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DTaP-IPV-HB-PRP-T vaccine (Hexacima / Hexaxim / Hexyon)

✓ Approved

Merck & Co. · Vaccine · Vaccine

What is DTaP-IPV-HB-PRP-T vaccine?

DTaP-IPV-HB-PRP-T vaccine is a vaccine developed by Merck & Co.. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or intravenous (iv).

Drug Profile

Brand NamesHexacima, Hexaxim, Hexyon
CompanyMerck & Co.
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection, Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Merck & Co.

Therapeutic Indications

DTaP-IPV-HB-PRP-T vaccine is developed for 5 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

Related Research Articles

PubMedPhotochemistry and photobiology2026-10-22

Combined effects of photobiomodulation and platelet-rich plasma on healing of acute Achilles tendon injuries in rats.

Wei Hao H, Liu Hongjun H, Yin Jing J, Hu Yuping Y et al.

Tendon injuries are challenging to treat due to limited intrinsic healing, and although photobiomodulation (PBM) and platelet-rich plasma (PRP) show therapeutic potential, their combined effects remain unclear. This study evaluated the individual and combined efficacy of PBM and PRP on Achilles tendon repair in rats. A total of 144 rats were assigned to six groups and treated with PBM, PRP, or combined PBM + PRP therapy; tissues were collected at 1 and 8 weeks for biochemical and histological assessment. Both PBM and PRP reduced IL-1β and TNF-α levels and improved collagen organization, while the combined therapy produced the most pronounced anti-inflammatory response and structural recovery. Notably, PBM + PRP significantly enhanced and prolonged PDGF-BB expression compared with either treatment alone. These findings demonstrate that PBM and PRP each promote tendon healing, but their combination yields superior therapeutic benefits through amplified modulation of inflammatory and regenerative pathways, highlighting their potential as an improved therapeutic strategy.

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PubMedFrontiers in neurology2026-10-22

Early hemoglobin trajectories and short-term mortality in ICU patients with traumatic brain injury: development in MIMIC-IV and external assessment in eICU-CRD.

Li Saijie S, Han Yanyu Y, Ding Feiyu F, Qiu Zhichao Z et al.

Hemoglobin (Hb) changes dynamically after traumatic brain injury (TBI), but the prognostic relevance of distinct longitudinal patterns and their added value beyond early Hb remain uncertain. We characterized early Hb trajectories in ICU patients with TBI and examined associations with mortality after a 120-h landmark. MIMIC-IV was used for model development and multicenter eICU-CRD for external assessment. Daily median Hb values across five 24-h windows were modeled using a latent class linear mixed model. The three-class MIMIC-IV model was frozen before transport to eICU. Cox models evaluated mortality from 120 h through ICU day 28, with sensitivity analyses addressing selection, landmark attrition, simpler Hb summaries, classification uncertainty, PRBC exposure, missingness, and nonproportional hazards. In MIMIC-IV, 2,466 patients entered trajectory analysis and 2,409 entered post-landmark analysis. Three trajectories were identified: relatively high and stable, rapidly declining, and persistently low Hb. In fully adjusted models, rapidly declining (HR 1.74, 95% CI 1.18-2.57) and persistently low Hb (HR 1.57, 95% CI 1.19-2.08) were associated with higher mortality. In eICU, 2,097 patients were classified and 1,557 entered outcome analysis; persistently low Hb remained associated with mortality (HR 1.58, 95% CI 1.03-2.43), whereas the rapidly declining association was less precise (HR 1.24, 95% CI 0.80-1.92). Adding trajectory class to the MIMIC-IV clinical model increased the C-index from 0.786 to 0.792. After adjustment for first-day Hb, the rapidly declining trajectory remained associated with mortality (HR 1.77, 95% CI 1.20-2.62), whereas the persistently low association attenuated (HR 1.27, 95% CI 0.83-1.93). Independent three-class refitting in eICU did not recover the same latent-class structure (ARI 0.169). Early Hb trajectories after TBI showed distinct prognostic associations. Persistently low Hb had the most consistent transported association but was attenuated after first-day Hb adjustment; rapid decline retained an association in MIMIC-IV but had limited external support. Incremental discrimination was modest. These patterns should be interpreted as treatment-embedded clinical courses rather than fixed biological phenotypes or evidence for trajectory-specific transfusion thresholds.

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PubMedFrontiers in immunology2026-10-22

Integrated immunoreactivity analysis of MHC-I epitopes derived from the Marburg virus glycoprotein.

Yang Yulin Y, Wang Jing J, Guan Enqi E, Wei Hengzheng H et al.

Marburg virus (MARV) is a hemorrhagic fever virus, and its glycoprotein (GP) represents an important target for vaccine research. MHC class I (MHC-I)-restricted T cell epitopes are critical for inducing cytotoxic CD8+ T cell responses. In this study, we aimed to identify MHC-I-restricted T cell epitopes derived from the MARV Angola strain GP through an integrated bioinformatics and experimental approach. We retrieved the MARV Angola strain GP sequence and divided it into 673 overlapping 9-mer peptides. By integrating five computational prediction algorithms, immunogenicity scoring tools and BLASTp conservation analysis, we screened 9-mer peptides from the MARV Angola GP. Molecular docking was performed with MHC-I structures using HPEPDOCK and molecular dynamics (MD) analysis. Bidirectional hierarchical clustering was used to analyze binding similarity across MHC-I molecules. Mutations identified in epitope regions were tested for their effect on affinity. Toxicity and allergenicity of the epitopes were predicted using dedicated tools. Finally, BALB/c and C57BL/6 mice were immunized with a DNA vaccine encoding MARV GP. IFN-γ secretion in mouse splenocytes was then measured by ELISpot, serum IgG by ELISA, and CD8+ T cell cytokine production by flow cytometry. Among 673 GP peptides, eight epitopes (GAFFLYDRI, REGDMFPFL, DMFPFLDGL, NENDCDAEL, AGLSWIPFF, NQNNLVCRL, TGWGLGGKW, SDWGVLTNL) were predicted to exhibit high-affinity MHC-I binding, strong immunogenicity, and intraspecies conservation. Bidirectional hierarchical clustering analysis, molecular docking, sequence alignment, and toxicity/allergenicity predictions suggested binding across selected alleles, structural stability, limited impact from identified mutations, and low predicted toxicity. In subsequent ELISpot validation, eight epitopes elicited strong IFN-γ responses. In addition, serum from GP-immunized mice contained IgG that bound the corresponding linear peptide sequences. An integrated computational-experimental pipeline identified eight conserved, immunogenic MHC-I epitopes from MARV GP. These selected epitopes may serve as promising candidates for future vaccine design.

PMID 42903143
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PubMedFrontiers in immunology2026-10-22

A subunit vaccine protects A129 mice from death and joint swelling against lethal Chikungunya virus challenge.

Li Jiangfan J, Fang Ting T, Song Liyuan L, Qiang Li L et al.

Chikungunya virus (CHIKV) is primarily transmitted to humans through bites of infected Aedes mosquitoes, causing febrile illness as well as acute or chronic arthritis. With increasing reports in previously non-endemic regions, it poses an emerging threat to public health and a growing risk to travelers. Despite the recent approval of live-attenuated and virus-like particle-based vaccines, a safe, efficacious, and cost-effective vaccine remains urgently needed. The envelope glycoproteins E1 and E2, which play crucial roles in viral attachment and entry, are the major immunodominant structural proteins and can effectively elicit protective antibodies. We engineered mammalian cells to produce the ectodomains of the E1 and E2 glycoproteins and evaluated the protective efficacy of the resulting vaccine formulations in vivo. A two-dose vaccination regimen elicited high levels of antibodies and provided full protection against lethal challenge in A129 mice, preventing both death and joint swelling. These findings demonstrate the potential of this vaccine candidate against CHIKV and warrant its further development.

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PubMedEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2026-10-22

[Strategies to address vaccine hesitancy in Brazil: evidence synthesis].

Marques Ana Paula da Costa APDC, Gubert Vanessa Terezinha VT, Dias Adriano da Costa ADC, Gasparoto Antonio Luiz Dal Bello ALDB et al.

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PubMedThe Journal of the Association of Physicians of India2026-10-22

An Epidemiological Study to Assess the Prevalence of Anemia and Its Determinants in Women of Reproductive Age Group (15-49 Years) in an Urban Slum of a Metropolitan City.

Deshmukh Kshitij Rajesh KR, Chavhan Smita Santosh SS, Tupe Sagar Dhondiram SD, Vakilna Roshni R et al.

Anemia is a serious public health concern among women of reproductive age (WRA) 15-49 years in India. The prevalence of anemia in WRA in Mumbai and the Mumbai suburban district was 45%-50%, respectively, as per National Family Health Survey-5 (NFHS-5) data. This study was done to assess the prevalence of anemia and its determinants in WRA in the urban slums of Mumbai. A total of 1,500 WRA were enrolled in this community-based cross-sectional study by the convenience sampling method. A structured validated questionnaire was used to record sociodemographic variables and determinants. Hemoglobin (Hb) estimation was done with a digital hemoglobinometer. SPSS v.18, Chi-square test, and binary logistic regression were used for analysis. The study was approved by the Institutional Ethics Committee of HBT Medical College and Dr. RN Cooper Hospital (Approval No. HBTMC/IEC/025-2025/RP/0/330/07072025/26) on 07/07/2025, and written informed consent was obtained from all participants. Prevalence of anemia in WRA was 57.9%. Significant associations were found between anemia and education level (p = 0.004), socioeconomic class (p < 0.001), gravida status (p < 0.001), spacing between pregnancies (p < 0.001), iron tablet consumption in the past 1 year (p = 0.014), duration of menses (p = 0.019), and pad changes per day (p = 0.013). Determinants such as education level, socioeconomic class, number of pregnancies, spacing between pregnancies, iron tablet consumption, duration of menses, and pad changes per day affect the Hb level of WRA.

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