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Factor VIII (HemoRel)

✓ Approved

Reliance Life Sciences Private Limited · F8 · Cell-based Therapies

What is Factor VIII?

Factor VIII is a cell-based therapies developed by Reliance Life Sciences Private Limited. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesHemoRel
CompanyReliance Life Sciences Private Limited
Drug ClassCell-based Therapies
Molecular TargetF8
RouteInjectable (Others), Intravenous (IV)
StatusApproved

Mechanism of Action

Molecular Targets

Factor VIII acts on 1 molecular target:

F8coagulation factor VIII (AHF, FVIII)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIII is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

Related Research Articles

PubMedAssessment2026-09-19

Evidence of Strong Overlap Between Perceived Stress Scale and Neuroticism Item Structure in Two Samples.

Vrshek-Schallhorn Suzanne S, Cole Elli E, Corneau Gail G, Meneses Christopher C et al.

Life stress is central to models of psychopathology, and traditions have focused on either assessing stress exposure-what occurs in the environment-or stress responding-the person's multimodal reaction to the exposure, including stress perception. The Perceived Stress Scale (PSS) is the most widely used measure of stress perception in psychopathology and health research; although it was intended to measure appraisals of transient stressors, it is often used as a stand-in for stress exposure. However, the PSS may inadvertently measure a general neuroticism factor (i.e. a stable tendency to experience negative emotion) rather than capture environmental conditions or situational appraisals. Therefore, we investigated the structural relationships between perceived stress and neuroticism in two samples. In secondary analyses of samples randomly split into two equal halves, we conducted exploratory factor analyses of perceived stress and neuroticism, followed by confirmatory factor analyses. The results suggest a substantially common structure characterized by a shared overwhelmed factor plus smaller specific factors for low self-efficacy (entirely derived from perceived stress) and self-dislike (derived from neuroticism). The PSS was also correlated more with neuroticism than with stress exposure in a subsample. Researchers using the PSS should consider that the measure may largely capture trait neuroticism and poor self-efficacy.

PubMedBMC psychology2026-09-19

Measuring body checking and avoidance in adolescents: validation of a behavioral questionnaire.

Beer Clara Sophie CS, Zillmer Stephan S, Drießnack Nelly N, Jaite Charlotte C et al.

Body image distortion (BID) is central to eating disorder (ED) pathology and is closely linked to body dissatisfaction. While most questionnaires assess affective, cognitive, or perceptual components of body image, the behavioral component manifesting in body checking (BC) and body avoidance (BA) has received comparatively little attention. Given that EDs typically emerge during adolescence, validated measures of behavioral BID are particularly needed for this age group. The Body Checking and Avoidance Questionnaire (BCAQ) is the only instrument assessing both BC and BA, but it has not yet been validated in adolescents. The present study aimed to evaluate the BCAQ in a clinical sample of female German adolescents with (atypical) anorexia nervosa. Factor structure, internal consistency, and convergent and known-groups validity were examined. An initial confirmatory factor analysis of the original 27-item BCAQ indicated poor model fit. An exploratory factor analysis identified four items with low or inconsistent loadings. Analyses of the resulting 23-item version yielded a preliminary three-factor structure and demonstrated good reliability (Cronbach's α = 0.78-0.94) and satisfactory convergent validity, while known-groups comparisons provided limited and exploratory evidence, with a small group difference observed only for avoidance behavior. These findings provide preliminary evidence for the use of the adapted 23-item BCAQ to assess behavioral aspects of body image distortion in adolescents with (atypical) anorexia nervosa. Further longitudinal research is needed to evaluate the measure's temporal stability.

PubMedGut pathogens2026-09-19

Retraction Note: Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor‑1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses.

Morgan Radwa N RN, Saleh Sarra E SE, Farrag Hala A HA, Aboulwafa Mohammad M MM

PubMedMedicine2026-09-19

Association between pericoronary CT fat attenuation index and coronary artery spasm.

Yu Chen C, Sheng Zhen-Qiang ZQ, Li Lei L, Zhou Shao-Ming SM et al.

Fat attenuation index (FAI) is currently used in research on coronary atherosclerotic heart disease, but there are no reports on FAI applications in coronary artery spasm (CAS). In this study, we explored the association between pericoronary FAI and CAS. Patients who had chest pain and stenosis < 50% in major coronary branches, as indicated by coronary CT angiography (CCTA) at our hospital from January 2022 to June 2023 were included. According to the diagnostic criteria for vasospastic angina published by the Japanese Circulation Society in 2013, patients confirmed to have CAS were assigned to a CAS group, while those who were not consistent with CAS and had a negative treadmill test were assigned to a control group. Pericoronary FAI and circulating inflammatory factor levels were measured at enrollment. Count data were analyzed using the χ2 test, measurement data using the t-test or nonparametric test, and CAS-related risk factors using multivariate logistic regression. There were 230 patients in the CAS group and 112 patients in the control group. The pericoronary FAI and smoking rate were significantly lower in the control group than in the CAS group (P < .05), but there were no significant differences in other data, including general clinical data, medication use, and circulating inflammatory factor levels (all P > .05). Univariate analysis exhibited that the CAS-related risk factors included smoking, diabetes, high-density lipoprotein cholesterol, and pericoronary FAI. Multivariate logistic regression indicated that smoking and FAI around the left anterior descending branch were significantly associated with CAS. Elevated pericoronary FAI is an independent risk factor for CAS. Local coronary inflammation plays a dominant role in CAS, while circulating inflammatory factor levels seem not to be associated with CAS.

PubMedSports medicine - open2026-09-19

Effects of Strength Training on Cognitive Function, Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 in Highly-Trained Young Female Soccer Players.

Bousselmi Mariem M, Zouhal Hassane H, Darragi Manel M, Karamti Houssem M HM et al.

Female soccer continues to gain global popularity. Selected components of physical fitness (e.g., muscle power, change-of-direction [CoD] speed) and cognitive function (e.g., attentional demand, training-induced) play an important role in soccer performance and should, therefore, be systematically developed. In this study, we examined the effects of 12 weeks of strength training (ST) on selected measures of physical fitness, soccer performance, cognitive function, and selected markers of neuroplasticity in young female soccer players. Twenty-two highly-trained female soccer players with Tier 3 training and performance caliber aged 14.9±0.8 years were randomly assigned to a strength training group (SG: n = 11) or an active control group (CG: n = 11). During the training period, SG performed two weekly upper and lower body ST sessions (3 sets, 12 repetitions per set) at an intensity of 60-80% of the one-repetition-maximum (1-RM) and three soccer-specific training sessions (tactical-technical drills). Players from CG continued their regular soccer-specific training routine consisting of five weekly sessions. Training volumes were similar between groups. Pre- and post-training tests were conducted for the assessment of body composition (e.g., body mass, skinfold site measurements), muscle strength (1-RM bench press/Lat pull-down/leg press),the Loughborough Soccer Passing Test (LSPT), cognitive function (Stroop test), and selected markers of blood neurotrophins, such as basal brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) serum concentrations. The following findings from post hoc analyses are based on significant (p <.05) group-by-time interactions. Post hoc analyses revealed ST-related increases in muscle strength for 1-RM bench press (p <0.001; ηp2=0.41), lat pull-down (p <0.001; ηp2=0.43), and leg press (p <0.001; ηp2=0.36) and improvements in soccer-specific performance for the LSPT in the SG (p =0.007; ηp2=0.22). Post hoc tests indicated improved cognitive function (Stroop test) in the SG (p <0.001; ηp2=0.56) but not in the CG. There were no significant group-by-time interactions for neuroplasticity markers, such as BDNF and IGF-1 basal serum concentrations (p>0.05; ηp2=0.00-0.04). A 12-week in-season ST program with two weekly sessions improved measures of physical fitness, soccer-specific performance, and cognitive function but not biomarkers of neuroplasticity in young highly-trained female soccer players. Accordingly, we recommend ST should be implemented to improve physical fitness and cognitive function of young female soccer athletes.

PubMedOncogene2026-09-19

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis.

Xu Yaping Y, Han Xinyan X, Li Junming J, Zhang Shirong S et al.

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcription factor activity by directly binding chromatin, thereby suppressing lung tumorigenesis. Hi-C analyses of human lung tumors identify SMAD4 as a potential regulator of 3D genome integrity. Using PTEN-deficient human bronchial epithelial cells and genetically engineered mouse models, we showed that SMAD4 loss induced widespread reorganization of chromatin compartments, topologically associating domain (TAD) boundaries, and chromatin loops, leading to oncogenic transcriptional rewiring during early tumorigenesis. Mechanistically, SMAD4 directly bound chromatin loops and spatially connected gene promoters with active or repressive regulatory elements to control transcription. Upon SMAD4 ablation, enhancer-promoter rewiring dysregulated critical oncogenic drivers, including ELF3. Functional manipulation of an SMAD4-regulated ELF3-associated chromatin loop altered ELF3 expression and cell survival both in vitro and in vivo. Collectively, our findings establish SMAD4 as a direct regulator of 3D genome architecture through classical transcription factor binding to chromatin loops and reveal enhancer-promoter rewiring as a key mechanism driving lung tumorigenesis and a potential therapeutic vulnerability in SMAD4-deficient lung cancer.

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