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PubMedChemical science2026-07-25

Catalytic C-S bond cleavage of simple sulfides with productive retention of thiol fragments.

Kawabe Yoshifumi Y, Hara Keisuke K, Aida Kazuhiro K, Ota Eisuke E et al.

A mild catalytic strategy for sulfur-retentive C-S bond cleavage of simple sulfides has been developed through cooperative zirconocene and photoredox catalysis. In contrast to conventional desulfurization and radical-generation strategies, which were primarily designed to exploit the carbon fragment upon C-S bond cleavage, this method converts structurally simple sulfides into carbon-centered radicals and isolable or synthetically usable thiols under mild conditions. The transformation is driven by the formation of a strong Zr-S bond and accommodates a broad range of substrates, including benzyl and allyl sulfides, thioglycolates, thioacetals, and cysteine derivatives. The carbon-centered radicals participate in hydrogenation and intermolecular alkylation reactions, while the thiol fragments are conserved as versatile synthetic handles for subsequent functionalization. This strategy establishes simple sulfides as bifunctional precursors that enable productive utilization of both fragments generated upon C-S bond cleavage.

PMID 42499579
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PubMedInternational journal for parasitology2026-07-25

Cryptic Biomphalaria spp. diversity, spatial population structure and contrasting schistosome infection patterns in the Lake Albert region.

Tumusiime Julius J, Tolo Casim Umba CU, Kagoro-Rugunda Grace G, Namirembe Daisy D et al.

Biomphalaria snails are intermediate hosts of Schistosoma mansoni, and their distribution predicts where intestinal schistosomiasis may occur. Here, we investigated the genetic diversity and distribution patterns of Biomphalaria spp. in the Lake Albert region and assessed their role in the transmission of schistosomes. Snails (n = 6,869) were screened for schistosome infections using cercariae shedding and molecular techniques. In total, 29,670 Biomphalaria snails were collected, 90% of which were in the upland sites. For a subset of snails (n = 184) we sequenced a partial cytochrome c oxidase subunit one (COX1) fragment for phylogeographic analyses. Biomphalaria sudanica, Biomphalaria pfeifferi and Biomphalaria stanleyi were identified, with the former two species having haplotypes shared at the lake and upland sites. We also report the presence of a cryptic lineage, tentatively named B. cf. pfeifferi, awaiting further description. Molecular assays revealed higher overall prevalence of S. mansoni (1.9%) and S. rodhaini (1.12%) among Biomphalaria spp. (n = 1,619) than inferred from cercarial shedding (0.66%). However, S. mansoni occurred exclusively at lake and nearby stream sites and was hosted predominantly by B. sudanica (24.7%, 22/89) and B. pfeifferi (5.4%; 5/147), while S. rodhaini, hosted mainly by B. cf. pfeifferi, was widely distribution in upland sites allopatric to S. mansoni. The wet season (October and November) had the highest S. mansoni prevalence. We argue that the lack of S. mansoni in upland sites reflects a more nuanced situation than simply the absence of suitable host snails, and suggest taxonomic revision of the B. pfeifferi complex.

PMID 42497943
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PubMedDrug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy2026-07-25

ZDHHC16-induced GPX2 S-palmitoylation promotes lenvatinib resistance and inhibits lenvatinib-induced immunogenic cell death in hepatocellular carcinoma.

He Long L, Zhang Guangquan G, Sun Yuxiu Y, Liu Xinli X et al.

S-palmitoylation is a common and reversible post-translational modification. This study aims to elucidate the functional role and mechanism of S-palmitoylation in lenvatinib resistance and lenvatinib-induced immunogenic cell death (ICD) in hepatocellular carcinoma (HCC). Using small interfering RNA (siRNA) screening in HCC cells, zinc finger DHHC-type palmitoyltransferase 16 (ZDHHC16) was identified as a lenvatinib resistance-associated palmitoyl acyltransferase. ZDHHC16 was abnormally overexpressed in both lenvatinib-resistant tissues and cells. ZDHHC16 knockdown improved the sensitivity of HCC cells to lenvatinib. Furthermore, ZDHHC16 knockdown boosted lenvatinib-induced ICD of HCC cells, characterized by an increase in the release of danger associated molecular patterns (DAMPs), including calreticulin (CRT) exposure on the tumor cell surface, high mobility group box 1 (HMGB1), annexin A1 (ANXA1), and adenosine-5'-triphosphate (ATP), as well as an increase in reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, and the secretion of cytotoxic cytokines (tumor necrosis factor (TNF)-α and interferon (IFN)-γ). Mechanistically, ZDHHC16 catalyzed the S-palmitoylation of glutathione peroxidase 2 (GPX2) at C67, which prevented ubiquitination-proteasome degradation of GPX2, thereby enhancing its protein stability. Targeting the ZDHHC16-mediated GPX2 S-palmitoylation improved lenvatinib-induced ICD and antitumor immunity, thereby enhancing the efficacy of lenvatinib. Collectively, our findings reveal that ZDHHC16-induced GPX2 S-palmitoylation plays a crucial role in modulating lenvatinib resistance and lenvatinib-induced ICD in HCC. Targeting this pathway is a promising approach to improve lenvatinib's antitumor activity.

PMID 42497564
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