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clindamycin phosphate (Clindesse / Clindesse)

✓ Approved

Lumara Health · Small Molecule · Small Molecule

What is clindamycin phosphate?

clindamycin phosphate is a small molecule developed by Lumara Health. It is approved for therapeutic indications via intravaginal.

Drug Profile

Brand NamesClindesse, Clindesse
CompanyLumara Health
Drug ClassSmall Molecule
RouteIntravaginal
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

clindamycin phosphate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsGynaecological chlamydia infection✓ Approved

Related Research Articles

PubMedMedical physics2026-11-11

Spectrometric characterization of x-ray attenuation in silicone-gel and saline breast implants under mammography and CT conditions.

Lefèvre Jérémie J, Kerfa Jade J, Bony Mathis M, Plagnard Johann J et al.

Breast implants alter x-ray beam attenuation, but quantitative energy-resolved data for commercial prostheses are largely missing from the literature. Current dosimetric protocols lack specific correction factors for implant materials. To measure the x-ray attenuation properties of silicone-gel (PDMS) and saline breast implants under mammography and computed tomography (CT) conditions. We performed transmission spectrometry on six breast implants (three PDMS, three saline-filled) from a single manufacturer, using a cadmium telluride (CdTe) detector in narrow-beam geometry. Energy-dependent linear attenuation coefficients, effective attenuation coefficients ( μ eff ), half-value layers, and bulk densities were determined for mammography (25-49 kV) and CT (80-120 kV) beam qualities. Combined uncertainties were 3%-5%. Under mammographic conditions, PDMS attenuates more than saline: μ eff values are roughly 1.5-2 times higher, because of enhanced photoelectric absorption linked to a higher effective atomic number ( Z eff = 11.7 vs. 7.5). Saline implants behave much like water and soft breast tissues. The monoenergetic attenuation curves of the two materials converge above ∼ 60 keV as Compton scattering comes to dominate, but the spectrum-weighted effective attenuation still differs by ∼ 40% at a representative 80 kV Al CT tube potential (0.48 vs. 0.34  cm - 1 ), narrowing to ∼ 10% only with harder filtration and higher tube potential combined (120 kV AlCu). We provide log-log polynomial fits suitable for dosimetric codes. These measurements supply energy-resolved attenuation data for silicone-gel and saline implants across the diagnostic range. PDMS and saline differ substantially at mammographic energies. Their monoenergetic attenuation converges in the Compton regime, but spectrum-weighted differences persist at 80 kV and should be accounted for in breast CT dosimetry. The results are consistent with recent phantom findings on AEC response and dose variations in the presence of silicone implants.

PMID 43010868
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PubMedAnalytical chemistry2026-11-11

Multi-Collector Extreme Ultraviolet Laser Mass Spectrometry (MC-EUV-MS): Using High-Energy Photoionization for High-Spatial-Resolution Isotope Ratio Mapping of Actinide Materials.

Rush Lydia A LA, Coble Matthew A MA, Menoni Carmen S CS, Duffin Andrew M AM

Isotope maps are typically collected with a multi-collector mass spectrometer (MC-MS) coupled to a high-spatial-resolution ionization source, yet few ionization sources compatible with MC-MS systems can operate robustly at the submicron scale. To meet this need, we couple an extreme ultraviolet (EUV) laser photon-based ionization source to a modified Thermo Scientific NeptunePlus MC-MS by removing and replacing the inductively coupled plasma (ICP) with the EUV laser system, herein called the MC-EUV-MS. The 46.9 nm EUV laser light is focused to sub-micrometer spots for sample ablation while simultaneously realizing high-energy photoionization using 26.4 eV photons. Thus, the EUV probe combines ablation and ionization in a single pulse. We characterize the newly built MC-EUV-MS by analyzing different actinide-bearing materials. We achieve a sample utilization efficiency (SUE) of 0.006% for 238U using the NIST 610 and 612 glasses at a low +2 kV extraction voltage for accelerating ions off the sample. Higher extraction voltages up to +5 kV point to increased ion yields. We measure 235U/238U isotope ratios from three uranium samples ranging from natural to low enriched. We demonstrate the high spatial resolution of the MC-EUV-MS by mapping uranium oxide microparticles using 500 nm ablation spots. Compared to isotope maps collected over the same sample area using large geometry secondary ion mass spectrometry, the MC-EUV-MS shows significantly higher spatial resolution within the scope of this study.

PMID 43010541
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PubMedRadiological physics and technology2026-11-11

Monte Carlo-based three-dimensional dose evaluation for rotational cerebral angiography: peak dose to brain and skin and Dose-Volume Histogram (DVH) analysis of the brain.

Miyazaki Hitoshi H, Fujibuchi Toshioh T, Han Donghee D, Oura Koji K et al.

Rotational cerebral angiography produces complex, nonuniform dose distributions; the mean brain dose may not sufficiently represent localized high-dose regions. This study aimed to visualize three-dimensional dose distributions in the brain and skin using PHITS, estimate peak brain dose (PBD) and peak skin dose (PSD), and evaluate the brain dose distribution using dose-volume histogram (DVH) analysis. X-ray spectra for 3D digital subtraction angiography (3D-DSA, 70 kV) and cone-beam computed tomography (CBCT, 109 kV) were generated using SpekPy and implemented in PHITS. A rotational irradiation model covering approximately 200° was constructed using a multisource approach based on projection-dependent tube current-time product values. The model was validated using a PMMA phantom. Three-dimensional dose distributions were calculated using the adult male mesh-type reference computational phantom; PBD, PSD, and brain DVH indices were evaluated. Calculated doses agreed with measured values within 5.2%. Dose concentrations were mainly observed in the occipital region. The PBD and PSD were 25.1 and 44.1 mGy for 3D-DSA and 101.3 and 139.1 mGy for CBCT, respectively. The PBD was 3.3 times higher than the mean brain dose for 3D-DSA and 2.3 times higher for CBCT. DVH analysis showed that CBCT shifted the brain-dose distribution toward higher-dose regions, with D10% values of 14.9 and 70.0 mGy for 3D-DSA and CBCT, respectively. PHITS-based three-dimensional dose evaluation allowed localized high-dose regions in the brain and skin to be visualized and quantified. DVH analysis complemented the peak dose assessment by providing volumetric information on the brain-dose distribution.

PMID 43009699
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PubMedAngewandte Chemie (International ed. in English)2026-11-11

Structural Evolution and Oxygen Evolution Performance of NiFe-Based Electrocatalysts in Phosphate-Containing Electrolytes at Non-Extreme pH.

Komiya Hiroki H, Obata Keisuke K, Jang Joonbaek J, Lasagna Samuele S et al.

Solid/liquid interfacial interactions play an important role in electrochemical reactions when supporting electrolyte components, such as buffer anions, interact directly with catalyst surfaces. Here, we show that phosphate addition selectively suppresses the oxygen evolution reaction (OER) performance of Ni-rich NiFeOx electrocatalysts at pH ∼9. Operando Raman spectroscopy and Ni K-edge X-ray absorption near-edge structure/extended X-ray absorption fine structure (XANES/EXAFS) analyses suggest that phosphate decreases a high-potential γ-NiOOH-like state and attenuates the associated Ni-centered structural response. No Fe K-edge change larger than the experimental uncertainty was resolved during OER. The current and redox response recovered immediately after phosphate was removed, demonstrating a reversible short-term electrolyte effect. In contrast, on-off cycling through the Ni reduction region caused progressive loss of redox charge and catalyst material, particularly for Ni-rich compositions. These findings highlight the importance of integrated electrolyte-electrocatalyst design for improving OER performance and durability, especially under mild pH conditions.

PMID 43012529
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PubMedACS applied materials & interfaces2026-11-11

Phosphate-Functionalized Macroporous Cellulose Sponges for Uranium Recovery from Seawater.

Sekine Yurina Y, Nankawa Takuya T, Sugita Asako A, Konda Miki M et al.

Cellulose-based adsorbents offer a sustainable platform for uranium recovery from seawater, but simple functionalization strategies that enable effective uranium capture under highly competitive marine conditions remain limited. Here, we report a post-phosphorylation strategy for introducing uranium-binding functionality into a preformed freeze-crosslinked carboxymethyl cellulose nanofiber (CMCF) sponge while retaining its interconnected macroporous architecture. Impregnation of the cellulose sponge with NH4H2PO4/urea followed by mild thermal treatment at 120 °C introduced up to 114 ± 18 mg P g-1 sponge. In seawater spiked with 10 mg L-1 U(VI), both nonphosphorylated and phosphorylated CMCF sponges showed similarly high U removal (>96%), largely obscuring the effect of phosphate functionalization. In contrast, a pronounced phosphate-dependent enhancement emerged under realistic seawater conditions: the nonphosphorylated sponge showed negligible U removal from natural seawater, whereas the post-phosphorylated P1-CMCF sponge achieved approximately 99% U removal within 24 h. SEM-EDX and XPS analyses further supported uranium accumulation at phosphate-rich cellulose interfaces and the involvement of phosphate-associated oxygen donor sites in U binding. The captured uranium was nearly quantitatively recovered using 0.1 mol L-1 NaHCO3, and adsorption performance was maintained over three adsorption-desorption cycles. These results demonstrate that simple post-phosphorylation of a preformed macroporous cellulose scaffold provides accessible uranium-binding interfaces while preserving the underlying transport architecture, offering a straightforward route to efficient and regenerable uranium recovery under chemically complex seawater conditions.

PMID 43012362
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PubMedIndian journal of dermatology2026-11-11

A Rare Case of Coexistent Hidradenitis Suppurativa, Steatocystoma Multiplex with Dorsal Aquagenic Keratoderma: The Elephant in the Room Regarding a 'Follicular Occlusion Pentad'.

De Sagnik S, Mohan Atul A, Singh Satyendra Kumar SK

Steatocystoma multiplex is characterised by skin-coloured papules and nodules over various parts of body. Hidradenitis suppurativa is a chronic inflammatory disorder characterised by nodules, discharging sinuses and scarring. Aquagenic keratoderma is characterised by thickened skin of palms and soles with white translucent papules which increases on water exposure. A 28-year-old male presented with progressively increasing asymptomatic yellowish papules and nodules without punctum or discharge over his face for 10 years. He also developed recurrent painful nodules with discharging sinuses and puckering of skin over bilateral axillae, groin, trunk, and buttocks for the last 2 years, with thickening of skin over the dorsal aspect of bilateral hands and feet for 1 year, which got accentuated on water exposure. Skin biopsies were done from lesions over the face, axillae, and hands, and histopathology findings were consistent with steatocystoma, hidradenitis suppurativa, and keratoderma, respectively. The patient was started on oral isotretinoin 0.5 mg/kg daily, topical clindamycin twice daily over axillae and urea-based emollient twice daily over hands and feet. There was complete resolution in nodules and sinuses and mild improvement in steatocystoma and keratoderma lesions after 6 months. We present this case due to the rarity of coexistence of the three conditions in a single patient, the unusual location of steatocystoma and aquagenic keratoderma, and possibly a new impending follicular occlusion pentad considering the addition of steatocystoma to the existing tetrad.

PMID 43011598
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