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SODAS-HC

✓ Approved

Elan · therapeutic agent

What is SODAS-HC?

SODAS-HC is a therapeutic agent developed by Elan. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyElan
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Elan

Therapeutic Indications

SODAS-HC is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedTranslational psychiatry2026-11-11

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression.

Heckel Julia M JM, Clouse Aaron A, Klemballa David D, Hernandez Joanna J et al.

Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications ("apps") have emerged as promising methods for assessing mental health-related outcomes in individuals' daily lives that can detect changes that unfold over time. Although smartphone apps have been used to evaluate executive functioning in individuals with neurological conditions and in other mental health disorders, few studies have examined this in MDD. The present study tested whether smartphone-assessed executive function is (1) impaired in individuals with current MDD (cMDD; n = 30) relative to healthy controls (HC; n = 42) and (2) related to resting-state functional connectivity within cognitive control-related neural networks. For two weeks, participants completed a set-shifting (Trail Making Test, TMT-B) task on their smartphone. Participants with cMDD had significantly lower TMT accuracy (β = -0.24, p = 0.044) and greater variability in TMT accuracy (β = 0.25, p = 0.049) compared to HC. Resting-state analyses revealed that the association between TMT accuracy and connectivity between nodes of the dorsal attention network (bilateral intraparietal sulcus) was greater in HC than cMDD. The results extend previous laboratory-based findings by demonstrating that individuals with cMDD exhibit poorer mean-level smartphone assessed set-shifting performance and greater variability, along with altered set-shifting-related functional connectivity within the dorsal attention network. Smartphone-based assessments may offer a scalable and accessible approach for identifying executive function deficits in individuals with depression, which could be a useful tool for monitoring cognitive performance over time.

PMID 43009487
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PubMedJournal of magnetic resonance imaging : JMRI2026-11-11

White Matter and Normal-Appearing White Matter in Low-Disability Patients With Multiple Sclerosis: A Diffusion Tensor MRI Study.

Umezaki Fabiana Bianca Hayashi FBH, Paulo Artur José Marques AJM, Handfas Benjamim Wolf BW, Junior Edson Amaro EA et al.

Diffusion tensor imaging (DTI) is sensitive to white matter (WM) microstructural alterations in multiple sclerosis (MS), but duration-defined "early MS" cohorts may be clinically heterogeneous. To investigate diffusion alterations in WM and normal-appearing white matter (NAWM) in low-disability MS versus healthy controls (HC). Retrospective cross-sectional case-control study. 20 patients with MS (Expanded Disability Status Scale ≤ 3.5; ambulatory without assistance) and 20 age- and sex-matched HC. 3.0 T; 3D T1-weighted and FLAIR sequences and a single-shot spin-echo echo-planar sequence with 60 diffusion directions (b = 1000 s/mm2) and nine b0 volumes. Tract-Based Spatial Statistics (TBSS) assessed fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) in conventional WM and lesion-masked NAWM. DeepLesionBrain (volBrain) automatically segmented WM lesions; a neuroradiologist with 10 years of experience reviewed and corrected segmentations when necessary. FMRIB Software Library (FSL) randomize using 10,000 permutations, threshold-free cluster enhancement, and family-wise error correction (p < 0.01). Permutation Analysis of Linear Models (PALM) used two-sided inference and FWE correction across diffusion metrics and directions. Standard TBSS showed lower FA in the right anterior corona radiata (ACR) and posterior thalamic radiation (PTR), and higher RD in the corpus callosum genu, in MS versus HC. NAWM-restricted TBSS showed lower FA in the corpus callosum genu, right PTR, and right tapetum, and higher RD in bilateral ACR, right posterior corona radiata, and an unclassified region. In randomized, AD and MD were nonsignificant (minimum corrected p = 0.0118 and 0.0103 in standard TBSS; p = 0.0103 and 0.0107 in NAWM, respectively). Under PALM across-metric correction, no metric remained significant: standard TBSS, FA p = 0.0861, AD p = 0.1273, RD p = 0.0271, MD p = 0.0177; NAWM, FA p = 0.0807, AD p = 0.1225, RD p = 0.0282, MD p = 0.0197. Functionally defined low-disability MS shows focal WM and NAWM microstructural alterations, predominantly reflected by reduced FA and increased RD. 4. Stage 1.

PMID 43012127
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PubMedArchives of suicide research : official journal of the International Academy for Suicide Research2026-11-11

Blood Biomarkers, Psychiatric History, and Mood Stabilizer Use Are Associated with Completed Suicide Among Psychiatric Inpatients Within 10 Years After Discharge: A Case-Control Study.

Ribeiro de Matos Marina M, Mädke Brenner Augusto A, Monteiro Burin Luísa L, Grazziotin Portal Pedro Henrico PH et al.

To investigate whether inflammatory and neurotrophic biomarkers, clinical variables, and psychiatric history are associated with completed suicide. This case-control study included 24 inpatients with severe mental disorders (SMD) over 10 years, including 8 individuals who completed suicide and 16 matched ill-controls (IC). The study also included 16 healthy controls (HC). We analyzed serum inflammatory markers, BDNF levels, medication use, clinical psychiatric scores, and psychiatric history. Compared with ICs, suicide cases showed significantly higher serum levels of BDNF and IFN-γ and lower levels of IL-17. No significant differences were observed for TNF-α, IL-2, IL-4, IL-6, or IL-10. Suicide cases had higher numbers of prior psychiatric hospitalizations, previous suicide attempts, and greater use of mood stabilizers. Clinical psychiatric scale scores were not significantly associated with suicide during follow-up. Specific biological markers-particularly BDNF, IFN-γ, and IL-17-along with psychiatric history, especially prior suicide attempts and hospitalizations, appear to be important factors in completed suicide risk among SMD inpatients.

PMID 43012871
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PubMedBJOG : an international journal of obstetrics and gynaecology2026-11-10

Hormonal Contraception Use and Changes in Body Mass Index: A Cohort Study.

Lund Mathilde M, Andersen Mikkel Porsborg MP, Sørensen Kathrine Kold KK, Møller Amalie Lykkemark AL et al.

To examine the potential association between hormonal contraceptive use and body mass index (BMI). Linear regression model was used to assess change in BMI between adolescence and adulthood according to hormonal contraception use. Hormonal contraception (HC) use was categorized according to hormonal composition. We included all Danish women with data on adolescence height and weight in the Danish National Child Health register and adult weight and height reported in the Safe Choice survey. The primary outcome was the difference in BMI from adolescence to adulthood, based on the assessed height and weight in adolescence and adulthood. We included 47 148 individuals with a median age of 21 years (1st-3rd quantile: 19-24) at the time of answering the Safe Choice survey. Regardless of HC use, BMI increased between the two measurements for all groups. Hormonal contraception containing oestrogen was associated with a larger BMI increase after 4-5 years of cumulated duration of use compared to participants who had never used HC (p-value < 0.001). After more than 5 years, among women with a history of HC use, BMI increased most in users of combined oestrogen-progestin contraceptives (3.14 BMI points; 95% CI: 2.98-3.30; p < 0.001) and least in progestin-only users (2.47 BMI points; 95% CI: 2.27-2.66; p < 0.001); in comparison, non-users experienced a BMI increase of 2.28 BMI points (95% CI: 2.10-2.45; p < 0.001). This study shows that BMI increased between the two measurements in all groups. Hormonal contraception containing oestrogen was associated with a larger BMI increase after 4-5 years of cumulative HC use compared to never-users. Among those with a cumulative duration of HC use greater than five years, the largest BMI increase was observed for combined HC, and the smallest was observed for progestin-only methods.

PMID 43008787
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PubMedJournal of evolutionary biology2026-11-10

Expression Characteristics of Hypoxia Adaptation-Associated Genes in Pastor roseus under Different Altitudinal Conditions.

Li Ran R, Sun Xixiu X, Yang Kun K, Lin Jun J et al.

Pastor roseus is a long-distance migratory bird that arrives annually in May at grasshopper-infested steppes of Xinjiang, characterized by a broad altitudinal gradient, for breeding. The dual physiological stressors of high metabolic demand during breeding and high-altitude hypoxia are key selective pressures driving the evolution of hypoxia adaptation in birds. Hypoxia-inducible factor (HIF) is critical for cellular hypoxia responses, and Prolyl hydroxylase 2 (PHD-2) maintains its homeostatic balance. We examined the molecular basis of hypoxia adaptation by measuring HIF-2α, HIF-1β, and PHD-2 expression via qRT-PCR in whole blood of birds sampled across an altitudinal gradient. Results showed: (1) HIF-2α expression was significantly higher at the WQ and XY sites than at the lowest-altitude HC site (P < 0.05). (2) HIF-1β remained relatively stable, being significantly higher at the highest-altitude (XY) site than in the HC and YN groups (P < 0.05), with no significant differences among the other groups. (3) PHD-2 expression was significantly higher in the YN and HM groups than in the lowest-altitude HC group (P < 0.05), with no significant differences among the other groups or between YN and HM. These findings indicate that HIF-2α, HIF-1β, and PHD-2 show distinct but coordinated expression along the altitudinal gradients of P. roseus breeding habitats, suggesting their potential joint involvement in the hypoxic stress response. This contributes to a deeper understanding of the molecular mechanisms underlying high-altitude hypoxia adaptation and provides a theoretical framework for conserving grasshopper natural enemies and investigating the ecological adaptability of migratory avian species.

PMID 43008310
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PubMedACS applied materials & interfaces2026-11-10

Electrospun Perforated Carbon Spheres with an Ultramicropore-Rich Architecture for Sodium-Ion Storage.

Deng Shuping S, Jiang Qianrong Q, Wang Lu L, Sawut Nurbiye N et al.

Hard carbon (HC) is a promising anode material for sodium-ion batteries (SIBs) because its disordered structure and relatively large interlayer spacing facilitate reversible Na+ storage. Polyacrylonitrile (PAN) is an attractive carbon precursor with high carbon yield and in situ nitrogen doping. However, conventional PAN-derived HC often suffers from sluggish ion transport and limited reversible capacity. Herein, electrospun perforated carbon spheres (PCS) with an ultramicropore-rich architecture were fabricated via coaxial electrospinning, sacrificial templating, and high-temperature carbonization. The optimized PCS exhibits a CO2-derived apparent specific surface area of 362.5 m2 g-1 and deliver a reversible capacity of 312.9 mAh g-1 at 20 mA g-1, including a plateau capacity of 180.2 mAh g-1. It also delivers a rate capability of 145.6 mAh g-1 at 2 A g-1 and retains 88.0% of its capacity after 400 cycles at 50 mA g-1. Ex situ XRD, in situ Raman spectroscopy and electrochemical analyses are consistent with an adsorption-intercalation/pore-filling sodium-storage mechanism. A full cell paired with a Na4Fe3(PO4)2P2O7 (NFPP) cathode delivers an energy density of 209 Wh kg-1 based on the total mass of active materials. These results demonstrate that electrospun carbon spheres with tailored pore structures are promising anodes for advanced SIBs.

PMID 43006881
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