Drug Database
GA

ganglioside ester (Sinassial / ganglioside ester / Sinaxial ester)

✓ Approved

Fidia · Small Molecule · Small Molecule

What is ganglioside ester?

ganglioside ester is a small molecule developed by Fidia. It is approved for therapeutic indications.

Drug Profile

Brand NamesSinassial, ganglioside ester, Sinaxial ester
CompanyFidia
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Fidia

Related Research Articles

PubMedJournal of agricultural and food chemistry2026-11-11

Brassinosteroid and Light Quality Synergistically Regulate Aroma Biosynthesis via the CmBES1-4-CmDof13 Module in Postharvest Oriental Melon (Cucumis melo).

Zhang Chong C, Ju Meng M, Wang Zhongbo Z, Pang Hongbo H et al.

Brassinosteroids and light quality regulate secondary metabolism in fruits, yet the synergistic control of volatile aroma biosynthesis in oriental melon (Cucumis melo var. makuwa) remains unclear. In this study, we used volatile metabolomics, RNA sequencing (RNA-seq), and DNA Affinity Purification Sequencing (DAP-seq) methods to show that red light combined with brassinosteroids effectively increased total volatiles, particularly esters, at day 6 after harvest. Weighted gene coexpression network analysis (WGCNA) identified a module strongly associated with ester content, in which the brassinosteroid-responsive transcription factor CmBES1-4 co-occurred with CmDof13 and the downstream target genes CmLOX18 and CmAAT1. DAP-seq analysis revealed that CmBES1-4 bound E-box and BRRE motifs genome-wide, thereby directly targeting CmDof13. Dual-luciferase, yeast one-hybrid, and EMSA assays confirmed that CmBES1-4 activated CmDof13 expression via E-box binding. These findings identified a novel light/BR-CmBES1-4-CmDof13-ester biosynthesis regulatory module, which provided theoretical insights for improving postharvest aroma quality in oriental melon.

PMID 43012713
Read full article →
PubMedThe Journal of organic chemistry2026-11-11

Visible-Light-Catalyzed Phosphorylation of Alkenes Enabled by Oxime Ether Reagents.

Wu Di D, Hu Meilin M, Hu Xiangnan X, Wang Kai K et al.

Existing photocatalytic alkene phosphorylation relies on oxime ester-based phosphorus radical precursors, while conventional oxime ethers are severely limited by their inert N-O bond cleavage under photochemical conditions, restricting their synthetic utility. To overcome this bottleneck, we rationally designed and synthesized a novel class of photocleavable oxime ether phosphorylating reagents by incorporating a labile C-Br bond as an exogenous radical initiation site. This tailored molecular design successfully circumvents the intrinsic photoinertness of classic oxime ethers and enables efficient visible-light-driven generation of key phosphoryl radicals. The mild protocol affords structurally diversified alkenyl phosphates with broad substrate tolerance, scalable synthetic capability, and excellent functional group compatibility. This work establishes a distinctive radical phosphorylation strategy and greatly expands the applicability of oxime ether scaffolds in photoredox catalysis and organophosphorus synthesis.

PMID 43012421
Read full article →
PubMedInternational urology and nephrology2026-11-11

Sex-specific serum metabolomic signatures of chronic kidney failure: a machine learning and interaction analysis based on the UK biobank.

Xu Xiaoting X, Wang Lihui L, Chen Qian Q, Sun Zhixia Z et al.

Whether circulating metabolites are associated with chronic kidney failure (CKF) differently in men and women remains poorly characterized, and metabolomic studies of kidney outcomes have rarely accounted for the dominant influence of renal filtration itself on the circulating metabolome. We aimed to delineate sex-specific serum metabolomic signatures of CKF under a design that separates feature selection from statistical inference and explicitly adjusts for renal function. We analyzed nuclear magnetic resonance (NMR) metabolomic profiles from 365,422 UK Biobank participants (199,540 women, 165,882 men). Sex-stratified LightGBM models with SHAP interpretation were fitted exclusively in a random 50% discovery partition; all association estimates were derived in the independent held-out 50% validation partition using multivariable logistic regression adjusted for age, Townsend deprivation index, ethnicity, fasting status, obesity, hypertension, type 2 diabetes, and baseline serum creatinine, with Benjamini-Hochberg correction across 39 sex × metabolite interaction tests. Serum creatinine was excluded from all predictive models to avoid outcome-predictor leakage. The metabolome provided statistically significant, but clinically modest incremental discrimination over clinical covariates (ΔAUC 0.037 [95% CI 0.031-0.043] in men and 0.026 [0.021-0.031] in women; continuous net reclassification improvement not significant). After creatinine adjustment, seven sex × metabolite interactions remained significant. The cholesteryl-ester fraction of small LDL particles was inversely associated with CKF in both sexes, but more strongly in men (OR per 1-SD 0.79 [0.77-0.81] vs 0.85 [0.83-0.87]; interaction FDR = 4.6×10⁻5), with a concordant pattern for medium LDL (FDR = 2.2×10⁻4); formal sex × spline tests confirmed steeper inverse dose-responses in men. In contrast, the apparently male-specific associations of isoleucine, alanine, and 3-hydroxybutyrate observed in unadjusted models were fully attenuated after creatinine adjustment, indicating confounding by renal filtration. Shared core metabolites were enriched for amino-acid, ketone-body, and glycolysis-related groups in both sexes (all FDR < 0.005). Sex differences in the CKF serum metabolome are concentrated in lipoprotein cholesteryl-ester composition and remain robust after renal-function adjustment, whereas amino-acid signatures largely reflect filtration-related confounding. Adjustment for baseline renal function is indispensable in metabolomic studies of kidney outcomes.

PMID 43009721
Read full article →
PubMedNano letters2026-11-11

Super-Toughness Self-Healing MOF-Based Composite Solid Electrolyte with Reaction-Transport Coupling Regulates Transportation of Ions and Polysulfides in High-Performance Solid-State Li-S Batteries.

Su Zhipeng Z, Peng Bo B, Yao Zhihong Z, Zou Feng F et al.

Lithium-sulfur batteries have emerged as a promising candidate for next-generation energy storage systems due to high theoretical energy density and low cost. However, the practical application is severely hindered by issues such as the polysulfide shuttle effect, sluggish ion transport, and lithium dendrite growth. Here, we proposed a synergistic strategy based on nanoconfinement polymerization and self-healing dynamic cross-linking to successfully fabricate a self-healing composite solid electrolyte, composed of PVDF-HFP, graphene oxide, UiO-66, linear polydopamine chains, and a boronic ester cross-linked network. The electrolyte demonstrates high ionic conductivity (1.7 × 10-4 S cm-1), good puncture resistance (9.7 N), high elongation at break (335%), and superior capacity retention (a capacity decay rate of 0.0276% per cycle over 500 cycles). Even under a high sulfur loading of 4 mg cm-2, the capacity retention remained as high as 94.8%, which exceeds previously reported electrolytes. This strategy offers a new pathway to designing advanced solid electrolytes for high-energy batteries.

PMID 43012596
Read full article →
PubMedAnalytical chemistry2026-11-11

DESI-Enabled Signature-Ion-Guided Natural Product Imaging (DESIGNi) for Rapid Screening of Aromatic Acylated Derivatives in Plant Tissues.

Xue Yuchen Y, Liu Jinmin J, Yao Mingju M, Zhang Xiaohui X et al.

Mass spectrometry imaging (MSI) enables in situ visualization of small-molecule distributions in plants. However, MSI data interpretation often relies on extensive prior chemical knowledge, limiting the rapid screening of specific compound classes. Furthermore, structural analysis via LC/MS typically depends on tandem mass spectrometry, which is not routinely integrated into standard MSI workflows. To address this, we established a desorption electrospray ionization (DESI)-enabled, signature-ion-guided natural product imaging (DESIGNi) method. By acquiring high-resolution fragment ion data using a multi-reflecting time-of-flight (MRT) mass spectrometer, this approach enables rapid visualization of compounds containing specific building blocks based on their diagnostic fragment ions. As a proof of concept, we focused on aromatic acylated derivatives. The method was developed and optimized using the phenylethanoid glycosides in Forsythia fruit, and the accuracy of the resulting distributions was validated by LC/MS. We applied this approach to seven additional medicinal or edible plants and mapped the distribution of phenylethanoid glycosides, phenolic acid oligomers, benzyl ester glycosides, amides, and diarylheptanoids. By tracing signature ions to their corresponding full-scan spectra, MSI enabled the discovery and preliminary identification of rare or potential novel compounds. This study presents a new strategy for rapid visual screening of plant natural products using MSI.

PMID 43010434
Read full article →
PubMedAnalytical chemistry2026-11-11

Multidentate 6-Thioguanine-Functionalized Nanoreactors with Hot-Spot-Rich toward SERS Enantiodiscrimination.

Zhang Zhipeng Z, Cheng Yujun Y, Li Ruili R, Zuo Jiasi J et al.

Surface-enhanced Raman scattering (SERS) has garnered considerable attention for chiral sensing owing to its high sensitivity to intermolecular interactions. However, achieving high enantioselectivity is still challenging, primarily due to the scarcity of effective molecular recognition elements and optimized SERS platforms. Herein, we report a SERS nanoreactor constructed from phenol formaldehyde resin microporous spheres embedded with densely packed gold nanoparticles (Au@HPFS), which collectively generate abundant and uniformly distributed SERS hotspots. This unique architecture ensures a high enhancement factor and excellent signal reproducibility. Crucially, this nanoreactor is functionalized with 6-thioguanine (6 TG), which serves as a novel multidentate receptor. The receptor specifically captures chiral target molecules through multiple active sites and precisely confines them within the electromagnetic hot spot regions of the nanoreactor. The synergy between the hotspot-rich nanoreactor and the selective receptor enables the highly enantioselective discrimination of eight chiral amino acids and their ester derivatives. Density functional theory (DFT) calculations indicated that the enantioselective SERS spectral behavior may be attributed to multiple hydrogen bond-induced electronic redistribution within the purine ring of the 6 TG receptor complex. This work not only provides a robust SERS strategy for chiral analysis but also offers critical insights into the design of advanced multidentate recognition systems and high-performance SERS nanoreactors, thereby advancing the field of enantioselective sensing.

PMID 43010465
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about ganglioside ester