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freeze-dried live attenuated hepatitis A vaccine

✓ Approved

Changchun Institute · Vaccine · Vaccine

What is freeze-dried live attenuated hepatitis A vaccine?

freeze-dried live attenuated hepatitis A vaccine is a vaccine developed by Changchun Institute. It is approved for therapeutic indications via injectable (others).

Drug Profile

CompanyChangchun Institute
Drug ClassVaccine, Large Molecules
RouteInjectable (Others)
StatusApproved

Therapeutic Indications

freeze-dried live attenuated hepatitis A vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresAntiviral prophylaxis✓ Approved

Related Research Articles

PubMedFrontiers in immunology2026-10-22

A subunit vaccine protects A129 mice from death and joint swelling against lethal Chikungunya virus challenge.

Li Jiangfan J, Fang Ting T, Song Liyuan L, Qiang Li L et al.

Chikungunya virus (CHIKV) is primarily transmitted to humans through bites of infected Aedes mosquitoes, causing febrile illness as well as acute or chronic arthritis. With increasing reports in previously non-endemic regions, it poses an emerging threat to public health and a growing risk to travelers. Despite the recent approval of live-attenuated and virus-like particle-based vaccines, a safe, efficacious, and cost-effective vaccine remains urgently needed. The envelope glycoproteins E1 and E2, which play crucial roles in viral attachment and entry, are the major immunodominant structural proteins and can effectively elicit protective antibodies. We engineered mammalian cells to produce the ectodomains of the E1 and E2 glycoproteins and evaluated the protective efficacy of the resulting vaccine formulations in vivo. A two-dose vaccination regimen elicited high levels of antibodies and provided full protection against lethal challenge in A129 mice, preventing both death and joint swelling. These findings demonstrate the potential of this vaccine candidate against CHIKV and warrant its further development.

PubMedJournal of microbiology and biotechnology2026-10-22

Live and Heat-Killed Lactiplantibacillus plantarum HY7715 Attenuate D-Galactose-Induced Aging-Related Brain Changes and Blood-Brain Barrier Disruption with Gut Microbiota Modulation in Mice.

Baik Jimin J, Gwon Hyeonjun H, Kim Joo-Yun JY, Shim Jae-Jung JJ et al.

Aging is associated with changes in systemic homeostasis, intestinal barrier integrity, and brain function. This study investigated the effects of Lactiplantibacillus plantarum HY7715 on aging-related alterations in a D-galactose-induced accelerated aging mouse model. Male C57BL/6J mice were administered D-galactose for 8 weeks and orally treated with live or heat-killed HY7715. D-galactose increased circulating advanced glycation end products (AGEs), blood-brain barrier (BBB) permeability, hippocampal inflammation, and aging-related molecular changes, while impairing cortical and colonic tight junction-associated markers. Both live and heat-killed HY7715 reduced serum AGE levels, Evans blue leakage, and hippocampal inflammatory responses, while restoring CLDN5 immunoreactivity, tight junction-associated gene expression, and antioxidant-related gene expression. HY7715 also attenuated senescence- and apoptosis-related changes in the hippocampus and colonic tight junction- and inflammation-related gene expression changes. Gut microbiota analysis showed taxon-specific changes following HY7715 treatment, including significant increases in Bifidobacterium in both HY7715-treated groups, whereas live HY7715 was associated with significant changes in microbial community structure. Several microbial taxa were correlated with serum AGEs, BBB permeability, and neuroinflammation-related parameters. Together, these results show that both live and heat-killed HY7715 attenuated multiple aging-related changes in the D-galactose-induced accelerated aging model, accompanied by changes in gut microbiota composition.

PubMedRevue medicale suisse2026-10-22

[Bucket-list destinations from an infectious disease perspective].

Grounauer Louise S LS, Prongué Estelle E, Zumbrunn Samuel K SK, Calamai Pietro P et al.

Tropical countries are among the most popular destinations for Swiss travelers and pose a health challenge in terms of infectious disease risk. Arboviral diseases are one of the major infectious risks, along with rabies, hepatitis A, and malaria. Several resurgences of vaccine-preventable diseases, such as polio and yellow fever, have also been identified. In light of these data, it would appear that the safest travel destinations from an infectious disease perspective are Cuba in Latin America, Hong Kong in Asia, and the Seychelles in Africa. However, these data are subject to change and may evolve rapidly.

PubMedFrontiers in psychiatry2026-10-22

Fight, flight, freeze, fawn: mapping emergency department staff stress responses to workplace violence - a mixed-methods study.

Davids Jennifer J, de Moore Greg G, Brown Martin M, Murphy Margaret M

Workplace violence and aggression are escalating in emergency departments (EDs) globally, yet the self-reported psychological and behavioural responses in clinicians to such stressors remain underexplored. Trauma theory conceptualises stress responses as fight, flight, freeze, and fawn (4Fs); but how these responses manifest in ED staff before, during and after violent incidents has received limited empirical attention. This mixed-methods study analysed data collected between 2019 and 2023 across four emergency departments within one Australian local health district. Data sources included semi-structured interviews (2019; n = 20), focus groups (2021; n = 30 participants), a cross-sectional survey (2023; n = 61), and follow-up interviews (2023; n = 12). Qualitative data were analysed using Braun and Clarke's six-phase thematic analysis, applying a deductive framework informed by the 4Fs. Quantitative survey data were integrated to examine the distribution of stress responses across reported incidents. Across all data sources, 123 ED staff described 145 coded instances of the 4F stress responses: fight (n=94); flight (n=24), freeze (n=15), and fawn (n=12). Four overarching themes that underpinned these responses were identified: 1) Moral and emotional impact on clinicians, 2) Safety systems interface, 3) Organisational constraints and environment and 4) Patient Complexity. Participants described sustained hyperarousal, anticipatory vigilance, moral distress, emotional withdrawal, and appeasement behaviours arising from repeated exposure to violence. While Code Black responses were viewed as a structured and effective "organised fight" mechanism, this was compromised by inconsistent training, role ambiguity, and limited post-incident support which contributed to burnout, disengagement, and workforce attrition. Emergency department clinicians operate in persistently threatening environments that drive recurrent activation of fight, flight, freeze, and fawn responses with cumulative individual and system-level consequences. Behavioural emergencies warrant the same level of preparation, standardisation, and organisational support as other high-risk clinical events, such as a Code Blue - a life-threatening medical event with a responding Medical Emergency Team. Trauma-informed education team-based training, and embedded post-incident support are critical to safeguarding staff wellbeing and sustaining the ED workforce.

PubMedFrontiers in immunology2026-10-22

Case Report: Acute liver failure in systemic lupus erythematosus with autoimmune hepatitis-primary biliary cholangitis overlap: a belimumab-containing regimen and longitudinal follow-up.

Zhang Lina L, Zhang Tong T, Zhang Jing J, Wang Xiuhong X et al.

Severe autoimmune liver injury as the first manifestation of systemic lupus erythematosus (SLE) is rare, and concomitant autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap is uncommon. B-cell-activating factor (BAFF) provides a biological rationale for adjunctive therapy, although clinical evidence remains limited. A 72-year-old woman presented with 4 weeks of fatigue and anorexia and developed coagulopathy (international normalized ratio [INR] 1.8), ascites, and hepatic encephalopathy. Autoimmune testing showed antinuclear antibody 1:1280, high-titer anti-double-stranded DNA antibodies with hypocomplementemia, immunoglobulin G (IgG) 30.0 g/L, and antimitochondrial antibody positivity. Hepatitis B surface antigen, hepatitis C antibody, hepatitis E antibody, and Epstein-Barr virus and cytomegalovirus DNA tests were negative. Liver biopsy 42 days after corticosteroid initiation demonstrated interface hepatitis, destructive small-bile-duct injury, plasma cell-rich inflammation, and Batts-Ludwig stage 2 fibrosis without cirrhosis, supporting a clinicopathologic diagnosis of AIH-PBC overlap. Previously unrecognized chronic autoimmune liver disease could not be excluded. Prednisolone was started at 50 mg/day, followed 10 days later by intravenous belimumab, with concomitant ursodeoxycholic acid. Tacrolimus was added during maintenance. By 10 October 2025, liver biochemistry had improved, IgG was 9.42 g/L, and prednisolone had been reduced to 2.5 mg/day. Liver stiffness decreased from 21.5 to 9.7 kPa. Sustained biochemical improvement occurred during a belimumab-containing multidrug regimen. This observation does not establish the independent efficacy of belimumab or histological regression of fibrosis.

PubMedThe Australian & New Zealand journal of obstetrics & gynaecology2026-10-22

Maternal Smoking and Sex Distribution Among Live Births in Western Sydney: A Population-Based Cohort Study.

Trinh Lieu Thi Thuy LTT, Clague Liesa L, Naz Sabrina S, Eljiz Kathy K

Maternal smoking may affect fetal survival, but evidence regarding offspring sex is inconsistent. We estimated the male proportion among live births and did not assess sex determination or pregnancy loss before the perinatal reporting threshold. To examine whether smoking during the first half of pregnancy was associated with male live birth and whether the association differed by smoking intensity. We analysed singleton live births of Western Sydney residents in the New South Wales Perinatal Data Collection, 2016-2023. Smoking was classified as non-smoking, ≤ 10 cigarettes/day, or > 10 cigarettes/day. Logistic regression estimated odds ratios (ORs), adjusted for calendar year and maternal demographic, socioeconomic and clinical characteristics. Of 119 756 eligible births, 721 (0.6%) had unknown smoking information, leaving 119,035 births. Male births comprised 51.6% among non-smokers, 52.2% among women smoking ≤ 10 cigarettes/day, and 52.4% among women smoking > 10 cigarettes/day. Crude differences were + 0.60 and + 0.78 percentage points (p = 0.608). The adjusted model included 117,745 births; adjusted ORs were 1.02 (95% CI 0.96-1.08) and 1.02 (95% CI 0.90-1.16), respectively. The heavier-smoking estimate was imprecise (n = 964). Lower-intensity smoking was not meaningfully associated with male live birth. Estimates for > 10 cigarettes/day were imprecise, and moderate effects in either direction could not be excluded. Findings apply only to live births reaching the reporting threshold.

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