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BCG polysaccharide and nucleic acid injection (intramuscular) (Disu / DI SU)

✓ Approved

3SBio · Cell-based Therapies · Cell-based Therapies

What is BCG polysaccharide and nucleic acid injection (intramuscular)?

BCG polysaccharide and nucleic acid injection (intramuscular) is a cell-based therapies developed by 3SBio. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesDisu, DI SU
Company3SBio
Drug ClassCell-based Therapies, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, 3SBio

Therapeutic Indications

BCG polysaccharide and nucleic acid injection (intramuscular) is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersBronchitis chronic✓ Approved
Infections and infestationsRhinovirus infection✓ Approved

Related Research Articles

PubMedChembiochem : a European journal of chemical biology2026-10-22

A DNA Platform-Assisted Cooperative Probe Addresses the Affinity-Selectivity Trade-Off in Hybridization-Based Nucleic Acid Detection at Room Temperature.

Bobkova Maria Y MY, Viskov Mikhail A MA, Zelenin Konstantin A KA, Gorbenko Daria A DA et al.

Hybridization-based nucleic acid detection remains central to molecular diagnostics but is often limited by slow kinetics, diminished sensitivity toward structured or double-stranded targets and low selectivity in recognizing single-nucleotide variation (SNV) at ambient temperatures. Here we introduce a DNA platform-assisted cooperative probe (PCP) that enhances the performance of conventional molecular beacon (MB) probes through cooperative analyte binding mediated by a DNA scaffold. The PCP architecture spatially organizes two analyte-binding arms (F and U) on a dsDNA platform for cooperative tight binding of nucleic acid analytes, which enables the use of a short platform-detached strand m for highly selective SNV recognition. Using clinically relevant targets from Mycoplasma genitalium (23S rRNA fragment) and Neisseria gonorrhoeae (penA gene fragment), we demonstrate that PCP improves SNV selectivity from 10% to 14% for MB probe up to 99%, and lowers the limit of detection by up to an order of magnitude but does not significantly improve hybridization rate. The PCP sensor further enables room-temperature detection of double-stranded polymerase chain reaction (PCR) amplicons. These results establish DNA platform-based probe organization as an advantageous strategy to resolve the affinity/specificity trade-off in hybridization-based diagnostics.

PMID 42902930
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PubMedBioconjugate chemistry2026-10-22

Macrophage-Targeted Quantum Dots with Short-Wave Infrared Emission for In Vivo Breast Cancer Imaging.

Xu Fengyuan F, Lee Wonseok W, Shi Kaichi K, Saha Urbi U et al.

In vivo characterization and visualization of tumors often relies on radioactive tracers and expensive, complex equipment, which limits the frequency of analysis, throughput, and accessibility. Short-wave infrared (SWIR) fluorescence is a new nonradioisotopic imaging modality with flexible readouts at high depth and high signal-to-background contrast. Here, we report semiconductor quantum dots (QDs) with SWIR fluorescence engineered to selectively target tumor-associated macrophages (TAMs) by functionalization with the polysaccharide dextran (Dex). TAMs are often abundant in the tumor microenvironment and mediate immune suppression, angiogenesis, metastatic progression, and therapy resistance, making them important targets for in situ analysis. We compare QD-Dex probes with QDs coated with polyethylene glycol (QD-PEG) as nontargeted controls with equivalent fluorescence, hydrodynamic size, and electrostatic charge. In vitro, QD-Dex exhibited receptor-mediated uptake by cultured macrophages whereas QD-PEG uptake was only through noncompetitive passive processes. In vivo, SWIR imaging of immunocompetent mice bearing TAM-rich orthotopic 4T1 mammary tumors revealed tumor retention of QD-Dex after intravenous administration. Tumor signals for QD-PEG were much lower in comparison. Tumor signals for QD-Dex exceeded blood levels ∼2 h after injection and decayed substantially after 24 h, providing an appropriate time window for preclinical imaging studies in rodents. These findings establish baseline metrics for macrophage-targeted SWIR nanoprobes as a platform for preclinical in vivo tumor analysis without ionizing radiation.

PMID 42902939
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PubMedMalawi medical journal : the journal of Medical Association of Malawi2026-10-22

Ketamine-Based Sedation Among Young Infants During MRI at Mzuzu Central Hospital: Initial Experience in a Resource-Limited Setting in Malawi.

Ren Junyi J, Moyo Joel J, Kondowe Blessed B, Manda Patrick P et al.

Magnetic resonance imaging (MRI) in young infants requires effective immobilization to ensure diagnostic image quality. Although non-pharmacological approaches such as the feed-and-swaddle technique are widely recommended, they are not always successful. Sedation in neonates remains controversial, particularly in resource-limited settings. This study aimed to evaluate the feasibility and observed safety profile of intramuscular ketamine for MRI sedation in young infants at Mzuzu Central Hospital, Malawi. This retrospective case series included five young infants (aged 3-90 days) who underwent abdominal MRI under ketamine sedation between August 2025 and March 2026. Diagnoses included three cases of congenital biliary atresia, one cloacal exstrophy, and one sacrococcygeal teratoma. All patients initially failed non-pharmacological sedation using the feed-and-swaddle technique alone. Sedation was performed by an experienced anesthesiologist using intramuscular atropine (0.01 mg/kg) followed by ketamine (4-5 mg/kg). MRI scans were performed using a 1.5 T system. Respiratory status was assessed via MRI respiratory gating waveforms. Clinical data were collected from medical records, including anesthesia records, and analyzed descriptively. All MRI examinations were successfully completed, with a mean scan time of 23 minutes. No clinically significant adverse events were observed, including oxygen desaturation or airway-related complications. No overt clinical signs suggestive of hemodynamic instability were noted. All images were of diagnostic quality as assessed by the radiologist. The target sedation depth was achieved in all cases without the need for additional dosing. The mean time to emergence was 40 minutes, and the mean time to full recovery was 94 minutes, with no cases of delayed recovery or agitation. Intramuscular ketamine, when used with appropriate precautions, appears to be a feasible option and may represent a safe alternative for MRI sedation in young infants in resource-limited settings.

PMID 42902986
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PubMedDrug development and industrial pharmacy2026-10-22

Synthesis, characterization, and in vivo evaluation of desvenlafaxine decanoate, a new long-acting injectable antidepressant.

Santos Maria Luiza Ferreira Dos MLFD, Oliveira Campos Philipe Raphael PR, Machado Renes Resende RR, Jardim Filho Nilo Edgar NE et al.

The aim of this study was to design, synthesize, and characterize a novel long-acting injectable antidepressant prodrug, desvenlafaxine decanoate. Long-acting injectable drugs represent a useful approach for the treatment of mental illnesses, since these formulations extend dosing intervals and are beneficial for patients unable to self-administer oral medication or to maintain adherence to treatment. Although some antipsychotic depot formulations are used in clinical practice, there is a lack of studies on long-acting injectable antidepressants. This prodrug was synthesized by esterifying desvenlafaxine with decanoic acid, affording the target compound in 75% yield. Structural characterization was performed by 1H and 13C NMR, high-resolution mass spectrometry (HRMS), and high-performance liquid chromatography (HPLC). An in vivo proof-of-concept study was conducted in mice following intramuscular administration of desvenlafaxine decanoate. A selective HPLC-DAD method was developed to separate desvenlafaxine succinate and desvenlafaxine decanoate, achieving retention times 6.08 and 15.70 min, respectively. LC-MS/MS analysis of plasma samples collected 2 hours after administration demonstrated significant levels of desvenlafaxine in systemic circulation. The plasma detection was a proof-of-concept for the in vivo hydrolysis of the ester prodrug. These findings support the feasibility of desvenlafaxine decanoate as a promising long-acting injectable antidepressant for patients requiring prolonged maintenance therapy.

PMID 42902977
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PubMedBioconjugate chemistry2026-10-22

Native Chemical Ligation-Driven Formation of Hyaluronic Acid-Based Injectable Hydrogels.

Vantou Camille C, Vigneron Nolwenn N, Keromnes Benoit B, Brusini Romain R et al.

We report the development of an injectable hyaluronic acid (HA)-based hydrogel using native chemical ligation (NCL) as a biocompatible and chemoselective crosslinking strategy for potential biomedical applications. High-molecular-weight HA was pre-modified with a glycinyl thioester derivative, while a bis-cysteine peptide served as the crosslinker, enabling rapid hydrogel formation under physiological conditions. After optimization of NCL parameters, the resulting hydrogel exhibits all key attributes for biomedical hydrogel injectables: cytocompatibility, injectability, tunable rheology adapted for soft-tissue delivery (e.g., skin and subcutaneous tissue), enzymatic degradability by hyaluronidase, adjustable swelling, and long-term shelf-life stability. It can be sterilized by autoclaving for injection purposes and also functions as a drug delivery matrix for localized, in situ release. This study presents a robust and scalable HA-based platform, available as either an injectable hydrogel or an in situ cross-linkable solution, with broad potential in drug delivery, regenerative medicine, and aesthetic applications.

PMID 42902940
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PubMedFrontiers in microbiology2026-10-22

Genomic insights into bacterial communities of coenocytic algae using metagenome-assembled genomes.

Laureano Gerardo G, Ramirez Xochitl X, Scoles Ashley A, Johne Christina C et al.

Coenocytic algae are organisms that undergo karyokinesis without cytokinesis, resulting in multinucleated cells. Most research on bacterial communities in coenocytic algae has used 16S rRNA sequencing, primarily focusing on the order Bryopsidales of green coenocytic algae. Recent studies have analyzed metagenome-assembled genomes (MAGs) from algal hosts across multiple taxa, such as Chlorophyta, Phaeophyta, and Rhodophyta, revealing further insights into bacterial biosynthetic machinery and potential symbiotic relationships. Given the cosmopolitan distribution of coenocytic algae, such as Bryopsis, Caulerpa, Codium, and the yellow-green alga Vaucheria, and their unique morphology, there is a need to better understand their associated bacterial communities. To address this, filaments of Vaucheria bursata LB2067 were sequenced using the Illumina NovaSeq instrument, and all publicly available short- and long-read datasets from coenocytic algae were screened for MAG recovery. All recovered MAGs from both Bryopsidales and Vaucheriales showed a high dominance of Pseudomonadota at the phylum level, but no consistent patterns at the order or family levels. Core metabolic pathways, including glycolysis, the TCA cycle, and amino acid biosynthesis, were present across MAGs from both coenocytic and non-coenocytic algae. Pathways with significantly higher completeness in coenocytic-associated MAGs included protein secretion (Sec-SRP), which showed the strongest effect, motility (flagellar assembly), thiamin biosynthesis, and polyhydroxybutyrate (PHB) synthesis (Mann-Whitney U, padj < 0.05). Notably, N-acetylglutaminylglutamine amide (NAGGN) biosynthetic gene clusters (BGCs) were found only in MAGs from coenocytic orders, whereas polysaccharide utilization loci (PULs) were present in all MAGs analyzed. These results indicate that bacterial communities associated with coenocytic algae are complex, with diverse survival strategies adapted to challenging and variable environments.

PMID 42903155
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