Drug Database
ST

Sterile Talc Powder (Sterile Talc Powder / Sterile Talc Powder)

✓ Approved

Bryan Corporation · Small Molecule · Small Molecule

What is Sterile Talc Powder?

Sterile Talc Powder is a small molecule developed by Bryan Corporation. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesSterile Talc Powder, Sterile Talc Powder
CompanyBryan Corporation
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Bryan Corporation

Therapeutic Indications

Sterile Talc Powder is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersMalignant pleural effusion✓ Approved

Related Research Articles

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Linolenic acid compound powder improves reproductive damage induced by high fat diet in male rats].

Wang Yibo Y, Sun Ruijie R, Ji Linpu L, Liu Qiaorui Q et al.

Objective To evaluate the effect of linolenic acid compound powder (flaxseed microcapsule powder, okra powder, mulberry leaf powder) on the reproductive function of male rats induced by high fat diet. Methods Ninety 8-week-old male SD rats were randomly divided into six groups, with 15 rats in each group. The rats in the blank group were fed with normal diet. While the rats in model group were fed with high-fat feed, and the low-, medium- and high-dose groups of linolenic acid combined powder were fed with low-, medium- and high-dose respectively, as well as the simvastatin positive control group. After 4 weeks of high-fat diet modeling, the compound powder was continuously administered by gavage for 4 weeks. The body weight, epididymis and testis weight of rats in each group were recorded. Sperm concentration and motility were detected. HE staining was used to observe testicular pathological damage, and Oil Red O staining was used to observe fat distribution. Lipid, oxidative stress and sex hormone indicators were also detected. Results Compared with the model group, treatment with the linolenic acid mixture or the positive control drug significantly increased body weight in rats to levels exceeding those in the blank control group (all P<0.05). There were no statistically significant differences in the testicular and epididymal coefficients parameters across the three experimental groups (P>0.05). Sperm motility and Sperm viability was significantly higher in all linolenic acid complex powder dose groups and the positive control group compared to the model group (all P<0.05). Compared with the model group, the testis interstitium of the linolenic acid compound powder groups returned to normal. The seminiferous tubules returned to order. The number of spermatogenic cells and Sertoli cells at all levels increased. All kinds of cells were dense and the structure was complete. Compared with the model group, the testicular tissue of the linolenic acid compound powder groups had less stained area and lighter color, and the medium-dose group had less stained area and lighter color than the low-dose group and the high-dose group. There was no significant difference in oxidative stress among groups (P>0.05). The level of LH in the model group was lower than that in the blank group. Which increased in the linolenic acid compound powder groups significantly (P<0.05). Administration of linolenic acid compound powder all doses and the positive control significantly decreased the levels of ALP, ALT and AST in liver tissue compared with the model group. Additionally, a significant reduction in serum CRE was observed in the low- and medium-dose groups (all P<0.05). Conclusion A high-fat diet leads to a decline in the physiological structure and antioxidant capacity of the testes in rats, as well as changes in sex hormone levels. Linoleic acid complex powder can improve the related symptoms and indicators of reproductive function in rats with high-fat diet.

PMID 43012198
Read full article →
PubMedJournal of education & teaching in emergency medicine2026-11-11

How to Place a Central Line: Preparing Your Kit & Performing the Procedure.

San Miguel Christopher C, Miller Krystin N KN, Close Alexander A, Yee Jennifer J

Senior Medical Students and Interns. Central venous catheter (CVC) placement is a critical, high-risk procedure, and it is considered a core component of emergency medicine training.1 Iatrogenic complications from improper technique-including arterial dilation, pneumothorax, and line-associated bloodstream infections-can significantly impact patient outcomes.2-7 Therefore, emergency medicine trainees should ideally demonstrate procedural competence and adherence to safety practices before performing CVC insertion in clinical settings. These videos serve as part of a mastery-based curriculum designed to reinforce standardized, evidence-based techniques and institutional safety protocols for internal jugular CVC placement.8 The procedural preparation video focuses on sterile technique, ultrasound setup, and CVC kit preparation, and the procedural performance video focuses on sterile technique, the leapfrog technique for ultrasound-guided needle cannulation, and the safe insertion of the central venous catheter. By the end of these videos, learners will be able to:Identify and gather all necessary materials for internal jugular (IJ) CVC placement.Describe the appropriate positioning of the patient, ultrasound machine, and proceduralist for CVC placement.List common complications of IJ CVC placement.Demonstrate sterile field preparation, including donning personal protective equipment (PPE), placing a sterile drape, and placement of a sterile ultrasound probe cover.Perform a proper pre-procedural time-out including at least two patient identifiers and site verification.Prepare and organize CVC kit components for efficient procedural flow.Identify key anatomical landmarks and optimal patient positioning for right IJ CVC placement using ultrasound guidance.Demonstrate stepwise needle insertion with real-time ultrasound visualization to safely cannulate the internal jugular vein.Verify proper guidewire placement using both short- and long-axis ultrasound views before vessel dilation.Perform safe dilation and catheter advancement using standard procedural technique.Exhibit best-practice behaviors, including port flushing, line securement, and sterile dressing application.Document the procedure and identify post-placement safety steps such as confirmatory chest imaging. These videos were watched by emergency medicine-bound, fourth-year medical students as asynchronous study material prior to their mastery-based central venous catheter assessment. Students watched these videos, underwent individual pre-test (baseline) assessments using a 58-item checklist, witnessed a faculty member perform a group demonstration, and then performed deliberate observed practice. The previously published, procedure checklist was developed by a multidisciplinary team of experts, and minimum passing standards were determined using the Mastery-Angoff Technique. Efficacy of the videos may be inferred through baseline assessment scores, since students were given access to the videos prior to completing their baseline assessment. Utilizing a quasi-experimental design, these scores were compared to previously published data from the previous 2 years in which students completed the baseline assessment without access to the videos.9. Ten fourth-year emergency medicine-bound medical students participated in a simulation-based mastery learning procedural course in March 2025. As part of their asynchronous preparation, they watched these two instructional videos: 1. Preparation to Place a Central Venous Cather and 2. Placement of a Central Venous Catheter. Learners were individually assessed in a simulation lab using a 58-item checklist. Pre-test scores ranged from 17 to 89% correct, with a median score of 67%. Previous cohorts from 2022 and 2023 had scores ranging from 19 to 84% with a median score of 43%. After deliberate practice, first post-test scores improved for participants and ranged from 89 to 98% correct. These educational videos were an effective component of a broader simulation-based mastery learning curriculum for central venous catheter placement. These videos provided a standardized introduction to both general and institution-specific patient safety practices related to CVC kit setup and CVC insertion. Although video views were not tracked, learners demonstrated significant improvement between pre- and post-testing, indicating the combined instructional approach was effective. Compared to previous years' cohorts, the students who had access to the instructional videos scored better on the baseline assessment, though the small number of participants kept this difference from reaching statistical significance. The videos also allowed students to engage with the material at their own pace, reinforcing safety principles and procedural preparation in a consistent and accessible way. Procedural Education, Central Venous Catheter, Emergency Medicine.

PMID 43011608
Read full article →
PubMedClinical case reports2026-11-11

False-Positive Elevation of Serum Levels of Human Chorionic Gonadotropin (hCG) Evoked by Dietary Supplements in a Patient With Testicular Seminoma-A Case Report.

Dieckmann Klaus-Peter KP, Angerer Markus M, Schnabel Claudia C, Wülfing Christian C

A 26-year-old patient developed false-positive elevation of human chorionic gonadotropin (hCG) serum levels 2 years after cure from testicular seminoma. The increased levels normalized without any intervention after cessation of oral intake of dietary supplements consisting of creatine, multivitamin pills, and amino acid powder.

PMID 43011507
Read full article →
PubMedGlobal spine journal2026-11-11

Intrawound Vancomycin Powder in Posterior Lumbar Fusion: In Vitro Osteoblast Effects and Clinical Outcomes in a Historical-Control Cohort.

Truumees Heili H, Friedman Lindley I N LIN, Schmirler Joshua J, Sinclair Sarina S et al.

Study DesignRetrospective analysis.ObjectivesTo analyze the immediate post-operative effects on osteoblast activity, and long-term impact on bone healing, of intrawound vancomycin powder following posterior lumbar fusion (PLF).MethodsThis study had two phases: (1) an in vitro analysis of vancomycin effects on osteoblasts and (2) a retrospective chart review-spanning over a decade-analyzing outcomes of vancomycin use in PLF patients. Cellular metabolic and osteogenic activities were evaluated using well-established in vitro assays. The retrospective chart review included patients ages 18+ who underwent PLF (four levels or fewer) between January 2007-December 2015. Patients were divided into two groups: the pre-vancomycin group (PVG) and the vancomycin group (VG). Statistical analyses included descriptive and comparative analyses across groups.ResultsPhase One included 56 patients. Drain vancomycin concentrations peaked at POD 0, averaging 1253.67 ng/µL. Osteoblasts exposed to vancomycin concentrations of 1,250 ng/µL had significantly lower ALP activity compared to those exposed to 0, 245, 285, and 500 ng/µL (ps<0.05). Phase Two included 425 patients: 232 in the PVG and 193 in the VG. SSIs requiring debridement were observed in 3.02% of PVG patients compared to 2.07% of VG patients (p=0.761). There were no differences in pseudoarthrosis across cohorts (p=0.886), but lucency was more common in the VG (25.39%) than the PVG (11.64%; p<0.001).ConclusionsLocal drain concentrations of vancomycin decreased significantly across the postoperative period, suggesting its effects on osteoblasts are limited to the early inflammatory phase. In the long-term, intrawound vancomycin may not impact risk of SSI or pseudoarthrosis.

PMID 43012129
Read full article →
PubMedAngewandte Chemie (International ed. in English)2026-11-11

A 68Ga-Substituted Keggin Phosphotungstate as an Intrinsically Radiolabeled Inorganic PET Tracer for Cell Tracking.

Duvanova Ella E, Rieger Joshua J, Bamminger Karsten K, Gumerova Nadiia I NI et al.

Polyoxometalates (POMs) offer unique physicochemical properties for radiopharmaceutical design, yet their integration with clinically relevant radionuclides remains largely unexplored. Here we report the isolation and comprehensive solid-state and solution characterization of the gallium-substituted Keggin phosphotungstate cesium salt, Cs4[Ga(H2O)PW11O39]·8H2O (CsGaPW11), including single-crystal and powder X-ray diffraction, multinuclear NMR (31P, 71Ga, 183W), IR spectroscopy, ESI-MS, elemental analysis, and TGA. The radiolabeled analogue Cs68GaPW11 (45-55 MBq, >96% radiochemical purity) was synthesized in under 60 min, dictated by the 68 min half-life of 68Ga, and retained full structural integrity after radioactive decay. In CHO-K1 cells, Cs68GaPW11 shows higher cellular uptake than 68GaCl3 and 68Ga-oxine, with radioactivity progressively shifting from the cell membrane to the intracellular compartment over 60 min. Together with low cytotoxicity (>90% viability at 100 µM), these findings identify the membrane-permeable Keggin anion as a viable inorganic platform for PET cell tracking.

PMID 43012513
Read full article →
PubMedAMB Express2026-11-11

Characterization of a carbaryl-degrading strain Serratia marcescens A4 and its application in trickle bed reactor.

Xu Yan Y, Wang Xingjie X, Hu Kaidi K, Li Jianlong J et al.

The presence of carbaryl in the environment and agricultural products poses uncertain risks to both ecosystems and human health. In the present study, a carbaryl-degrading Serratia marcescens strain A4 was isolated from orchard soil, demonstrating a degradation rate of 83.16% (50 mg L- 1) after 108 h of incubation. Results from batch degradation experiments indicated that the carbaryl degradation rate was positively correlated with microbial biomass, and the strain exhibited a degree of resistance to environmental disturbances. Additionally, it displayed versatility in degrading various insecticides, including pyrethroids, carbamates, and organophosphate pesticides, showing potential for real-world applications. High-performance liquid chromatography and gas chromatography-mass spectrometry analyses revealed that the organism degrades carbaryl by hydrolyzing it to 1-naphthol, which is further metabolized. To treat carbaryl-contaminated water, a trickle bed reactor was constructed by immobilizing strain A4 in calcium alginate. Under non‑sterile sequencing batch operation, carbaryl removal peaked at 43.25%, and a removal rate above 20% was sustained for six consecutive batches. Adsorption by the carrier contributed significantly to pesticide removal, accounting for 74.76% of the experimental group's total removal. Although further work is required to improve reactor performance, this study highlights the potential of S. marcescens A4 and demonstrates the feasibility of bacterial treatment for pesticide-contaminated environments.

PMID 43009716
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about Sterile Talc Powder