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brucellosis vaccine

✓ Approved

China National Pharmaceutical · Cell-based Therapies · Cell-based Therapies

What is brucellosis vaccine?

brucellosis vaccine is a cell-based therapies developed by China National Pharmaceutical. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyChina National Pharmaceutical
Drug ClassCell-based Therapies, Vaccine
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, China National Pharmaceutical

Therapeutic Indications

brucellosis vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsBrucellosis✓ Approved

Related Research Articles

PubMedFrontiers in immunology2026-10-22

A subunit vaccine protects A129 mice from death and joint swelling against lethal Chikungunya virus challenge.

Li Jiangfan J, Fang Ting T, Song Liyuan L, Qiang Li L et al.

Chikungunya virus (CHIKV) is primarily transmitted to humans through bites of infected Aedes mosquitoes, causing febrile illness as well as acute or chronic arthritis. With increasing reports in previously non-endemic regions, it poses an emerging threat to public health and a growing risk to travelers. Despite the recent approval of live-attenuated and virus-like particle-based vaccines, a safe, efficacious, and cost-effective vaccine remains urgently needed. The envelope glycoproteins E1 and E2, which play crucial roles in viral attachment and entry, are the major immunodominant structural proteins and can effectively elicit protective antibodies. We engineered mammalian cells to produce the ectodomains of the E1 and E2 glycoproteins and evaluated the protective efficacy of the resulting vaccine formulations in vivo. A two-dose vaccination regimen elicited high levels of antibodies and provided full protection against lethal challenge in A129 mice, preventing both death and joint swelling. These findings demonstrate the potential of this vaccine candidate against CHIKV and warrant its further development.

PMID 42903135
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PubMedKidney research and clinical practice2026-10-22

Clinical effects of third doses of mRNA COVID-19 vaccines among hemodialysis patients: a nationwide retrospective cohort study.

Cho AJin A, Jeong Seon A SA, Seo Yu Bin YB, Park Hayne Cho HC et al.

Evidence on the effectiveness of third-dose messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccination during the Omicron-dominant period in Asian hemodialysis (HD) patients remains limited. We evaluated the clinical effectiveness of a third mRNA vaccine dose against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospitalization, and mortality in Korean HD patients. Using the Korea Disease Control and Prevention Agency-National Health Insurance Service database, we conducted a nationwide cohort study of HD patients aged ≥18 years who received two or three doses of BNT162b2 or mRNA-1273 before January 16, 2022. Study outcomes were SARS-CoV-2 infection, hospitalization, and death. Cox proportional hazards models were used to assess the associations between third-dose vaccination and clinical outcomes. Among 66,389 HD patients (mean age, 65.7 ± 12.9 years; 60.5% male), 55,125 (83.0%) received three vaccine doses and 11,264 (17.0%) received two doses. Receipt of three doses was associated with a significantly lower risk of SARS-CoV-2 infection (adjusted hazard ratio [aHR], 0.58; 95% confidence interval [CI], 0.56-0.60). Among 17,886 patients with SARS-CoV-2 infection, third-dose vaccine recipients had a lower risk of hospitalization (aHR, 0.65; 95% CI, 0.62-0.70) and 30-day mortality (aHR, 0.35; 95% CI, 0.30-0.41) compared with those who received two doses. Receipt of mRNA-1273 as the third dose was associated with lower observed risks of infection and hospitalization than receipt of BNT162b2. A third dose of an mRNA COVID-19 vaccine was associated with lower risks of SARS-CoV-2 infection, hospitalization, and mortality among HD patients during the Omicron-dominant period. These findings support the clinical importance of booster vaccination in this high-risk population.

PMID 42902884
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PubMedFrontiers in plant science2026-10-22

Leaf economic strategy and stand structural complexity are associated with net woody productivity in a subtropical mixed forest.

Wu Juyang J, Huang Jingjing J, Ai Xunru X, Xiang Qin Q et al.

The associations of net woody productivity with biodiversity, functional composition, and stand structure remain poorly resolved in subtropical mixed evergreen-deciduous broad-leaved forests. We used the 2016 and 2021 censuses of 150 contiguous 20 × 20 m subplots in a 6-ha permanent plot at Jinzi Mountain, central China. Net woody productivity was calculated as the annualized net change in live woody biomass. Univariate and multiple linear regressions, random forests, and piecewise structural equation modeling were used to examine relationships with community attributes measured in 2016. Live woody biomass increased from 144.78 to 167.86 t·ha-1, corresponding to a mean net woody productivity of 4.62 t·ha-1·yr-1. Net gains were concentrated in the tree stratum and larger diameter and height classes; classes with a diameter at breast height ≥29 cm accounted for 78.53% of community net woody productivity. In univariate regressions, productivity was positively associated with community-weighted mean (CWM) leaf thickness and negatively associated with CWM specific leaf area and leaf area. Multiple regression also identified species relative-abundance structure and stand structural heterogeneity as significant correlates. In the piecewise structural equation model, species diversity and structural diversity had significant positive direct associations with productivity. A principal component representing higher CWM specific leaf area and leaf area but lower CWM leaf thickness had a significant negative direct association. Functional and phylogenetic diversity had nonsignificant direct paths, although Rao's quadratic entropy was negatively associated with productivity in the multiple regression. These relationships may partly reflect differences in baseline biomass stocks, which were not included as predictors. Retention of healthy large canopy trees, woody-species diversity, and heterogeneous stand structure warrants consideration in close-to-nature forest management, but its consequences for productivity require further testing.

PMID 42903184
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PubMedThe Australian & New Zealand journal of obstetrics & gynaecology2026-10-22

Maternal Smoking and Sex Distribution Among Live Births in Western Sydney: A Population-Based Cohort Study.

Trinh Lieu Thi Thuy LTT, Clague Liesa L, Naz Sabrina S, Eljiz Kathy K

Maternal smoking may affect fetal survival, but evidence regarding offspring sex is inconsistent. We estimated the male proportion among live births and did not assess sex determination or pregnancy loss before the perinatal reporting threshold. To examine whether smoking during the first half of pregnancy was associated with male live birth and whether the association differed by smoking intensity. We analysed singleton live births of Western Sydney residents in the New South Wales Perinatal Data Collection, 2016-2023. Smoking was classified as non-smoking, ≤ 10 cigarettes/day, or > 10 cigarettes/day. Logistic regression estimated odds ratios (ORs), adjusted for calendar year and maternal demographic, socioeconomic and clinical characteristics. Of 119 756 eligible births, 721 (0.6%) had unknown smoking information, leaving 119,035 births. Male births comprised 51.6% among non-smokers, 52.2% among women smoking ≤ 10 cigarettes/day, and 52.4% among women smoking > 10 cigarettes/day. Crude differences were + 0.60 and + 0.78 percentage points (p = 0.608). The adjusted model included 117,745 births; adjusted ORs were 1.02 (95% CI 0.96-1.08) and 1.02 (95% CI 0.90-1.16), respectively. The heavier-smoking estimate was imprecise (n = 964). Lower-intensity smoking was not meaningfully associated with male live birth. Estimates for > 10 cigarettes/day were imprecise, and moderate effects in either direction could not be excluded. Findings apply only to live births reaching the reporting threshold.

PMID 42902832
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PubMedFrontiers in public health2026-10-22

Ambient air pollution and meteorological factors associated with hand, foot, and mouth disease risk in Shenzhen, China: a time-series study.

Jiang Shuai S, Liu Jingwen J, Ji Jiajia J, Cheng Yanpeng Y et al.

In China, hand, foot, and mouth disease (HFMD) persists as a prevalent infectious disease with high transmissibility. Nevertheless, the link between environmental determinants and HFMD incidence has not been fully elucidated. The study assessed associations between air pollution, meteorological conditions, and HFMD incidence in Shenzhen, China, while also evaluating shifts in these associations before and after the Enterovirus 71 vaccine and during the COVID-19 epidemic. Daily data on HFMD cases, air pollutants (such as PM2.5, PM10, SO2, NO2, CO, and O3), and meteorological variables (including mean temperature, relative humidity, atmospheric pressure, and wind speed) were collected for the period from 2013 to 2022. Associations were assessed using distributed lag non-linear models (DLNM), accounting for immediate and delayed effects. Spearman correlation analysis showed that HFMD was positively correlated with SO₂, mean temperature, relative humidity, and wind speed, and negatively with PM₂.₅, PM₁₀, NO₂, CO, and atmospheric pressure. DLNM models revealed that SO₂ and CO both elevated cumulative risk at extremely high concentrations, with SO₂ showing delayed effects. However, SO₂ unexpectedly displayed protective effects in single-lag analysis. NO₂ exhibited a U-shaped risk at extreme concentrations despite an overall decreasing trend. O₃ showed dual peaks, with protective effects at extremely high concentrations after lag 1. PM2.5 and PM10 showed risk peaks at low concentrations but protective effects at extremely high concentrations. Temperature exhibited a dual-peak risk pattern at extremely low and extremely high temperatures, with extreme heat producing sustained effects and extreme cold shorter-lived risk. HFMD risk increased under conditions of extremely high humidity. In general, the risk associated with atmospheric pressure rose as pressure levels increased, and asymmetric lagged effects were observed at both low- and high-concentration extremes. Extremely high wind speed causing short-term harm and extremely low wind speed leading to delayed cumulative risk. Meteorological factors exhibit more consistent associations than air pollutants. Mean temperature showed a dual-peak distribution with persistent effects from high temperatures, while atmospheric pressure presented long-lasting impacts of low pressure. There is a positive correlation between relative humidity and the incidence of HFMD. Air pollutants showed inconsistent associations with HFMD. These findings support targeted public health interventions for meteorological factors.

PMID 42903182
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PubMedJournal of microbiology and biotechnology2026-10-22

Live and Heat-Killed Lactiplantibacillus plantarum HY7715 Attenuate D-Galactose-Induced Aging-Related Brain Changes and Blood-Brain Barrier Disruption with Gut Microbiota Modulation in Mice.

Baik Jimin J, Gwon Hyeonjun H, Kim Joo-Yun JY, Shim Jae-Jung JJ et al.

Aging is associated with changes in systemic homeostasis, intestinal barrier integrity, and brain function. This study investigated the effects of Lactiplantibacillus plantarum HY7715 on aging-related alterations in a D-galactose-induced accelerated aging mouse model. Male C57BL/6J mice were administered D-galactose for 8 weeks and orally treated with live or heat-killed HY7715. D-galactose increased circulating advanced glycation end products (AGEs), blood-brain barrier (BBB) permeability, hippocampal inflammation, and aging-related molecular changes, while impairing cortical and colonic tight junction-associated markers. Both live and heat-killed HY7715 reduced serum AGE levels, Evans blue leakage, and hippocampal inflammatory responses, while restoring CLDN5 immunoreactivity, tight junction-associated gene expression, and antioxidant-related gene expression. HY7715 also attenuated senescence- and apoptosis-related changes in the hippocampus and colonic tight junction- and inflammation-related gene expression changes. Gut microbiota analysis showed taxon-specific changes following HY7715 treatment, including significant increases in Bifidobacterium in both HY7715-treated groups, whereas live HY7715 was associated with significant changes in microbial community structure. Several microbial taxa were correlated with serum AGEs, BBB permeability, and neuroinflammation-related parameters. Together, these results show that both live and heat-killed HY7715 attenuated multiple aging-related changes in the D-galactose-induced accelerated aging model, accompanied by changes in gut microbiota composition.

PMID 42902892
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