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ethinylestradiol + levonorgestrel (Logynon / Trionetta / Ange 28)

✓ Approved

ASKA Pharmaceutical · ESR1 · Steroids

What is ethinylestradiol + levonorgestrel?

ethinylestradiol + levonorgestrel is a steroids developed by ASKA Pharmaceutical. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLogynon, Trionetta, Ange 28
CompanyASKA Pharmaceutical
Drug ClassSteroids, Small Molecule
Molecular TargetESR1, PGR
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

ethinylestradiol + levonorgestrel acts on 2 molecular targets:

ESR1estrogen receptor 1 (ER, ESR)
PGRprogesterone receptor (NR3C3, PR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Related Research Articles

PubMedThe European physical journal. E, Soft matter2026-10-21

Measurement of thermodiffusion in liquid Ag 60 Cu 40 .

Krüger Asbjørn Torsvik AT, Sondermann Elke E, Meyer Andreas A

Thermodiffusion, or the Soret effect, designates a diffusive motion of particles driven by a temperature gradient, leading to a build-up of a concentration gradient. This effect is here measured in the liquid state on the eutectic alloy Ag 60 Cu 40 , which shows negligible excess volume. No significant thermodiffusion was observed using both in situ X-ray radiography or ex situ energy-dispersive X-ray spectroscopy on separately solidified parts of the sample. This is in contrast to the significant Soret coefficients observed in molten Ag-Al and Al-Ni. Molecular dynamics simulations of thermodiffusion in liquid Ag-Cu [Sarder et al., Philos. Mag. 99, 468-491 (2019)] report significantly stronger thermodiffusion. However, the trend that thermodiffusion in liquid Ag-Cu is weaker than in other liquid alloys like Al-Ni is supported by our experiment.

PubMedApplied optics2026-10-20

Enhanced UV photodetection of Ag-decorated GaN/Si heterojunctions prepared by pulsed laser ablation in liquid and hydrothermal deposition.

Fadhil Rawan B RB, Salim Evan T ET, Gopinath Subash C B SCB, Qaeed Motahher A MA

In this study, GaN nanoparticles were synthesized by pulsed laser ablation in liquid (PLAL) followed by hydrothermal deposition. Different AgNO3 concentrations were comparatively investigated to determine the optimum amount for fabricating the Ag-decorated GaN/Si UV photodetector. Among the investigated amounts, the sample prepared using 0.01 g AgNO3 exhibited the highest figure of merit and was therefore selected for detailed characterization and device fabrication. Ag diffraction peaks and the hexagonal wurtzite GaN phase were confirmed by XRD investigation. Optical measurements showed a bandgap of 3.37 eV. FESEM and AFM analyses revealed a uniform distribution of Ag nanoparticles, indicating successful surface modification. Based on these improved physical properties, the Ag-decorated GaN/Si heterojunction photodetector was fabricated, exhibiting enhanced responsivity, detectivity, and overall UV-photodetection performance. The Ag-decorated device exhibited improved electrical performance and higher responsivity and detectivity at 380 nm compared with the pure GaN/Si device. The ideality factor (n) was reduced to 1.6 for the Ag-decorated GaN/Si heterojunction device. The faster response of the Ag-decorated GaN/Si device demonstrates its potential for fast-switching optoelectronic applications.

PubMedRSC advances2026-10-20

Montmorillonite-supported Ag/Sn@CeO2 via phyto-mechanochemical engineering: enhanced crystal violet adsorption and CO2 capture.

Rehman Mobeen Ur MU, Usman Muhammad M, Taj Muhammad Babar MB, Altowerqi Amal Marzoqi AM et al.

Crystal Violet (CV) dye and CO2 emissions represent two major environmental threats that demand cost-effective and multifunctional remediation materials. In this study, a silver/tin co-doped cerium oxide nanocomposite supported on montmorillonite (Mt-Ag/Sn@CeO2) was synthesized via continuous phyto-mechanochemical twin screw extrusion using Melothria scabra leaf extract as a green reducing agent. The composite was characterized by using FTIR, XRD, SEM, EDS, zeta potential, N2 adsorption-desorption isotherm, BJH pore size analysis, and ICP-OES. The adsorption performance of Mt-Ag/Sn@CeO2 and Ag/Sn@CeO2 toward CV dye was systematically evaluated by optimizing pH, contact time, adsorbent dose, initial dye concentration, and temperature. For CV dye removal, Mt-Ag/Sn@CeO2 achieved 96.08% removal compared with 89.22% for Ag/Sn@CeO2 (10 mg L-1 dye, 20 mg dose, pH 9, 298 K, 180 min). The maximum adsorption capacities, estimated from the Langmuir model, were 36.50 mg g-1 and 28.77 mg g-1, respectively. Adsorption data were best described by the Freundlich isotherm alongside the pseudo-second-order kinetic model, consistent with chemisorption on a heterogeneous surface with multilayer dye uptake. Thermodynamic analysis confirmed that the adsorption process is exothermic and spontaneous (ΔG° < 0 at all studied temperatures). Furthermore, Mt-Ag/Sn@CeO2 demonstrated CO2 adsorption capacity of 3.92 mmol g-1 at 298 K and 900 mmHg, surpassing several reported clay-based adsorbents. These results confirmed that the mechanochemically engineered Mt-Ag/Sn@CeO2 composite is an effective dual-function adsorbent with potential for simultaneous water and air remediation.

PubMedInternational journal of nanomedicine2026-10-20

PVP-Stabilized Ag@SiO2 Nanocarriers for Usnic Acid: Physicochemical Characterization and Exploratory in vitro Anticancer, Antimicrobial, and Immunomodulatory Activity.

Pyrczak-Felczykowska Agnieszka A, Kowalska Agata A, Adamska Elżbieta E, Bogucka Aleksandra A et al.

Usnic acid (UA) is a lichen-derived metabolite with recognized anticancer, anti-inflammatory, and antibacterial properties; however, its clinical application is limited by poor aqueous solubility and dose-dependent toxicity. This study aimed to develop a multifunctional nanosystem to improve UA aqueous dispersibility and efficacy against breast cancer cells in vitro. A nanosystem consisting of a silver core-silica shell coated with polyvinylpyrrolidone (PVP) and conjugated UA (Ag@SiO2/PVP/UA) was synthesized and characterized regarding morphology, physicochemical properties, colloidal stability, drug loading, and release behavior. Antiproliferative activity was evaluated using breast cancer cells (MCF-7 and MDA-MB-231). Cytotoxicity was assessed using the MTT viability assay, reactive oxygen species (ROS) production by flow cytometry, and metabolic alterations through LC-MS/MS-based metabolomic analysis. Antimicrobial activity against Gram-positive and Gram-negative bacteria was expressed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Immunomodulatory properties were assessed in human peripheral blood mononuclear cells (PBMCs) using ELISA, while fibroblast migration was analyzed using an in vitro wound healing assay. The developed nanostructures exhibited a stable core-shell architecture, uniform particle size (~200 nm), and enhanced hydrophilicity, resulting in improved aqueous dispersibility and sustained UA release. Nanoencapsulation significantly enhanced UA's anticancer activity against breast cancer cells in vitro while maintaining lower toxicity toward normal cells. Mechanistically, Ag@SiO2/PVP/UA induced ROS-mediated oxidative stress and metabolic reprogramming associated with altered purine metabolism, lipid biosynthesis, redox balance, and activation of glycolytic pathways. The nanosystem also demonstrated broad-spectrum antimicrobial activity, including improved efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and selected Gram-negative bacteria, while exerting immunomodulatory effects by reducing pro-inflammatory cytokine secretion and enhancing IL-10 production without affecting fibroblast migration. Ag@SiO2/PVP/UA represents a promising multifunctional therapeutic platform combining enhanced anticancer efficacy with antimicrobial and anti-inflammatory properties, potentially improving the therapeutic applicability of UA.

PubMedACS applied materials & interfaces2026-10-20

Dual-Interface Engineering of Cs2CuBiBr6-Based Memristive Synaptic Devices for Neuromorphic Computing.

Kim Chae-Eun CE, Cho Sungwon S, Choi Yoon-Seo YS, Lee Jeong-Yeon JY et al.

Pb-free double perovskite Cs2CuBiBr6 (CCBB)-based resistive random-access memory (ReRAM) synaptic devices are developed using a dual-interface engineering approach to achieve stable resistive switching and neuromorphic functionality. High-quality CCBB thin films are obtained via optimized antisolvent-assisted crystallization, enabling enhanced crystallinity and reduced defect-induced energetic disorder. Modification of the bottom interface with a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) interlayer improves CCBB film continuity and provides a more favorable environment for homogeneous charge injection. The introduction of an ultrathin bathocuproine (BCP) interlayer at the top interface regulates the spatial redistribution of Ag-related species. The cooperative regulation of charge injection and Ag-related electro-ionic processes promotes more reproducible formation and rupture of localized conductive pathways, resulting in improved switching stability and device-to-device reproducibility. The CCBB-based ReRAM exhibits reliable bipolar resistive switching over 600 cycles, an on/off current ratio of approximately 103, and stable data retention up to 104 s. Gradual and repeatable conductance modulation under electrical pulse stimulation further demonstrates synaptic potentiation and depression behaviors. MNIST-based neural network simulations reveal excellent neuromorphic performance, with up to 90% recognition accuracy. This work highlights cooperative dual-interface regulation of charge injection and Ag-related electro-ionic processes as an effective design strategy for achieving reliable Pb-free perovskite ReRAM and neuromorphic synaptic operation.

PubMedDalton transactions (Cambridge, England : 2003)2026-10-20

Low thermal quenching of a 3D Ag-MOF with 2D inorganic layers and π-conjugated skeletons for light-emitting diode.

Lan Hong-Hong HH, Wang Jian-Ge JG, Wang Wei-Zhou WZ, Miao Shao-Bin SB et al.

Developing phosphor materials with desirable thermal quenching resistance for phosphor-converted light-emitting diodes (PC-LEDs) is still a formidable challenge. Herein, an Ag-based 3D metal-organic framework [AgNO3(BTD)0.5] (1) was facilely synthesized at room temperature in the presence of the 2,1,3-benzothiadiazole (BTD) electron acceptor. This complex exhibits alternating arrangement of inorganic silver nitrate layers and organic BTD π-conjugated chains. Meanwhile, the BTD π-conjugated moieties are anchored via coordination bonds, π⋯π stacking, hydrogen bonds, and chalcogen bonds, which collectively construct a compact network architecture. It shows intense yellow-orange emission with a long lifetime of 81 μs. Thermal quenching measurements confirm that this complex only undergoes a luminescence loss of 5.91% relative to room temperature at 150 °C. The successful fabrication and operation of a PC-LED device verify the potential application of this complex in solid-state lighting.

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