Drug Database
TR

Trinity ELITE (Trinity ELITE)

✓ Approved

Orthofix · Cell-based Therapies · Cell-based Therapies

What is Trinity ELITE?

Trinity ELITE is a cell-based therapies developed by Orthofix. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesTrinity ELITE
CompanyOrthofix
Drug ClassCell-based Therapies
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Orthofix

Therapeutic Indications

Trinity ELITE is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersMusculoskeletal disorder✓ Approved

Related Research Articles

PubMedSports health2026-10-22

Athletes and Medical Staff in Elite Contact Sports: a Quantitative Analysis of Use, Knowledge, and Attitudes Regarding Cannabinoids.

Thompson Elizabeth S ES, Alcorn Jane J, Laprairie Robert R, Rohatinsky Noelle N et al.

Cannabis use among elite contact sport athletes increases with legal reform and commercial availability. Limited education in cannabinoid pharmacology, use, and risk persists among athletes and medical staff, fostering stigma and reducing evidence-based guidance and communication. Athletes use cannabis but perceive stigma and discomfort discussing cannabis with medical staff. Quantitative, descriptive cross-sectional surveys. Level 4. Two anonymous online surveys were administered to elite and professional contact sport athletes (Canada, United States, Australia) and medical and training staff (February 2023 to July 2024). Descriptive statistics assessed demographics, use patterns, knowledge, education needs, attitudes, stigma, communication, and league policies. A total of 166 athletes (89.7% male, 35.2% aged 18-23 years) and 64 medical staff (physicians, athletic therapists, strength and conditioning coaches, etc) responded. Knowledge (pharmacology, interactions, dosing) was low. Overall, 56% of athletes currently used cannabinoids (81% having ever used), but only 21.7% knew the endocannabinoid system and 67.4% were unfamiliar with therapeutic dosing. Among medical staff, 59.5% were unfamiliar with mechanisms, only 14% were familiar with dosing protocols, and 71.4% lacked confidence in making treatment plans. Of the athletes, 86.5% believed cannabis had therapeutic value, 72.3% wanted education, and 74.1% favored qualified scientists as instructors. Of the medical staff, 79.5% reported strong educational need, with 100% of staff desiring athlete-specific cannabinoid education. Stigma and communication barriers were substantial: 81.3% of athletes perceived public stigma, 66.1% perceived staff stigma, and only 21.4% felt comfortable discussing cannabis with medical staff. Staff believed athletes would be honest if approached; however, <50% believed athletes trusted them enough to start the conversation. Both athletes and medical staff categorized cannabinoids as supplements or medications (unlike street drugs) and both supported legalization and a revision and update on league cannabis policies. Athletes and medical staff exhibit parallel knowledge gaps and strong educational needs amid high interest, use, and significant communication barriers. Evidence-informed education and stigma-reducing strategies are urgently needed. Athletes increasingly use cannabinoids for pain, sleep, and recovery, while medical staff report insufficient training and low confidence. System-level education, communication, and policy updates may improve safety, decision-making, and trust.

PMID 42902901
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PubMedFrontiers in cognition2026-10-22

Neural dynamics of emotionally expressive piano performance: a single-case study.

Proverbio Alice Mado AM, Carta Giulia G

Understanding how expert performers translate expressive intent into sound remains a central question in the neuroscience of music. We recorded continuous 128-channel EEG from a professional, internationally active concert pianist during a concert-like, uninterrupted performance (~27 min) of six works by Bach, Beethoven, and Chopin. From the continuous recording, 99 two-second clean EEG segments were extracted and assigned to one of six previously validated performance-emotion categories based on independent listener evaluations (Joy, Peacefulness, Melancholy, Argumentative, Tension, Power). Each 2-s fragment contained 1,024 time points per channel, yielding 131,072 EEG data points. Cortical and subcortical source generators were reconstructed with standardized weighted Low-Resolution Electromagnetic Tomography (swLORETA), and activation was quantified both as frequency of occurrence and as dipole magnitude across three macro-regions (anterior, posterior, subcortical). A chi-square test on activation frequencies showed a significant association between cortical/subcortical region and emotional category. Repeated-measures ANOVAs revealed significant region- and emotion-dependent differences in dipole magnitude. Across virtually every emotional category, the left basal ganglia, left thalamus, and left precentral gyrus (BA4) emerged as the most consistently recruited generators, indicating a stable left-lateralized fronto-striato-thalamic axis subserving fine motor control within this performance. Superimposed on this stable motor substrate, emotion-specific modulations emerged: Joy was associated with the highest subcortical activation magnitude, while Melancholy showed the lowest subcortical magnitude together with a selective recruitment of right-hemisphere generators (right BA10, right somatosensory cortex, right insula), consistent with valence-based hemispheric asymmetry accounts. Pearson correlations further linked activation of the left basal ganglia, left thalamus, and left premotor cortex (BA6) to objective performance parameters (gestures per second, notes per phrase, acoustic intensity), suggesting that neurofunctional engagement scales with the motor complexity of the material performed. These findings provide a performer-side perspective complementary to models of music-evoked emotion largely derived from listeners, and suggest that, in this elite performer, expressive intent was instantiated in a specialized, left-dominant sensorimotor-limbic network modulated by affective valence. The study is complemented by animated audiovisual materials that dynamically trace the moment-to-moment evolution of LORETA source activity in synchrony with the unfolding musical passage.

PMID 42903125
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PubMedJournal of sports sciences2026-10-21

Using 360-video to investigate visual exploratory activity in 7v7 and 9v9 sided games in women's soccer.

Feist James J, Datson Naomi N, Runswick Oliver R OR, Pocock Chris C

Immersive technology such as 360-video offers opportunities to analyse visual exploratory activity (VEA) under varying task constraints in controlled experimental settings. The study aimed to investigate the effect of pitch location and sided‑game format on VEA and verbal action responses in 360-video. Nineteen sub-elite female soccer players (21 ± 4 years) viewed 40 soccer videos in a head-mounted display. Footage was recorded using a stationary GoPro 360 Max camera at eye height in defensive and attacking central midfield locations. VEA was measured as the number of "scans" away from the ball across 32 analysed trials. Upon receiving a pass in 360-video, participants simulated and verbalised an action to continue play. A 2 × 2 repeated‑measures ANOVA showed a significant main effect of pitch location (p = 0.016), with higher scan frequencies in defensive (0.31 ± 0.15 scans/s) than attacking midfield (0.29 ± 0.15 scans/s), with no significant effect of sided‑game or interaction effect (p > 0.05). Findings demonstrate players had significantly higher scan frequencies in defensive central midfield compared with attacking central midfield, with the most verbal actions per trial in the 9v9 attacking midfield condition. Future research should assess agreement between VEA measured in 360-video and on-field activities.

PMID 42902495
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PubMedPlant communications2026-10-21

Trait-Informed Machine Learning Improves Precise Genomic Selection and Hybrid Design in Wheat.

Pang Yunlong Y, Yan Qiang Q, Lu Yue Y, Wang Liming L et al.

Machine learning can unlock genomic selection (GS) for polygenic traits, but only if millions of SNPs are distilled into breeder-actionable loci. Here, we presented genome-wide association signal ranking with linkage disequilibrium pruning and Random Forest feature importance selection (GLRS), a trait-informed framework for deriving ultra-sparse marker sets for pure-line and hybrid GS breeding in wheat. Training on 768 diverse accessions phenotyped for nine yield-related traits across six environments and 570,441 SNPs, GLRS compressed markers for each trait to a few hundred yet raised cross-validation accuracy by 7.2% relative to conventional GS using random selected markers. Independent evaluation using a publicly available wheat dataset further supported the robustness and general applicability of the GLRS strategy. Validation in 1,163 advanced breeding lines from seven independent trials further demonstrated the robustness of GLRS, with prediction accuracy improvement of 14.4% and 5.8% over random markers and genome-wide association signal ranking with linkage disequilibrium pruning markers, respectively. GLRS also delivered accurate predictions of F1 performance (r = 0.790), general combining ability (r = 0.851) and heterosis (r = 0.541) in 292 hybrid combinations, enabling simultaneous hybrid wheat and elite inbred variety development. Finally, we proposed a combining-ability-based GS strategy for wheat pure-line and hybrid breeding. This study provided an efficient GLRS pipeline to facilitate the practical application of trait-informed GS in wheat high-yield breeding.

PMID 42902559
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PubMedPhysiological reports2026-10-20

Exercise in pregnant elite athletes: Physiological considerations, risks, and benefits.

Madera Ibelle I, Bhargava Vedanti V, Patel Jhillika J, Singh Kritika K et al.

The American College of Obstetricians and Gynecologists (ACOG) recommends engagement in moderate exercise throughout pregnancy, including aerobic and strengthening activities, which has been shown to offer numerous benefits during pregnancy. However, the intersection of pregnancy and athletics presents a unique set of challenges. ACOG guidelines on exercise during pregnancy primarily target recreational exercisers. Tailored recommendations are needed for pregnant elite athletes. This study examines both how pregnancy affects physiology and the risks/benefits of high-intensity exercise. Two independent reviews were conducted, using MESH search terms including "pregnant athletes," "female elite athlete," "maternal health," "exercise pregnancy." From 56 total studies, 40 studies with clinical data on over 4163 women, including elite athletes, were included in the review. Regular exercise during pregnancy can improve cardiovascular fitness and fetal vascular function while reducing risks of gestational diabetes, hypertensive disorders, delivering a large-for-gestational-age infant, and excessive weight gain. High-intensity activities can compromise fetal blood flow. Endurance athletes may safely maintain their training regimens during pregnancy, whereas those in high-altitude or contact sports require adjustments. Routine, non-intense exercise during pregnancy offers significant maternal and fetal health benefits. Future work should establish individualized recommendations supporting pregnant elite athlete health.

PMID 42897929
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PubMedPlant communications2026-10-20

Telomere-to-telomere genome assembly of the elite peanut cultivar Yuhua 15 identifies AhYABBY as a key regulator of pod and seed size.

Sun Ziqi Z, Qi Feiyan F, Wang Xiaobo X, Liu Hongfei H et al.

PMID 42897845
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