Drug Database
TJ

TJ-23 (TSS)

✓ Approved

Tsumura · ESR1

What is TJ-23?

TJ-23 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTSS
CompanyTsumura
Molecular TargetESR1
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

TJ-23 acts on 1 molecular target:

ESR1estrogen receptor 1 (ER, ESR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

TJ-23 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Reproductive system and breast disordersInfertility female✓ Approved

Related Research Articles

PubMedJournal of agricultural and food chemistry2026-11-11

Discovery of Structurally Unusual and Diverse Indole Diterpenoids with Antisteatotic Activity from the Endophytic Fungus Penicillium Paxilli BM-6.

Li Lei L, Fan Run-Zhu RZ, Xu Xin-Xiang XX, Deng Hao-Kang HK et al.

Small molecule accurate recognition technology (SMART)-guided isolation of the endophytic fungus Penicillium paxilli BM-6 afforded 36 indole diterpenoids (IDTs) including eight new ones (1-8). Their structures were elucidated by HRMS and NMR data, DP4+ probability analysis based on calculated NMR chemical shifts, ECD calculations, and X-ray crystallography. Penipaxiline A (1) features an unprecedented 6/5/5/6/7/4 hexacyclic skeleton derived from the paspaline framework, representing a new carbon skeleton in the IDT family. Paxillindole A (2) possesses an unusual 10,30-γ-lactone moiety, whose formation introduces an extra five-membered ring, resulting in a novel 6/5/5/6/6/6/5 heptacyclic system. Antisteatotic activity screening identified 12 active compounds surpassing resmetirom, with compound 23 showing the highest inhibition rate (90.4% at 50 μM). Mechanistically, 23 reduced lipid accumulation by inhibiting lipogenesis and promoting fatty acid oxidation. These findings uncover a new pharmacological application of IDTs for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD).

PubMedBMC pediatrics2026-11-11

Mothers' perspectives on children's nutrition and oral health: a qualitative study with descriptive anthropometric characteristics.

Güney Hilal Doğan HD, Göbel Pınar P

This qualitative study explored mothers' knowledge, attitudes, and experiences concerning their children's nutrition and oral health. Semi-structured interviews were conducted with 23 mothers who attended the Family Dentistry Department in Karabük. A semi-structured interview guide addressed nutrition and oral and dental health. Maternal and child anthropometric measurements and demographic characteristics were collected to describe the study sample and were not treated as a separate quantitative component. The children's mean body weight was 25.4 ± 2.45 kg and their mean height was 129.5 ± 3.00 cm; 56.5% were within the normal BMI-for-age range. The mothers' mean body weight was 67.5 ± 6.50 kg and their mean height was 161.6 ± 5.8 cm; 56.5% had a BMI within the normal range and 30.4% were overweight. Twenty-two of the 23 children (95.7%) had their own toothbrush, and 73.9% brushed their teeth several times a day. Three themes were identified: changes across generations; maternal knowledge, attitudes, and practices; and access to products and services and related barriers. Mothers described knowledge of healthy nutrition and oral health practices but also reported difficulty applying this knowledge in daily life. In this single-centre sample, mothers described a gap between their knowledge of healthy nutrition and oral health practices and their ability to apply that knowledge. Reported barriers included the availability and marketing of unhealthy foods, economic constraints, and difficulties accessing dental services. These findings may inform future research and locally tailored family-support initiatives; they should not be generalized beyond the study context.

PubMedAnalytical chemistry2026-11-11

GRIFFINs and GoBleNs: A Non-Fictional Tool for Identifying Trace Controlled Substance Surrogates in Complex Mixtures.

Holman Aidan P AP, Borak Larissa L, Kurouski Dmitry D

Drug overdose deaths have tripled over the past two decades, and methamphetamine remains the second most frequently identified drug involved in such fatalities. Within the United States, the Drug Enforcement Administration seizes tens of thousands of kg of clandestine powders, tablets, crystals, and liquids that may contain anywhere from 1-100% pure methamphetamine every year. Unfortunately, current portable techniques, such as Raman and infrared spectroscopy, fail to reliably identify methamphetamine and other analogs below ∼23 wt % due to interference from cutting agents. We introduce GRIFFINs, a tool for the gold-enhanced Raman identification for forensic field inspection of narcotics. GRIFFINs uses gold-blended nanoparticles (GoBleNs), a novel cationic, lipophilic-specific, and highly selective surface-enhanced Raman spectroscopic (SERS) substrate for the identification of low amounts (<23 wt %) of chemicals like alkylamines in complex matrices that mimic the components of real clandestine samples. Using machine learning, we trained the model on 10 independent dilution series for each of three controlled substance surrogates (phenylethylamine, serotonin, and dopamine) and three other SERS-responsive cutting agents (lidocaine, benzocaine, and caffeine) before testing at least 85 independent mixtures that mimic real evidence samples. The novel SERS substrate, GoBleNs, was mixed with HPLC-compatible samples before being analyzed with a commercially available, portable Raman spectrometer equipped with 830 nm excitation in less than 1 min. Using extreme gradient boosting discriminant analysis, limits of identification ranged between <0.1 and 0.1 wt % depending on the analyte. This study demonstrates the first application of SERS for improving the portable Raman analysis of trace amphetamine and tryptamine surrogates for seized drug analysis.

PubMedFrontiers in immunology2026-11-11

Th17 suppression strategies: targeting IL-17 and RORγt pathways in autoimmune diseases.

Zian Zeineb Z, Aliyu Mansur M, Hossain Fariha F, Zohora Fatema Tuz FT et al.

T helper 17 (Th17) cells and their key effector cytokine, particularly IL-17A and IL-17F, play central roles in host defense against extracellular pathogens. However, they are also critically involved in the pathogenesis of many autoimmune and inflammatory diseases. Th17 cell differentiation, stabilization, plasticity, and pathogenicity are regulated by a network of cytokines and transcription factors, including IL-6, TGF-β, IL-23, STAT3, and the key transcription factor RORγt. RORγt-dependent pathways are also relevant to other immune populations, including group 3 innate lymphoid cells (ILC3s), highlighting the complexity of the IL-17 axis across tissues. Dysregulation of these pathways can lead to chronic inflammation and tissue damage in diseases such as psoriasis, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Therapeutic targeting of the Th17 axis has led to clinically established approaches, particularly direct blockade of IL-17 signaling and inhibition of IL-23, whereas direct RORγt inhibition remains an investigational strategy. RORγt inhibitors may modulate Th17 differentiation and broader RORγt-dependent transcriptional programs, but their clinical development has been challenged by variable efficacy, safety considerations, and translational limitations. This review provides a comprehensive overview of Th17 biology, focusing on differentiation, plasticity, tissue-specific functions, and the contribution of Th17 and other RORγt-expression populations to autoimmune diseases. Furthermore, it critically compares established IL-17-targeted therapies with emerging RORγt inhibitors, emphasizing their distinct mechanisms, cellular and molecular targets, clinical evidence, safety, and developmental status. Finally, we discuss combination strategies, translational challenges, and emerging biomarkers that may contribute to more individualized therapeutic approaches and patient stratification.

PubMedBMC infectious diseases2026-11-11

Brucellosis prevalence in Nigerian livestock: a systematic review and meta-analysis.

Gaddafi Mohammed Sani MS, Jolayemi Kelvin Olutimilehin KO, Lawal Habiba H, Musawa Ibrahim Aliyu IA et al.

Brucella spp. are priority neglected zoonotic pathogens whose true burden in endemic settings remains systematically obscured by diagnostic heterogeneity. Although a prior systematic review has summarised brucellosis prevalence in Nigerian livestock, whether reported prevalence differences across studies reflect genuine epidemiological variation or methodological artefacts of diagnostic tool choice has not previously been formally tested using multivariable meta-regression, a distinction with fundamentally different policy consequences. This study aimed to estimate the pooled prevalence of brucellosis in Nigerian domestic animals and to formally quantify the contribution of diagnostic method, host species, geographic region, sample type, and sampling context to between-study heterogeneity. We conducted a systematic review and multivariable meta-regression of 98 publications (181 study arms; 72,362 animals; 9,785 positive cases) from PubMed, Scopus, Web of Science, and African Journals Online (AJOL), identified from a search covering 1 January 2000 to 31 December 2025 following PRISMA 2020 guidelines; the earliest eligible study was published in 2003, so the included evidence base spans 2003-2025 (23 years). The overall pooled brucellosis prevalence was 12.0% (95% CI: 10.0-14.0%; I²=97.3%, p < 0.001). Prevalence was highest in horses (26.0%, 95% CI: 11.0%-51.0%) and lowest in avian species (3.0%, 95% CI: 2.0-4.0%). Diagnostic method emerged as the dominant explainable source of between-study heterogeneity (R²=25.4%) as the confirmatory ELISA + LFA+Culture combination had 49.0% (95% CI: 45.0-53.0%; k = 4 study arms) in comparison to 6.0% for RBPT alone (95% CI: 4.0%-10.0%; k = 42), an eight-fold difference. Hygroma fluid had the highest sample type positivity (54.0%, 95% CI: 27.0%-79.0%). The multivariable model explained 51.2% of between-study variance (QM[df = 45] = 158.68, p < 0.001). No significant temporal trend was identified across 23 years of surveillance (β = -0.008, p = 0.603). These findings reframe the Nigerian brucellosis evidence base and argue urgently for World Organisation for Animal Health-aligned standardised diagnostic methods, species-targeted surveillance, and integrated One Health control strategies.

PubMedSports health2026-11-11

Different Patterns of Rapid Weight Loss in National-Team Judo and Muay Thai Athletes: Magnitude, Frequency, Methods, and Sources of Influence.

Gómez Diego Felipe DF, Solarte Mateo Salazar MS, Rojas Padilla Isabel Cristina IC

Rapid weight loss (RWL) is common in weight-class sports, but its magnitude, frequency, methods, and social determinants may differ between disciplines. This study characterized RWL practices among national-team judo and Muay Thai athletes and explored differences between sports. RWL patterns would differ between judo and Muay Thai, particularly in magnitude, frequency, methods, and sources of influence. Cross-sectional study. Level 3. A total of 25 adult national-team athletes (11 judo, 14 Muay Thai) completed the Rapid Weight Loss Questionnaire (RWLQ). We summarized prevalence, magnitude, frequency, duration, age at onset, postcompetition weight regain, weight-loss methods, and perceived sources of influence. The primary RWLQ score was evaluable for 23 athletes. Between-sport comparisons used Fisher exact tests and permutation-based Wilcoxon rank-sum tests; Benjamini-Hochberg adjustment was used for method-use and influence-score comparison families. Previous RWL was reported by 24 of 25 athletes (96.0%). Among athletes with previous RWL, the median number of episodes in the previous year was 3.5 (interquartile range [IQR], 1.0-10.5). Habitual loss was 6.8% of usual body mass (IQR, 3.9%-8.3%; n = 22). Dehydration-related methods were reported by 22 of 24 (91.7%) and fasting or skipping meals by 18 of 24 (75.0%) participants. Annual episodes were higher in judo (median, 10.0 vs 2.0; P = 0.02), whereas habitual loss was higher in Muay Thai (6.9% vs 4.5%; P = 0.11). Among 23 athletes with evaluable primary RWLQ scores, the medians were 40.0 in judo and 34.0 in Muay Thai (P = 0.19). Coaches were the most frequently reported influence (20 of 24; 83.3%). RWL was common in this sample and frequently involved dehydration-related practices and food restriction. Exploratory comparisons suggested differences in the frequency and magnitude of weight loss between sports, but the small sample and imbalance in sex distribution limit sport-specific inference. Multidimensional assessment should consider the athlete's wider sporting environment.

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about TJ-23