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SH-U-454

✓ Approved

Bayer AG · Small Molecule · Small Molecule

What is SH-U-454?

SH-U-454 is a small molecule developed by Bayer AG. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

CompanyBayer AG
Drug ClassSmall Molecule, Imaging Agents
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Bayer AG

Therapeutic Indications

SH-U-454 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersArteriosclerosis coronary artery✓ Approved

Related Research Articles

PubMedBehavior therapy2026-06-12

Efficacy of the STEP-Home Transdiagnostic Group Workshop to Improve Functioning, Anger, and Impulse Control in Post-9/11 U.S. Veterans: A Randomized Clinical Trial.

Fortier Catherine B CB, Kenna Alexandra A, Katz Dylan D, Currao Alyssa A et al.

Post-9/11 U.S. combat veterans are clinically complex with multiple co-occurring mental and physical health conditions that often lead to difficulty reintegrating and functioning in civilian life after military service. Difficulty controlling anger is the most frequently reported reintegration problem and is often present across a wide range of both mental and physical conditions. This randomized controlled trial tested the efficacy of the STEP-Home (SH) transdiagnostic intervention compared to Present Centered Group Therapy (PCGT) to improve functioning and impulse control/anger in veterans. One hundred and eighty-four (139M/45F) post-9/11 U.S. military veterans were randomized to either 12 sessions of SH or PCGT. Assessments were conducted at baseline, posttreatment, and 3-month follow-up. Linear mixed model analysis was based on intention to treat. Primary outcomes were reintegration functioning and impulse control/anger. At follow-up, SH and PCGT conditions demonstrated improvements in reintegration functioning with moderate to large within-group effect sizes (SH d = 0.86; PCGT d = 0.69). SH showed improvements in impulse control/anger with a moderate within-group effect size (d = 0.74). A significant Treatment x Time interaction indicated that SH uniquely improved impulse control/anger (B = -5.35, 95% CI: -8.39, -2.30). Both SH and PCGT improved daily functioning across multiple domains but only SH improved impulse control/anger. SH expands available treatment options for veterans that suffer from multiple co-occurring psychological and physical injuries and conditions common after combat. Transdiagnostic integrative approaches to mental health can address common symptoms across diagnostic categories and reduce treatment wait time offering efficient, acceptable alternatives to single modality treatment approaches.

PMID 42276693
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PubMedInternational journal of molecular sciences2026-06-12

An Exploratory Study of High-Concentration Trace Amine Effects and Adrenoceptor Expression Patterns in SH-SY5Y Cells and Neuroblastoma.

Lopachev Aleksandr V AV, Kazanskaya Rogneda B RB, Gainetdinov Raul R RR, Kanov Evgeny V EV et al.

The antitumoral activity of monoamine receptor ligands appears to be important as a potential approach to cancer medication. In the present study, we evaluated the effects of trace amine compounds, including octopamine, tyramine, 3-methoxytyramine, and synephrine, on SH-SY5Y neuroblastoma cells. Previously, these compounds exhibited TAAR1-specific activity at nanomolar concentrations. However, in SH-SY5Y neuroblastoma cells, the effect of octopamine and 3-methoxytyramine was identified in concentrations of 1000 µM or above and is apparently non-specific. Neither public transcriptomic datasets nor qPCR analysis detected significant TAAR1 expression in SH-SY5Y cells, suggesting that the observed effects may be mediated by adrenoceptors. Among these, ADRA2C was the most highly expressed in SH-SY5Y cells. Analysis of transcriptomic data from the GEO database revealed that adrenoceptors are widely expressed in neuroblastomas. The expression profiles of adrenoceptors in tumors are polymorphic and more complex than in SH-SY5Y cells. Thus, the effects of trace amines on other neuroblastoma cell lines and in vivo tumors warrant further investigation, and the involvement of adrenoceptors in this process may be speculated. Our findings suggest the non-specific activity of trace amines against tumor cells, with a paradoxical stimulatory effect in differentiated neuroblastoma cells, which highlights the need for caution in studies involving TAAR1-specific compounds.

PMID 42278562
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PubMedFoods (Basel, Switzerland)2026-06-12

Comprehensive Extraction of Shrimp Head Lipids and Peptides from Litopenaeus vannamei: Evaluation of Neuroprotective Potential and Constituent Analysis.

Zhao Jiawen J, Zhou Longjian L, Liu Yayue Y, Yang Zhiyou Z et al.

The increasing prevalence of Alzheimer's disease has created a substantial and urgent need for brain-healthy functional foods. The processing of Pacific white shrimp (Litopenaeus vannamei) generates considerable amounts of head waste, which is rich in bioactive compounds, including lipids and peptides, holding great promise for the development of nutraceuticals to support human brain health. However, traditional extraction methods are time-consuming and inefficient in fully utilizing these compounds. This study aimed to explore the functional properties of these shrimp head-derived ingredients using "one-step" three-phase partitioning (TPP) followed by successive proteolysis. The extracted polar lipid (PL-SH), protein (P-SH) and proteolytic peptidic product (Pep-SH) from shrimp heads were screened for their antioxidant, neuroprotective, and anti-neuroinflammatory activities. Antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+), and hydroxyl free radical scavenging assays, all of which revealed strong antioxidant potential for all three products. Neuroprotective activities were assessed using HT-22 mouse hippocampal neuronal cells challenged with Aβ25-35, and anti-neuroinflammatory activities were evaluated using BV-2 microglial cells stimulated with lipopolysaccharide (LPS). The results suggested that both PL-SH and Pep-SH exerted protective effects against Aβ25-35-induced cell damage under the tested conditions, and PL-SH also reduced nitric oxide (NO) production induced by LPS, indicating potential anti-neuroinflammatory activity. However, further studies with additional biomarkers (e.g., ROS, apoptosis markers, and cytokines) are required to confirm these effects. The lipid composition of PL-SH was further characterized by thin-layer chromatography and LC-MS/MS-based lipidomics, revealing various classes of phospholipids. Furthermore, analysis of the molecular weight distribution and sequences of peptides in Pep-SH revealed peptide sizes ranging from 70 to 1700 Da and a high degree of homology to known antioxidant and neuroprotective peptide sequences. These findings suggest that lipids and peptides from Pacific white shrimp heads possess valuable functional properties, supporting their potential use in the development of functional foods for neuroprotection and anti-neuroinflammation.

PMID 42279785
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PubMedScientific reports2026-06-12

Synthesis of thiol-functionalized metal phthalocyanines-silver nanoparticles assemblies and their photophysics.

Suman Victor V, Airinei Anton A, Potlog Tamara T

In this paper, the photophysical properties of thiol-functionalized zinc phthalocyanine (ZnPc(SH)8) conjugated with silver nanoparticles (AgNPs) were investigated. AgNPs were synthesized using modified citrate and tannic acid reduction methods, producing nanoparticles with distinct plasmonic features. ZnPc(SH)8 was obtained via cyclotetramerization of tetra(alkylthio)phthalonitrile in the presence of zinc acetate and subsequently conjugated to AgNPs through thiol anchoring groups. UV-Vis spectroscopy confirmed the formation of ZnPc(SH)8/AgNPs assemblies, showing characteristic ZnPc Soret and Q bands alongside AgNPs surface plasmon resonance bands. Variations in absorption intensity and band positions reflected differences in nanoparticle size, aggregation, and coupling strength. Fluorescence measurements revealed plasmon-mediated modulation of ZnPc emission, including quenching and enhancement effects depending on the AgNPs characteristics. Transient absorption spectroscopy indicated dominant ground-state bleaching and long-lived excited or charge-separated states, suggesting plasmon-molecule coupling and charge-transfer dynamics. Time-resolved fluorescence showed shortened singlet lifetimes in the presence of AgNPs, while phosphorescence measurements revealed prolonged triplet-state lifetimes, consistent with modified radiative and non-radiative decay pathways induced by plasmonic interactions. These results demonstrate that AgNPs conjugation significantly alters the photophysical behavior of ZnPc(SH)8, highlighting the potential of ZnPc(SH)8/AgNPs nanocomposites as plasmon-enhanced photosensitizers for photodynamic therapy and other photonic applications.

PMID 42277105
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PubMedWork (Reading, Mass.)2026-06-12

Psychometric properties of the Arabic version of the short professional quality of life scale in nurses.

Alelayan Hasan H

BackgroundProfessional quality of life (ProQoL) encompasses the positive and negative experiences associated with one's professional role. Accurate assessment of ProQoL necessitates psychometrically sound instruments.ObjectiveThis study examined the reliability and validity of the Short Professional Quality of Life Scale (Sh-ProQoL) in a sample of Arab nurses.MethodsA cross-sectional design was employed using convenience sampling. The study included 200 nurses from hospitals in Dubai. Psychometric evaluation comprised assessments of reliability and inter-scale correlations. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to determine the factor structure. Convergent validity was assessed through average variance extracted (AVE) and Pearson correlation coefficients between the Ar-Sh-ProQoL and external measures: Job Satisfaction (JS), Perceived Quality of Care (PQC), and Intention to Leave (ITL).ResultsThe scale and its subscales demonstrated strong internal consistency, with test-retest reliability coefficients of ICC ≥ 0.70. EFA and CFA supported a 3-factor structure for the Ar-Sh-ProQoL, explaining 74.57% of the total variance. Factor loadings from EFA ranged from 0.73 to 0.87, and CFA yielded acceptable fit indices: χ2/df = 1.51, RMSEA = 0.05, GFI = 0.96 and CFI = 0.98. Square root AVE values ranged from 0.87 to 0.88, and AVE values ranged from 0.75 to 0.80, confirming strong discriminant and convergent validity. The scale also showed significant correlations with JS (r = 0.51), PQC (r = 0.45), and ITL (r = 0.48).ConclusionThe Ar-Sh-ProQoL demonstrated robust psychometric properties and is a valid and reliable instrument for assessing the ProQoL among Arab nurses.Conclusion: The Ar-Sh-ProQoL, consisting of nine items, demonstrated robust psychometric properties and is a valid and reliable instrument for assessing the professional quality of life among Arab nurses.

PMID 42283226
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PubMedBiophysical journal2026-06-12

Second harmonic imaging of membrane potentials: comparing water and chromophores as probes.

Swiderska Iwona I, Lee Seonwoo S, Flór Mischa M, Roke Sylvie S

The electrostatic potential of lipid membranes is an important metric to gain insight into the physiological state of cells. Second harmonic (SH) imaging has emerged as a powerful tool to perform in-situ and in-vivo electrostatic potential measurements, either using targeted probes, or label-free by using water as a probe. In this work we compare both modalities, by performing SH imaging on freestanding lipid membranes (FLMs) in aqueous solutions. Correlating the SH intensity to an applied external potential bias, the resonant voltage probe and the water response display distinctly different responses, which can be traced back to different nonlinear optical mechanisms. These mechanisms ensure that the water imaging provides a clean readout of the transmembrane potential, while the chromophore emission reports on the surface potential in the leaflet where it resides in, together with differences in chromophore density, structure and tilt angles. This means that, while both methods may show similar results, they cannot be compared directly. A combination of both methods is suggested as a useful strategy as the water response is accurate but currently limited to sub-second temporal resolution, while the resonant probe permits a sub-millisecond temporal resolution, but is hampered by convoluted structural effects and chemical modification.

PMID 42281207
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