Drug Database
PE

pemetrexed solution (Pemta / CJ30045)

✓ Approved

HK inno.N · DHFR · Small Molecule

What is pemetrexed solution?

pemetrexed solution is a small molecule developed by HK inno.N. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesPemta, CJ30045
CompanyHK inno.N
Drug ClassSmall Molecule
Molecular TargetDHFR, GART, TYMS
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, HK inno.N

Mechanism of Action

Molecular Targets

pemetrexed solution acts on 3 molecular targets:

DHFRdihydrofolate reductase (DHFRP1, DHFR1)
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (PGFT, GARTF)
TYMSthymidylate synthetase (TS, HST422)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

pemetrexed solution is developed for 3 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Mesothelioma malignant✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-small cell lung cancer stage IV✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-small cell lung cancer metastatic✓ Approved

Related Research Articles

PubMedMalawi medical journal : the journal of Medical Association of Malawi2026-10-22

Key Factors Influencing Intention to Use Digital Health Systems Among Healthcare Workers in Malawi.

Nkoloma Mayamiko M, Gombachika Harry H, Mikeka Chomora C, Maluwa Alfred A

Digital Health systems (DHS) have the potential to strengthen healthcare delivery, yet their adoption remains limited in many low- and middle-income countries. Despite progress in digital health implementation, Malawi continues to face challenges related to effective use of DHS. This study investigates the key factors influencing healthcare workers' intention to use DHS in Malawi. This was a cross-sectional quantitative design that used a structured questionnaire to collect data from a sample of 615 healthcare workers across Malawi. Factor analysis and reliability testing were conducted to assess construct validity and internal consistency. Multiple linear regression was used to identify factors influencing intention to use DHS, while generalized structural equation modelling (GSEM) examined relationships involving categorical variables. The results indicated that healthcare workers' intention to use DHS is influenced by several factors including, perceived ease of use (β = 0.358, p <0.001), perceived usefulness (β = 0.284, p = 0.001), job relevance (β = 0.274, p = 0.001) and subjective norms (β = 0.127, p <0.001). These findings suggest that healthcare workers are more likely to use DHS when they perceive them as useful, relevant to their daily work, easy to use, and are supported by their peers. In contrast, computer anxiety indicated a significant negative effect (β = -0.061, p = 0.001), suggesting that higher levels of computer anxiety reduce the likelihood of DHS use. Demographic and contextual factors, including gender, age, and education level were not significant factors influencing DHS. These findings highlight the importance of aligning digital health systems with healthcare workers' job roles, ensuring system usability, and leveraging social influence to promote adoption. Addressing computer anxiety through targeted training and capacity building may also enhance digital confidence and sustained system use.

PMID 42902989
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PubMedJournal of advanced nursing2026-10-22

It's All in Your Head: A Qualitative Examination of the Help-Seeking Experiences of Women Suffering Postpartum Psychosis.

McMahon Donna D, Rutherford Tess T, Smout Reilly R, McGregor Leanne L et al.

Postpartum psychosis (PPP) is a rare, yet severe, perinatal psychiatric disorder that typically presents abruptly within several days after childbirth and requires urgent in-patient psychiatric care. Despite its severity, postpartum psychosis remains underrepresented in research and can be poorly understood in clinical healthcare settings, particularly regarding the detection of the disorder. This exploratory qualitative analysis examines lived-experience perspectives on help-seeking, including barriers encountered when help-seeking, to develop a clearer understanding of the current pathways to detection and diagnosis of PPP. A qualitative study design was used to analyse interview transcripts. Semi-structured interviews were conducted with 15 participants during 2024 which were thematically analysed. Four key themes were identified: (1) recognising the unnameable (women's early insights and difficulties in articulating their experiences and symptoms), (2) invisible until visibly unwell (barriers to recognition of PPP healthcare professionals), (3) speaking without being heard (Frequency of misdiagnosis and lack of thorough medical investigation) and (4) falling through the cracks (the Australian healthcare systems inadequate capacity to support women experiencing PPP). Unintentional medical gaslighting, which is the dismissal, reframing or invalidation of symptoms and or patient experiences, was evident through the frequent reframing and dismissal of the women's experiences and led to a disconnect between them and the Australian healthcare system. Misrecognition was evident across multiple dimensions including interpersonally and institutionally. It delayed access to care, fractured relationships and trust within the healthcare system and exacerbated psychological distress. This study emphasises that enhancing outcomes for women affected by postpartum psychosis requires increased focus within both research and clinical domains, ensuring that maternal distress is accurately identified, comprehended and validated. This study examined the help-seeking experiences of women experiencing postpartum psychosis in Australia. Medical gaslighting and frequent dismissal and reframing of the women's experiences by healthcare professionals were evident, which led to a disconnect between the women and the Australian healthcare system. This disconnect can impact the mother, the infant, the whole family unit by increasing psychological distress, the burden on family members, and disruptions to the mother-infant attachment, and the healthcare systems collectively. It emphasises that research and clinical domains need to focus on ensuring maternal distress is accurately identified, comprehended and validated. This study adhered to the COREQ for reporting interview-based qualitative research. This study did not include patient or public involvement in its design, conduct or reporting.

PMID 42902834
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PubMedDeath studies2026-10-22

A critical implementation gap in suicide prevention in oncology: Systematic review and content framework of training programs for healthcare professionals.

Schwinn Tamara T, Hirschmiller Judith J, Wiltink Jörg J, Zwerenz Rüdiger R et al.

Cancer patients face elevated risk of suicidality, yet suicide prevention remains inconsistently implemented in oncology care. Training healthcare professionals is widely recommended, but it is unclear whether existing programs address oncology-specific needs. In this pre-registered review (PROSPERO-ID: CRD42023393187), we systematically searched PubMed/Medline, CINAHL, PsycINFO, Cochrane Library, and Web of Science. Oncology reports were examined closely using the Mixed Methods Appraisal Tool. A qualitative content-analysis synthesized training contents. Of 6,526 reports identified; 351 met inclusion criteria, including 202 programs in healthcare settings. Only eight addressed oncology, just two fulfilled nearly all quality criteria. Most programs were evaluated (84.16%). Content-analysis of 129 studies focused on assessment, risk management, and intervention/referral strategies. Professionals' development and theoretical knowledge dominated, ethics and standard procedures appeared less often. While structured suicide prevention training exists in general healthcare, oncology remains largely unintegrated. This synthesis provides a framework that may inform adaptation and implementation.

PMID 42902905
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PubMedMalawi medical journal : the journal of Medical Association of Malawi2026-10-22

Training Non-Neurologist Healthcare Professionals in the Recognition and Management of Movement Disorders in Malawi.

Gwedela Mayeso Naomi Victoria MNV, Mwale Matthew M, Munthali Miriam M, Phiri Tiwonge Elisa TE et al.

Many patients with neurological disorders in Malawi are seen by non-neurologist healthcare professionals due to the low number of neurologists available in the country. Movement disorders are a growing concern at neurology clinics and patients often present late, having spent years before getting a neurology referral. In line with the WHO's global action plan on improving neurological care, we organized a workshop for non-neurologist healthcare professionals on the clinical overview of common movement disorders. The 2-day in-person workshop was held in Blantyre city and included pre- and post-workshop knowledge assessments, lectures, and neurologist-guided patient sessions. Sessions covered the pathophysiology, presentation, and management of common movement disorders (e.g Parkinson's disease, essential tremor, dystonia and chorea). At the end, participants provided feedback on the workshop through an anonymous post-workshop evaluation form with point Likert scale and open-ended questions. Forty-five participants from all tiers of Malawi's healthcare system, including general practitioners, internists, physiotherapists, and residents in non-neurology disciplines, attended the workshop. On reflection, many planned to improve their clinical practice with the knowledge and skills gained during the workshop. Participants expressed high satisfaction with the workshop content and the majority rated patient sessions as the most preferred type of learning format. Some sessions, including dystonia, functional movement disorders, and movement disorders in psychiatry, were rated as difficult and warranted further training. Participants felt the workshop could be improved by holding regular trainings for longer and including more primary healthcare professionals. This first workshop on movement disorders in Malawi was an effective continuing professional development program which facilitated interprofessional learning and intended changes in clinical practice. It provided lessons on improving neurological care through training of non-neurologist healthcare workers which can be adopted for other high-burden neurological disorders in Malawi.

PMID 42902981
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PubMedJournal of intellectual disabilities : JOID2026-10-22

Why clinicians in acute hospitals may fail to engage in direct communication with people with intellectual disability.

Elbagoury Amany A, Zia Asif A, Sawhney Indermeet I

This case highlights the healthcare inequities faced by people with intellectual disability, including diagnostic overshadowing, communication barriers, and the need for personalised, meaningful adjustments in care. A woman in her fifties with mild intellectual disability, epilepsy, and diabetes insipidus experienced delayed diagnosis and treatment because healthcare providers assumed she could not tolerate magnetic resonance imaging; however, when the scan was eventually completed with supported communication, it revealed a serious brain tumour with metastases. The case shows that diagnostic overshadowing can arise not only from misattributing symptoms, but also from untested assumptions about a patient's ability to engage with diagnostic procedures. It also underscores the importance of involving patients and families directly in healthcare decisions to support autonomy and prevent avoidable harm. Addressing these systemic issues is essential to deliver equitable, patient-centred care in acute hospital settings.

PMID 42902893
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PubMedMalawi medical journal : the journal of Medical Association of Malawi2026-10-22

Conflict of Interest vs Conflict of Incentives: Rethinking Dual Practice in Light of Malawi's Presidential Executive Order No. 1 of 2026.

Patel Parth K PK, Nair Supriya S

Dual practice-where health professionals simultaneously participate in public and private healthcare markets-is common in many health systems but presents complex governance challenges. In 2026, the Government of Malawi issued Presidential Executive Order No. 1 of 2026, prohibiting public health workers from soliciting informal payments in public facilities and restricting their ownership or financial interests in private healthcare establishments. The policy has generated significant national debate regarding its implications for health system governance and workforce incentives. This commentary examines the policy rationale and potential implications of the Executive Order, focusing on the tension between addressing conflicts of interest and maintaining appropriate incentives for health workforce retention. Drawing on international literature and comparative policy experiences, the commentary situates Malawi's reform within the broader global discourse on dual practice regulation. Evidence from multiple health systems indicates that physician ownership of private facilities can introduce structural conflicts of interest that undermine public sector performance through patient diversion, reduced public sector effort, and erosion of public trust. However, outright restrictions on private sector engagement may also carry unintended consequences in settings where public sector remuneration is limited and specialist workforce shortages are acute. International experiences demonstrate that successful regulation of dual practice requires careful alignment of governance mechanisms, workforce incentives, and health system accountability. Malawi's Executive Order represents a decisive attempt to strengthen the integrity of public healthcare delivery by addressing ownership-based conflicts of interest. Its long-term effectiveness will depend on balanced implementation, transparent regulatory guidance, and complementary reforms that address workforce incentives and health system capacity. The current debate offers an opportunity to move beyond polarized narratives and instead focus on building a governance framework that simultaneously protects public trust and supports a sustainable health workforce.

PMID 42902984
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