Drug Database
IG

IG-RD-001 (Tesalin / Ze 339 / Ze339)

✓ Approved

China Medical System · therapeutic agent

What is IG-RD-001?

IG-RD-001 is a therapeutic agent developed by China Medical System. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTesalin, Ze 339, Ze339
CompanyChina Medical System
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, China Medical System

Therapeutic Indications

IG-RD-001 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedInternational journal of MS care2026-10-22

Long-Term Changes in Patient-Reported Outcome Measures in People With Multiple Sclerosis 55 Years and Older: Analysis From the New York State Multiple Sclerosis Consortium.

Jakimovski Dejan D, Kavak Katelyn S KS, Coyle Patricia K PK, Goodman Andrew D AD et al.

Patient-reported outcome measures (PROMs) are increasingly utilized in observational and regulated studies of people with multiple sclerosis (MS). However, the impact of aging on PROMs for people with MS remains largely unknown. This study explores the cross-sectional characteristics and longitudinal trajectories of PROMs to determine their ability to predict clinical progression in a large group of people with MS 55 years and older. Included in the analysis were people with MS enrolled in the New York State Multiple Sclerosis Consortium (NYSMSC), 55 years or older, with at least 3 clinical visits recorded in the consortium database. All people in the NYSMSC complete PROMs through the LIFEware questionnaire. Additional clinical measures were also collected. The percentage of people with MS who reported severe limitations within each of the LIFEware domains was compared at their baseline visit (≥ 55 years) and at the most recent follow-up visit (average follow-up of 8.3 years). Comparisons between people with MS with stable or increasing disability were also performed. Of 658 eligible people in the NYSMSC (mean age at most recent follow-up, 66.6 years), a greater percentage reported decreased ability since baseline in all physical PROMs domains (getting up from sofa, 38.4% to 48.8%, P < .001; standing for more than 30 minutes, 59.3% vs 66.9%, P < .001; and functional limitations in all extremities, P < .007). Contrarily, the group reported improvement in multiple psychosocial domains, including pessimism (P < .001), feeling tense (P < .001), feeling annoyed (P = .02), or having morbid thoughts (P = .018). People with increasing disability had significantly worse baseline physical PROMs when compared with people with stable MS. An increase in physical limitations does not necessarily contribute to a rise in psychosocial limitations. Instead, as people with MS age, they tend to report improvements in their mental health over time. PROMs can be a complementary predictive indicator of future disease progression as individuals with MS age.

PMID 42902994
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PubMedInternational journal of MS care2026-10-22

Ocrelizumab Wearing-Off Phenomenon: Prevalence, Predictors, and Outcomes After Intervention.

Rincones Alexandra A, Fitzsimmons Marjorie M, Kolli Avinash A, Brugal Luis Compres LC et al.

Studies have suggested a wearing-off phenomenon characterized by subjective worsening of symptoms prior to subsequent infusions in more than half of people with multiple sclerosis (MS) treated with ocrelizumab. This study assesses the prevalence, characteristics, predictive factors, and impacts of different interventions on wearing off in a large cohort of people with MS receiving ocrelizumab. Clinical records of people with MS receiving ocrelizumab were reviewed to collect demographic variables, clinical characteristics, comorbidities, presence of wearing off and its specific symptoms, and responses after interventions to wearing off. Logistic regression modeling was used to assess predictors of wearing off. Wearing off was observed in 24.8% of 528 people with MS receiving ocrelizumab, most often characterized by worsening residual focal symptoms (79.4%) and fatigue (67.2%). Risk factors for wearing off included obesity (OR, 1.93; P = .013), fatigue (OR, 2.22; P < .001), and use of an assistive device for ambulation (OR, 2.16; P = .004). Any intervention, such as shortening ocrelizumab infusion intervals or switching therapies, improved or resolved wearing off in over 80% of participants (P < .001). Wearing off was observed in nearly a quarter of people with MS receiving ocrelizumab. Clinicians should be aware of predictive factors for wearing off with ocrelizumab and that interventions were generally effective at mitigating this phenomenon.

PMID 42903011
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PubMedAcademic medicine : journal of the Association of American Medical Colleges2026-10-22

Monitoring plans and the probability of higher-intensity learning plans in competency-based medical education: a multi-program path analysis.

Hamza Deena M DM

Competency-based medical education (CBME) emphasizes low-stakes interventions to support learner development. Yet, limited empirical evidence exists on whether such formative program-delivered supports mitigate the need for later high-stakes remediation. This study used structural equation modelling to examine direct and indirect (mediated) pathways, testing the hypothesis that lower-stakes interventions are negatively (inversely) associated with the probability of receiving higher-intensity learning plans. This retrospective cohort study used secondary data from 470 residents enrolled in 42 postgraduate specialty programs at an institution in Canada across six academic years (July 2019- June 2025). Learning plans were classified as monitoring, minor, or major. Structural equation modelling, specifically path analysis, was used to model hypothesized directional relationships among plan types while controlling for program size and academic year. Cluster analysis identified naturalistic groups of programs with similar patterns of learning plan use. Monitoring plans were associated with a significantly lower probability of also receiving both minor (β = -0.264, p < .001) and major plans (β = -0.174, p < .001). Within the model, minor plans were not significantly associated with major plans (β = -0.035 p = 0.324). The indirect pathway from monitoring to major plans via minor plans was small and not statistically significant. Larger program size was associated with a slightly higher probability of minor learning plan use, while later academic years were associated with greater use of major learning plans. Cluster analysis revealed four distinct program profiles, ranging from those emphasizing frequent monitoring to those relying heavily on more intensive learning plans. The model suggests that low-stakes learning plans are associated with a lower probability of higher-intensity interventions, suggesting their potential formative value. Program variation suggests local culture, faculty practices, and implementation norms influence realizing CBME's intent to provide individualized and supportive assessment processes.

PMID 42902784
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PubMedPhysical chemistry chemical physics : PCCP2026-10-22

Direct observation of opposite migration of photo-generated electrons and holes along the [001] direction in wurtzite ZnO.

Du Xiao X, Xie Rujia R, Luo Qi Q, Qu Jiaoyang J et al.

To date, the mechanism of photogenerated charge separation in photocatalysts remains unclear, and there is no atomic scale structural model to guide the synthesis of photocatalysts. To demonstrate the polar superstructure photocatalytic model, here, we use the polar [0001] direction of wurtzite ZnO as a model to study the separation of photogenerated charges along the polar direction. We observed diode rectification, spontaneous voltage, directional electron migration, photovoltage, and photocurrent along the polar [0001] direction. The rectification ratio and spontaneous voltage were 54 ± 4 and 34.8 ± 2.4 mV, respectively. At a light power density of 0.120 W cm-2, the photocurrent and photovoltage were 46.6 ± 1.4 nA and 20.0 ± 1.0 mV, respectively. However, none of these phenomena are observed along the non-polar [12̄"10] direction perpendicular to [0001]. Moreover, along the [0001] direction, the migration of photogenerated electrons and the subsequent reverse migration of holes are observed. All these observations indicate the existence of spontaneous electric field (Es) in the [0001] polar direction of ZnO. The Es drives the directional migration of electrons and photogenerated electrons, and thus these phenomena occur in the [0001] direction. These findings offer conclusive evidence supporting the polar superstructure photocatalytic model. This photocatalytic model not only contributes to the understanding of morphology- and crystal facet-dependent photocatalytic properties as well as facet-selective photodeposition but also enables the atomic-scale design and synthesis of highly efficient photocatalysts.

PMID 42902710
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PubMedEuropean journal of psychotraumatology2026-10-22

Germany's Verschickungskinder: parent-child separation and mental health.

Yim Ilona S IS, Rivera Precious J PJ, von Majewski Kristin K, Rohleder Nicolas N et al.

Background: Parent-child separations have been associated with adverse health and well-being, with most research focusing on prolonged separations driven by war, famine or disease. Verschickungskinder ('sent-away children') - the eight to twelve million German children who, in the decades following World War II, were separated from their families for several weeks to stay in so-called children's health resorts - represent a largely overlooked case of short-term separation. Despite growing recognition of adverse experiences and abuse in these settings, little is known about the long-term mental health of this population or which characteristics of the sent-away experience are associated with these outcomes.Objective: To examine whether sent-away children show more depressive symptoms, anxiety symptoms, and stress overload compared with peers, and to identify which characteristics of the sent-away experience are associated with these outcomes.Method: An anonymous online survey was conducted with 334 sent-away children and 77 participants in a convenience comparison group (M = 61.1 yrs.; 72.7% female). Linear regression models, adjusting for ACEs and sociodemographics, examined group differences and associations between characteristics of the sent-away experience (age at separation, sex, number of separations, emotional memory) and these outcomes.Results: Sent-away children reported more depressive symptoms, anxiety symptoms, and stress overload than comparison participants (all p < .001). Bivariate comparisons among the sent-away children indicated that younger age at separation was associated with more depressive symptoms, repeated separations with higher stress overload, and very negative memories with all three outcomes; no sex differences were observed. When entered simultaneously in regression models, emotional memory of the event was the only sent-away characteristic associated with depressive (p = .02) and anxiety symptoms (p = .009).Conclusions: Findings highlight the potential long-term mental health relevance of the sent-away experience, particularly among those with very negative memories of their experiences.

PMID 42902774
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PubMedJMIR medical education2026-10-22

Effects of a Generative AI Virtual Patient on Serious Illness Communication Skills: Randomized Controlled Trial.

Haut Kurtis G KG, Hasan Masum M, Carroll Thomas T, Epstein Ronald M RM et al.

Serious illness communication (SIC) is a critical skill in medical education, especially in end-of-life care, yet clinicians often lack sufficient opportunities for deliberate practice. Standardized patients (SPs) remain the gold standard for SIC training, but they are limited by cost, availability, and consistency. To support wider access to SIC training, scalable alternatives are needed. The aim of this study is to evaluate whether SOPHIE (Standardized Online Patient for Healthcare Interaction Education), an AI-powered virtual patient that provides real-time dialogue and automated feedback, improves SIC skills among clinicians and trainees. We conducted a single-blind, parallel-group, randomized controlled trial from June to December 2024 via videoconferencing. Participants were randomized in a 1:1 ratio to the intervention (SOPHIE training) or control (reading module) group. Blinded SP actors and 4 independent raters evaluated outcomes preintervention and postintervention. The intervention group completed 3 interactive SOPHIE modules (Empathize, Be Explicit, and Empower) for 30 minutes, combining dialogue with an interactive virtual patient and automated feedback. Control participants reviewed reading materials covering the same framework for the same duration. The primary outcome was the change in communication skills (Empathize, Be Explicit, and Empower) assessed by SPs and blinded raters using a rubric based on an established clinical communication training framework. Secondary outcomes included self-reported confidence in communication skills. Fifty-one medical, nursing, and physician assistant students and practicing clinicians (mean age 30.6, SD 13.2 years; women: 40/51, 78.4%) were recruited from academic and clinical settings. Participants were stratified by training level and randomized; all completed the study. Compared with controls, SOPHIE participants demonstrated significantly greater improvement in Empower (β=.11, 95% CI .04-.17; P=.002), Be Explicit (β=.08, 95% CI .03-.13; P=.002), Empathize (β=.07, 95% CI .01-.13; P=.03), and overall communication score (β=.09, 95% CI .04-.14; P=.001). Here, β represents the additional pre-to-post improvement in the SOPHIE arm relative to the control arm, estimated from linear mixed effects models. SOPHIE participants also reported higher confidence in their communication skills than controls (mean score of 4.31 vs 3.83 on a 5-point Likert scale; P=.009). Training with an AI-powered virtual patient significantly improved SIC skills and confidence compared with reading modules. Generative AI-based simulations may provide a scalable, accessible, and effective adjunct or alternative to traditional SP training in clinical education.

PMID 42902927
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