diclofenac (Oxa Gel / diclofenac, topical)

✓ Approved

Actavis · PTGS1 · Small Molecule

What is diclofenac?

diclofenac is a small molecule developed by Actavis. It is approved for therapeutic indications via transdermal.

diclofenac acts on 2 molecular targets:

PTGS1	prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2	prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)

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There are currently 78 clinical trials registered

Trial ID	Phase	Title	Status
NCT06510062	Phase 1	Comparative Evaluation of Sustained Acoustic Medicine Device on Circulation	Completed
NCT04402047	NA	Electroacupuncture vs Topical Diclofenac Sodium Gel for Patients With Hand Osteoarthritis: Study Pro	Unknown
NCT04421911	Phase 3	A Study to Comparing the Efficacy and Safety of the Ketoprofen and Diclofenac in Patients With Osteo	Completed
NCT00276419	Phase 2	Topical Diclofenac for the Treatment of Noncyclic Breast Pain	Terminated
NCT00471393	NA	Double-blind Randomized Clinical Study on Topical Diclofenac Efficacy in Symptomatic Relief of Tempo	Completed
NCT01761071	Phase 3	Time Serial Analysis on Preemptive Analgesia of Preoperative Topical Diclofenac and Ketorolac in Pho	Completed

+74 more trials available with a free account

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diclofenac is developed for 5 unique indications across 3 therapeutic areas.

Therapeutic Area	Condition	Phase
Musculoskeletal and connective tissue disorders	Musculoskeletal pain	✓ Approved
Musculoskeletal and connective tissue disorders	Myositis	✓ Approved
Musculoskeletal and connective tissue disorders	Rheumatoid arthritis	✓ Approved
Injury, poisoning and procedural complications	Traumatic shock	✓ Approved
Skin and subcutaneous tissue disorders	Actinic keratosis	Phase III