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ciclosporin A (Ikervis / STN 1007603 / Nova22007)

✓ Approved

Santen Pharmaceutical Co., Ltd. · PPIA · Small Molecule

What is ciclosporin A?

ciclosporin A is a small molecule developed by Santen Pharmaceutical Co., Ltd.. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesIkervis, STN 1007603, Nova22007
CompanySanten Pharmaceutical Co., Ltd.
Drug ClassSmall Molecule
Molecular TargetPPIA
RouteOthers, Topical
StatusApproved

Mechanism of Action

Molecular Targets

ciclosporin A acts on 1 molecular target:

PPIApeptidylprolyl isomerase A (HEL-S-69p, CYPH)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ciclosporin A is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersDry eye✓ Approved
Eye disordersVernal keratoconjunctivitis✓ Approved
Immune system disordersCorneal graft rejectionPreclinical

Related Research Articles

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A multi-granularity narrative cloud selection framework for architectural meaning-making integrating the PIA model and three-way decision theory.

Li Qi Q

Architectural experience depends not only on perceptual fluency but also on whether users can successfully construct higher-order semantic meaning from complex built form. In the Pleasure-Interest Model of Aesthetic Liking (PIA model), the controlled-processing stage differentiates interest, confusion, and boredom. In conventional architectural cognition research, however, confusion is often treated as a negative indicator of communicative failure. This paper challenges that assumption and argues that confusion is especially important in architectural meaning-making because it identifies a population that still possesses interpretive motivation but has not yet achieved semantic resolution due to a mismatch between narrative granularity and cognitive accessibility. To address this problem, the paper proposes a conceptual and heuristic framework that integrates the PIA model, three-way decision theory, and granular computing. First, the three states in the controlled-processing stage of the PIA model are reinterpreted through a three-way decision structure, in which confusion is reconstructed as a strategic boundary region rather than as a purely negative endpoint. Second, a multi-granularity optimization mechanism and a utility-based selection function are introduced to identify narrative descriptions that balance novelty and comprehensibility for target perceivers. Third, a memorial-hall case and a computer-simulated illustrative statement-scoring exercise are used to illustrate the feasibility of the proposed procedure. Rather than claiming full empirical validation, the paper positions its contribution as a design-oriented framework for improving architectural communication, user-centered narrative intervention, and the cultural-social dimension of human-centered sustainability in the built environment.

PubMedInterdisciplinary cardiovascular and thoracic surgery2026-10-22

Stenosis of a novel frozen elephant trunk in a patient with chronic dissection.

Tokunaga Shigeto S, Okamura Homare H, Yamaguchi Atsushi A

A partial elephant trunk (PET), a new type of frozen elephant trunk, was designed to prevent distal stent graft-induced new entry using a thinner nitinol wire with less radial force. We report a case of PET stenosis in chronic dissection. Total arch replacement was performed using a PET. After weaning from cardiopulmonary bypass, the lower-limb blood pressure decreased to 90% of the upper-limb blood pressure. Intraoperative transesophageal echocardiography revealed incomplete PET expansion, and on postoperative day 1, the lower-to-upper body blood pressure ratio further decreased to 70% due to PET stenosis at the steeply angulated arch. Emergency thoracic endovascular aortic repair was successfully performed, completely resolving the pressure gradient.

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[Neurosyphilis in dementia cases].

Lunen Mikkel Suurballe MS

This case report describes a middle-aged male who presented with symptoms of dementia. During a routine screening in a lumbar puncture, a total of 209 × 109 leukocytes was found in his cerebrospinal fluid, 208 of which were mononuclear. The patient was admitted to an infectious disease ward, and serum analyses showed a positive Wassermann reaction and a rapid plasma reagin of 128. The man was diagnosed with neurosyphilis and started on penicillin treatment. This lasted 14 days, and the symptoms of dementia decreased substantially.

PubMedRevue medicale suisse2026-10-22

[What should you request to the laboratory for a patient bitten by a tick ?]

Lienhard Reto R, Ackermann-Gäumann Rahel R, Croxatto Antony A

Ticks are a growing concern for the public, owing to their abundance and a longer activity season. In Switzerland, more than 99% of ticks removed from humans are of the species Ixodes ricinus. This article reviews the tick-borne diseases documented in the country : Lyme borreliosis, tick-borne encephalitis, tularaemia, neoehrlichiosis, anaplasmosis, babesiosis, Borrelia miyamotoi relapsing fever, and rickettsiosis. Carriage of a microorganism by a tick does not imply infection, just as isolated seropositivity does not imply disease. Testing should be guided by pretest probability and disease stage, using validated assays only. Here, the laboratory is a key partner : it guides test selection and the interpretation of results, helping to avoid both under and overdiagnosis.

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Intravascular Lithotripsy of Aortic and Renal Lesions as a Therapeutic Tool for Pickering Syndrome: A Case Report.

Martínez-Cachero García Miguel M, Ariza Molina Carlos C, Sanmartino González Susana Ana SA, Zanabili Al-Sibbai Amer A

We report the case of a 73-year-old woman admitted with Pickering syndrome, a life-threatening condition characterized by recurrent flash pulmonary edema secondary to severe renovascular disease. Computed tomography angiography demonstrated an atrophic left kidney, a heavily calcified visceral aorta with a coral-reef morphology, and a near-occlusive stenosis of the right renal artery. Urgent endovascular treatment was performed with intravascular lithotripsy for plaque modification of the suprarenal aorta and the right renal artery, followed by renal artery stenting. The patient showed prompt clinical recovery, with resolution of pulmonary edema, stabilization of blood pressure, and improvement of renal function. This case illustrates the potential role of intravascular lithotripsy as a minimally invasive adjunct for managing severely calcified aorto-renal disease in high-risk patients, enabling endovascular treatment in otherwise challenging anatomy.

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Diagnostic performance of fine-needle aspiration in salivary gland tumours.

Kristensen Emilie Søby ES, Rosenørn Marie Røsland MR, Wennervaldt Kasper K, Hvilsom Gitte Bjørn GB

The aim of this study was to evaluate the diagnostic performance of fine-needle aspiration (FNA) cytology and further evaluate the risk of malignancy (ROM) in patients with salivary gland neoplasms in a five-year period in Region Zealand, Denmark. Retrospectively, we identified all patients with an FNA from a salivary gland neoplasm who underwent surgery from 1 January 2020 through 31 December 2024. Descriptive statistics were performed, and sensitivity, specificity, positive and negative predictive values and ROM were estimated. We identified 435 patients who had a preoperative FNA and underwent surgical excision within the study period. The cohort had a small female preponderance, a mean age of 59.2 years and involvement of the parotid gland in 84.6% of cases. An assessment of the diagnostic efficacy of the FNA between benign and malignant cases reported a sensitivity of 50.0%, a specificity of 97.9%, a positive predictive value of 78.4%, a negative predictive value of 92.7% and an accuracy of 92.0%. The risk of malignancy was low in benign FNAs (0-0.6%) and high in FNAs with malignancy or suspicion hereof (75.0-100%). With an accuracy of 91.5% in distinguishing benign from malignant neoplasms, FNA plays a crucial role in both diagnosis and patient counselling. The inherent uncertainty must be considered when recommending and planning surgical interventions or follow-up, especially in unresolved cases. None. Not relevant.

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