Drug Database
NI

nifedipine once daily (Unipene / Unipene XL / nifedipine, Triglas)

✓ Approved

Actavis · CACNA1C · Small Molecule

What is nifedipine once daily?

nifedipine once daily is a small molecule developed by Actavis. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesUnipene, Unipene XL, nifedipine, Triglas
CompanyActavis
Drug ClassSmall Molecule
Molecular TargetCACNA1C
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Actavis

Mechanism of Action

Molecular Targets

nifedipine once daily acts on 1 molecular target:

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
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Therapeutic Indications

nifedipine once daily is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedFrontiers in cellular neuroscience2026-10-22

Daily regulation of glucocerebrosidase activity and impact of fixed-time rotarod training in a mouse model of Gba1-associated Parkinson's disease.

Bertasini Chiara C, Tavakolian Haghighi Shima S, Bruno Maria Giusy MG, Paio Fabio F et al.

Mutations in the glucocerebrosidase (GBA1) gene are a major genetic risk factor for Parkinson's disease (PD) and result in dysfunctional glucocerebrosidase (GCase), the lysosomal enzyme responsible for cleaving glucosylceramide into glucose and ceramide. The pathogenic L444P variant disrupts the enzyme structure and activity, leading to lysosomal accumulation of glucosylceramide and ultimately impairing the clearance of monomeric α-synuclein (α-syn). Given the functional crosstalk among lysosomal homeostasis, the molecular circadian clock, and physical activity, we investigated whether GCase activity exhibits daily rhythmicity, and can be modulated by daily, fixed-time rotarod activity in healthy and Gba1-mutant mice. C57BL/6J healthy controls and Gba1-mutant PD model mice were housed under a 12 h light/dark cycle, and blood samples were collected at four Zeitgeber times (ZT2, ZT8, ZT14, and ZT20), with and without daily, fixed-time rotarod training. A fluorometric assay was performed on plasma samples to investigate the daily pattern of GCase activity. Our results showed that rotarod performance was influenced by genotype-dependent vulnerabilities and by daily, fixed-time physical activity, with overall better performance during the dark-phase training. The fluorometric assay revealed that GCase activity shows a ZT-dependent daily pattern in healthy mice, whereas this pattern was disrupted in Gba1-mutant PD models and partially rescued by timed physical activity. Overall, both the time of day and daily fixed-time physical activity influenced GCase regulation. Our findings reveal a functional interplay between daily biological timing and lysosomal enzyme regulation, suggesting that optimizing drug dosing and timing of administration may improve the efficacy of GCase-targeted treatments.

PMID 42903149
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PubMedThe journals of gerontology. Series B, Psychological sciences and social sciences2026-10-22

Spending time helping others and well-being of givers: Age differences in immediate and long-term effects on well-being.

Cho Kyoungmin K, Charles Susan T ST, Almeida David M DM, Lee Soomi S

The extant literature suggests that spending time helping others is associated with both beneficial and detrimental effects on givers' emotional experiences. To reconcile these findings, the current study examined the daily- and monthly-level associations between spending time helping others and well-being. We predicted that spending time helping others would be associated with lower hedonic well-being at the daily level but higher eudaimonic well-being at the monthly level. We further hypothesized that age would moderate these associations. We used data from the main survey and the National Study of Daily Experiences (NSDE) in MIDUS 3 (N=865) and MIDUS Refresher 1 (N=612). Participants reported their daily and monthly time spent helping others. Measures included hedonic well-being (negative affect and positive affect) and eudaimonic well-being (social and psychological well-being). At the daily level, our sample of adults experienced mixed emotional consequences on days when they spent more time helping others, reporting both higher negative and positive affect. Age moderation showed young and middle-aged adults experienced more negative affect. At the monthly level, spending time helping others was associated with higher social and psychological well-being. This association was significantly stronger among older adults than middle-aged adults in Refresher 1. Monthly spending time helping others was not associated with hedonic well-being. These findings suggest that spending time helping others can be both taxing and enjoyable in the short term while contributing to eudaimonic benefits over the long term. Older age may reduce costs and enhance benefits of spending time helping others.

PMID 42902779
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PubMedFrontiers in public health2026-10-22

Higher-level functional capacity and incident long-term care insurance certification: a competing risks analysis.

Qian Meiling M, Zhang Jinrui J, Li Shuanghong S, Shigeeda Maiko M et al.

Higher-level functional capacity (HLFC) may capture functional vulnerability beyond basic activities of daily living in older adults. However, the association of baseline HLFC with subsequent incident long-term care insurance (LTCI) certification remains unclear when death is considered a competing event. This prospective cohort study included 688 community-dwelling Japanese adults aged 65 years or older who participated in the 2017 wave of the Community Empowerment and Care for Well-being and Healthy Longevity Study. HLFC was assessed once at baseline using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC), including the total score and the formal subdomain scores for Instrumental Self-Maintenance, Intellectual Activity, and Social Role. Participants were followed for 8 years. Incident LTCI certification at Support Level 1 or higher was analyzed using Fine-Gray competing-risk regression, with death before certification treated as a competing event. The fully adjusted Fine-Gray model included age group, sex, living arrangement, physical activity, smoking status, alcohol consumption, and disease status. Among 688 complete-case participants, 145 developed incident LTCI certification and 79 died before certification. In the fully adjusted model, higher HLFC total score was associated with a lower cumulative incidence of incident LTCI certification (sHR per 1-point increase, 0.941; 95% CI, 0.891-0.994; p = 0.029). Higher Social Role score was also associated with a lower cumulative incidence (sHR, 0.803; 95% CI, 0.702-0.918; p = 0.001), whereas the continuous per-point Instrumental Self-Maintenance and Intellectual Activity estimates included the null after full adjustment. Multiple-imputation and lagged-event analyses generally retained the direction and broad magnitude of the complete-case estimates. Exposure-by-log(time) diagnostics indicated that the Fine-Gray associations varied over follow-up. Estimates also varied under alternative age specifications, with particularly marked attenuation of the total-score association. Higher baseline HLFC total and Social Role scores were associated with a lower subsequent cumulative incidence of incident LTCI certification in the prespecified age-group-adjusted analysis. The total-score association was substantially attenuated under alternative age adjustments, while the magnitude of the Social Role association also varied.

PMID 42903110
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Smartphone Usage Sleep Quality and Behavioral Health in Adolescents: A Cross-sectional Study from Eastern India.

Chatterjee Rupak R, Sarkar Subhajit Dey SD, Mukherjee Shatavisa S, Chatterjee Nandini N

Widespread smartphone use has raised concerns regarding its effects on adolescent health, particularly sleep quality and behavioral outcomes. The associations between smartphone usage patterns, sleep disturbances, and markers of obesity and vision health have yet to be systematically evaluated in India. To assess the prevalence of smartphone usage, bedtime usage patterns, and their association with sleep quality, overweight status, and visual acuity among adolescents in Eastern India. A cross-sectional study was conducted among 140 adolescents aged 13-19 years attending urban and rural schools in Eastern India. Participants completed a structured questionnaire covering demographics, daily and bedtime smartphone use, and sleep quality. Sleep quality was assessed using a modified Pittsburgh Sleep Quality Index (PSQI), and smartphone addiction was estimated using behavioral proxies. Chi-square tests were employed to assess associations, and logistic regression was used to identify predictors of poor sleep quality. The mean age of participants was 16.8 ± 1.9 years, with 55% male participants and 70% from urban areas. Smartphone usage at bedtime was reported by 89.3% of participants, and 42.1% reported poor sleep quality. Longer bedtime smartphone use (>30 minutes) was significantly associated with poor sleep quality (χ2 = 42.5, p < 0.001). Daily usage exceeding 2 hours was significantly associated with overweight status (χ2 = 21.9, p = 0.001). A high prevalence of bedtime smartphone use among adolescents in Eastern India is significantly associated with poor sleep quality. Excessive daily smartphone use is also linked with overweight status. Public health strategies should include digital hygiene awareness and school-based interventions.

PMID 42902647
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PubMedHead & neck2026-10-22

Cost Effectiveness Analysis of the Presto-Trial: A Three-Armed RCT Evaluating Prophylactic Swallowing Exercises in Head and Neck Cancer Patients During (Chemo)radio Treatment.

Vergauwen Alice A, Van den Steen Leen L, Baudelet Margot M, Goeleven Ann A et al.

Research on oropharyngeal head and neck cancer (HNC) patients indicates that prophylactic swallowing exercises (PSE) during (C)RT can positively affect muscle strength, swallowing function and quality of life (QOL). Primary analyses of the PRESTO-trial showed higher adherence rates for PSE when exercising daily with a speech-language pathologist (SLP), compared to self-guided exercises with either an exercise diary or a digital application. Additionally, higher adherence rates were related to greater improvements in swallowing function and QOL. However, given limited healthcare resources, cost-effectiveness analyses are essential to inform the implementation of such rehabilitation strategies in dysphagia care. This secondary analysis of the PRESTO-data compares the costs and health effects of the three different service models: app-based, therapist-led (daily face-to-face, 20 sessions during (C)RT), and paper-led therapy. One hundred fifty patients receiving (chemo)radiotherapy (C)RT for oropharyngeal HNC were randomly assigned to one of the three exercise groups. All performing the same PSE protocol. The treatment protocol required daily training during the first 4 weeks of the (C)RT treatment program. Patients in the therapy group thereby received a total of 20 face-to-face therapy sessions. Health outcomes were expressed as utilities based on the EQ5D5L instrument measured at baseline, post (C)RT and 3 months post (C)RT. Costs were estimated from a health service perspective, including staff time, therapy resources and consumables. Incremental cost-effectiveness ratios (ICERs) were calculated as ΔCosts/ ΔQALYs. No significant between-group differences were found for utilities. Only significant time effects were observed, with a significant decrease in utilities from baseline to post (C)RT and a significant increase from post (C)RT to 3 months post (C)RT. The therapist-led intervention was associated with the highest costs. The app-group intervention was dominated by the paper group in terms of cost-effectiveness as the utilities were comparable but at a higher cost in the app-group. Consequently, the ICER was computed between the paper-group and therapist-group and resulted in € 124 061,54/QALY. Despite the overall positive HR-QOL effects post 3 months, the daily therapist-led delivery of PSE therapy was not cost-effective relative to paper-based self-management. Under current resource constraints, low-cost delivery models represent the most economically efficient option. Future research should explore whether hybrid or targeted therapist involvement yields better value by preserving clinical benefit while reducing cost.

PMID 42902836
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PubMedJournal of the Korean Society of Radiology2026-10-22

Continual Learning in Medical Image Analysis: Appropriate Use and Lifecycle Governance.

Yoo Min Kyoon MK, Park Yu Rang YR

AI models for medical imaging are typically trained once and deployed unchanged; however, as scanners, protocols, and patient populations continue to evolve, model performance may degrade over time. Continual learning offers a way to incorporate newly acquired data while limiting the loss of previously learned diagnostic knowledge; therefore, it is particularly suited to clinical environments in which historical images cannot be freely retained or reused. This review outlines the continual learning scenarios and methodological families most relevant to radiology, examines when continual updating is preferable to periodic retraining or simple recalibration, and summarizes the applications in classification, segmentation, detection, and multi-joint radiographic grading. It then addresses the clinical constraints that determine feasibility: privacy and regulatory limits on data retention, delayed and noisy labels, class imbalance, and evaluation requirements beyond the average accuracy. Therefore, continual learning should be implemented as a governed, auditable maintenance process rather than as a single algorithmic choice.

PMID 42903021
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