Drug Database
T1

T1/C20 (T1/C20)

✓ Approved

Canndoc · therapeutic agent

What is T1/C20?

T1/C20 is a therapeutic agent developed by Canndoc. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesT1/C20
CompanyCanndoc
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Canndoc

Therapeutic Indications

T1/C20 is developed for 7 unique indications across 4 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersColitis ulcerative✓ Approved
Gastrointestinal disordersCrohn's disease✓ Approved
Nervous system disordersEpilepsy✓ Approved
Nervous system disordersMultiple sclerosis✓ Approved
Psychiatric disordersPost-traumatic stress disorder✓ Approved

+2 more indications available with a free account

Sign up free to view all indications →

Related Research Articles

PubMedFrontiers in oncology2026-10-22

Network analysis of core symptom changes in hepatocellular carcinoma survivors after transarterial chemoembolization: A longitudinal study.

Wang Suping S, Wang Xiuyan X, Jiang Ni N, Hu Yongpei Y et al.

The aims of this study were to explore the longitudinal trajectories of core symptoms in survivors with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) and to analyze their associations with health-related quality of life (HRQoL) and unmet supportive care needs. This longitudinal study enrolled 271 HCC survivors undergoing TACE in China. Patient-reported outcomes were assessed at three time points-24 h (T1), 7 days (T2), and 1 month (T3) post-TACE-using four validated instruments: the MD Anderson Symptom Inventory-Chinese Version (MDASI-C), the Tumor Symptom Measure for Primary Liver Cancer (TSM-PLC), the Quality of Life Instrument for Liver Cancer (QOL-LC V2.0), and the Short Form of Survivors' Unmet Needs Scale (SF-SUNS). Exploratory factor analysis was conducted to extract discrete symptom clusters, and network analysis was used to calculate strength centrality (rs)-an index quantifying the sum of absolute edge weights connecting each symptom to all others-to identify core symptoms. Five symptom clusters were identified at T1: Fatigue-Cognitive, Post-embolization, Somatic, Emotional, and Hepatobiliary-Specific. The Post-embolization cluster was present only at T1, whereas the remaining four clusters persisted at T2 and T3. However, the core symptom shifted over time: nausea at T1 (rs = 1.154), lack of appetite at T2 (rs = 1.229), and sadness at T3 (rs = 1.107). HRQoL was lowest at T1, improved at T2, and declined at T3, with all pairwise comparisons significant (all p < 0.001). Unmet needs were highest at T3, with all time-point differences significant (all p < 0.001). The largest gaps were observed in information provision, care continuity, and emotional support. Greater symptom severity was significantly associated with poorer HRQoL at all time points (all p < 0.01). During the first month post-TACE, the sequence of core symptoms transitioned from nausea to lack of appetite and then to sadness, suggesting time-specific supportive care strategies-including antiemetic prophylaxis, nutritional support, and psychosocial care. Routine assessment of unmet needs may help reduce symptom burden and optimize long-term HRQoL for these survivors.

PMID 42903105
Read full article →
PubMedKidney research and clinical practice2026-10-22

Association of alkaline phosphatase with mortality in patients on peritoneal dialysis.

Kim Jae Young JY, Chang Tae Ik TI, Kang Ea Wha EW

Patients with end-stage kidney disease (ESKD) undergoing peritoneal dialysis (PD) experience high mortality rates, necessitating the establishment of reliable prognostic markers. Although serum alkaline phosphatase (ALP) is routinely measured while assessing chronic kidney disease-mineral and bone disorder, its clinical relevance for mortality risk in patients undergoing PD has not been fully established. Using multivariable Cox proportional hazards models, this retrospective cohort study examined the association between baseline ALP levels and risk of all-cause and cardiovascular mortality in 1,108 patients with ESKD who newly initiated PD between 2000 and 2020. The median ALP level of the overall cohort was 76.0 IU/L (interquartile range, 60.0-95.3 IU/L). The mean age of the patients was 60.6 years (standard deviation [SD], 14.4 years), and 55.8% were male. During a median follow-up of 4.0 years, a 1-SD increase in ALP level was significantly associated with a 23% and 64% higher risk of all-cause mortality (95% confidence interval [CI], 1.09-1.38) and cardiovascular mortality (95% CI, 1.21-2.24), respectively. The patients were stratified into tertiles (T1-T3) based on ALP level. Compared with the T1 group, the adjusted hazard ratios for all-cause mortality were 1.11 (95% CI, 0.84-1.48) in T2 and 1.39 (95% CI, 1.05-1.85) in T3. The relationship between elevated ALP and higher risk of all-cause mortality was consistent when ALP was treated as a time-dependent variable. Elevated ALP levels were associated with increased risk of all-cause and cardiovascular mortality in patients undergoing PD.

PMID 42902883
Read full article →
PubMedFrontiers in plant science2026-10-22

Integrated multi-omics analysis reveals key genes and metabolic regulatory networks involved in the drought stress response of potato.

Liu Yaqi Y, Suri Guga G, Wuyun Dalai D, Chu Ying Y et al.

Against the backdrop of global warming, drought events have become increasingly frequent and represent a major environmental stress factor limits potato yield stability and sustained yield improvement. In this study, integrated transcriptomics and widely targeted metabolomics were used to characterize the response of the potato cultivar 'Jizhangshu 12' to moderate (T1) and severe (T2) drought stress, and RT-qPCR was used to validate key genes. 1,135 differentially expressed genes and 39 differentially accumulated metabolites were identified under moderate drought stress, whereas 505 differentially expressed genes and 158 differentially accumulated metabolites were identified under severe drought stress. GO and KEGG enrichment analyses indicated that phenylpropanoid-flavonoid biosynthesis, α-linolenic acid metabolism, glycerophospholipid metabolism, and MAPK-hormone signaling pathways were core modules involved in the drought response of potato. The COMT1 gene LOC102601955, F3'H gene LOC102596126, ABCG transporter gene LOC102602737, and WRKY transcription factor gene LOC102587289 were identified as core candidate drought-tolerance genes. The MAPK pathway may positively regulate lipid and steroid accumulation while negatively regulating flavonoid and phenolic biosynthesis. These findings elucidate distinct transcriptional-metabolic regulatory networks and provide candidate genes and metabolites for breeding drought-tolerant potato cultivars.

PMID 42903084
Read full article →
PubMedEuropean journal of pain (London, England)2026-10-22

Structural Reorganization of Hypothalamic Subfields in Postherpetic Neuralgia: Volumetric and Morphometric Covariance Network Analyses.

Oh Daeseok D, Lee Dong Ah DA, Lee Ho-Joon HJ, Park Kang Min KM

Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition associated with central nervous system reorganization, but hypothalamic alterations remain poorly understood. We investigated hypothalamic subfield volumes and morphometric covariance network organization in patients with PHN. This prospective cross-sectional study included 42 patients with PHN and 41 healthy controls whose hypothalamic subfield volumes were obtained from T1-weighted MRI using automated FreeSurfer segmentation. Bilateral mean raw subfield volumes were compared between groups using analysis of covariance, adjusting for age, sex and estimated total intracranial volume, with false discovery rate correction for multiple comparisons. Morphometric covariance networks were constructed from age- and sex-residualized subfield volumes and graph-theoretical measures were compared using permutation testing. After adjustment for estimated total intracranial volume, age and sex, the tubular superior subfield was nominally larger in PHN (adjusted difference, 4.95 mm3; 95% CI, 0.05-9.85; p = 0.048), but did not survive FDR correction. No other subfield or whole-hypothalamic volume differed significantly. PHN showed reduced local efficiency and clustering coefficient and increased characteristic path length, without a significant difference in global efficiency. No pain-side-dependent lateralization or significant associations between subfield volumes and pain measures or disease duration were observed. PHN was associated with altered hypothalamic morphometric covariance organization, characterized by reduced local network segregation and increased characteristic path length, while regional volume differences were limited after intracranial volume correction. These findings suggest that PHN-related central reorganization may involve hypothalamic systems related to homeostatic regulation and stress adaptation. This study demonstrates altered morphometric covariance organization of hypothalamic subfields in postherpetic neuralgia, despite limited evidence of regional volumetric differences after intracranial volume adjustment. These findings suggest that hypothalamic involvement in PHN may be better reflected by altered coordinated structural organization than by regional volume changes alone.

PMID 42902843
Read full article →
PubMedFrontiers in nutrition2026-10-22

Prognostic value of postoperative dynamic PNI trajectories for biochemical recurrence in patients with high-risk localized prostate cancer: a longitudinal trajectory clustering study.

Yu Bo B, Dai Xuchao X, Zhu Jianguo J

The prognostic nutritional index (PNI) reflects nutritional-immune status, but the value of a single baseline PNI for predicting biochemical recurrence (BCR) after radical prostatectomy in high-risk localized prostate cancer remains unclear. We aimed to identify postoperative PNI trajectories and compare their BCR predictive value with baseline PNI. We retrospectively included 436 patients. PNI was measured preoperatively (T0) and at 3 (T1) and 12 (T2) months post-surgery. Longitudinal trajectory clustering identified three PNI trajectory classes: persistently high (PHigh, n = 169, 46.4%), persistently low (PLow, n = 146, 40.1%), and declining (Declining, n = 49, 13.5%). Cox regression assessed associations with BCR; a Cox-based time-to-event prediction model was evaluated using time-dependent AUC, IPCW Brier score, and calibration at 3-year and 5-year horizons. A 12-month landmark analysis was performed to address potential guarantee-time bias. During median 38.2-month follow-up, 122 (28.0%) developed BCR. Baseline PNI was not independently associated with BCR (continuous HR = 0.97, p = 0.320; dichotomized HR = 1.23, p = 0.347). Three trajectories emerged: persistently high (PHigh, 46.4%), persistently low (PLow, 40.1%), and declining (Declining, 13.5%). Relative to PHigh, PLow (HR = 2.95) and Declining (HR = 5.80) both had significantly higher BCR risk (p < 0.001). A 12-month landmark analysis confirmed these findings (PLow HR = 2.72, p = 0.002; Declining HR = 4.79, p = 1.24 × 10-6). The multivariable Cox model combining trajectory, log PSA, surgical margin, and nodal metastasis achieved a 3-year time-dependent AUC of 0.823 (optimism-corrected 0.815) and a 5-year AUC of 0.790 (optimism-corrected 0.781). The Brier score was 0.117 at 3 years (25.8% improvement over null) and 0.166 at 5 years; the calibration slope was 1.057 (optimism-corrected 0.989) at 3 years and 1.001 (optimism-corrected 0.940) at 5 years. Postoperative PNI follows three distinct change-pattern subgroups. Dynamic PNI trajectories are strongly associated with BCR risk, whereas a single baseline PNI is not. Patients with persistently low or declining PNI are at high risk, supporting routine PNI monitoring to guide individualized follow-up. These observational findings require prospective multicenter validation.

PMID 42903118
Read full article →
PubMedAdvances in simulation (London, England)2026-10-21

Collaborative, digital and sustainable skills through multimodal simulations: evidence-based, interprofessional training in primary health care - the REALISE study.

Kern Christine C, Roth Melanie M, Brunner Marlene M, Bamberger Eva Maria EM et al.

Interprofessional collaboration is crucial for enhancing healthcare delivery, particularly in primary care settings, where effective teamwork between healthcare and social professionals (HCSPs) is essential. Despite its importance, there is limited research on the impact of structured interprofessional training programs on interprofessionality in simulated environments, particularly concerning primary care contexts. The REALISE study constitutes of a prospective feasibility study examining the impact on interprofessionality of multimodal, interprofessional learning paths on HCSPs as well as students within a simulated primary healthcare (PHC) setting. The three-week learning paths were specially developed, proprietary, case-oriented, and consisted of simulations (acting patients, high-fidelity manikins, virtual reality) and didactic on- and offline elements. The study employed a mixed-methods approach, incorporating three conducted interprofessional intervention groups to evaluate outcomes across both quantitative (two standardized assessments: Interprofessional Collaborative Competency Attainment Survey (ICCAS), Interprofessional Socialization and Valuing Scale 9a&b (ISVS)) and qualitative (proprietary open-ended questions) domains. Data was collected before (t0), directly after (t1) and two months after t1 (t2) to evaluate the impact on interprofessional collaboration. Regarding the quantitative outcomes, no significant change was observed in participants' ISVS scores between pre- and post-intervention assessments, neither in the entire sample (t0 = 5.41 ± 1.20, t1 = 5.85 ± 1.18; p = 0.108), nor in the student or HCSP group. Also, no time*group effects became evident. This suggests stable self-perceived values and attitudes toward interprofessional collaboration. In contrast, ICCAS scores increased significantly in total and across all dimensions (e.g., total score t₀ = 3.00 ± 0.77, t₁ = 3.99 ± 0.53; p < 0.001, d = 0.91). The strongest effects for the entire sample were observed in the dimensions "Team Functioning" (0.973) and "Collaboration" (0.922) and significant time*group (students vs. HCSPs) effects were found in 3 of the 6 dimensions ("Collaboration", "Roles and Responsibilities" and "Team Functioning"), indicating substantial self-reported improvements in interprofessional competencies following the training and differences in amplitude of improvements. The results of the qualitative thematic analysis showed clear differences and overlaps between groups and time points. At t0, the students described communication difficulties, unclear responsibilities and role confusion as central challenges. In contrast, HCSPs focused on structural problems such as time pressure and limited coordination. At t1, the students reported increased role clarity and improved team communication, while HCSPs noted greater awareness of their own role and greater flexibility in interdisciplinary cooperation. As part of the follow-up (t2) the HCSPs reported a further deepening of interprofessional cooperation in their daily practice. While participants' self-perceived attitudes remained stable, significant improvements in interprofessional competencies such as team functioning and collaboration, showed that the training effectively supported collaborative practice. The intervention was feasible to implement and was positively evaluated across all professional groups.

PMID 42902366
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about T1/C20