Drug Database
OX

oxybutynin hydrochloride (Oablok / Neoxy Tape)

✓ Approved

Asahi Kasei · Small Molecule · Small Molecule

What is oxybutynin hydrochloride?

oxybutynin hydrochloride is a small molecule developed by Asahi Kasei. It is approved for therapeutic indications via topical or transdermal.

Drug Profile

Brand NamesOablok, Neoxy Tape
CompanyAsahi Kasei
Drug ClassSmall Molecule
RouteTopical, Transdermal
StatusApproved
Sources: ClinicalTrials.gov, Asahi Kasei

Therapeutic Indications

oxybutynin hydrochloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersHypertonic bladder✓ Approved

Related Research Articles

PubMedNature communications2026-11-11

Supramolecular janus eutectic engineered from panthenol and bisabolol overcomes transdermal delivery paradoxes.

Wang Hao H, Tao Qingsheng Q, He Xiaofeng X, Hsu Kung Chi KC et al.

Conventional transdermal delivery systems are constrained by inherent trade-offs among penetration efficiency, bioactive potency, and skin biocompatibility. To overcome these limitations, here we show a supramolecular Janus eutectic engineered from D-panthenol and α-(-)-bisabolol (SPB). This carrier-free system effectively integrates autonomous permeation with multimodal therapeutic functions. SPB demonstrates synergistic enhancement of panthenol transdermal delivery while markedly improving the biocompatibility of bisabolol, alongside multiplex anti-irritation and pro-repair efficacy-a combination unattainable by its individual components or physical mixtures. Mechanistic investigations indicate that the supramolecular architecture modulates the active transport pathway and antagonizes the TRPV1 receptor. This work provides a practical strategy for designing biofunctional materials that intrinsically unify delivery, efficacy, and safety.

PMID 43009484
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PubMedFrontiers in physiology2026-11-11

Applications and mechanisms of therapeutic ultrasound in skin repair and regeneration.

He Zeyu Z, Shao Shiwen S, Fang Yi Y, Xu Xuegang X et al.

Ultrasound modulates cellular and tissue processes underlying skin repair and regeneration via thermal and mechanical effects, including cavitation, and can act as an external trigger to facilitate transdermal delivery or activate ultrasound-responsive materials. This review summarizes the acoustic fundamentals and Mechanotransduction pathways of different types of ultrasounds, as well as research advances in wound healing, pathological scar intervention, skin tissue remodeling, skin appendage regeneration, and synergistic applications with ultrasound-responsive materials. Emphasis is placed on the molecular and cellular mechanisms by which ultrasound regulates inflammatory responses, angiogenesis, re-epithelialization, and extracellular matrix remodeling. Currently, apart from studies on focused ultrasound and ultrasound-assisted wound therapy, most supporting evidence is derived from in vitro experiments, animal models, or small-sample clinical studies. Inconsistent acoustic parameters and outcome measures, as well as insufficient long-term safety data, represent major barriers to its clinical translation.

PMID 43011743
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PubMedFrontiers in endocrinology2026-11-11

The improvement effect of androgen priming on fertility in patients with diminished ovarian reserve and its impact on in vitro fertilization outcomes: a systematic review and meta-analysis.

Li Xuanling X, Sui Chenlin C, Zhang Baofang B, Bai Yuquan Y et al.

Evaluate the effect of using androgen supplements (including transdermal testosterone gel and dehydroepiandrosterone (DHEA)) to priming androgens in the body and improve fertility in patients with diminished ovarian reserve (DOR). Electronic searches were conducted on seven databases, including Scopus, Web of Science, PubMed, Springer, VIP Information, Wanfang, and China National Knowledge Infrastructure (CNKI), to search for studies published as of July 5, 2026. Randomized controlled trails (RCTs) and non-randomized controlled trails of using androgen supplements (i.e. dehydroepiandrosterone (DHEA) and transdermal testosterone gel (TTG)) to intervene in improving fertility and IVF outcomes in patients with DOR were embodied. The study applied systematic review and meta-analysis methods to systematically summarize the main outcome measures, including FSH, AMH, AFC, retrieved oocytes, and clinical pregnancy rate. In addition, indicators such as the number of fertilized embryos, top-quality day-3 embryos, live birth rate and miscarriage rate were also evaluated. The meta-analysis included 14 studies with 2132 participants. Analyses of RCTs and non-randomized controlled trials were conducted separately. A comprehensive analysis of existing evidence indicated that androgen supplementation, including DHEA and TTG, can improve count of retrieved oocytes [RCTs (MD = 0.79, 95% CI [0.50,1.09], p<0.00001)]. A retrospective analysis of non-randomized controlled trials showed that androgen supplementation can significantly increase the number of Top-quality day-3 embryos (MD 0.47, [95% CI: [0.28, 0.66], p < 0.00001), the count of fertilized embryos (MD 0.78, [95% CI: [0.49, 1.06], p < 0.00001), and clinical pregnancy rate (OR = 2.23, 95% CI [1.49,3.36], p = 0.0001). Besides, androgen supplementation showed Intervention with androgen supplements for 2 months was beneficial for retrieving more oocytes (p < 0.05) through the results in RCT. And also showed a more significant improvement in retrieved oocytes and metaphase II oocytes in DOR patients with an average age of over 40 years (p < 0.05). The subgroup analysis results indicated that the application of GnRH antagonists as IVF stimulation protocol was more beneficial in increasing the number of retrieved oocytes than the adopt of GnRH agonists.The sensitivity analysis concludes that our conclusion is robust. Androgen priming (including DHEA and TTG) may be beneficial for improving the fertility of DOR patients undergoing IVF, enhancing their ovarian response, mainly manifested as an increase in oocyte retrieval. However, whether this therapy can improve the clinical pregnancy rate and other outcome indicators of DOR women undergoing in vitro fertilization remains to be further determined by more randomized controlled trials. More high-quality and large sample RCTs are still needed in the future to clarify whether they have an auxiliary effect on improving the fertility outcomes of DOR. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420261438943.

PMID 43010994
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PubMedCurrent drug discovery technologies2026-11-11

Phytocannabinoids: Promising New Candidates for TYRP1 Protein Inhibition in Melanoma.

Ghicha Ikram I, Baghrous Sanae S, Bousselham Fatiha F, Kadil Youness Y et al.

Phytocannabinoids, cannabinoids that occur naturally in cannabis, have gained significant attention due to their potential therapeutic benefits in managing diseases, including cancer. Tyrosinase-related protein 1 (TYRP1) plays an important role in melanogenesis and has been implicated in melanoma. This study was conducted to investigate the inhibitory potential of selected phytocannabinoids against TYRP1 and to identify these compounds as potential drugs for managing melanoma. An in silico study was conducted, and molecular docking was performed to assess the binding affinity between phytocannabinoids and TYRP1. Pharmacokinetics was conducted using ADMET analysis, while toxicity was predicted using ProTox-II. In addition, molecular dynamics simulations were performed using GROMACS to evaluate the stability of the protein-ligand complex. The study showed that cannabichromene (CBC) has high binding affinity for this target. This was confirmed by molecular docking, which revealed stable interactions between the protein's active site and the ligand. In addition, a molecular dynamics simulation was performed, and the results confirmed that the protein-ligand complex remained stable throughout the simulation period. ADMET analysis showed that CBC has good intestinal absorption and moderate transdermal permeability. Furthermore, ProTox-II results showed that CBC has low toxicity. The results demonstrate the potential of phytocannabinoids, especially CBC, as inhibitors of TYRP1. The high binding affinity and molecular stability suggest that CBC may have TYRP1 inhibitory activity. The TYRP1 interference may be responsible for its effects on melanogenesis and melanoma progression. Additionally, its pharmacokinetic profile and low toxicity make CBC a promising phytocannabinoid for its intended application. This study has identified cannabichromene as a promising phytocannabinoid with potential inhibitory activity against TYRP1. This has provided a basis for experimental validation to prove its therapeutic potential in melanoma and pigment disorders.

PMID 43012272
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Effect of esketamine on anesthesia and postoperative analgesia in patients with prostate resection: Based on oxidative stress response].

Liu Dapeng D, Feng Lingling L, Yao Qun Q, Li Jianwei J et al.

Objective To investigate the effects of esketamine on postoperative analgesia, cognitive function, oxidative stress and safety in patients with electroprostatectomy. Methods One hundred and twenty patients who underwent electroprostatectomy in Zaozhuang Municipal Hospital from October 2021 to May 2022 were selected and divided into experimental group and control group according to the different treatment, with 60 cases in each group. The patients in control group were treated with routine sufentanil during the operation. And esketamine hydrochloride was used in the experimental group at the dosage of 0.2 mg/kg 10 minutes before the end of the operation. VAS score and MMSE score were recorded at 0.5, 2, 4 and 12 h after surgery. The levels of oxidative stress indexes including NE and GSH-Px were compared between the two groups, and the postoperative urinary tract irritation and adverse reactions were analyzed. Results There was significant difference in VAS score between the two groups at 0.5 h and 2 h after surgery (P<0.05), but no significant difference at 4 h and 12 h (P>0.05). There was significant difference in MMSE score at 0.5 h after operation (P<0.05). The scores of urethral irritation in the experimental group were significantly lower than those in the control group at 0.5 h and 2 h after operation (P<0.05), and the inhibition effect on urethral irritation was significant. After anesthesia, the levels of NE and GSH-Px in experimental group showed a more dramatic improvement compared to control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Esketamine has good postoperative analgesic effect in elderly patients undergoing transurethral resection of prostate with a temporary effect on early postoperative cognitive function, which alleviates symptoms of urinary duct irritation and oxidative stress caused by surgery.

PMID 43012260
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Clinical efficacy and mechanism of Liniao Tonglin decoction in treating UU-infected oligoasthenospermia with dampness-heat pouring down syndrome].

Zhu Fanyu F, Li Ninghua N, Yang Wentao W

Objective To explore the clinical effect and mechanism of Liniao Tonglin decoction on oligoasthenospermia caused by Ureaplasma urealyticum (UU) infection with dampness-heat pouring down syndrome. Methods Eighty-eight patients were randomly divided into control group and observation group, with 44 cases in each group. The patients in control group were treated with doxycycline hydrochloride enteric-coated capsules and doxycycline tablets. While the patients in observation group were treated with Liniao Tonglin decoction on the basis of the treatment given to the control group. Both groups were treated for 14 days. Sperm concentration, total sperm count, progressive motility sperm rate(PR%), sperm motility rate（［PR+NP］%）, seminal plasmic elastase, interleukin-6(IL-6), interleukin-17(IL-17) levels TCM syndrome score and negative conversion rate of UU were compared between the two groups before and after the treatment. Results The overall efficacy rate of the observation group was significantly higher than that in the control group (86.05% vs 66.67% , χ2=4.435, P<0.05). UU negative conversion rate was also superior in the observation group (95.35% vs 88.10%，P>0.05). The increases in sperm concentration, total count, PR%, and （PR+NP）% (P<0.05) exhibited in both of two groups after the treatment, with significantly greater improvements in the observation group (P<0.05). The levels of seminal elastase, IL-6, IL-17 and TCM syndrome scores declined in both groups (P<0.05), with greater improvements in the observation group as well (P<0.05). Conclusion Liniao Tonglin decoction combined with antibiotics improves the count and motility of sperm and TCM syndrome score of oligoasthenospermia induced by UU infection with dampness-heat pouring down syndrome, increases the negative rate of UU, inhibits the expression of inflammatory factors, and changes the patency of reproductive tract and the living environment of sperm.

PMID 43012219
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