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creatinol-O-phosphate (Aplodan)

✓ Approved

AstraZeneca UK Limited · Small Molecule · Small Molecule

What is creatinol-O-phosphate?

creatinol-O-phosphate is a small molecule developed by AstraZeneca UK Limited. It is approved for therapeutic indications.

Drug Profile

Brand NamesAplodan
CompanyAstraZeneca UK Limited
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, AstraZeneca UK Limited

Therapeutic Indications

creatinol-O-phosphate is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersCachexia✓ Approved
Cardiac disordersDilated cardiomyopathy✓ Approved

Related Research Articles

PubMedAngewandte Chemie (International ed. in English)2026-11-11

Structural Evolution and Oxygen Evolution Performance of NiFe-Based Electrocatalysts in Phosphate-Containing Electrolytes at Non-Extreme pH.

Komiya Hiroki H, Obata Keisuke K, Jang Joonbaek J, Lasagna Samuele S et al.

Solid/liquid interfacial interactions play an important role in electrochemical reactions when supporting electrolyte components, such as buffer anions, interact directly with catalyst surfaces. Here, we show that phosphate addition selectively suppresses the oxygen evolution reaction (OER) performance of Ni-rich NiFeOx electrocatalysts at pH ∼9. Operando Raman spectroscopy and Ni K-edge X-ray absorption near-edge structure/extended X-ray absorption fine structure (XANES/EXAFS) analyses suggest that phosphate decreases a high-potential γ-NiOOH-like state and attenuates the associated Ni-centered structural response. No Fe K-edge change larger than the experimental uncertainty was resolved during OER. The current and redox response recovered immediately after phosphate was removed, demonstrating a reversible short-term electrolyte effect. In contrast, on-off cycling through the Ni reduction region caused progressive loss of redox charge and catalyst material, particularly for Ni-rich compositions. These findings highlight the importance of integrated electrolyte-electrocatalyst design for improving OER performance and durability, especially under mild pH conditions.

PMID 43012529
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PubMedACS applied materials & interfaces2026-11-11

Phosphate-Functionalized Macroporous Cellulose Sponges for Uranium Recovery from Seawater.

Sekine Yurina Y, Nankawa Takuya T, Sugita Asako A, Konda Miki M et al.

Cellulose-based adsorbents offer a sustainable platform for uranium recovery from seawater, but simple functionalization strategies that enable effective uranium capture under highly competitive marine conditions remain limited. Here, we report a post-phosphorylation strategy for introducing uranium-binding functionality into a preformed freeze-crosslinked carboxymethyl cellulose nanofiber (CMCF) sponge while retaining its interconnected macroporous architecture. Impregnation of the cellulose sponge with NH4H2PO4/urea followed by mild thermal treatment at 120 °C introduced up to 114 ± 18 mg P g-1 sponge. In seawater spiked with 10 mg L-1 U(VI), both nonphosphorylated and phosphorylated CMCF sponges showed similarly high U removal (>96%), largely obscuring the effect of phosphate functionalization. In contrast, a pronounced phosphate-dependent enhancement emerged under realistic seawater conditions: the nonphosphorylated sponge showed negligible U removal from natural seawater, whereas the post-phosphorylated P1-CMCF sponge achieved approximately 99% U removal within 24 h. SEM-EDX and XPS analyses further supported uranium accumulation at phosphate-rich cellulose interfaces and the involvement of phosphate-associated oxygen donor sites in U binding. The captured uranium was nearly quantitatively recovered using 0.1 mol L-1 NaHCO3, and adsorption performance was maintained over three adsorption-desorption cycles. These results demonstrate that simple post-phosphorylation of a preformed macroporous cellulose scaffold provides accessible uranium-binding interfaces while preserving the underlying transport architecture, offering a straightforward route to efficient and regenerable uranium recovery under chemically complex seawater conditions.

PMID 43012362
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PubMedRSC advances2026-11-11

When phosphorus takes over: hyperconjugation-driven intramolecular O-H⋯O[double bond, length as m-dash]P hydrogen bonds beyond classical RAHB.

Pietrzak Anna A, Nowak Przemysław P, Capelli Silvia C SC, Dudek Marta K MK et al.

Intramolecular hydrogen bonds embedded in conjugated frameworks are commonly rationalized within the resonance-assisted hydrogen bonding (RAHB) paradigm, in which π-electron delocalization cooperatively strengthens the O-H⋯O interaction. Here, we demonstrate that RAHB-like geometries can arise from a fundamentally different electronic mechanism. A family of phosphorylated hydroquinolinols featuring rare intramolecular O-H⋯O[double bond, length as m-dash]P hydrogen bonds was investigated using single-crystal X-ray and neutron diffraction, NBO analysis, and solution-state NMR and IR spectroscopy. Although the hydrogen-bond-closed quasi-rings display structural signatures reminiscent of classical RAHB systems, bond-length equalization is limited and exhibits only minor variation across the investigated substitution series. Electronic structure analysis reveals that the phosphoryl group acts as a σ-resonance and negative-hyperconjugation-dominated hydrogen-bond acceptor, indicating that classical cooperative π-resonance is not the dominant factor governing hydrogen-bond strength within the investigated series. As a result, these O-H⋯O[double bond, length as m-dash]P interactions are strong, persistent in solution, and exhibit only limited sensitivity to the structural modifications examined in the present series. These findings establish phosphoryl-centered intramolecular hydrogen bonds as a distinct electronic regime beyond classical RAHB and extend the concept of resonance assistance to heteronuclear, hyperconjugation-dominated frameworks.

PMID 43011468
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PubMedThe Journal of physiology2026-11-11

Increased inspiratory work exacerbates skin hypoperfusion and attenuates the pressor response during high-intensity exercise in the heat.

Koike Jun J, Fujii Naoto N

During exercise in the heat, skin vasodilatation occurs as heat loss response. Increased respiratory muscle work by inspiratory loading during high-intensity exercise causes vasoconstriction in active skeletal muscles without altering arterial blood pressure. We hypothesized that, during high-intensity exercise in the heat, inspiratory loading would induce skin vasoconstriction and thus reduce skin blood flow to maintain the pressor response associated with high-intensity exercise. Fifteen healthy young men cycled in the heat (35°C, 50% relative humidity), consisting of 14 min at 50% peak oxygen uptake ( V . O 2 peak ) followed by 3 min at 90%  V . O 2 peak . A 1 min inspiratory loading was applied 10 min into exercise at 50%  V . O 2 peak and 1 min into exercise at 90%  V . O 2 peak . The protocol without inspiratory loading was performed on a separate day as the control. Upper back skin blood flow was measured using a laser-Doppler flowmeter. Arterial blood pressure was measured using finger photoplethysmography, and skin vascular conductance was calculated as skin blood flow/mean arterial pressure. Skin blood flow decreased, whereas mean arterial pressure increased gradually during exercise at 90%  V . O 2 peak , and these responses were greater and smaller, in the inspiratory load than control (P < 0.003). Skin vascular conductance did not differ between conditions at 90%  V . O 2 peak . At 50%  V . O 2 peak , the inspiratory loading slightly reduced mean arterial pressure but did not modulate skin blood flow or skin vascular conductance. We show that increased respiratory muscle work augments the reduction in skin blood flow, whereas it attenuates the pressor response during high-intensity exercise in the heat, without modulating skin vasoconstriction. KEY POINTS: Skin vasodilatation plays a pivotal role in heat loss during exercise in the heat. Breathing, and thus respiratory muscle work, can be augmented by hyperthermia, ageing and lung or cardiovascular disease. However, whether increased respiratory muscle work influences skin vasodilatation during exercise in the heat remains unknown. Inspiratory loading, which increased the work of breathing, was applied during exercise at 50%  V . O 2 peak and at 90%  V . O 2 peak in the heat. We showed that an inspiratory load reduced skin blood flow and attenuated the increase in mean arterial pressure during exercise at 90%  V . O 2 peak without influencing skin vascular conductance. However, these effects associated with inspiratory loading were not clearly observed during exercise at 50%  V . O 2 peak . Our findings suggest that increased inspiratory muscle work may reduce heat loss associated with increases in skin blood flow and blunted pressor response during high-intensity exercise in the heat.

PMID 43012303
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PubMedJournal of agricultural and food chemistry2026-11-11

Metabonomic Profiling and Gene Expression Analysis Reveal Anthocyanin Biosynthesis Mechanisms Underlying Tissue-Specific Color Variation in Chinese Cabbage (Brassica rapa L. ssp. pekinensis).

Zhao Wenbin W, Xiong Wenqing W, Han Xiaobao X, Yuan Chenran C et al.

Detailed profiles of anthocyanins and their underlying biosynthetic mechanisms in tissues exhibiting distinct purple pigmentation in purple-heading Chinese cabbages remain poorly characterized. Here, we performed an integrated transcriptional and metabolomic analysis of anthocyanin metabolism. A total of 68 anthocyanins were identified, including 34 cyanidin-, 9 delphinidin-, 3 malvidin-, 9 pelargonidin-, 9 peonidin-, and 4 petunidin-derived compounds, along with two procyanidins. Cyanidin-3-O-glucoside (4.285 to 12.799 mg kg-1), delphinidin-3-O-(2‴-O-p-coumaroyl)rutinoside-7-O-glucoside (0.020 to 11.088 mg kg-1), and delphinidin-3-O-sophoroside (0.432 to 14.396 mg kg-1) were predominant anthocyanins. Tissues proximal to the growing point (flower buds, siliques) are clearly separated from those close to underground (rosette leaves, roots). The conjoint and coexpression analysis revealed that BrMYB2, BrMYBL2.1, and BrEGL3.1 might affect the expression of BrPAL4.0, Br4CL4.2, BrCHSs, BrDFR1, BrANS1, BrUFGTs, BrATs, and BrGSTs, thereby modulating anthocyanin biosynthesis; besides, BrPAL3.2, BrCHS5, BrF3'H, BrUGT84A1.1, BrTT2, and BrTT8 also governed the production of procyanidin B2 in siliques.

PMID 43012710
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PubMedArthroscopy techniques2026-11-11

Endoscopically Assisted Periacetabular Osteotomy for Treatment of Hip Dysplasia: The Orthopaedic Total Extraperitoneal Approach.

Öztürk Vedat V, Çelik Malik M, Çağdaşer Salih S, Hürmeydan Önder Murat ÖM et al.

The orthopaedic total extraperitoneal (O-TEP) approach is an endoscopic technique that has recently emerged as an option, particularly for the surgical management of pelvic and acetabular fractures. Unlike conventional orthopaedic endoscopic procedures, O-TEP was developed by adapting the laparoscopic totally extraperitoneal approach, commonly used for inguinal hernia repair, to orthopaedic surgery. In technically demanding procedures such as periacetabular osteotomy (PAO), minimizing soft-tissue dissection and directly visualizing critical neurovascular structures are essential. Owing to its minimally invasive design, the O-TEP PAO technique is intended to limit soft-tissue dissection while enabling direct visualization of key vascular and neural structures at risk. This Technical Note provides a step-by-step description of O-TEP PAO technique for acetabular dysplasia and discusses its feasibility, potential advantages, and key limitations in the context of the current literature on endoscopy-assisted PAO techniques.

PMID 43011239
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