Drug Database
PH

phenylephrine hydrochloride

✓ Approved

Akorn Operating Company LLC · Small Molecule · Small Molecule

What is phenylephrine hydrochloride?

phenylephrine hydrochloride is a small molecule developed by Akorn Operating Company LLC. It is approved for therapeutic indications via others.

Drug Profile

CompanyAkorn Operating Company LLC
Drug ClassSmall Molecule
RouteOthers
StatusApproved

Therapeutic Indications

phenylephrine hydrochloride is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Eye disordersEye pain✓ Approved
Eye disordersGlaucoma✓ Approved

Related Research Articles

PubMedPhysiological reports2026-11-11

Impact of gestational stress on postpartum endothelial function.

de Souza Pedro Ribeiro PR, de Souza Monnerat Juliana Arruda JA, Luchetti Bianca Bittencourt BB, Mentzinger Juliana J et al.

Variable stress (VS) is associated with increased cardiovascular risk, and its effects may be intensified during pregnancy. However, the cardiovascular impacts of VS during pregnancy on maternal health are not yet understood. Thus, the aim of this study was to evaluate the impact of VS during gestation on the endothelial function of Wistar rats in the postpartum period. Pregnant rats were divided into Control (C) and VS groups. Stress protocol was applied during the third week of gestation and lasted 8 days. After the lactation period, thoracic aorta and blood were collected for vascular reactivity assessment and platelet aggregation evaluation. Protein abundance was evaluated by western blot. Mothers who experienced VS had higher levels of corticosterone (p = 0.04), confirming the effectiveness of the model. VS animals showed greater sensitivity (p = 0.05) to phenylephrine and reduced relaxation by acetylcholine (p = 0.048), as well as a lower expression of eNOSpser1177 (p = 0.007) and increased platelet aggregation (p = 0.02). Variable stress at the end of gestation seems to cause alterations in both the vasoconstrictor response and endothelium-dependent vasodilation and may be related to reduced eNOS activation that persists even after lactation.

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Effect of esketamine on anesthesia and postoperative analgesia in patients with prostate resection: Based on oxidative stress response].

Liu Dapeng D, Feng Lingling L, Yao Qun Q, Li Jianwei J et al.

Objective To investigate the effects of esketamine on postoperative analgesia, cognitive function, oxidative stress and safety in patients with electroprostatectomy. Methods One hundred and twenty patients who underwent electroprostatectomy in Zaozhuang Municipal Hospital from October 2021 to May 2022 were selected and divided into experimental group and control group according to the different treatment, with 60 cases in each group. The patients in control group were treated with routine sufentanil during the operation. And esketamine hydrochloride was used in the experimental group at the dosage of 0.2 mg/kg 10 minutes before the end of the operation. VAS score and MMSE score were recorded at 0.5, 2, 4 and 12 h after surgery. The levels of oxidative stress indexes including NE and GSH-Px were compared between the two groups, and the postoperative urinary tract irritation and adverse reactions were analyzed. Results There was significant difference in VAS score between the two groups at 0.5 h and 2 h after surgery (P<0.05), but no significant difference at 4 h and 12 h (P>0.05). There was significant difference in MMSE score at 0.5 h after operation (P<0.05). The scores of urethral irritation in the experimental group were significantly lower than those in the control group at 0.5 h and 2 h after operation (P<0.05), and the inhibition effect on urethral irritation was significant. After anesthesia, the levels of NE and GSH-Px in experimental group showed a more dramatic improvement compared to control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Esketamine has good postoperative analgesic effect in elderly patients undergoing transurethral resection of prostate with a temporary effect on early postoperative cognitive function, which alleviates symptoms of urinary duct irritation and oxidative stress caused by surgery.

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Clinical efficacy and mechanism of Liniao Tonglin decoction in treating UU-infected oligoasthenospermia with dampness-heat pouring down syndrome].

Zhu Fanyu F, Li Ninghua N, Yang Wentao W

Objective To explore the clinical effect and mechanism of Liniao Tonglin decoction on oligoasthenospermia caused by Ureaplasma urealyticum (UU) infection with dampness-heat pouring down syndrome. Methods Eighty-eight patients were randomly divided into control group and observation group, with 44 cases in each group. The patients in control group were treated with doxycycline hydrochloride enteric-coated capsules and doxycycline tablets. While the patients in observation group were treated with Liniao Tonglin decoction on the basis of the treatment given to the control group. Both groups were treated for 14 days. Sperm concentration, total sperm count, progressive motility sperm rate(PR%), sperm motility rate([PR+NP]%), seminal plasmic elastase, interleukin-6(IL-6), interleukin-17(IL-17) levels TCM syndrome score and negative conversion rate of UU were compared between the two groups before and after the treatment. Results The overall efficacy rate of the observation group was significantly higher than that in the control group (86.05% vs 66.67% , χ2=4.435, P<0.05). UU negative conversion rate was also superior in the observation group (95.35% vs 88.10%,P>0.05). The increases in sperm concentration, total count, PR%, and (PR+NP)% (P<0.05) exhibited in both of two groups after the treatment, with significantly greater improvements in the observation group (P<0.05). The levels of seminal elastase, IL-6, IL-17 and TCM syndrome scores declined in both groups (P<0.05), with greater improvements in the observation group as well (P<0.05). Conclusion Liniao Tonglin decoction combined with antibiotics improves the count and motility of sperm and TCM syndrome score of oligoasthenospermia induced by UU infection with dampness-heat pouring down syndrome, increases the negative rate of UU, inhibits the expression of inflammatory factors, and changes the patency of reproductive tract and the living environment of sperm.

PubMedZhonghua zhong liu za zhi [Chinese journal of oncology]2026-11-11

[Mitoxantrone hydrochloride liposomes combined with R-GDP regimen in the treatment of relapsed/refractory diffuse large B-cell lymphoma: a single-arm, multicenter, exploratory clinical study].

Ma L L, Zhao J J, Wang J R JR, Zheng M J MJ et al.

Objective: To evaluate the efficacy and safety of the mitoxantrone liposome combined with R-GDP regimen (R-GDP-Mito regimen) in the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Methods: From May 2023 to September 2025, a total of 33 patients with relapsed/refractory DLBCL(R/R DLBCL) were enrolled from multiple centers, including Shanxi Provincial Cancer Hospital, Jincheng People's Hospital of Shanxi Province, Heping Hospital Affiliated to Changzhi Medical College, and Datong Second People's Hospital of Shanxi Province. All patients received 2 to 6 cycles of the R-GDP-Mito regimen. The short-term and long-term efficacy as well as adverse events were analyzed. Results: Among the 33 patients, 16 achieved complete remission (CR), 11 achieved partial remission (PR), 3 had stable disease (SD), and 3 experienced disease progression (PD). The objective response rate (ORR) was 81.8% (27/33), with a 95% CI of 61.4% to 92.3%. The median time to best response was 1.9 months. With a median follow-up of 4.8 months, disease progression was observed in 4 patients, and 5 patient deaths were recorded, attributed to disease progression and severe pulmonary infection, respectively. The median progression-free survival (PFS) was not reached, while the median overall survival (OS) was 16.1 months. The 1-year PFS and OS rates were 56.6% and 90.5%, respectively. All 33 patients experienced adverse events (AEs). Hematological AEs occurred in 60.6% (20/33) of patients, and non-hematological AEs occurred in 81.8% (27/33) of them. Conclusion: The R-GDP-Mitoregimen demonstrates high antitumor activity and well-controlled safety profile in R/R-DLBCL patients, offering a promising new therapeutic option, particularly for those unable to immediately access or tolerate novel targeted or immunotherapy regimens.

PubMedJournal of education & teaching in emergency medicine2026-11-11

Priapism Got You Down? A Novel Method to Build Your Own Moderate Fidelity Task Trainer.

Moore Malia J MJ, Laughlin Rachell R, Cooper Dylan D DD

This task trainer was designed to instruct emergency medicine (EM) residents and faculty at all levels of training. Priapism management is time-sensitive, and the clinical opportunities to perform dorsal penile nerve block and corporal aspiration are seldom practiced. Despite knowledge of the importance of prompt recognition and management of priapism, many emergency physicians may not actually perform the recommended procedures to manage it for a variety of reasons.1 Due to the sensitive nature of the condition, physicians are eager to learn about and practice these intimate maneuvers in the safe setting of simulation; however, there is not a commercial task trainer available.2 Some low-fidelity creations have been published as solutions, but they are less realistic and time consuming to make, limiting feasibility and usability.3-7 One published creation inspired this task trainer, but the main structure is no longer available to be purchased, underscoring the need for a model that can be reproduced and recreated by the educator with flexible starting materials.3 Others are more time-consuming to make and require specific simulation equipment4 or may not be easily reused.5, 6 Other published low-fidelity creations are less anatomically accurate, limiting the fidelity of practice regarding the most intimate aspects of the procedure.7, 8. By the end of this educational session, participants should be able to: 1) identify indications, contraindications, and potential complications of priapism management, 2) gather appropriate supplies and describe relevant landmarks, anatomy, and patient positioning for management of priapism, 3) demonstrate a dorsal penile nerve block, aspiration of corpus cavernosum, and intracavernosal phenylephrine administration to treat priapism, and 4) develop an approach to manage common pitfalls of priapism care. We developed a more realistic and replicable priapism task trainer using materials readily accessible in a simulation lab. Emergency medicine faculty and simulation center staff collaborated to create a task trainer constructed from silicone and internal tubing, using the mold of a phallic-shaped candle (see attachment). This model was then used in a 30-minute training session, which included ten minutes of interactive discussion reviewing the steps of dorsal penile block and priapism management with PowerPoint images as a visual aid. Next, learners performed the procedure from start to finish with faculty guidance, followed by an opportunity to ask questions. The training session was open to EM residents, pediatric emergency medicine (PEM) fellows, EM community physicians, and EM academic faculty. This study was approved as exempt status by the Indiana University Institutional Review Board. Following the educational session, participants completed a voluntary survey evaluating the task trainer's realism, its usefulness as a teaching tool, and their change in confidence in performing priapism management. The mixed group included 14 EM residents, five PEM fellows, four EM community physicians, and four EM academic physicians. Of 27 participants who used the task trainer, the majority (92.6%) of survey respondents agreed or strongly agreed that the task trainer was realistic. Learners reported increased confidence in knowledge of the procedural steps and increased confidence in potentially performing the procedure in the clinical setting (Table 1). Most participants would recommend the training to a provider of a similar level of training. Overall, the educational content was effective since learners reported an increase in knowledge of the steps of the procedure in addition to improved confidence to perform the procedure safely and successfully in the clinical environment. While many learners had never performed this procedure before in the clinical setting, the majority would recommend this training to a colleague of the same level of training. While the need for training in this procedure is clear,1-2 the options for available task trainers have remained limited. There is no commercial priapism task trainer, and published creations have varied strengths and weaknesses in balancing fidelity, cost-effectiveness, reproducibility, and reusability.3-7 The main takeaway from this training is that a realistic, durable, and low-cost task trainer can be developed to effectively teach how to treat a rare and sensitive procedure. Priapism, penile nerve block, dorsal nerve block, urology, aspiration, decompression.

PubMedChemphyschem : a European journal of chemical physics and physical chemistry2026-11-10

Interconversion Among Different Forms of Lumichrome in Aqueous Pluronic P84 Solutions: Effects of Glucose, Urea, and Guanidine Hydrochloride.

Giri Suman Kalyan SK, Manna Sagar Kumar SK, Seth Debabrata D

This work represents a detailed photophysical investigation of Lumichrome (LuC) in a hydrophobic triblock copolymer, Pluronic P84, as a function of the kosmotropic osmolyte, glucose, and the chaotropic osmolytes, urea and guanidine hydrochloride (GH). The spectral characteristics of LuC demonstrate that, addition of glucose lowers the critical micelle temperature (CMT) of P84, suggesting that dehydration of poly (propylene oxide) (PPO) blocks of P84 through the "sugaring-out" phenomena promotes micellization. In contrast, urea and GH increase the CMT of P84, indicating enhanced polymer hydration and weakened hydrophobic interactions that hinder micellization. Fluorescence spectra of LuC illustrate that osmolytes and temperature modulate the microenvironment of LuC. This was confirmed by finding different forms of LuC in P84 micelles with help of steady state and time resolved fluorescence emission studies. The emission spectrum shows a blueshift as temperature increases. The addition of glucose produced no significant shift in the dominant ~460 nm emission band, while additional emission features/shoulders appeared around ~530 and ~436 nm. Fluorescence lifetime data suggest that, along with 7,8-dimethylalloxazine (DMAL) form, A10, A3 and 7,8-dimethylisoalloxazine (DMIS) species of LuC may also exist within the P84 micelle. Fluorescence anisotropy measurements revealed distinct osmolyte-dependent rotational dynamics, indicating changes in the microenvironment surrounding LuC.

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