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AM

amiodarone (Nexterone / PM101 / amiodarone, Prism)

✓ Approved

Baxter International, Inc. · SCN5A · Small Molecule

What is amiodarone?

amiodarone is a small molecule developed by Baxter International, Inc.. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesNexterone, PM101, amiodarone, Prism
CompanyBaxter International, Inc.
Drug ClassSmall Molecule
Molecular TargetSCN5A
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Baxter International, Inc.

Mechanism of Action

Molecular Targets

amiodarone acts on 1 molecular target:

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

amiodarone is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersVentricular fibrillation✓ Approved
Cardiac disordersVentricular tachycardia✓ Approved

Related Research Articles

PubMedClinical ophthalmology (Auckland, N.Z.)2026-10-20

Outcomes of Simultaneous Three- or Four-Horizontal Muscle Surgery for Very Large-Angle Convergence Insufficiency-Type and Basic-Type Exotropia.

Yagasaki Ayaka A, Yagasaki Teiji T, Ichikawa Kazuo K

We investigated the outcomes of simultaneous three- or four-horizontal muscle surgery for very large-angle exotropia (> 60 prism diopters [Δ]). This retrospective study included 24 patients (16 with convergence insufficiency-type and 8 with basic-type exotropia). The deviation angle was measured using the alternate prism and cover test, and stereopsis was evaluated. Patients were classified into three groups (F: ≤ 60 arcsec ("), C: 60"<, and N: nil stereoacuity). A successful motor outcome was defined as ≤ 10Δ of orthotropia. Pre- and postoperative results were compared. Mean preoperative exodeviation at distance and near were 75.2 ± 13.0Δ and 89.2 ± 18.0Δ, respectively. Mean age at surgery was 47.8 ± 16.5 years, and mean follow-up period was 3.6 ± 4.2 years. Thirteen and 11 patients underwent four- and three-muscle surgeries, respectively. The mean distant and near deviations at 3 months postoperatively and at the final visit were 5.3 ± 10.4Δ and 8.4 ± 9.5Δ, 5.5 ± 8.6Δ and 9.4 ± 9.0Δ, respectively. No differences were found in the near and distant deviations between the two time points. The motor success rates at both time points were 63%. Stereopsis at the final visit improved significantly from F:4%, C:38%, and N:58% before surgery to F:38%, C:50% and N:13% at the final visit (P = 0.002, McNemar-Bowker test). Three- or four-horizontal muscle surgeries for very large-angle exotropia are effective in achieving favorable motor outcomes and stereopsis.

PMID 42898777
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PubMedApplied optics2026-10-20

On the use of Sanderson prisms for variable beam separation FLDI applications.

Berger Alexandre R AR, Benitez Elizabeth K EK, Borg Matthew P MP

The effect of variable beam separation on the performance of focused laser differential interferometry (FLDI) in detecting second-mode instabilities is investigated experimentally using what we believe to be a novel co-linear Sanderson prism-based FLDI and schlieren system. Experiments are conducted in a Mach-6 Ludwieg Tube on a 7° cone with a sharp nose tip. Beam separations of 100, 150, 250, and 400 µm are tested. The 250 µm case provides the clearest spectral peaks, highest coherence, and highest in-band to out-of-band root-mean-square (RMS) amplitude ratio. Overall, diagnostic performance improves with increasing beam separation, consistent with trends predicted by previous FLDI simulations. The reduced performance for the 400 µm separation is attributed to its lower position within the boundary layer. These results illustrate the importance of matching beam separation to the relevant flow structure scales.

PMID 42900066
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PubMedThe Journal of innovations in cardiac rhythm management2026-10-20

Failure of Implantable Cardioverter-defibrillator Pacing Capture in BRASH Syndrome with Severe Hyperkalemia.

Roche Stephen S, Kanan Michael M, Mikhalkova Deana D

This case report describes a 54-year-old woman with end-stage renal disease and heart failure who presented with BRASH syndrome: a synergistic cycle of bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia. The patient, who was adherent to metoprolol and amiodarone, presented with a profound ventricular escape rhythm of 16 bpm and hemodynamic instability after missing 4 days of hemodialysis. An interesting complication was the failure of her implantable cardioverter-defibrillator (ICD) to achieve pacing capture, a phenomenon likely driven by a potassium level of 7.8 mEq/L causing myocardial inexcitability. Additionally, the recent uptitration of a carotid sinus nerve stimulator for baroreflex activation therapy may have contributed to the bradycardic cycle. Immediate medical management of hyperkalemia with calcium, insulin, and dextrose successfully restored ICD capture, followed by emergent dialysis, which normalized her rhythm. This case emphasizes that BRASH syndrome should be considered in undifferentiated bradycardia, particularly when refractory to atropine, and highlights that correcting the underlying metabolic derangement is essential to restoring cardiac excitability and device function.

PMID 42899269
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PubMedBMC ophthalmology2026-10-20

Motor alignment and sensory outcomes in pediatric patients with basic-type intermittent exotropia after bilateral lateral rectus recession versus unilateral recession-resection.

Simsek Merve M, Sabaner Mehmet Cem MC, Yunlu Nida N, Simsek Cem C et al.

To compare motor alignment and sensory outcomes after bilateral lateral rectus recession (BLR) versus unilateral lateral rectus recession with medial rectus resection (R&R) in children with basic-type intermittent exotropia (IXT). This retrospective cohort study included 48 patients with basic-type IXT who underwent BLR (n = 26) or unilateral R&R (n = 22). Assessments were performed preoperatively and at 1 month and 1 year postoperatively. Deviation angles were measured in prism diopters (PD). Near stereopsis was analyzed after log transformation, and sensory status was evaluated using the Worth 4-dot test. The primary outcome was 1-year motor success, defined as a residual deviation ≤ 10 PD. Baseline characteristics were similar between groups (all p > 0.05). Motor success rates were comparable between BLR and R&R at 1 month (92% vs. 91%; p = 1.000) and 1 year (88% vs. 86%; p = 1.000). Orthophoria rates (77% vs. 68%; p = 0.497) and reoperation rates (12% vs. 14%; p = 0.827) were also similar. Deviation decreased significantly over time (p < 0.001). Stereopsis improved postoperatively and was maintained at 1 year (p < 0.001). In an exploratory multivariable analysis, higher preoperative deviation was associated with lower odds of motor success (aOR 0.71; p = 0.024); however, this estimate should be interpreted cautiously because of the limited number of failure events. BLR and unilateral R&R yielded comparable motor and sensory outcomes at 1 year postoperatively in basic-type IXT. The exploratory association between higher preoperative deviation and lower motor success requires confirmation in larger cohorts.

PMID 42897512
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PubMedBMC medicine2026-10-20

Targeted lipidomics unveils complex lipids in cervicovaginal environment as diagnostic and prognostic biomarkers for endometrial cancer.

Garwolinska Anita A, Łaniewski Paweł P, Herbst-Kralovetz Melissa M MM

Global incidence of endometrial cancer (EC) is on the rise. EC-associated risk factors like obesity, metabolic syndrome, and genetic predisposition increase a person's risk for developing EC in their lifetime and negatively affect prognostic outcomes. Present methods for EC diagnosis rely on invasive endometrial biopsies or dilation and curettage. Our previous global untargeted metabolomics analysis of minimally invasive cervicovaginal lavage (CVL) samples revealed an enrichment in simple lipid signatures associated with EC presence and pathophysiology. This study investigated complex lipids beyond those reported previously, with intent to identify novel lipid biomarkers for accurate, minimally invasive EC detection and prognosis. We analysed 223 CVL samples collected by a physician from women diagnosed with EC (n = 66), benign pathological conditions (n = 108) and asymptomatic, healthy women (n = 49). The concentrations (nmol/mL) of 914 individual lipid species, 14 lipid classes and 28 fatty acid (FA) side chains were detected across CVL samples using the Complex Lipid Targeted Panel (Metabolon Inc.). Tumour size, grade, myometrial invasion, and mismatch repair (MMR) status in women with EC were determined from histopathologic reports. MetaboAnalyst and Prism were used for statistical and biomarker analysis which included Receiver Operating Characteristic (ROC) curves, measuring the Area Under the Curve (AUC) and Youden Index (J). Women with EC exhibited significant enrichment of neutral lipid species, especially those containing long chained polyunsaturated fatty acid side chains. Cholesteryl ester (CE) species, specifically CE(22:4), were consistently identified as top predictive features when applied individually and when incorporated into multivariable diagnostic models. A 10-feature model developed in the exploratory dataset, discriminated EC from a combined group of benign and healthy controls with ≥75% sensitivity and specificity when validated using previously internal held-out samples. Top predictive CE species for EC also held prognostic value as they related to MMR status and histologic type. These findings revealed EC-associated alterations in lipid metabolism within the cervicovaginal environment, highlighting the potential use of complex lipid species detected in CVLs as minimally invasive diagnostic biomarkers for EC and markers associated with EC prognostic features.

PMID 42897615
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PubMedPediatric nephrology (Berlin, Germany)2026-10-19

Differential associations of early fluid accumulation with acute kidney injury and mortality in critically ill children: a prospective cohort study with mediation and propensity-score analyses.

Angadi Akshata A, Bhargava Maneesha M, Mehta Amarjeet A

Cumulative fluid accumulation (FA), historically termed fluid overload, is reported to increase mortality in critically ill children, but whether its associations differ across renal and mortality outcomes-and whether any mortality association reflects a direct pathway, confounding, or mediation via acute kidney injury (AKI)-is unresolved. We applied convergent causal-inference methods. In a prospective cohort of 360 children (1 month-18 years) admitted ≥24 h to a tertiary paediatric intensive care unit, early fluid accumulation (first 24 h, Goldstein formula; historically termed fluid overload) was dichotomised at ≥5%. AKI (AKI Network criteria); secondary outcomes: PICU mortality, mechanical ventilation duration, length of stay. sequential multivariable regression, restricted cubic splines, propensity score matching, additive/multiplicative interaction, incremental discrimination, and exploratory mediation, all adjusted for the Paediatric Risk of Mortality III (PRISM III) score. FA ≥ 5% occurred in 23.1%, AKI in 24.7%, mortality 19.4%. FA predicted AKI (adjusted OR 4.45; propensity-matched 2.72), with a non-linear dose-response inflecting at 2-5%. FA did not predict mortality: the crude association disappeared on AKI adjustment, the adjusted spline was flat, the matched estimate was null (OR 1.36), and FA added negligibly to PRISM III discrimination (ΔAUC 0.007). AKI dominated mortality (10.0% to 77.8% stagewise); the FA×AKI interaction was sub-additive; mediation attributed FA's small total association to AKI. FA was associated with longer PICU stay and ventilation. Early FA shows differential associations: a potentially modifiable risk marker for AKI, associated with longer intensive care, but not independently associated with death once severity and AKI are considered. Limiting early FA may be a reasonable target for AKI prevention, although this requires interventional confirmation; PRISM III remains the mortality-prognostic tool.

PMID 42895576
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