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aripiprazole lauroxil nanocrystal dispersion (Aristada Initio)

✓ Approved

Alkermes plc · DRD2 · Small Molecule

What is aripiprazole lauroxil nanocrystal dispersion?

aripiprazole lauroxil nanocrystal dispersion is a small molecule developed by Alkermes plc. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAristada Initio
CompanyAlkermes plc
Drug ClassSmall Molecule
Molecular TargetDRD2, HTR1A, HTR2A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Alkermes plc

Mechanism of Action

Molecular Targets

aripiprazole lauroxil nanocrystal dispersion acts on 3 molecular targets:

DRD2dopamine receptor D2 (D2DR, D2R)
HTR1A5-hydroxytryptamine receptor 1A (PFMCD, 5-HT1A)
HTR2A5-hydroxytryptamine receptor 2A (5-HT2A, HTR2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

aripiprazole lauroxil nanocrystal dispersion is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersSchizophrenia✓ Approved

Related Research Articles

PubMedThe Journal of chemical physics2026-11-11

Determination of fundamental properties of nitrogen from first principles. I. Atomic polarizabilities and long-range dispersion coefficients.

Przybytek Michał M, Lang Jakub J, Lesiuk Michał M

This work is the first in a series of papers in which we perform theoretical calculations of various fundamental properties of nitrogen relevant for gas thermometry experiments. In this part, we focus on the properties of the nitrogen atom, namely, dynamic polarizabilities and dispersion coefficients that describe interaction between two nitrogen atoms at large internuclear separations. These quantities are calculated using a composite scheme based on coupled cluster and full configuration interaction methods and large Gaussian basis sets optimized specifically for the purposes of this work. The dispersion coefficients, Cn with n = 6, 8, 10, are obtained using Casimir-Polder formulas by numerical integration over dipole, quadrupole, and octupole polarizabilities for imaginary frequencies represented analytically by Padé approximants. Special attention is paid to careful error control and uncertainty estimation of the calculated quantities.

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PubMedAnalytical chemistry2026-11-11

Antifouling Electrochemical Biosensor Based on Liquid Metal-Incorporated Hydrogel and Multifunctional Peptide for Robust Interleukin-1β Sensing in Saliva.

Du Qiushu Q, Han Rui R, Luo Xiliang X

Enhancing the practical applicability of electrochemical biosensors in complex biological fluids hinges on addressing biofouling. Antifouling hydrogels, while effective at resisting nonspecific biomolecule adsorption, are intrinsically insulating, which poses a challenge in reconciling their antifouling capability with the need for high-sensitivity detection. To address these challenges, we developed a multifunctional hydrogel. During ultrasonication, cellulose nanocrystal (CNC) stabilized liquid metal (LM) droplets generated free radicals that initiated acrylamide (AM) polymerization to form polyacrylamide (PAM) and crosslinked with chitosan (CS), yielding the LM@CNC-PAM-CS hydrogel without external initiators or crosslinkers. This hydrogel was then combined with a multifunctional peptide (Pep) featuring antifouling and recognition functions to construct an antifouling biosensor for IL-1β detection. Electrochemical characterization and fluorescence imaging confirmed that the synergistic antifouling interface enhanced nonspecific adsorption resistance, improving biosensor stability and accuracy. The sensor detected IL-1β over 1 pg mL-1 -1 μg mL-1 with a limit of detection (LOD) of 0.34 pg mL-1, and correlated well with enzyme-linked immunosorbent assay (ELISA) in real human saliva samples. Thus, this design offers a viable strategy for clinical diagnostics in real samples with antifouling electrochemical biosensors.

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PubMedMacromolecular rapid communications2026-11-11

Janus Nanosheet-Assisted CO2 Foaming of Polypropylene.

Wang Xinyu X, Xu Yaohui Y, Zhang Yuehan Y, Sun Dayin D et al.

Polypropylene (PP) foaming using CO2 as a physical blowing agent is challenged by the limited CO2 solubility in PP, inefficient heterogeneous nucleation, poor additive dispersion, and insufficient melt strength. Herein, we report a Janus nanosheet (JNS)-assisted foaming strategy based on interfacial engineering. JNS feature an octadecyl-functionalized face designed to improve filler-matrix compatibility and an amine-functionalized face designed to promote CO2 uptake. These nanosheets are generated in situ by fragmentation of Janus hollow microspheres during screw extrusion with PP. The dispersion state, crystallization and melting behavior, CO2 uptake, and rheological properties of the composites were systematically investigated. A JNS loading of 0.6 wt% provides the most favorable balance between bubble nucleation and cell growth, yielding a relatively uniform cellular structure (50 ± 10 µm) and a high cell density (6 × 108 cells/cm3). Comparative experiments using JNS containing a higher amine content, JNS with reduced PP compatibility, and hydrophobic silica without amine groups indicate the combined effects of surface chemistry, CO2 uptake, and PP-filler interactions on foaming. The composite expanded beads were molded into foams with enhanced mechanical properties and further fabricated into full-size foldable stools, demonstrating the product-scale processability of the JNS-based formulation.

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PubMedChemSusChem2026-11-11

Aqueous Guar Gum Binder Enables Regulated Surface Structure Evolution and Enhanced Electrochemical Performance of NFPP/Activated Carbon Composite Cathodes for Sodium-Ion Batteries.

Cai Benzhen B, Huang Linran L, Shao Haitao H, Li Lunjie L et al.

Na4Fe3(PO4)2(P2O7) (NFPP) has emerged as a promising low-cost, structurally stable cathode material for sodium-ion batteries. However, the intrinsically low electronic conductivity of NFPP limits NFPP/activated carbon (NFPP/AC) composite performance. Considering that polymer binders control electrode microstructures and sodium-ion reaction kinetics, the authors incorporated an aqueous guar gum (GG) binder into an NFPP/AC cathode and benchmarked it against polyvinylidene fluoride (PVDF) and carboxymethyl cellulose (CMC)/styrene-butadiene rubber (SBR) systems. The GG-based electrode slurry demonstrates superior rheological properties that facilitate electrolyte infiltration, promote uniform particle dispersion and improve electrode structural integrity. This effect is primarily ascribed to the hydroxyl-rich structure of GG, which establishes hydrogen-bond-mediated multipoint interfacial interactions between NFPP and AC particles, enhancing particle dispersion, slurry structural recovery and interparticle contact. GG also promotes a uniform, dense, inorganic-rich cathode-electrode interface, minimizing charge-transfer resistance and activation energy (61.1 kJ·mol-1). Consequently, the GG-based electrode maintains a high Na+ diffusion coefficient during cycling, retaining 73.8 mAh·g-1 at 5C and showing negligible capacity fading after 400 cycles at 1C. Overall, GG constructs a continuous interfacial binding network between NFPP and AC, regulating interfacial chemistry, structural integrity and Na+ transport pathways.

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PubMedJournal of magnetic resonance imaging : JMRI2026-11-11

MRI Assessment of Baseline White Matter Microstructure and Its Relationship With the Onset and Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients.

Zhou Xiaoyu X, Wu Yanglei Y, Liu Meiling M, Huang Yao Y et al.

White matter microstructure may be affected by cancer and its treatment, yet its association with subsequent cancer-related cognitive impairment (CRCI) remains unclear. To investigate whether baseline white matter diffusion metrics are associated with the time to CRCI onset and longitudinal cognitive trajectories. Prospective longitudinal study. A total of 230 female patients (49.4 ± 8.6 years) with histopathologically confirmed breast cancer (50 Stage II, 180 Stage III) with planned neoadjuvant chemotherapy before surgery. A 3 T, multi-shell SE-EPI DWI. Diffusion MRI was performed before chemotherapy (baseline). Neuropsychological assessments were carried out at baseline, after the first cycle of chemotherapy, after completion of chemotherapy but before surgery, and at 2-4 years after surgery. Diffusion tensor metrics (mean, radial, and axial diffusivity [MD, RD, and AD]), diffusion kurtosis metrics (axial and radial kurtosis [AK and RK]), and neurite orientation dispersion and density imaging metrics (orientation dispersion index [ODI], neurite density index [NDI]) were extracted from 25 white matter tracts, capturing both mean values and peak width. Cox regression and linear mixed-effects models assessed associations with time to CRCI onset and cognitive trajectories, respectively. A p value < 0.05 was considered significant. Higher ODI (anterior limb of the internal capsule [ALIC]: HR = 1.28), lower AD (ALIC: HR = 0.72, external capsule [EC]: HR = 0.73, superior fronto-occipital fasciculus [SFO]: HR = 0.70), and greater peak width of AK (ALIC: HR = 1.29, EC: HR = 1.24, genu of the corpus callosum [GCC]: HR = 1.32) were associated with earlier CRCI onset. Lower FA, RK, and MK (β = 0.13 to 0.27 × 10-3), higher MD, RD, ODI, and ISOVF (β = -0.23 to -0.13 × 10-3), and higher peak width metrics (β = -0.34 to -0.13 × 10-3) were associated with poorer longitudinal cognitive trajectories. Pretreatment white matter microstructure may help identify patients at greater risk of CRCI and poorer cognitive trajectories. Stage 3.

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PubMedAlzheimer's & dementia (Amsterdam, Netherlands)2026-11-11

Diffusion MRI metrics of white matter association tracts are associated with cognitive migration in older adults without dementia.

Duran Tugce T, Barcus Richard A RA, Gaussoin Sarah A SA, Bacci Julia R JR et al.

We analyzed baseline diffusion magnetic resonance imaging (MRI) data including diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to predict cognitive transitions over a 1-year follow-up in older adults without dementia. A total of 366 participants from the Wake Forest Alzheimer's Disease Research Center (ADRC) Healthy Brain Study (HBS) were included. The outcome was cognitive migration (CM), defined based on Clinical Dementia Rating (CDR) global score transitions: CDR 0 to 0 (CDR-0 Stable), CDR 0 to 0.5 (Migrant-), CDR 0.5 to 0.5 (CDR-0.5 Stable), and CDR 0.5 to 0 (Reverter+). NODDI free water (FW) and DTI metrics (fractional anisotropy [FA] and mean diffusivity [MD]) from whole brain and white matter (WM) association tracts were examined for their association with 1-year CM status. CM transition rates were: 46% CDR-0 Stable, 29% CDR-0.5 Stable, 16% Reverter+, and 9% Migrant-. In WM association tracts, the Reverter+ group had higher DTI FA and lower MD than the CDR-0.5 Stable group. FA and MD (not FW) may be sensitive markers for reversion during early transitions in WM association tracts.

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