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CSF-G

✓ Approved

Dong-A ST · CSF3R · Recombinant Proteins

What is CSF-G?

CSF-G is a recombinant proteins developed by Dong-A ST. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

CompanyDong-A ST
Drug ClassRecombinant Proteins
Molecular TargetCSF3R
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Dong-A ST

Mechanism of Action

Molecular Targets

CSF-G acts on 1 molecular target:

CSF3Rcolony stimulating factor 3 receptor (CD114, GCSFR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

CSF-G is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersNeutropenia✓ Approved

Related Research Articles

PubMedImmunotherapy advances2026-07-25

Growth factor supportive care for chemotherapy-induced neutropenia suppresses antitumour immunity in checkpoint blockade-responsive pancreatic cancer.

Parent Brendan D BD, Kelly Anthony E AE, Hoffman Megan T MT, Dougan Michael M et al.

Growth factors, including granulocyte colony-stimulating factor (G-CSF; pegfilgrastim, filgrastim), are used for prophylaxis or treatment of chemotherapy-induced neutropenia, yet their effects on antitumour immunity remain incompletely understood. We previously found that serum from patients with pancreatic ductal adenocarcinoma (PDAC) treated with multiagent chemotherapy plus G-CSF drove differentiation of T cell-suppressive monocytes in vitro, suggesting that supportive care interventions may shape immune responses in this disease. We evaluated the immunologic and therapeutic impact of G-CSF in two murine PDAC models that differ in their baseline frequencies of infiltrating T cells and in their responsiveness to checkpoint blockade immunotherapy. In poorly immunogenic, T-cell-low tumours, use of G-CSF did not affect tumour growth or response to chemo- or immunotherapy, although neutrophil recovery was improved in mice receiving FOLFIRINOX and G-CSF compared to chemotherapy alone. In immunogenic tumours with a robust endogenous T-cell response, combination anti-PD1 and anti-CTLA-4 therapy resulted in durable tumour clearance. Combination with G-CSF diminished the effectiveness of checkpoint blockade and resulted in significantly fewer cured mice. G-CSF, commonly used for supportive care with FOLFIRINOX and other chemotherapy regimens, induces systemic immune suppression that can reduce the efficacy of T-cell-targeting immunotherapies.

PMID 42500327
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PubMedMedicine2026-07-25

Integrated analysis of scRNA-seq and TCR-seq on T cells in aneurysmal subarachnoid hemorrhage: A descriptive, hypothesis-generating case study.

Meng Ningqin N, Li Xingrao X, Ye Ziming Z, Xie Xufeng X et al.

This studthe transcriptomic profiles and T cell receptor (TCR) repertoires of T cells in paired cerebrospinal fluid (CSF) and peripheral blood (PB) from 2 patients with aneurysmal subarachnoid hemorrhage (SAH). This descriptive work primarily generates research hypotheses and does not explore causal biological mechanisms. Single-cell RNA sequencing (scRNA-seq) and T cell receptor sequencing (TCR-seq) were performed on T cells isolated from CSF and PB samples collected on day 7 post-onset from 2 male patients. A series of descriptive analyses were conducted, including T cell subset classification, pseudotime trajectory reconstruction, pathway enrichment, CellChat-based cell-cell communication analysis, and TCR clonality assessment. Public scRNA-seq data of CSF samples from 8 healthy individuals were downloaded from the Gene Expression Omnibus database and used as external healthy controls. A total of 6058 T cells for scRNA-seq and 5008 T cells for TCR-seq were analyzed in this study. Five distinct T cell subsets were observed. In these 2 patients, CSF-derived T cells showed stronger signaling pathway activation and increased clonal expansion than PB-derived T cells. Compared with healthy controls from the public dataset, T cells from SAH patients presented enhanced signaling pathway activity and more extensive cell-cell interactions. All above observations are limited to these 2 individuals and cannot be generalized to all SAH patients without large independent cohort validation. This descriptive case-based study establishes a high-resolution single-cell atlas of T cells from 2 SAH patients. The observed differences between CSF and PB, as well as between SAH patients and healthy controls, provide directions for future mechanistic investigations.

PMID 42499108
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PubMedJournal of immunology (Baltimore, Md. : 1950)2026-07-25

Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation.

Yeo Franklin J FJ, Wang Mengbo M, Park Sungtae S, Rodriguez J Alejandra JA et al.

Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT) effects mediated by donor T cells. However, up to 60% of recipients develop graft-versus-host disease (GVHD), with intestinal involvement being a major contributor to morbidity and mortality. While CD8 T cells drive GVT, CD4 T helper (Th) cells are largely the key mediators of intestinal GVHD. Although IFN-γ-producing Th1 cells have been implicated in this process, recent evidence suggests a more complex role for Th cell subtypes. In our study, we identify the transcription factor GATA3, often associated with Th2 function, as a key regulator of Th cell proliferation, gut persistence, and cytokine production. Specifically, donor cell GATA3 was required for the early production of gut‑damaging granzyme A by intestinal Th cells and sustained granulocyte-macrophage colony-stimulating factor (GM‑CSF) production at later phases of the intestinal GVHD response. GATA3‑mediated maintenance of GM‑CSF expression during these later stages of disease was associated with increased intestinal eosinophil recruitment and activation, features that have been linked to GVHD severity in humans. Collectively, our findings demonstrate that GATA3‑expressing Th cells contribute to intestinal GVHD pathogenesis by sustaining GM-CSF-driven inflammatory circuits and promoting chronic eosinophilia. Targeting GATA3, or its downstream effector pathways, may therefore represent a novel therapeutic strategy to attenuate intestinal GVHD while preserving the overall efficacy of HCT.

PMID 42498264
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PubMedIndian journal of clinical biochemistry : IJCB2026-07-25

hsa-miR-885-5p As Post Transcription Regulator of Matrix metalloproteinase 9 in Tuberculous Meningitis.

Aggarwal Apoorva A, Singla Neeraj N, Konar Monidipa M, Kaur Maninder M et al.

Matrix metalloproteinase 9 (MMP9) has a potent role in neuroinflammation in tuberculous meningitis (TBM). Recent researches have highlighted the regulation of MMP9 levels by microRNAs, thereby altering their level and affecting critical functions, such as blood-brain barrier integrity. In this study, the activity of MMP9 was assessed by gelatin zymography, and the expression of hsa-miR-885-5p was evaluated by qRT-PCR in the cerebrospinal fluid (CSF) of TBM patients and healthy controls (HC). MMP9 expression was observed in the CSF of TBM patients only and none in HC. Additionally, hsa-miR-885-5p expression was significantly downregulated in TBM patients compared to healthy controls. These findings suggest that the dysregulation of hsa-miR-885-5p may lead to altered MMP9 levels in TBM patients, contributing to neuroinflammation. Therefore, targeting these microRNAs could serve as a new treatment modality to combat neuroinflammation in TBM patients.

PMID 42500334
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PubMedCureus2026-07-25

Coccidioidal Meningitis in an Immunocompetent Patient: A Rare Central Nervous System Infection.

Chávez Durón Norlando José NJ, Aragón Conrado Lorenzo E LE, Robleto Francgiliz J FJ, Zeledon Ledixa L et al.

Coccidioidomycosis is a systemic fungal infection caused by Coccidioides immitis and Coccidioides posadasii. Although well recognized in parts of the southwestern United States, it remains underdiagnosed in Mexico and Central America. While most cases present as self-limited pulmonary infection, approximately 1% of immunocompetent individuals develop disseminated disease, with coccidioidal meningitis (CM) being the most severe manifestation. We describe a 46-year-old immunocompetent male from Oaxaca, Mexico, who presented with progressive headache, neurocognitive decline, and altered mental status. Initial cerebrospinal fluid (CSF) analysis suggested cryptococcal meningitis, yet cryptococcal antigen testing and fungal cultures were negative. Empirical antifungal therapy produced only partial improvement. Given his occupational exposure in Texas and evolving clinical course, coccidioidomycosis was suspected. Serologic testing (enzyme immunoassay, EIA) and a coccidioidin skin test were positive, and prolonged CSF culture ultimately yielded Coccidioides spp., confirming CM. High-dose fluconazole led to progressive neurologic recovery, and the patient remains asymptomatic on maintenance therapy. This case highlights the diagnostic challenges of CM in regions where coccidioidomycosis is not traditionally considered endemic. Non-specific presentations and initial negative studies may delay diagnosis, underscoring the importance of epidemiologic suspicion, repeated testing, and prolonged fungal culture. Early recognition and timely initiation of azole therapy are essential to prevent the high morbidity and mortality associated with this condition.

PMID 42500770
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PubMedRSC advances2026-07-25

LC-MS/MS-based phytochemical characterization and biological activities of the endemic species Stachys milasensis.

Sisik Busra B, Sarikurkcu Cengiz C

Stachys milasensis Ö. Güner is a recently described endemic species of Türkiye for which phytochemical and biological data are currently unavailable. In this study, aqueous and methanolic extracts obtained from the aerial parts of S. milasensis were comprehensively evaluated for their phenolic composition, antioxidant capacity, and enzyme inhibitory activities. Total phenolic and flavonoid contents were determined spectrophotometrically, while individual phytochemicals were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Antioxidant properties were assessed by DPPH, ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), phosphomolybdenum, and metal-chelating assays, whereas enzyme inhibitory activities against cholinesterases, tyrosinase, α-amylase, and α-glucosidase were investigated. The methanolic extract exhibited higher total phenolic and flavonoid contents, reaching 77.69 mg gallic acid equivalents (GAE) per g extract and 71.53 mg rutin equivalents (RE) per g extract, respectively. LC-MS/MS analysis identified chlorogenic acid as the predominant constituent in both extracts, with concentrations of 10 613 and 11 160 µg g-1 extract in the aqueous and methanolic extracts, respectively. The methanolic extract also contained considerable amounts of verbascoside (730 µg g-1 extract), hyperoside (95.5 µg g-1 extract), and luteolin-7-glucoside (83.4 µg g-1 extract). Among the antioxidant assays, the methanolic extract demonstrated stronger DPPH radical scavenging (96.80 mg trolox equivalents (TE) per g extract), CUPRAC (297.89 mg TE per g extract), and FRAP (157.56 mg TE per g extract) activities. Furthermore, among the tested extracts, the methanolic extract exhibited the highest inhibitory activities against α-glucosidase (1009.48 mg acarbose equivalents (ACE) per g extract), α-amylase (247.54 mg ACE per g extract), and tyrosinase (67.79 mg kojic acid equivalents (KAE) per g extract). This study provides the first comprehensive phytochemical and biological characterization of S. milasensis, contributes the chemotaxonomic knowledge of the genus Stachys, and establishes a foundation for future comparative phytochemical studies.

PMID 42500417
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